Cited by 693Axon Guidance and Neuronal SignalingNeuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology Research

Branching out: mechanisms of dendritic arborization

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Jan, Yuh-Nung, Jan, Lily Yeh·2010·Nature Reviews Neuroscience

Abstract

Type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated. During the past two decades, studies on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species. Transcription factors, receptor-ligand interactions, various signalling pathways, local translational machinery, cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry. Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders.

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Crossref · 10.1038/nrn2836

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  • Dendritic morphogenesis, synaptogenesis and continued activity-dependent remodelling of synaptic connections are critical for the development and maintenance of functional neuronal networks.

    “Dendritic morphogenesis, synaptogenesis and continued activity-dependent remodelling of synaptic connections are critical for the development and maintenance of functional neuronal networks.11, 12, 13, 14, 15”

    From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [11]

    The section on dendrite morphogenesis says that neurons coordinate their dendritic fields, and the section on synaptic proteins links dendrite morphology with synaptic function (page numbers not supplied). The review thus supports the importance of dendritic development to neuronal circuitry, but it does not establish the claim about synaptogenesis and continued activity-dependent remodelling of synaptic connections. (LLM, conf=0.85)

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Research works printed but not linked: 2

  1. [12]Bestman J Silva JSD Cline HT Stuart G Spruston N Häusser M Dendrites 69 94 Oxford University Press Oxford 2008
  2. [13]Polleux F Ghosh A Stuart G Spruston N Häusser M Dendrites 95 115 Oxford University Press Oxford 2008

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Authors
Jan, Y.-N., & Jan, L. Y.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Jan, Yuh-Nung
Venue
Nature Reviews Neuroscience
Published
2010-05
Volume
11
Issue
5
Pages
316-328
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2065943966
Cited by
693
References
162
Citations by year
2026: 15 · 2025: 41 · 2024: 24 · 2023: 29 · 2022: 33 · 2021: 41 · 2020: 71 · 2019: 41 · 2018: 45 · 2017: 49 · 2016: 52 · 2015: 38 · 2014: 58 · 2013: 53 · 2012: 53
FWCI
4.49
Type
journal article
Language
en
Update notices
erratum (2010-06-01)
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health
  • National Institute of Mental Health (R01MH084234)
  • National Institute of Neurological Disorders and Stroke (R37NS040929)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
dendritic branching, dendrite morphogenesis, dendritic morphology, Drosophila melanogaster, transcription factors, ligand-receptor interactions, signaling pathways, local translation, cytoskeleton, endosomes, autism spectrum disorder, neurodevelopmental disorders, neural circuits
MeSH terms
Animals, Axons, Dendrites, Humans, Models, Neurological, Morphogenesis, Neurons, Signal Transduction

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