The DOI matches its Crossref record; 231 of the 232 references it cites were found in a registry or an index.
The Science of Stroke: Mechanisms in Search of Treatments
Open accessAbstract
This review focuses on mechanisms and emerging concepts that drive the science of stroke in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing evidence has led to the realization that the biological processes underlying stroke are driven by the interaction of neurons, glia, vascular cells, and matrix components, which actively participate in mechanisms of tissue injury and repair. As new targets are identified, new opportunities emerge that build on an appreciation of acute cellular events acting in a broader context of ongoing destructive, protective, and reparative processes. The burden of disease is great, and its magnitude widens as a role for blood vessels and stroke in vascular and nonvascular dementias becomes more clearly established. This review then poses a number of fundamental questions, the answers to which may generate new directions for research and possibly new treatments that could reduce the impact of this enormous economic and societal burden.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The brain depends on a continuous blood supply, and interruption of cerebral blood flow (CBF) leads to brain dysfunction and death.86”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Liu, D., Cheng, T., Guo, H., Fernández, J. A., Griffin, J. H., Song, X., & Zloković, B. V. (2004) · Nature Medicine · doi:10.1038/nm1122 · Cited by 198
RetractedTakahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
Bernard, S. A., Gray, T. W., Buist, M., Jones, B. M., Silvester, W., Gutteridge, G. A., & Smith, K. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa003289 · Cited by 5,388
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Pathobiology of ischaemic stroke: an integrated view
Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943
Self-citationHeart Disease and Stroke Statistics—2009 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Carnethon, M. R., SIMONE, G. D., Ferguson, T. B., Flegal, K. M., Ford, E. S., Furie, K. L., Go, A. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191259 · Cited by 3,915
Regeneration beyond the glial scar
Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140
Flagged first, then by citations
1 of the 232 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Self-citationNeurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
Self-citationThe Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857
“On the other hand, if the reduction in CBF is sustained and severe, ischemic stroke ensues (Moskowitz et al., 2010).”
Self-citationHallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789
Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed
Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748
The Vascular Endothelium and Human Diseases
Rajendran, P., Rengarajan, T., Thangavel, J., Nishigaki, Y., Sakthisekaran, D., Sethi, G., & Nishigaki, I. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.7502 · Cited by 1,550
Neuroinflammation: friend and foe for ischemic stroke
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1516-2 · Cited by 1,479
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242
Chamorro, Á., Dirnagl, U., Urra, X., & Planas, A. M. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00114-9 · Cited by 1,198
Inflammation and Stroke: An Overview
Anrather, J., & Iadecola, C. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0483-x · Cited by 966
Self-citationCentral nervous system pericytes in health and disease
Winkler, E. A., Bell, R. D., & Zlokovic, B. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2946 · Cited by 962
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Qin, C., Yang, S., Chu, Y., Zhang, H., Pang, X., Chen, L., Zhou, L., Chen, M., Tian, D., & Wang, W. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01064-1 · Cited by 997
Immune responses to stroke: mechanisms, modulation, and therapeutic potential.
Iadecola, C., Buckwalter, M. S., & Anrather, J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135530 · Cited by 853
Self-citationThe biphasic function of microglia in ischemic stroke
Ma, Y., Wang, J., Wang, Y., & Yang, G.-Y. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.005 · Cited by 655
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications
Tuo, Q., Zhang, S., & Lei, P. (2021) · Medicinal Research Reviews · doi:10.1002/med.21817 · Cited by 758
History and progress of hypotheses and clinical trials for Alzheimer’s disease
Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723
Dyall, S. C., Balas, L., Bazan, N. G., Brenna, J. T., Chiang, N., Souza, F. D. C., Dalli, J., Durand, T., Galano, J., Lein, P. J., et al. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101165 · Cited by 707
Animal models of ischemic stroke and their application in clinical research
Kleinschnitz, C., Fluri, F., & Schuhmann, M. K. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s56071 · Cited by 664
The blood-brain barrier: an engineering perspective
Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E., & Searson, P. C. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00007 · Cited by 662
Pathogenic mechanisms following ischemic stroke
Khoshnam, S. E., Winlow, W., Farzaneh, M., Farbood, Y., & Moghaddam, H. F. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2938-1 · Cited by 636
Ischemic stroke: experimental models and reality
Sommer, C. J. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1667-0 · Cited by 599
Cui, Y., Zhang, Y., Zhao, X., Shao, L., Liu, G., Sun, C., Xu, R., & Zhang, Z. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.003 · Cited by 605
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
Liu, Z., & Chopp, M. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.008 · Cited by 610
Maida, C. D., Norrito, R. L., Daidone, M., Tuttolomondo, A., & Pinto, A. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186454 · Cited by 594
Removing brakes on adult brain plasticity: From molecular to behavioral interventions
Bavelier, D., Levi, D. M., Li, R. W., Dan, Y., & Hensch, T. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4812-10.2010 · Cited by 589
Engaging neuroscience to advance translational research in brain barrier biology
Neuwelt, E. A., Bauer, B., Fahlke, C. M., Fricker, G., Iadecola, C., Janigro, D., Leybaert, L., Molnár, Z., O’Donnell, M. E., Povlishock, J. T., et al. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn2995 · Cited by 594
Self-citationNeurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease
Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.016 · Cited by 559
The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
Iadecola, C. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0718-6 · Cited by 557
Self-citationExosomes — beyond stem cells for restorative therapy in stroke and neurological injury
Zhang, Z. G., Buller, B., & Chopp, M. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0126-4 · Cited by 503
Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke
Alsbrook, D. L., Napoli, M. D., Bhatia, K., Biller, J., Andalib, S., Hinduja, A., Rodrigues, R., Rodriguez, M., Sabbagh, S. Y., Selim, M. H., et al. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01282-2 · Cited by 573
Leuschner, F., Rauch, P. J., Ueno, T., Gorbatov, R., Marinelli, B. S., Lee, W. W., Dutta, P., Wei, Y., Robbins, C. S., Iwamoto, Y., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111009 · Cited by 540
Self-citationMorrison, H. W., & Filosa, J. A. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-4 · Cited by 506
Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain
Shichita, T., Hasegawa, E., Kimura, A., Morita, R., Sakaguchi, R., Takada, I., Sekiya, T., Ooboshi, H., Kitazono, T., Yanagawa, T., et al. (2012) · Nature Medicine · doi:10.1038/nm.2749 · Cited by 455
Diverse roles of mitochondria in ischemic stroke
Yang, J., Mukda, S., & Chen, S. (2018) · Redox Biology · doi:10.1016/j.redox.2018.03.002 · Cited by 459
Yang, C., Zhang, X., Fan, H., & Liu, Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.009 · Cited by 444
Shi, Y., Zhang, L., Pu, H., Mao, L., Hu, X., Jiang, X., Xu, N., Stetler, R. A., Zhang, F., Liu, X., et al. (2016) · Nature Communications · doi:10.1038/ncomms10523 · Cited by 431
Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations
Pietrobon, D., & Moskowitz, M. A. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3770 · Cited by 424
Self-citationPathophysiologic Cascades in Ischemic Stroke
Xing, C., Arai, K., Lo, E. H., & Hommel, M. (2012) · International Journal of Stroke · doi:10.1111/j.1747-4949.2012.00839.x · Cited by 445
Self-citationIto, M., Shichita, T., Okada, M., Komine, R., Noguchi, Y., Yoshimura, A., & Morita, R. (2015) · Nature Communications · doi:10.1038/ncomms8360 · Cited by 417
Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke
Kanazawa, M., Ninomiya, I., Hatakeyama, M., Takahashi, T., & Shimohata, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102135 · Cited by 405
Wang, P., Shao, B., Deng, Z., Chen, S., Yue, Z., & Miao, C. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.01.001 · Cited by 400
Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments
George, P. M., & Steinberg, G. K. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.041 · Cited by 404
Stroke research at a crossroad: asking the brain for directions
Iadecola, C., & Anrather, J. (2011) · Nature Neuroscience · doi:10.1038/nn.2953 · Cited by 398
Self-citationSOD2 in mitochondrial dysfunction and neurodegeneration
Flynn, J. M., & Melov, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.027 · Cited by 390
Global Burden, Risk Factor Analysis, and Prediction Study of Ischemic Stroke, 1990–2030
Fan, J., Li, X., Yu, X., Liu, Z., Jiang, Y., Fang, Y., Zong, M., Suo, C., Man, Q., & Xiong, L. (2023) · Neurology · doi:10.1212/wnl.0000000000207387 · Cited by 380
Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke
Wang, L., Zhang, X., Xiong, X., Zhu, H., Chen, R., Zhang, S., Chen, G., & Jian, Z. (2022) · Antioxidants · doi:10.3390/antiox11122377 · Cited by 367
Phagocytosis executes delayed neuronal death after focal brain ischemia
Neher, J. J., Emmrich, J., Fricker, M., Mander, P. K., Théry, C., & Brown, G. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308679110 · Cited by 357
The emerging field of epigenetics in neurodegeneration and neuroprotection
Hwang, J.-Y., Aromolaran, K. A., & Zukin, R. S. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.46 · Cited by 353
Acute ischemic stroke therapy overview
Catanese, L., Tarsia, J., & Fisher, M. (2017) · Circulation Research · doi:10.1161/circresaha.116.309278 · Cited by 341
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics
Ajoolabady, A., Wang, S., Kroemer, G., Penninger, J. M., Uversky, V. N., Praticò, D., Henninger, N., Reiter, R. J., Bruno, A., JOSHIPURA, K. J., et al. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107848 · Cited by 334
Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials.
Liu, J., Wang, Y., Akamatsu, Y., Lee, C. C., Stetler, R. A., Lawton, M. T., & Yang, G.-Y. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.004 · Cited by 335
Pathogenesis of acute stroke and the role of inflammasomes
Fann, D. Y., Lee, S.-Y., Manzanero, S., Chunduri, P., Sobey, C. G., & Arumugam, T. V. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.004 · Cited by 334
Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia
Chen, S., Yang, D., Lin, T., Shaw, F.-Z., Liou, C., & Chuang, Y. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107199 · Cited by 339
Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury
Manzanero, S., Santro, T., & Arumugam, T. V. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.11.009 · Cited by 334
Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306
Microglia–blood vessel interactions: a double-edged sword in brain pathologies
Dudvarski Stankovic, N., Teodorczyk, M., Ploen, R., Zipp, F., & Schmidt, M. H. H. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1524-y · Cited by 301
Functional differences between microglia and monocytes after ischemic stroke
Ritzel, R. M., Patel, A. R., Grenier, J. M., Crapser, J., Verma, R., Jellison, E. R., & McCullough, L. D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0329-1 · Cited by 295
Bax regulates primary necrosis through mitochondrial dynamics
Whelan, R. S., Konstantinidis, K., Wei, A.-C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201608109 · Cited by 290
Alternative cell death mechanisms in development and beyondPreprint
Yuan, J., & Kroemer, G. (2010) · Genes & Development · doi:10.1101/gad.1984410 · Cited by 290
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy
Binet, F., Cagnone, G., Crespo-Garcia, S., Hata, M., Neault, M., Dejda, A., Wilson, A. M., Buscarlet, M., Mawambo, G. T., Howard, J. P., et al. (2020) · Science · doi:10.1126/science.aay5356 · Cited by 283
Machine Learning for Brain Stroke: A Review
Sirsat, M. S., Fermé, E., & Câmara, J. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105162 · Cited by 300
The Pericyte: A Forgotten Cell Type with Important Implications for A lzheimer's Disease?
Winkler, E. A., Sagare, A. P., & Zloković, B. V. (2014) · Brain Pathology · doi:10.1111/bpa.12152 · Cited by 284
RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research
Lapchak, P. A., Zhang, J. H., & Noble‐Haeusslein, L. J. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0209-2 · Cited by 272
Manganese Superoxide Dismutase and Oxidative Stress Modulation
Bresciani, G., da Cruz, I. B. M., & González‐Gallego, J. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.11.001 · Cited by 284
Macrae, I. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01398.x · Cited by 274
Inflammatory Disequilibrium in Stroke
Petrovic‐Djergovic, D., Goonewardena, S. N., & Pinsky, D. J. (2016) · Circulation Research · doi:10.1161/circresaha.116.308022 · Cited by 271
Perivascular microglia promote blood vessel disintegration in the ischemic penumbra
Jolivel, V., Bicker, F., Binamé, F., Ploen, R., Keller, S., Gollan, R., Jurek, B., Birkenstock, J., Poisa-Beiro, L., Bruttger, J., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1372-1 · Cited by 272
The neurovascular link in health and disease: molecular mechanisms and therapeutic implications
Quaegebeur, A., Lange, C., & Carmeliet, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.013 · Cited by 247
Prentice, H. M., Modi, J. P., & Wu, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/964518 · Cited by 263
Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila
Wu, S.-C., Cao, Z.-S., Chang, K.-M., & Juang, J. (2017) · Nature Communications · doi:10.1038/s41467-017-00040-6 · Cited by 261
Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential
Wu, Y., Wang, X., Zhou, X., Cheng, B., Li, G., & Bai, B. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00001 · Cited by 254
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke
Wu, L.-J., Wu, G., Sharif, M. R. A., Baker, A., Jia, Y., Fahey, F. H., Luo, H. R., Feener, E. P., & Clapham, D. E. (2012) · Nature Neuroscience · doi:10.1038/nn.3059 · Cited by 252
Neurovascular Dysfunction and Faulty Amyloid -Peptide Clearance in Alzheimer Disease
Sagare, A. P., Bell, R. D., & Zlokovic, B. V. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011452 · Cited by 251
The role of microglia and myeloid immune cells in acute cerebral ischemia
Benakis, C., García‐Bonilla, L., Iadecola, C., & Anrather, J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00461 · Cited by 259
Self-citationShichita, T., Ito, M., Morita, R., Komai, K., Noguchi, Y., Ooboshi, H., Koshida, R., Takahashi, S., Kodama, T., & Yoshimura, A. (2017) · Nature Medicine · doi:10.1038/nm.4312 · Cited by 253
Noninvasive Molecular Imaging of Neuroinflammation
Jacobs, A. H., Tavitian, B., & the INMiND consortium (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.53 · Cited by 245
The Ischemic Environment Drives Microglia and Macrophage Function
Fumagalli, S., Perego, C., Pischiutta, F., Zanier, E. R., & Simoni, M. G. D. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00081 · Cited by 261
Bano, D., & Prehn, J. H. M. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.03.016 · Cited by 241
Discovery and Development of Calcium Channel Blockers
Godfraind, T. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00286 · Cited by 252
Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage
Hernández‐Jiménez, M., Hurtado, O., Cuartero, M. I., Ballesteros, I., Moraga, A., Pradillo, J. M., McBurney, M. W., Lizasoaín, I., & Moro, M. Á. (2013) · Stroke · doi:10.1161/strokeaha.113.001715 · Cited by 234
Chassagnon, I. R., McCarthy, C. A., Chin, Y. K. ‐., Pineda, S. S., Keramidas, A., Mobli, M., Pham, V., Silva, T. M. D., Lynch, J. W., Widdop, R. E., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614728114 · Cited by 230
Redox signaling in cardiovascular health and disease
Madamanchi, N. R., & Runge, M. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.001 · Cited by 227
Exosomes in stroke pathogenesis and therapy
Zhang, Z. G., & Chopp, M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81133 · Cited by 228
Elkins, J., Veltkamp, R., Montaner, J., Johnston, S. C., Singhal, A. B., Becker, K., Lansberg, M. G., Tang, W., Chang, I., Muralidharan, K., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30357-x · Cited by 224
Advances in Acute Ischemic Stroke Therapy
Xiong, Y., Wakhloo, A. K., & Fisher, M. (2022) · Circulation Research · doi:10.1161/circresaha.121.319948 · Cited by 221
Post-Ischemic Inflammation in the Brain
Shichita, T., Sakaguchi, R., Suzuki, M., & Yoshimura, A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00132 · Cited by 221
Clonal Hematopoiesis Is Associated With Higher Risk of Stroke
Bhattacharya, R., Zekavat, S. M., Haessler, J., Fornage, M., Raffield, L. M., Uddin, M. M., Bick, A. G., Niroula, A., Yu, B., Gibson, C. J., et al. (2021) · Stroke · doi:10.1161/strokeaha.121.037388 · Cited by 217
The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke
Pawluk, H., Woźniak, A., Grześk, G., Kołodziejska, R., Kozakiewicz, M., Kopkowska, E., Grzechowiak, E., & Kozera, G. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s233909 · Cited by 218
Pathobiology of injury after stroke: the neurovascular unit and beyond
Dirnagl, U. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06691.x · Cited by 208
Wang, D., Liu, F., Zhu, L., Lin, P., Han, F., Wang, X., Tan, X., Lin, L., & Xiong, Y. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01921-2 · Cited by 211
Blondeau, N., Lipsky, R. H., Bourourou, M., Duncan, M. W., Gorelick, P. B., & Marini, A. M. (2015) · BioMed Research International · doi:10.1155/2015/519830 · Cited by 224
The impact of cerebrovascular aging on vascular cognitive impairment and dementia
Yang, T., Sun, Y., Lu, Z., Leak, R. K., & Zhang, F. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.007 · Cited by 214
Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases
Whitaker, R. M., Corum, D. G., Beeson, C., & Schnellmann, R. G. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103155 · Cited by 202
Pharmacological brain cytoprotection in acute ischaemic stroke — renewed hope in the reperfusion era
Fisher, M., & Savitz, S. I. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-021-00605-6 · Cited by 200
Li, Q., Zhang, T., Wang, J., Zhang, Z., Zhai, Y., Yang, G.-Y., & Sun, X. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.032 · Cited by 209
Targeting the Nrf2–Keap1 antioxidant defence pathway for neurovascular protection in stroke
Alfieri, A., Srivastava, S., Siow, R. C. M., Modo, M., Fraser, P. A., & Mann, G. E. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.210294 · Cited by 198
Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke
Baron, J. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0002-2 · Cited by 197
Protecting against vascular disease in brain
Faraci, F. M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01310.2010 · Cited by 196
Metadata
- Authors
- Moskowitz, M. A., Lo, E. H., & Iadecola, C.
- Affiliations
- Massachusetts General Hospital (US)
- Weill Cornell Medicine (US)
- Corresponding author
- Moskowitz, Michael A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 67
- Issue
- 2
- Pages
- 181-198
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2957363
- OpenAlex
- W2063541896
- Cited by
- 1,930
- References
- 232
- Citations by year
- 2026: 76 · 2025: 108 · 2024: 99 · 2023: 118 · 2022: 136 · 2021: 183 · 2020: 140 · 2019: 140 · 2018: 125 · 2017: 152 · 2016: 129 · 2015: 114 · 2014: 125 · 2013: 104 · 2012: 101
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-10-06)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS034179, R01NS037853)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- stroke, stroke pathophysiology, neurovascular interactions, glial cells, vascular cells, extracellular matrix, tissue damage, tissue repair, vascular dementia, stroke burden
- MeSH terms
- Animals, Blood Vessels, Humans, Models, Biological, Risk Factors, Cost of Illness, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
