The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Open accessAbstract
SUMMARY Leptin acts in the brain to prevent obesity. The underlying neurocircuitry responsible for this is poorly understood, in part due to incomplete knowledge regarding first order, leptin-responsive neurons. To address this, we and others have been removing leptin receptors from candidate first order neurons. While functionally relevant neurons have been identified, the observed effects have been small suggesting that most first order neurons remain unidentified. Here we take an alternative approach and test whether first order neurons are inhibitory (GABAergic, VGAT+) or excitatory (glutamatergic, VGLUT2+). Remarkably, the vast majority of leptin’s anti-obesity effects are mediated by GABAergic neurons; glutamatergic neurons play only a minor role. Leptin, working directly on presynaptic GABAergic neurons, many of which appear not to express AgRP, reduces inhibitory tone to postsynaptic POMC neurons. As POMC neurons prevent obesity, their disinhibition by leptin action on presynaptic GABAergic neurons likely mediates, at least in part, leptin’s anti-obesity effects.
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
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Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
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Self-citationA molecular census of arcuate hypothalamus and median eminence cell types
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Metadata
- Authors
- Vong, L., Ye, C., Yang, Z., Choi, B., Chua, S., & Lowell, B. B.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 71
- Issue
- 1
- Pages
- 142-154
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2061072142
- Cited by
- 1,235
- References
- 21
- FWCI
- 17.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vong, L., Ye, C., Yang, Z., Choi, B., Chua, S., & Lowell, B. B. (2011). Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons. Neuron. https://doi.org/10.1016/j.neuron.2011.05.028
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