Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain
Open accessAbstract
We used affinity-purification mass spectrometry to identify 747 candidate proteins that are complexed with Huntingtin (Htt) in distinct brain regions and ages in Huntington's disease (HD) and wild-type mouse brains. To gain a systems-level view of the Htt interactome, we applied Weighted Correlation Network Analysis to the entire proteomic data set to unveil a verifiable rank of Htt-correlated proteins and a network of Htt-interacting protein modules, with each module highlighting distinct aspects of Htt biology. Importantly, the Htt-containing module is highly enriched with proteins involved in 14-3-3 signaling, microtubule-based transport, and proteostasis. Top-ranked proteins in this module were validated as Htt interactors and genetic modifiers in an HD Drosophila model. Our study provides a compendium of spatiotemporal Htt-interacting proteins in the mammalian brain and presents an approach for analyzing proteomic interactome data sets to build in vivo protein networks in complex tissues, such as the brain.
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- Authors
- Shirasaki, D. I., Greiner, E. R., Al-Ramahi, I., Gray, M., Boontheung, P., Geschwind, D. H., Botas, J., Coppola, G., Horvath, S., Loo, J. A., & Yang, X. W.
- Affiliations
- University of California, Los Angeles (US)
- Baylor College of Medicine (US)
- Corresponding author
- Loo, Joseph A.
- Yang, X. William
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 75
- Issue
- 1
- Pages
- 41-57
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3432264
- OpenAlex
- W2028159081
- Cited by
- 297
- References
- 77
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 17 · 2023: 13 · 2022: 28 · 2021: 31 · 2020: 26 · 2019: 18 · 2018: 27 · 2017: 28 · 2016: 22 · 2015: 19 · 2014: 22 · 2013: 19 · 2012: 1
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R37MH060233)
- National Institute on Drug Abuse (R01DA030913)
- National Institute of General Medical Sciences (T32GM008496, R01GM103479)
- National Institute of Neurological Disorders and Stroke (T32NS043124, R01NS049501, R01NS074312, P30NS062691)
- National Center for Research Resources (R01RR020004, R01RR20004)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- huntingtin, protein-protein interaction network, Huntington's disease, brain regions, age-related changes, microtubule transport, proteostasis, genetic modifiers, Drosophila model, weighted gene co-expression network analysis
- MeSH terms
- Huntingtin Protein, Animals, Brain, Disease Models, Animal, Drosophila, Female, Humans, Mice, Transgenic, Nerve Tissue Proteins, Proteomics, Mice, Gene Regulatory Networks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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