Sensory experience during locomotion promotes recovery of function in adult visual cortex
Open accessAbstract
Recovery from sensory deprivation is slow and incomplete in adult visual cortex. In this study, we show that visual stimulation during locomotion, which increases the gain of visual responses in primary visual cortex, dramatically enhances recovery in the mouse. Excitatory neurons regained normal levels of response, while narrow-spiking (inhibitory) neurons remained less active. Visual stimulation or locomotion alone did not enhance recovery. Responses to the particular visual stimuli viewed by the animal during locomotion recovered, while those to another normally effective stimulus did not, suggesting that locomotion promotes the recovery only of the neural circuits that are activated concurrent with the locomotion. These findings may provide an avenue for improving recovery from amblyopia in humans.
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Locomotion paired with visual stimuli dramatically enhances recovery of visual responses in mice with monocular deprivation in an NMDA receptor-dependent manner, whereas locomotion or visual stimuli alone are insufficient to rescue such responses.
“Locomotion paired with visual stimuli dramatically enhances the recovery of visual responses in mice with monocular deprivation in an NMDA receptor-dependent manner, whereas locomotion or visual stimuli alone are insufficient to rescue such responses56.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [56]
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- Authors
- Kaneko, M., & Stryker, M. P.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Stryker, Michael P
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2014-06-26
- Volume
- 3
- Pages
- e02798-e02798
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC4070284
- OpenAlex
- W2165750738
- Cited by
- 126
- References
- 27
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 14 · 2023: 8 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 12 · 2018: 9 · 2017: 22 · 2016: 12 · 2015: 9 · 2014: 5
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (NIH) (R01 EY02874, T32 MH089920)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- sensory deprivation, visual cortex, locomotion, amblyopia, primary visual cortex, excitatory neurons, inhibitory interneurons, visual stimulation, mouse model
- MeSH terms
- Amblyopia, Animals, Disease Models, Animal, Humans, Locomotion, Mice, Inbred C57BL, Neurons, Photic Stimulation, Physical Conditioning, Animal, Sensory Deprivation, Visual Cortex, Recovery of Function, Mice
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