Cited by 310Genetic Neurodegenerative DiseasesGenetics and Neurodevelopmental DisordersBioinformatics and Genomic Networks

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Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

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Shirasaki, Dyna I., Greiner, Erin R., Al-Ramahi, Ismael, Gray, Michelle, Boontheung, Pinmanee, Geschwind, Daniel H., Botas, Juan, Coppola, Giovanni, Horvath, Steve, Loo, Joseph A., Yang, X. William·2012·Neuron

DOI 10.1016/j.neuron.2012.05.024PMC PMC3432264

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Abstract

We used affinity-purification mass spectrometry to identify 747 candidate proteins that are complexed with Huntingtin (Htt) in distinct brain regions and ages in Huntington's disease (HD) and wild-type mouse brains. To gain a systems-level view of the Htt interactome, we applied Weighted Correlation Network Analysis to the entire proteomic data set to unveil a verifiable rank of Htt-correlated proteins and a network of Htt-interacting protein modules, with each module highlighting distinct aspects of Htt biology. Importantly, the Htt-containing module is highly enriched with proteins involved in 14-3-3 signaling, microtubule-based transport, and proteostasis. Top-ranked proteins in this module were validated as Htt interactors and genetic modifiers in an HD Drosophila model. Our study provides a compendium of spatiotemporal Htt-interacting proteins in the mammalian brain and presents an approach for analyzing proteomic interactome data sets to build in vivo protein networks in complex tissues, such as the brain.

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Authors: Shirasaki, D. I., Greiner, E. R., Al-Ramahi, I., Gray, M., Boontheung, P., Geschwind, D. H., Botas, J., Coppola, G., Horvath, S., Loo, J. A., & Yang, X. W.
Affiliations: University of California, Los Angeles (US)
Baylor College of Medicine (US)
Corresponding author: Loo, Joseph A.
Yang, X. William
ORCID: Gray, Michelle
Geschwind, Daniel H.
Botas, Juan
Coppola, Giovanni
Horvath, Steve
Loo, Joseph A.
Venue: Neuron
Publisher: Elsevier BV
Published: 2012-07
Volume: 75
Issue: 1
Pages: 41-57
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2012.05.024
PMC: PMC3432264
OpenAlex: W2028159081
Cited by: 297
References: 77
Citations by year: 2026: 12 · 2025: 14 · 2024: 17 · 2023: 13 · 2022: 28 · 2021: 31 · 2020: 26 · 2019: 18 · 2018: 27 · 2017: 28 · 2016: 22 · 2015: 19 · 2014: 22 · 2013: 19 · 2012: 1
FWCI: 8.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 381 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R37MH060233)
National Institute on Drug Abuse (R01DA030913)
National Institute of General Medical Sciences (T32GM008496, R01GM103479)
National Institute of Neurological Disorders and Stroke (T32NS043124, R01NS049501, R01NS074312, P30NS062691)
National Center for Research Resources (R01RR020004, R01RR20004)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords: huntingtin, protein-protein interaction network, Huntington's disease, brain regions, age-related changes, microtubule transport, proteostasis, genetic modifiers, Drosophila model, weighted gene co-expression network analysis
MeSH terms: Huntingtin Protein, Animals, Brain, Disease Models, Animal, Drosophila, Female, Humans, Mice, Transgenic, Nerve Tissue Proteins, Proteomics, Mice, Gene Regulatory Networks

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Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

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