Neuronal Morphogenesis: Golgi Outposts, Acentrosomal Microtubule Nucleation, and Dendritic Branching
Open accessAbstract
In large cells like neurons, how is microtubule polymerization initiated at large distances from the cell body and the main microtubule-organizing center? In this issue of Neuron, Ori-McKenney et al. (2012) demonstrate that Golgi outposts mediate acentrosomal microtubule nucleation and reveal it is crucial for dendrite morphogenesis.
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Neuronal network morphogenesis is based on an effective equilibrium between neuroplasticity and neurodegeneration, as well as the formation of new cells through proliferation/survival signalling and cytoskeletal structures.
“Neuronal network morphogenesis is based on an effective equilibrium between neuroplasticity and neurodegeneration, as well as the formation of new cells through proliferation/survival signalling and cytoskeletal structures [120].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [120]
Cites
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Rivero, S., Cardenas, J. M., Bornens, M., & Rios, R. M. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.47 · Cited by 319 · see citing works
Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation
Stieß, M., Maghelli, N., Kapitein, L. C., Gomis-Rüth, S., Wilsch‐Bräuninger, M., Hoogenraad, C. C., Tolić, I. M., & Bradke, F. (2010) · Science · doi:10.1126/science.1182179 · Cited by 290 · see citing works
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Self-citationMicrotubule nucleating γ-TuSC assembles structures with 13-fold microtubule-like symmetry
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- Authors
- Lewis, T. L., & Polleux, F.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Polleux, Franck
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 76
- Issue
- 5
- Pages
- 862-864
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1996642171
- Cited by
- 9
- References
- 15
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2017: 1 · 2015: 2 · 2013: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG031524)
- National Institute of Neurological Disorders and Stroke (F32NS080464)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuronal morphogenesis, dendritic branching, microtubule assembly, microtubule organizing center, Golgi apparatus, dendrite formation
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