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Cited by 209Visual perception and processing mechanismsNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Critical Period Plasticity Matches Binocular Orientation Preference in the Visual Cortex

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Wang, Bor-Shuen, Sarnaik, Rashmi, Cang, Jianhua·2010·Neuron
DOI 10.1016/j.neuron.2010.01.002PMC PMC2822731
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Abstract

SUMMARY Changes of ocular dominance in the visual cortex can be induced by visual manipulations during a critical period in early life. However, the role of critical period plasticity in normal development is unknown. Here we show that at the onset of this time window, the preferred orientations of individual cortical cells in the mouse are mismatched through the two eyes and the mismatch decreases and reaches adult levels by the end of the period. Deprivation of visual experience during this period irreversibly blocks the binocular matching of orientation preference, but has no effect in adulthood. The critical period of binocular matching can be delayed by long-term visual deprivation from birth, like that of ocular dominance plasticity. These results demonstrate that activity-dependent changes induced by normal visual experience during the well-studied critical period serve to match eye-specific inputs in the cortex, thus revealing a physiological role for critical period plasticity during normal development.

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Crossref · 10.1016/j.neuron.2010.01.002

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  • A major function of critical period plasticity is to promote experience-dependent matching of orientation tuning through the two eyes.

    “A major function of critical period plasticity is to promote the experience-dependent matching of orientation tuning through the two eyes (42).”

    From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [42]

  • Shortly after eye opening, V1 neurons exhibit orientation tuning and respond to both eyes, but orientation preference is binocularly mismatched; this mismatch is progressively corrected through visual experience during the critical period.

    “Shortly after eye opening, V1 neurons exhibit orientation tuning and respond to stimulus to both eyes, but the orientation preference is binocularly mismatched.This initial mismatch is then progressively corrected through visual experience during the critical period, such that individual binocular neurons become tuned to similar orientations through the two eyes (42),”

    From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [42]

  • The degree of binocular orientation matching in ~P30 MeCP2-null mice is significantly worse than age-matched WT and remains at a pre-critical-period level.

    “The degree of matching in ∼P30 MeCP2 -/y mice was significantly worse than agematched WTs (which had reached the adult level by P30, Fig. 7L) and in fact remained at a level preceding the critical period (∼P20 WT mice) and similar to that observed after long-term visual deprivation from birth (42).”

    From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [42]

  • Those cells are tuned to matching orientations in both eyes.

    “that are tuned to the same orientation in the two eyes [97]”

    From Role of emergent neural activity in visual map development (2014) · cites this paper as [97]

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Authors
Wang, B.-S., Sarnaik, R., & Cang, J.
Affiliations
Northwestern University (US)
Corresponding author
Cang, Jianhua
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2010-01
Volume
65
Issue
2
Pages
246-256
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2010.01.002
PMC
PMC2822731
OpenAlex
W2014906957
Cited by
209
References
6
Citations by year
2026: 10 · 2025: 13 · 2024: 9 · 2023: 15 · 2022: 17 · 2021: 11 · 2020: 18 · 2019: 15 · 2018: 8 · 2017: 21 · 2016: 11 · 2015: 7 · 2014: 15 · 2013: 18 · 2012: 8
FWCI
7.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Brain Research Foundation
  • Neurosciences Research Foundation
  • Stryker
  • National Eye Institute (EY-018621, R01EY018621)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
critical period plasticity, ocular dominance, visual cortex development, visual deprivation, orientation maps, binocular matching, activity-dependent development, mouse visual system
MeSH terms
Age Factors, Animals, Animals, Newborn, Mice, Inbred C57BL, Neuronal Plasticity, Orientation, Photic Stimulation, Sensory Deprivation, Visual Cortex, Vision, Binocular, Mice

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