Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain
Shirasaki, Dyna I., Greiner, Erin R., Al-Ramahi, Ismael, Gray, Michelle, Boontheung, Pinmanee, Geschwind, Daniel H., Botas, Juan, Coppola, Giovanni +3 more·2012·Neuron
Cited by (310)
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- Molecular interaction networks in the analyses of sequence variation and proteomics dataUlrich Stelzl · 2013 · PROTEOMICS - CLINICAL APPLICATIONS
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- Impaired Replenishment of Cortico-Striatal Synaptic Glutamate in Huntington’s Disease Mouse ModelCaodu Buren, Gaqi Tu, Lynn A. Raymond · 2020 · Journal of Huntington s Disease
- Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the “better” may become the “enemy of the good” in the course of evolutionEmmanuel Brouillet · 2022 · Cell Death and Differentiation
- Structural-functional analyses of the huntingtin/HAP40 complex in Drosophila and humansStephen Matthew Farmer, Amanda Solbach, Shiyu Xu, Beatriz Rios, Xin Ye, Amy Gao, Daniela Covarrubias, Yue Yu, Lili Ye, Vicky Chuong et al. · 2025 · Journal of Biomolecular Structure and Dynamics
- Group dynamics goes awry: PolyQ-expanded huntingtin gains unwanted partnersLeonardo E. Dionisio, X William Yang · 2022 · Cell Systems
- Huntingtin protein–protein interactions: From biology to therapeutic targetsEduardo Silva Ramos, Todd M. Greco, Ileana M. Cristea, Erich E. Wanker · 2024 · Elsevier eBooks
- The Brain–Heart Network of SyncopeSailen Barik, Thomas Riddell · 2024 · International Journal of Molecular Sciences
- Huntington's disease: easing the NMDAR traffic jamAnthony Daggett, X William Yang · 2013 · Nature Medicine
- Omics and Network-based Approaches in Understanding HD PathogenesisChristiana C. Christodoulou, Eleni Zamba Papanicolaou · 2024 · IntechOpen eBooks
- Genome-scale transcriptional regulatory network models for the mouse and human striatum predict roles for SMAD3 and other transcription factors in Huntington’s diseaseSeth A. Ament, Jocelynn R. Pearl, Robert M. Bragg, Peter J. Skene, Sydney R. Coffey, Dani E. Bergey, Christopher L. Plaisier, Vanessa Chantal Wheeler, Marcy E. MacDonald, Nitin S. Baliga et al. · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
- HAP40 is a conserved central regulator of Huntingtin and a specific modulator of mutant Huntingtin toxicityShiyu Xu, Gang� Li, Xin Ye, Dongsheng Chen, Zhihua Chen, Zhen Xu, Lili Ye, Erin E. Furr-Stimming, Deanna M. Marchionini, Sheng Zhang · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- HLH-30/TFEB rewires the chaperone network to promote proteostasis under conditions of Coenzyme A and Iron-Sulfur Cluster DeficiencyRewayd Shalash, Mor Levi‐Ferber, Henrik von Chrzanowski, Mohammad Khaled Atrash, Yaron Shav‐Tal, Sivan Henis‐Korenblit · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Huntingtin reduction results in altered nuclear structure and heterochromatic instabilityJessica C. Barron, Sean T Coady, Abigayle C Fleming, Samantha J. Carew, Makenna C A Taylor, Emily P. Hurley, Firoozeh Nafar, Matthew P. Parsons · 2025 · Human Molecular Genetics
- Huntingtin and its allies at the cortico-striatal synapseChiara Zuccato, Andrea Scolz, Raffaele Iennaco · 2026 · Cell Death and Disease
- Wild-type huntingtin in neurodevelopmentLaura Chan, Blair R. Leavitt · 2026 · Journal of Huntington s Disease
- Reconstructing Causal Network Models of Human DiseaseEric E. Schadt · 2016 · Elsevier eBooks
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- Dynamics of social network structure for Alzheimer and Lymphoma scientific communitiesShahar Barbash · 2015 · Biology Direct
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- Impairment of neuronal mitophagy by mutant huntingtinSandra Franco-Iborra, Ainhoa Plaza‐Zabala, David Sebastián, Miquel Vila, Marta Martínez‐Vicente · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- 14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril modelRachel Underwood, Mary A. Gannon, Aneesh Pathak, Navya Kapa, Sidhanth Chandra, Alyssa Klop, Talene A. Yacoubian · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Regulatory network underlying alterations of gene expression in early death of Huntington's diseaseZhike Zhou, Fenqin Chen, Shanshan Zhong, Yi Zhou, Rongwei Zhang, Kexin Kang, Xiaoqian Zhang, Mei Zhao, Ying Xu, Chuansheng Zhao · 2020
- Perturbed actin cap and nuclear morphology in primary fibroblasts of Huntington’s disease patients as a new phenotypic marker for personalized drug evaluationSaja Gharaba, Omri Paz, Lea Feld, Anastasia Abashidze, Maydan Weinrab, Haguy Wolfenson, Miguel Weil · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Systematic Analysis of disease pathways in Congenital, Infantile and Juvenile Neuronal Ceroid LipofuscinosesEnzo Scifo · 2014 · Työväentutkimus Vuosikirja
- Huntington’s Disease Studies at the Interface of Chemistry, Physics, and BiologyKenneth W. Drombosky · 2016 · D-Scholarship@Pitt (University of Pittsburgh)
- 6 Huntington’s Disease and Stem CellsKaren L. Ring, Robert O’Brien, Ningzhe Zhang, Lisa Ellerby · 2017 · CRC Press eBooks
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- Understanding Huntington's disease using Machine Learning ApproachesSonali Lokhande · 2017
- The impact of proteostasis imbalance on proteome solubilityXiaojing Sui · 2019 · Minerva Access (University of Melbourne)
- Microglial Mitophagy and Neurodegenerative DisordersEyitayo Adeyemi Oyindamola, Maxwell Kwadwo Agyemang, Joseph Owusu-Sarfo, Kofi Oduro Yeboah, Newman Osafo · 2020 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
- Aberrant chloride homeostasis and inhibitory synaptic transmission in Huntington's diseaseZahra Dargaei · 2018 · TSpace (University of Toronto)
- Protein interaction partners of neuronal chloride transportersVivek Mahadevan · 2020 · Elsevier eBooks
- Role of Optineurin In Metabotropic Glutamate Receptor 5-Regulated AutophagyCaitlyn McLaren · 2020 · uO Research (University of Ottawa)
- Ion mobility-mass spectrometry for structural characterization and applied 'omics: A study in neurodegenerative diseasesJames R. Arndt · 2015
- A meta-analysis of transcriptomic profiles from Huntington’s disease patients points to a pathophysiological role of CDC42, NFY, DLX1 and PRMT3Manuel Seefelder, Stefan Kochanek · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Structure/Function Analysis of the Huntingtin N-terminus Encoded by Htt Exon 1 Using Knock-In Mouse ModelsEmily A. André · 2017
- Faculty Opinions recommendation of The cryo-electron microscopy structure of huntingtin.Michael J. Ragusa · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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- Network Methods for Elucidating the Complexity of Common Human DiseasesEric E. Schadt · 2017 · Oxford University Press eBooks
- Plant extracts ameliorate Huntington’s disease symptomsMagisetty Obulesu · 2022 · Elsevier eBooks
- Aberrant Hydrogen Sulfide Signaling in A lzheimer's DiseaseBindu Diana Paul · 2022
- Proteomics in Huntington’s Disease Biomarker DiscoveryJakub Červenka, Katerina Budkova, Rita Suchá, Petr Vodička, Eleni Voukali · 2023 · Contemporary clinical neuroscience
- Additional file 2 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 10 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 11 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 9 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 4 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 3 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 1 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 6 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 12 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 5 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 8 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
- Additional file 7 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinManuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang P. Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek · 2020 · Figshare
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- Huntingtin functions in the regulation of axonal transport : consequences on neuronal network homeostasis and behavior, in health and diseaseHélène Vitet · 2020 · theses.fr (ABES)
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