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Cited by 289

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Prestin-Driven Cochlear Amplification Is Not Limited by the Outer Hair Cell Membrane Time Constant

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Johnson, Stuart L., Beurg, Maryline, Marcotti, Walter, Fettiplace, Robert·2011·Neuron
DOI 10.1016/j.neuron.2011.04.024
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Abstract

Outer hair cells (OHCs) provide amplification in the mammalian cochlea using somatic force generation underpinned by voltage-dependent conformational changes of the motor protein prestin. However, prestin must be gated by changes in membrane potential on a cycle-by-cycle basis and the periodic component of the receptor potential may be greatly attenuated by low-pass filtering due to the OHC time constant (τ(m)), questioning the functional relevance of this mechanism. Here, we measured τ(m) from OHCs with a range of characteristic frequencies (CF) and found that, at physiological endolymphatic calcium concentrations, approximately half of the mechanotransducer (MT) channels are opened at rest, depolarizing the membrane potential to near -40 mV. The depolarized resting potential activates a voltage-dependent K+ conductance, thus minimizing τ(m) and expanding the membrane filter so there is little receptor potential attenuation at the cell's CF. These data suggest that minimal τ(m) filtering in vivo ensures optimal activation of prestin.

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Metadata

Authors
Johnson, S. L., Beurg, M., Marcotti, W., & Fettiplace, R.
Venue
Neuron
Publisher
Elsevier BV
Published
2011-06
Volume
70
Issue
6
Pages
1143-1154
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2011.04.024
OpenAlex
W1964532154
Cited by
289
References
37
FWCI
12.10
Type
journal article
Language
en
Open access
hybrid

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