Neurobiology of food intake in health and disease

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326 · see citing works

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949 · see citing works

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works

Role of leptin in the neuroendocrine response to fasting

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061 · see citing works

Comment on: American Diabetes Association. Standards of Medical Care in Diabetes—2011. Diabetes Care 2011;34(Suppl. 1):S11–S61

Basevi, V., Mario, S. D., Morciano, C., Nonino, F., & Magrini, N. (2011) · Diabetes Care · doi:10.2337/dc11-0174 · Cited by 3,058 · see citing works

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works

10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study

Diabetes Prevention Program Research Group (2009) · The Lancet · doi:10.1016/s0140-6736(09)61457-4 · Cited by 3,020 · see citing works

Standards of medical care in diabetes—2011

American Diabetes Association (2011) · Diabetes Care · doi:10.2337/dc11-s011 · Cited by 2,880 · see citing works

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works

Gut hormone PYY3-36 physiologically inhibits food intake

Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351 · see citing works

Abnormal splicing of the leptin receptor in diabetic mice

Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327 · see citing works

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works

Changes in Energy Expenditure Resulting from Altered Body Weight

Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012 · see citing works

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works

A role for glucagon-like peptide-1 in the central regulation of feeding

Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950 · see citing works

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,902 · see citing works

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works

Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene

Farooqi, I. S., Keogh, J. M., Yeo, G. S. H., Lank, E. J., Cheetham, T., & O'Rahilly, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022050 · Cited by 1,778 · see citing works

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578 · see citing works

Cholecystokinin decreases food intake in rats.

Gibbs, J., Young, R. C., & Smith, G. P. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0034870 · Cited by 1,498 · see citing works

The role of depot fat in the hypothalamic control of food intake in the rat

Gc, K. (1953) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1953.0009 · Cited by 1,432 · see citing works

Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial

Heymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P., et al. (1999) · JAMA · doi:10.1001/jama.282.16.1568 · Cited by 1,422 · see citing works

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350 · see citing works

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,203 · see citing works

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171 · see citing works

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

Hahn, T. M., Breininger, J. F., Baskin, D. G., & Schwartz, M. W. (1998) · Nature Neuroscience · doi:10.1038/1082 · Cited by 1,164 · see citing works

A frameshift mutation in MC4R associated with dominantly inherited human obesity

Yeo, G. S. H., Farooqi, I. S., Aminian, S., Halsall, D. J., Stanhope, R. G., & O'Rahilly, S. (1998) · Nature Genetics · doi:10.1038/2404 · Cited by 1,159 · see citing works

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157 · see citing works

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157 · see citing works

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,122 · see citing works

The Need to Feed

Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120 · see citing works

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114 · see citing works

A frameshift mutation in human MC4R is associated with a dominant form of obesity

Vaisse, C., Clément, K., Guy-grand, B., & Froguel, P. (1998) · Nature Genetics · doi:10.1038/2407 · Cited by 1,091 · see citing works

Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial

Gadde, K. M., Allison, D. B., Ryan, D. H., Peterson, C. A., Troupin, B., Schwiers, M. L., & Day, W. W. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60205-5 · Cited by 1,064 · see citing works

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033 · see citing works

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014 · see citing works

Deconstruction of a neural circuit for hunger

Atasoy, D., Betley, J. N., Su, H. H., & Sternson, S. M. (2012) · Nature · doi:10.1038/nature11270 · Cited by 969 · see citing works

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935 · see citing works

Multicenter, placebo-controlled trial of lorcaserin for weight management.

Smith, S. R., Weissman, N. J., Anderson, C. M., Sanchez, M., Chuang, E., Stubbe, S., Bays, H., & Shanahan, W. R. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0909809 · Cited by 911 · see citing works

Obesity and leptin resistance: distinguishing cause from effect

Myers, M. G., Leibel, R. L., Seeley, R. J., & Schwartz, M. W. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.002 · Cited by 906 · see citing works

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in <i>ob/ob</i> Mice

Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904 · see citing works

Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding

Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · see citing works

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887 · see citing works

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879 · see citing works

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works

Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward

Kelley, A. E., Baldo, B. A., Pratt, W. E., & Will, M. J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.066 · Cited by 752 · see citing works

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

Tong, Q., Ye, C.-P., Jones, J. E., Elmquist, J. K., & Lowell, B. B. (2008) · Nature Neuroscience · doi:10.1038/nn.2167 · Cited by 689 · see citing works

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

Rossi, J., Balthasar, N., Olson, D., Scott, M., Berglund, E., Lee, C. E., Choi, M. J., Lauzon, D., Lowell, B. B., & Elmquist, J. K. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.010 · Cited by 672 · see citing works

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

Bagdade, J. D., Bierman, E. L., & Porte, D. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105646 · Cited by 672 · see citing works

Leptin Regulation of the Mesoaccumbens Dopamine Pathway

Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.006 · Cited by 644 · see citing works

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D., & Ashford, M. L. J. (1997) · Nature · doi:10.1038/37379 · Cited by 628 · see citing works

Leptin Regulates Striatal Regions and Human Eating Behavior

Farooqi, I. S., Bullmore, E., Keogh, J., Gillard, J., O'Rahilly, S., & Fletcher, P. C. (2007) · Science · doi:10.1126/science.1144599 · Cited by 622 · see citing works

Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

Cowley, M. A., Pronchuk, N., Fan, W., Dinulescu, D. M., Colmers, W. F., & Cone, R. D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80829-6 · Cited by 616 · see citing works

Genetic identification of a neural circuit that suppresses appetite

Carter, M. E., Soden, M. E., Zweifel, L. S., & Palmiter, R. D. (2013) · Nature · doi:10.1038/nature12596 · Cited by 587 · see citing works

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

Posey, K. A., Clegg, D. J., Printz, R. L., Byun, J., Morton, G. J., Vivekanandan-Giri, A., Pennathur, S., Baskin, D. G., Heinecke, J. W., Woods, S. C., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90377.2008 · Cited by 586 · see citing works

Endocrine and Metabolic Effects of Experimental Obesity in Man

Sims, E. A. H., Danforth, E., Horton, E. S., Bray, G. A., Glennon, J. A., & Salans, L. B. (1973) · Elsevier eBooks · doi:10.1016/b978-0-12-571129-6.50016-6 · Cited by 563 · see citing works

Insulin‐associated weight gain in diabetes – causes, effects and coping strategies

Russell-Jones, D. L., & Khan, R. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00686.x · Cited by 556 · see citing works

The Epidemiology of Obesity

Nguyen, D. M., & El-Serag, H. B. (2010) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2009.12.014 · Cited by 531 · see citing works

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J. (2000) · Nature Neuroscience · doi:10.1038/77660 · Cited by 495 · see citing works

The selfish brain: Competition for energy resources

Peters, A., Schweiger, U., Pellerin, L., Hubold, C., Oltmanns, K. M., Conrad, M., Schultes, B., Born, J., & Fehm, H. L. (2004) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.002 · Cited by 489 · see citing works

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

Wu, Q., Boyle, M. P., & Palmiter, R. D. (2009) · Cell · doi:10.1016/j.cell.2009.04.022 · Cited by 465 · see citing works

Differences in attention to food and food intake between overweight/obese and normal-weight females under conditions of hunger and satiety

Nijs, I. M. T., Muris, P., Euser, A. S., & Franken, I. H. A. (2009) · Appetite · doi:10.1016/j.appet.2009.11.004 · Cited by 448 · see citing works

Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice

Barrachina, M. D., Martínez, V., Wang, L., Wei, J. Y., & Taché, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10455 · Cited by 440 · see citing works

Role of Glucagon, Catecholamines, and Growth Hormone in Human Glucose Counterregulation

Rizza, R. A., Cryer, P. E., & Gerich, J. E. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109464 · Cited by 421 · see citing works

Modulation of Brain Reward Circuitry by Leptin

Fulton, S. E., Woodside, B. C., & Shizgal, P. (2000) · Science · doi:10.1126/science.287.5450.125 · Cited by 421 · see citing works

Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases

Swaab, D. F., Purba, J. S., & Hofman, M. A. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.2.7852523 · Cited by 421 · see citing works

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

Leinninger, G. M., Jo, Y.-H., Leshan, R. L., Louis, G. W., Yang, H., Barrera, J. G., Wilson, H., Opland, D. M., Faouzi, M. A., Gong, Y., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.011 · Cited by 412 · see citing works

Profound obesity associated with a balanced translocation that disrupts the SIM1 gene

L., J., Jr. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.1.101 · Cited by 400 · see citing works

Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake

Grill, H. J., Schwartz, M. W., Kaplan, J. M., Foxhall, J. S., Breininger, J., & Baskin, D. G. (2002) · Endocrinology · doi:10.1210/endo.143.1.8589 · Cited by 395 · see citing works

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.002 · Cited by 391 · see citing works

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

Sipols, A. J., Baskin, D. G., & Schwartz, M. W. (1995) · Diabetes · doi:10.2337/diab.44.2.147 · Cited by 389 · see citing works

Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat

LEIBOWITZ, S. F., Hammer, N. J., & Chang, K. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90366-8 · Cited by 384 · see citing works

Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats

West, D. B., Fey, D., & Woods, S. C. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.5.r776 · Cited by 378 · see citing works

The energy expenditure and food intake of individual men.

Edholm, O. G., Fletcher, J. G., Widdowson, E. M., & McCance, R. A. (1955) · British Journal Of Nutrition · doi:10.1079/bjn19550040 · Cited by 377 · see citing works

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

Krashes, M. J., Shah, B. P., Koda, S., & Lowell, B. B. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.009 · Cited by 373 · see citing works

Sixteen years and counting: an update on leptin in energy balance

Gautron, L., & Elmquist, J. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45888 · Cited by 367 · see citing works

Deciphering a neuronal circuit that mediates appetite

Wu, Q., Clark, M. S., & Palmiter, R. D. (2012) · Nature · doi:10.1038/nature10899 · Cited by 359 · see citing works

Prevention of Human Diabetic Ketoacidosis by Somatostatin

Gerich, J. E., Lorenzi, M., Bier, D. M., Schneider, V. B., Tsalikian, E., Karam, J. H., & Forsham, P. H. (1975) · New England Journal of Medicine · doi:10.1056/nejm197505082921901 · Cited by 353 · see citing works

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

Williams, K. W., Margatho, L. O., Lee, C. E., Choi, M., Lee, S., Scott, M. M., Elias, C. F., & Elmquist, J. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3118-09.2010 · Cited by 352 · see citing works

Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.

Baskin, D. G., Breininger, J. F., & Schwartz, M. W. (1999) · Diabetes · doi:10.2337/diabetes.48.4.828 · Cited by 351 · see citing works

The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man.

Garber, A. J., Cryer, P. E., Santiago, J. V., Haymond, M. W., Pagliara, A. S., & Kipnis, D. M. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108460 · Cited by 351 · see citing works

Adaptive thermogenesis in humans

Rosenbaum, M., & Leibel, R. L. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.184 · Cited by 349 · see citing works

Neurobiology of Feeding and Energy Expenditure

Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346 · see citing works

Targeting neurons and photons for optogenetics

Packer, A. M., Roska, B., & Häusser, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3427 · Cited by 345 · see citing works

Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion

van de Wall, E., Leshan, R., Xu, A. W., Balthasar, N., Coppari, R., Liu, S. M., Jo, Y. H., MacKenzie, R. G., Allison, D. B., Dun, N. J., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1132 · Cited by 338 · see citing works

Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size

Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332 · see citing works

Influence of oxytocin on feeding behavior in the rat

Arletti, R., Benelli, A., & Bertolini, A. (1989) · Peptides · doi:10.1016/0196-9781(89)90082-x · Cited by 328 · see citing works

Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade

Hagan, M. M., Rushing, P. A., Pritchard, L. M., Schwartz, M. W., Strack, A. M., der Ploeg, L. H. T. V., Woods, S. C., & Seeley, R. J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.1.r47 · Cited by 320 · see citing works

Homeostatic and Non‐homeostatic Pathways Involved in the Control of Food Intake and Energy Balance

Berthoud, H. (2006) · Obesity · doi:10.1038/oby.2006.308 · Cited by 309 · see citing works

Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

Williams, D. L., Baskin, D. G., & Schwartz, M. W. (2009) · Endocrinology · doi:10.1210/en.2008-1045 · Cited by 300 · see citing works

Oxytocin receptor-deficient mice developed late-onset obesity

Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3283021ca9 · Cited by 294 · see citing works

Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons

Morton, G. J., Gelling, R. W., Niswender, K. D., Morrison, C. D., Rhodes, C. J., & Schwartz, M. W. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.009 · Cited by 292 · see citing works

Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse

Wilding, J. P. H., Gilbey, S. G., Bailey, C. J., Batt, R. A., Williams, G., Ghatei, M. A., & Bloom, S. R. (1993) · Endocrinology · doi:10.1210/endo.132.5.7682936 · Cited by 285 · see citing works

Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats

Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283 · see citing works

All Bariatric Surgeries Are Not Created Equal: Insights from Mechanistic Comparisons

Stefater, M. A., Wilson, H., Chambers, A. P., Sandoval, D. A., & Seeley, R. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1044 · Cited by 281 · see citing works

Food reward, hyperphagia, and obesity

Berthoud, H.-R., Lenard, N. R., & Shin, A. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2011 · Cited by 275 · see citing works

The contribution of brain reward circuits to the obesity epidemic

Stice, E., Figlewicz, D. P., Gosnell, B. A., Levine, A. S., & Pratt, W. E. (2013) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.001 · Cited by 274 · see citing works

Neuronal circuits that regulate feeding behavior and metabolism

Sohn, J., Elmquist, J. K., & Williams, K. W. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.05.003 · Cited by 273 · see citing works

Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation

Ritter, S., Bugarith, K., & Dinh, T. T. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1097 · Cited by 257 · see citing works

Glucagon-Like Peptide 1 Receptors in Nucleus Accumbens Affect Food Intake

Dossat, A. M., Lilly, N., Kay, K. E., & Williams, D. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3262-11.2011 · Cited by 254 · see citing works

Leptin action in the forebrain regulates the hindbrain response to satiety signals

Morton, G. J., Blevins, J. E., Williams, D. L., Niswender, K. D., Gelling, R. W., Rhodes, C. J., Baskin, D. G., & Schwartz, M. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22081 · Cited by 253 · see citing works

Oxytocin inhibits food and fluid intake in rats

Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 246 · see citing works

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

Hayes, M. R., Skibicka, K. P., Leichner, T. M., Guarnieri, D. J., Dileone, R., Bence, K. K., & Grill, H. J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.009 · Cited by 245 · see citing works

Optogenetic pharmacology for control of native neuronal signaling proteins

Krämer, R., Mourot, A., & Adesnik, H. (2013) · Nature Neuroscience · doi:10.1038/nn.3424 · Cited by 240 · see citing works

Oxytocin Deficiency Mediates Hyperphagic Obesity of Sim1 Haploinsufficient Mice

Kublaoui, B. M., Gemelli, T., Tolson, K. P., Wang, Y., & Zinn, A. R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0067 · Cited by 239 · see citing works

Glucose-sensing neurons

Routh, V. H. (2002) · Physiology &amp; Behavior · doi:10.1016/s0031-9384(02)00761-8 · Cited by 237 · see citing works

Low sympathetic tone and obese phenotype in oxytocin-deficient mice

Camerino, C. (2009) · Obesity · doi:10.1038/oby.2009.12 · Cited by 235 · see citing works

Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis

Berglund, E. D., Liu, C., Sohn, J., Liu, T., Kim, M. H., Lee, C. E., Vianna, C. R., Williams, K. W., Xu, Y., & Elmquist, J. K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70338 · Cited by 230 · see citing works

Central leptin modulates behavioral and neural responsivity to CCK

Emond, M. H., Schwartz, G. J., Ladenheim, E. E., & Moran, T. H. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1545 · Cited by 225 · see citing works

Experimental obesity in man.

Sims, E. A. H., Goldman, R. F., Gluck, C., Horton, E. S., Kelleher, P. C., & Rowe, D. W. (1968) · PubMed · Cited by 224 · see citing works

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

Fujikawa, T., Chuang, J.-C., Sakata, I., Ramadori, G., & Coppari, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008025107 · Cited by 221 · see citing works

Adiposity signals and food reward: expanding the CNS roles of insulin and leptin

Figlewicz, D. P. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00602.2002 · Cited by 221 · see citing works

GLP-1 and energy balance: an integrated model of short-term and long-term control

Barrera, J. G., Sandoval, D. A., D'Alessio, D. A., & Seeley, R. J. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.77 · Cited by 220 · see citing works

Hypoglycemia in Type 1 Diabetes

McCrimmon, R. J., & Sherwin, R. S. (2010) · Diabetes · doi:10.2337/db10-0103 · Cited by 216 · see citing works

Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats

Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2011 · Cited by 213 · see citing works

Role of the CNS Melanocortin System in the Response to Overfeeding

Hagan, M. M., Rushing, P. A., Schwartz, M. W., Yagaloff, K. A., Burn, P., Woods, S. C., & Seeley, R. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02362.1999 · Cited by 210 · see citing works

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

Thaler, J. P., Guyenet, S. J., Dorfman, M. D., Wisse, B. E., & Schwartz, M. W. (2013) · Diabetes · doi:10.2337/db12-1605 · Cited by 203 · see citing works

Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin

Havel, P. J., Uriu-Hare, J. Y., Liu, T., Stanhope, K. L., Stern, J. S., Keen, C. L., & Ahrén, B. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.5.r1482 · Cited by 198 · see citing works

Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels

Sohn, J., Xu, Y., Jones, J. E., Wickman, K., Williams, K. W., & Elmquist, J. K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.012 · Cited by 196 · see citing works

Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands

Giraudo, S. Q., Billington, C. J., & Levine, A. S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00837-3 · Cited by 191 · see citing works

Increased hypothalamic neuropeptide Y expression following food deprivation

White, J. D., & Kershaw, M. (1990) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(90)90040-b · Cited by 190 · see citing works

Metabolic response to experimental overfeeding in lean and overweight healthy volunteers

Diaz, E., Prentice, A. M., Goldberg, G., Murgatroyd, P. R., & Coward, W. A. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/56.4.641 · Cited by 187 · see citing works

Sweet talk in the brain: Glucosensing, neural networks, and hypoglycemic counterregulation

Watts, A. G., & Donovan, C. M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.006 · Cited by 176 · see citing works

Rare variants in single-minded 1 (SIM1) are associated with severe obesity

Ramachandrappa, S., Raimondo, A., Cali, A. M. G., Keogh, J. M., Henning, E., Saeed, S., Thompson, A., Garg, S., Bochukova, E. G., Brage, S., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68016 · Cited by 172 · see citing works

The Timing of Meals.

STRUBBE, J. H., & Woods, S. C. (2004) · Psychological Review · doi:10.1037/0033-295x.111.1.128 · Cited by 171 · see citing works

Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia

German, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2011) · Endocrinology · doi:10.1210/en.2010-0890 · Cited by 169 · see citing works

Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin

Blevins, J. E., Eakin, T. J., Murphy, J. A., Schwartz, M. W., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.036 · Cited by 164 · see citing works

Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance

Leshan, R. L., Greenwald-Yarnell, M. L., Patterson, C. M., Gonzalez, I. E., & Myers, M. G. (2012) · Nature Medicine · doi:10.1038/nm.2724 · Cited by 163 · see citing works

Hypothalamic mechanisms in cachexia

Grossberg, A. J., Scarlett, J. M., & Marks, D. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.011 · Cited by 160 · see citing works

Chronic administration of OB protein decreases food intake by selectively reducing meal size in female rats

Eckel, L. A., Langhans, W., Kahler, A., Campfield, L. A., Smith, F. J., & Geary, N. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.1.r186 · Cited by 159 · see citing works

Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features

Bonnefond, A., Raimondo, A., Stutzmann, F., Ghoussaini, M., Ramachandrappa, S., Bersten, D. C., Durand, E., Vatin, V., Balkau, B., Lantieri, O., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68035 · Cited by 152 · see citing works

The parabrachial nucleus and conditioned taste aversion

Reilly, S. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00173-7 · Cited by 146 · see citing works

NPY/AgRP neurons are not essential for feeding responses to glucoprivation

Luquet, S. H., Phillips, C. T., & Palmiter, R. D. (2006) · Peptides · doi:10.1016/j.peptides.2006.08.036 · Cited by 140 · see citing works

Leptin Deficiency Induced by Fasting Impairs the Satiety Response to Cholecystokinin

McMinn, J. E., Sindelar, D. K., Havel, P. J., & Schwartz, M. W. (2000) · Endocrinology · doi:10.1210/endo.141.12.7815 · Cited by 129 · see citing works

Regional brain response to visual food cues is a marker of satiety that predicts food choice

Mehta, S. H., Melhorn, S. J., Smeraglio, A., Tyagi, V., Grabowski, T. J., Schwartz, M. W., & Schur, E. A. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.042341 · Cited by 129 · see citing works

Neuronal regulation of homeostasis by nutrient sensing

Lam, T. K. T. (2010) · Nature Medicine · doi:10.1038/nm0410-392 · Cited by 125 · see citing works

Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

Lin, C.-Y., Higginbotham, D. A., Judd, R. L., & White, B. D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00489.2001 · Cited by 124 · see citing works

Cellular Warriors at the Battle of the Bulge

Marx, J. (2003) · Science · doi:10.1126/science.299.5608.846 · Cited by 121 · see citing works

Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus

Sergeyev, V., Broberger, C., Gorbatyuk, O. S., & Hökfelt, T. (2000) · Neuroreport · doi:10.1097/00001756-200001170-00023 · Cited by 119 · see citing works

Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

Ring, L. E., & Zeltser, L. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41985 · Cited by 115 · see citing works

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

Ryan, K. K., Woods, S. C., & Seeley, R. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.013 · Cited by 112 · see citing works

Energy regulatory signals and food reward

Figlewicz, D. P., & Sipols, A. J. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.03.002 · Cited by 111 · see citing works

Role of oxytocin signaling in the regulation of body weight

Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108 · see citing works

Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin‐induced diabetic rats

Hidaka, S., Yoshimatsu, H., Kondou, S., Tsuruta, Y., Oka, K., Noguchi, H., Okamoto, K., Sakino, H., Teshima, Y., Okeda, T., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0164com · Cited by 108 · see citing works

Pathophysiology and treatment of inflammatory anorexia in chronic disease

Braun, T. P., & Marks, D. L. (2010) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-010-0015-1 · Cited by 99 · see citing works

Adiposity Signaling and Biological Defense Against Weight Gain: Absence of Protection or Central Hormone Resistance?

Schwartz, M. W., & Niswender, K. D. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-0906 · Cited by 93 · see citing works

Decreased sensitivity of Zucker obese rats to the putative satiety agent cholecystokinin

McLaughlin, C. L., & Baile, C. A. (1980) · Physiology & Behavior · doi:10.1016/0031-9384(80)90119-5 · Cited by 91 · see citing works

Diet, behavior modification, and exercise: a review of obesity treatments from a long-term perspective.

Safer, D. J. (1991) · PubMed · Cited by 87 · see citing works

Energy balance in man studies carried out by the Division of Human Physiology, National Institute for Medical Research.

Edholm, O. G. (1977) · PubMed · Cited by 86 · see citing works

Lean-body-mass composition and resting energy expenditure before and after long-term overfeeding

Dériaz, O., Fournier, G., Tremblay, A., Després, J., & Bouchard, C. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/56.5.840 · Cited by 82 · see citing works

Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats

Kahler, A., Geary, N., Eckel, L. A., Campfield, L. A., Smith, F. J., & Langhans, W. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.1.r180 · Cited by 82 · see citing works

Minireview: The Value of Looking Backward: The Essential Role of the Hindbrain in Counterregulatory Responses to Glucose Deficit

Ritter, S., Li, A., Wang, Q., & Dinh, T. T. (2011) · Endocrinology · doi:10.1210/en.2010-1458 · Cited by 81 · see citing works

Neuropeptide Y Is Required for Hyperphagic Feeding in Response to Neuroglucopenia

Sindelar, D. K., Marie, L. S., Miura, G. I., Palmiter, R. D., McMinn, J. E., Morton, G. J., & Schwartz, M. W. (2004) · Endocrinology · doi:10.1210/en.2003-1727 · Cited by 78 · see citing works

Diet, Behavior Modification, and Exercise

Safer, D. J. (1991) · Southern Medical Journal · doi:10.1097/00007611-199112000-00015 · Cited by 73 · see citing works

Corrective responses in human food intake identified from an analysis of 7-d food-intake records

Bray, G. A., Flatt, J.-P., Volaufova, J., DeLany, J. P., & Champagne, C. M. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26289 · Cited by 72 · see citing works

Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons

Figlewicz, D. P., Stein, L. J., West, D., Porte, D., & Woods, S. C. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.250.5.r856 · Cited by 69 · see citing works

The physiology and pathophysiology of the neural control of the counterregulatory response

Beall, C., Ashford, M. L., & McCrimmon, R. J. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00531.2011 · Cited by 63 · see citing works

Lateral parabrachial nucleus lesions in the rat: aversive and appetitive gustatory conditioning

Reilly, S., & Trifunovic, R. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00263-x · Cited by 59 · see citing works

Lateral parabrachial nucleus lesions in the rat: neophobia and conditioned taste aversion

Reilly, S., & Trifunovic, R. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00517-2 · Cited by 52 · see citing works

5-Thio-D-glucose causes increased feeding and hyperglycemia in the rat

Ritter, R. C., & Slusser, P. G. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.238.2.e141 · Cited by 52 · see citing works

Intracerebroventricular (i.c.v.) Administration of Mouse Leptin in RatsBehavioral Specificity and Effects on Meal Patterns

Hulsey, M. G., LU, H., WANG, T., MARTIN, R., & Baile, C. A. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00180-2 · Cited by 37 · see citing works

Unchanged hypothalamic neuropeptide Y concentrations in hyperphagic, hypoglycemic rats: Evidence for specific metabolic regulation of hypothalamic NPY

Corrin, S. E., McCarthy, H. D., McKibbin, P. E., & Williams, G. (1991) · Peptides · doi:10.1016/0196-9781(91)90080-9 · Cited by 30 · see citing works

Hyperphagia induced by hypoglycemia in rats is independent of leptin and hypothalamic neuropeptide Y (NPY)

Dryden, S. D., Pickavance, L. C., Henderson, L., & Williams, G. (1998) · Peptides · doi:10.1016/s0196-9781(98)00106-5 · Cited by 21 · see citing works

Effect of Alloxan on Feed Consumption and on Replacement Therapy With Graded Levels of Insulin in Rats.

Kumaresan, P., & Turner, C. W. (1966) · Experimental Biology and Medicine · doi:10.3181/00379727-122-31180 · Cited by 14 · see citing works

Untitled work

Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4

Obesity Pathogenesis: An Endocrine Society Scientific Statement

Schwartz, M. W., Seeley, R. J., Zeltser, L. M., Drewnowski, A., Ravussin, E., Redman, L. M., & Leibel, R. L. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00111 · Cited by 727 · see citing works

Non-Homeostatic Body Weight Regulation Through a Brainstem-Restricted Receptor for GDF15

Hsu, J.-Y., Crawley, S., Chen, M., Ayupova, D. A., Lindhout, D. A., Higbee, J., Kutach, A., Joo, W., Gao, Z., Fu, D., et al. (2017) · Nature · doi:10.1038/nature24042 · Cited by 616 · see citing works

The hypothalamus

Saper, C. B., & Lowell, B. B. (2014) · Current Biology · doi:10.1016/j.cub.2014.10.023 · Cited by 423 · see citing works

Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists

Cena, H., Chiovato, L., & Nappi, R. E. (2020) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/clinem/dgaa285 · Cited by 356 · see citing works

Genetics and epigenetics in obesity

Rohde, K., Keller, M., la Cour Poulsen, L., Blüher, M., Kovacs, P., & Böttcher, Y. (2019) · Metabolism · doi:10.1016/j.metabol.2018.10.007 · Cited by 355 · see citing works

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

Siljee, J. E., Wang, Y., Bernard, A. A., Ersoy, B. A., Zhang, S., Marley, A., Von Zastrow, M., Reiter, J. F., & Vaisse, C. (2018) · Nature Genetics · doi:10.1038/s41588-017-0020-9 · Cited by 247 · see citing works

Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice

Bagarolli, R. A., Tobar, N., Oliveira, A. G., Araújo, T. G., Carvalho, B. M., Rocha, G. Z., Vecina, J. F., Calisto, K., Guadagnini, D., Prada, P. O., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.08.006 · Cited by 266 · see citing works

Parabrachial CGRP Neurons Control Meal Termination

Campos, C. A., Bowen, A. J., Schwartz, M. W., & Palmiter, R. D. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.006 · Cited by 262 · see citing works

A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

Fenselau, H., Campbell, J. N., Verstegen, A. M. J., Madara, J. C., Xu, J., Shah, B. P., Resch, J. M., Yang, Z., Mandelblat-Cerf, Y., Livneh, Y., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4442 · Cited by 233 · see citing works

Leptin dysregulation is specifically associated with major depression with atypical features: evidence for a mechanism connecting obesity and depression

Milaneschi, Y., Lamers, F., Bot, M., Drent, M. L., & Penninx, B. W. J. H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.023 · Cited by 209 · see citing works

The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits

Li, M. M., Madara, J. C., Steger, J. S., Krashes, M. J., Balthasar, N., Campbell, J. N., Resch, J. M., Conley, N. J., Garfield, A. S., & Lowell, B. B. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.028 · Cited by 195 · see citing works

The L-cell in nutritional sensing and the regulation of appetite

Spreckley, E. (2015) · Frontiers in Nutrition · doi:10.3389/fnut.2015.00023 · Cited by 198 · see citing works

Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit

D'Agostino, G., Lyons, D. J., Cristiano, C., Burke, L. K., Madara, J. C., Campbell, J. N., Garcia, A. P., Land, B. B., Lowell, B. B., Dileone, R. J., et al. (2016) · eLife · doi:10.7554/elife.12225 · Cited by 193 · see citing works

Integrative Physiology of Fasting

Secor, S. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150013 · Cited by 183 · see citing works

Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism

Vercruysse, P., Vieau, D., Blum, D., Petersén, Å., & Dupuis, L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00002 · Cited by 172 · see citing works

Selective Insulin Resistance in Homeostatic and Cognitive Control Brain Areas in Overweight and Obese Adults

Kullmann, S., Heni, M., Veit, R., Scheffler, K., Machann, J., Häring, H.-U., Fritsche, A., & Preissl, H. (2015) · Diabetes Care · doi:10.2337/dc14-2319 · Cited by 175 · see citing works

Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society

Mozaffarian, D., Agarwal, M., Aggarwal, M., Alexander, L., Apovian, C. M., Bindlish, S., Bonnet, J., Butsch, W. S., Christensen, S., Gianos, E., et al. (2025) · The American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.04.023 · Cited by 154 · see citing works

Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review

Bodnaruc, A. M., Prud’homme, D., Blanchet, R., & Giroux, I. (2016) · Nutrition &amp; Metabolism · doi:10.1186/s12986-016-0153-3 · Cited by 139 · see citing works

Nutritional priorities to support <scp>GLP</scp> ‐1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society

Mozaffarian, D., Agarwal, M., Aggarwal, M., Alexander, L., Apovian, C. M., Bindlish, S., Bonnet, J., Butsch, W. S., Christensen, S., Gianos, E., et al. (2025) · Obesity · doi:10.1002/oby.24336 · Cited by 143 · see citing works

Psychopharmacological advances in eating disorders

Himmerich, H., & Treasure, J. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1383895 · Cited by 119 · see citing works

Central insulin modulates food valuation via mesolimbic pathways

Tiedemann, L. J., Schmid, S. M., Hettel, J., Giesen, K., Francke, P., Büchel, C., & Brassen, S. (2017) · Nature Communications · doi:10.1038/ncomms16052 · Cited by 113 · see citing works

Intranasal insulin

Hallschmid, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12934 · Cited by 113 · see citing works

Postprandial glycaemic dips predict appetite and energy intake in healthy individuals

Wyatt, P., Berry, S. E., Finlayson, G., O’Driscoll, R., Hadjigeorgiou, G., Drew, D. A., Khatib, H. A., Nguyen, L. H., Linenberg, I., Chan, A. T., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00383-x · Cited by 109 · see citing works

FGF21 and the physiological regulation of macronutrient preference

Hill, C. M., Qualls-Creekmore, E., Berthoud, H.-R., Soto, P., Yu, S., McDougal, D. H., Münzberg, H., & Morrison, C. D. (2020) · Endocrinology · doi:10.1210/endocr/bqaa019 · Cited by 99 · see citing works

A tale of two circuits: CCK NTS neuron stimulation controls appetite and induces opposing motivational states by projections to distinct brain regions

Roman, C. W., Sloat, S. R., & Palmiter, R. D. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.06.049 · Cited by 89 · see citing works

Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation

Belfort-DeAguiar, R., & Seo, D. (2018) · Current Obesity Reports · doi:10.1007/s13679-018-0303-1 · Cited by 84 · see citing works

Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress

Diz-Chaves, Y., Herrera-Pérez, S., González-Matías, L. C., Lamas, J. A., & Mallo, F. (2020) · Nutrients · doi:10.3390/nu12113304 · Cited by 84 · see citing works

Exploring the concept of homeostasis and considering its implications for economics

Damasio, A., & Damasio, H. (2016) · Journal of Economic Behavior &amp; Organization · doi:10.1016/j.jebo.2015.12.003 · Cited by 70 · see citing works

Modulation of midbrain neurocircuitry by intranasal insulin

Edwin Thanarajah, S., Iglesias, S., Kuzmanovic, B., Rigoux, L., Stephan, K. E., Brüning, J. C., & Tittgemeyer, M. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.03.050 · Cited by 55 · see citing works

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Quarta, C., Fisette, A., Xu, Y., Colldén, G., Legutko, B., Tseng, Y.-T., Reim, A., Wierer, M., De Rosa, M. C., Klaus, V., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0028-1 · Cited by 54 · see citing works

Preclinical evidence for the addiction potential of highly palatable foods: Current developments related to maternal influence

Wiss, D. A., Criscitelli, K., Gold, M., & Avena, N. (2017) · Appetite · doi:10.1016/j.appet.2016.12.019 · Cited by 53 · see citing works

An open-label trial on the efficacy and tolerability of naltrexone/bupropion SR for treating altered eating behaviours and weight loss in binge eating disorder

Carbone, E. A., Caroleo, M., Rania, M., Calabrò, G., Staltari, F. A., de Filippis, R., Aloi, M., Condoleo, F., Arturi, F., & Segura-Garcia, C. (2021) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-020-00910-x · Cited by 52 · see citing works

Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases

Zakariassen, H. L., John, L. M., & Lutz, T. A. (2020) · Basic &amp; Clinical Pharmacology &amp; Toxicology · doi:10.1111/bcpt.13427 · Cited by 37 · see citing works

Hypothalamic primary cilium: A hub for metabolic homeostasis

Yang, D. J., Hong, J., & Kim, K. W. (2021) · Experimental &amp; Molecular Medicine · doi:10.1038/s12276-021-00644-5 · Cited by 34 · see citing works

Nutritional priorities to support GLP-1 therapy for obesity: A joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and the Obesity Society

Mozaffarian, D., Agarwal, M., Aggarwal, M., Alexander, L., Apovian, C. M., Bindlish, S., Bonnet, J., Butsch, W. S., Christensen, S., Gianos, E., et al. (2025) · Obesity Pillars · doi:10.1016/j.obpill.2025.100181 · Cited by 28 · see citing works

Central Nervous Insulin Administration before Nocturnal Sleep Decreases Breakfast Intake in Healthy Young and Elderly Subjects

Santiago, J. C. P., & Hallschmid, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00054 · Cited by 18 · see citing works

Spatiotemporal profile of altered neural reactivity to food images in obesity: Reward system is altered automatically and predicts efficacy of weight loss intervention

Poghosyan, V., Ioannou, S., Al-Amri, K. M., Al-Mashhadi, S. A., Al-Mohammed, F., Al-Otaibi, T., & Al-Saeed, W. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.948063 · Cited by 8 · see citing works

A large-scale concordance study of toxicity findings across preclinical species and humans for small molecules and biologics

Liu, X., & Fan, F. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1731947 · Cited by 4 · see citing works

Reconstruction of cultured neural circuits, using micropatterns of permissive and repulsive signals

Kim, J. H., Ryu, J. R., & Sun, W. (2019) · IBRO Reports · doi:10.1016/j.ibror.2019.07.1760

Recent Progress in the 3D Reconstruction of Drosophila Neural Circuits

Shinomiya, K., & Ito, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-57363-2_3 · Cited by 1 · see citing works

Nature over Nurture: Functional neuronal circuits emerge in the absence of developmental activityPreprint

Barabási, D. L., Schuhknecht, G. F. P., & Engert, F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.24.513526 · Cited by 6 · see citing works

Neuronal basis of behavior

Kristan, W. B. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90134-7 · Cited by 8 · see citing works

[Escape Behaviors and Its Underlying Neuronal Circuits].

Oda, Y. (2015) · PubMed · doi:10.11477/mf.1416200281 · Cited by 1 · see citing works