The DOI matches its Crossref record; 231 of the 232 references it cites were found in a registry or an index.
The Science of Stroke: Mechanisms in Search of Treatments
Open accessAbstract
This review focuses on mechanisms and emerging concepts that drive the science of stroke in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing evidence has led to the realization that the biological processes underlying stroke are driven by the interaction of neurons, glia, vascular cells, and matrix components, which actively participate in mechanisms of tissue injury and repair. As new targets are identified, new opportunities emerge that build on an appreciation of acute cellular events acting in a broader context of ongoing destructive, protective, and reparative processes. The burden of disease is great, and its magnitude widens as a role for blood vessels and stroke in vascular and nonvascular dementias becomes more clearly established. This review then poses a number of fundamental questions, the answers to which may generate new directions for research and possibly new treatments that could reduce the impact of this enormous economic and societal burden.
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“The brain depends on a continuous blood supply, and interruption of cerebral blood flow (CBF) leads to brain dysfunction and death.86”
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Liu, D., Cheng, T., Guo, H., Fernández, J. A., Griffin, J. H., Song, X., & Zloković, B. V. (2004) · Nature Medicine · doi:10.1038/nm1122 · Cited by 198
RetractedTakahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Nitric Oxide and Peroxynitrite in Health and Disease
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Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
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Pathobiology of ischaemic stroke: an integrated view
Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943
Self-citationHeart Disease and Stroke Statistics—2009 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Carnethon, M. R., SIMONE, G. D., Ferguson, T. B., Flegal, K. M., Ford, E. S., Furie, K. L., Go, A. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191259 · Cited by 3,915
Regeneration beyond the glial scar
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1 of the 232 references couldn’t be matched to a known paper.
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Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Self-citationNeurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
Self-citationThe Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857
“On the other hand, if the reduction in CBF is sustained and severe, ischemic stroke ensues (Moskowitz et al., 2010).”
Self-citationHallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789
Metadata
- Authors
- Moskowitz, M. A., Lo, E. H., & Iadecola, C.
- Affiliations
- Massachusetts General Hospital (US)
- Weill Cornell Medicine (US)
- Corresponding author
- Moskowitz, Michael A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 67
- Issue
- 2
- Pages
- 181-198
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2957363
- OpenAlex
- W2063541896
- Cited by
- 1,930
- References
- 232
- Citations by year
- 2026: 76 · 2025: 108 · 2024: 99 · 2023: 118 · 2022: 136 · 2021: 183 · 2020: 140 · 2019: 140 · 2018: 125 · 2017: 152 · 2016: 129 · 2015: 114 · 2014: 125 · 2013: 104 · 2012: 101
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-10-06)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS034179, R01NS037853)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- stroke, stroke pathophysiology, neurovascular interactions, glial cells, vascular cells, extracellular matrix, tissue damage, tissue repair, vascular dementia, stroke burden
- MeSH terms
- Animals, Blood Vessels, Humans, Models, Biological, Risk Factors, Cost of Illness, Stroke
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