ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

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  2. Altered Balance of Reelin Proteolytic Fragments in the Cerebrospinal Fluid of Alzheimer’s Disease Patients
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  5. The Effect of the APOE-ε4 Allele on the Cholinergic Circuitry for Subjects With Different Levels of Cognitive Impairment
    Ying-Liang Larry Lai, Kuan Chen, Tzu-Wei Lee, Chao-Wei Tso, Hui-Hsien Lin, Li‐Wei Kuo, Cheng‐Yu Chen, Huashan Liu · 2021 · Frontiers in Neurology
  6. Evaluation of mild cognitive impairment genetic susceptibility risks in a Chinese population
    Yelei Zhang, Xiaoyue Li, Yu Xin Hu, Hongwei Yuan, Xiaodong Wu, Yating Yang, Tongtong Zhao, Ke Hu, Zhiqiang Wang, Guoqiang Wang et al. · 2022 · BMC Psychiatry
  7. Models of cerebral amyloid angiopathy-related intracerebral hemorrhage
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  8. Dietary Phytochemicals in Neurodegenerative Disease
    Aurélie de Rus Jacquet, Mitali Arun Tambe, Jean‐Christophe Rochet · 2017 · Elsevier eBooks
  9. The Genetic Basis of Alzheimer's Disease
    Basavaraj V. Hooli, Rudolph E. Tanzi · 2016 · Elsevier eBooks
  10. Low-Density Lipoprotein Particle Size Subfractions and Cerebral Amyloidosis
    Sung Lee, Trusha Parekh, Sarah M. King, Bruce Reed, Helena Chang Chui, Ronald M. Krauss, Hussein N. Yassine · 2019 · Journal of Alzheimer s Disease
  11. HDL mimetic peptides affect apolipoprotein E metabolism: equal supplement or functional enhancer?
    Wenzhang Wang, Xiongwei Zhu · 2018 · Journal of Neurochemistry
  12. Identifying pathogenic variants associated with Alzeimer by integrating genomic databases and bioinformatics approaches
    Danang Prasetyaning Amukti, Annisa Rizqita Wazni, Lalu Muhammad Irham, Nanik Sulistyani, Muhammad Farid Ma’ruf, Wirawan Adikusuma, Made Ary Sarasmita, Sabiah Khairi, Barkah Djaka Purwanto, Suyatmi Suyatmi et al. · 2024 · E3S Web of Conferences
  13. CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
    Lena Duchateau, Fahri Küҫükali, Arne De Roeck, Mandy Melissa Jane Wittens, Joke Temmerman, Ilse Weets, Maarten Timmers, Sebastiaan Engelborghs, Maria Bjerke, Kristel Sleegers · 2023 · Alzheimer s Research & Therapy
  14. Apolipoprotein E ε4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment
    Yuda Huang, Yongzhi Shan, Wen Qin, Guoguang Zhao · 2023 · Frontiers in Aging Neuroscience
  15. The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of APOE4 in Alzheimer’s Disease
    Mirna Safieh, Ori Liraz, Maayan Ovadia, Danny M. Michaelson · 2024 · Journal of Alzheimer s Disease
  16. Temporal Characterization of the Amyloidogenic APPswe/PS1dE9;hAPOE4 Mouse Model of Alzheimer’s Disease
    Martine B. Grenon, Maria-Tzousi Papavergi, Praveen Bathini, Martin J. Sadowski, Cynthia Ann Lemere · 2024 · International Journal of Molecular Sciences
  17. Thyroid Hormone and Alzheimer Disease: Bridging Epidemiology to Mechanism
    Sergio Escamilla, Federico Salas-Lucia · 2024 · Endocrinology
  18. A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner
    Sourav Dasadhikari, Shamasree Ghosh, Sudip Pal, Tuomas P. J. Knowles, Kanchan Garai · 2025 · Communications Chemistry
  19. Type I interferon drives T cell responses to amyloid beta in the central nervous system
    Julius J. Michel, Khwab Sanghvi, Jakob Rosenbauer, Lea Humbs, Clara Tejido, Saskia Grudzenski, Viktoria Sachs, Kristine Jähne, Karoline Degenhardt, Lutz Froelich et al. · 2026 · Nature Communications
  20. Alzheimer’s disease: unraveling APOE4 binding to amyloid-beta peptide and lipids with molecular dynamics and quantum mechanics
    Jean-Numa Gillet · 2020 · Journal of Biomolecular Structure and Dynamics
  21. Insights on the pathogenesis of type 2 diabetes as revealed by signature genomic classifiers in an African American population in the Washington, DC area
    Tanmoy Mondal, Christopher A. Loffredo, Jyothirmai J. Simhadri, Gail Nunlee‐Bland, Brent A. Korba, Jheannelle Johnson, Sharleine T. Cotin, Gemeyel Moses, Ruth I. Quartey, Charles D. Howell et al. · 2022 · Diabetes/Metabolism Research and Reviews
  22. Investigation of the Relationship between Apolipoprotein E Alleles and Serum Lipids in Alzheimer’s Disease: A Meta-Analysis
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  23. Insights into therapeutic approaches for the treatment of neurodegenerative diseases targeting metabolic syndrome
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  24. Electrochemical biosensors for early detection of Alzheimer’s disease
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  25. In Silico Analysis of the Antagonist Effect of Enoxaparin on the ApoE4–Amyloid-Beta (Aβ) Complex at Different pH Conditions
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  26. Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD
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  27. Aβ regulation-based multitarget strategy for drug discovery against Alzheimer’s disease
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  28. Association between dementia and vascular disease-associated polymorphisms in a Tunisian population
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  29. Identification of Apolipoprotein E as a Potential Diagnostic Biomarker of Nasopharyngeal Carcinoma
    Ying Xue, Shuo Huang, Jing Huang, Shuang Li, Cen Zhang, Xuhong Zhou · 2020 · Cancer Management and Research
  30. Tongqiaohuoxue Hinders Development and Progression of Atherosclerosis: A Possible Role in Alzheimer’s Disease
    Eunyoung Ha, Mi Kyung Kim, Jaemoo Chun, Chang‐Seob Seo, You Mee Ahn, Jeeyoun Jung · 2020 · Biology
  31. Dexamethasone ameliorates Alzheimer’s pathological condition via inhibiting Nf-κB and mTOR signaling pathways
    2020 · Biointerface Research in Applied Chemistry
  32. Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease
    Eugene Hone, Florence Lim, Ian James Martins · 2019 · Wiley eBooks
  33. Unraveling APOE4: The dual role in CNS and peripheral inflammation in Alzheimer's disease
    Xiaohan Li, Zekun Li, Hua Chen, Hongmin Guo, Yihao Ge, Fang Dong, Fan Zhang, Feng Zhang · 2025 · International Immunopharmacology
  34. Integrative epigenomic landscape of Alzheimer’s Disease brains reveals oligodendrocyte molecular perturbations associated with tau
    Oatman, Stephanie R., Reddy, Joseph S., Atashgaran, Amin, Wang, Xue, Min, Yuhao, Quicksall, Zachary, Vanelderen, Floor, Carrasquillo, Minerva M., Liu, Chia-Chen, Yamazaki, Yu et al. · 2026 · Nature Communications
  35. Alzheimer's Disease; Mechanism, Mutations, and Applications of Nano-Medicine
    Muhammad Maisam, Muhammad Tahir Khan, Madeeha Shahzad Lodhi, Kejie Mou, Zili Liu, Dong‐Qing Wei · 2023 · Frontiers in Bioscience-Landmark
  36. Cholesterol metabolism regulates Tauopathy in Alzheimer’s disease
    Subashchandrabose Chinnathambi, Anusree Adityan, Madhura Chandrashekar · 2024 · Advances in protein chemistry and structural biology
  37. Topographical APOE ɛ4 Genotype Influence on Cerebral Metabolism in the Continuum of Alzheimer’s Disease: Amyloid Burden Adjusted Analysis
    Eun Hyun Seo, Alzheimer’s Disease Neuroimaging Initiative, Sang Hoon Kim, Sang Hag Park, Seong‐Ho Kang, Il Han Choo · 2016 · Journal of Alzheimer s Disease
  38. Patents on Natural Products for Diagnosing/Preventing/Treating Alzheimer's Disease
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  39. NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production
    Jung Hwan Yoon, Yeon Soo Lee, Olga Kim, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Won Sang Park · 2019 · World Journal of Gastroenterology
  40. Alz-Disc: A Tool to Discriminate Disease-causing and Neutral Mutations in Alzheimer's Disease
    M. Michael Gromiha, Arulsamy Kulandaisamy, S. Akila Parvathy Dharshini · 2022 · Combinatorial Chemistry & High Throughput Screening
  41. Advances in the Study of APOE and Innate Immunity in Alzheimer’s Disease
    Yujiao Li, Jun Chang, Xi Chen, Jianwei Liu, Lan Zhao · 2023 · Journal of Alzheimer s Disease
  42. APOE4 poses opposite effects of plasma LDL on white matter integrity in older adults
    Zhenyao Ye, Yezhi Pan, Rozalina G. McCoy, Chuan Bi, Chen Mo, Li Feng, Jiaao Yu, Tong Lu, Song Liu, J. Carson Smith et al. · 2023 · Neurobiology of Aging
  43. Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer’s Disease
    Takahisa Kanekiyo, Guojun Bu · 2016 · Elsevier eBooks
  44. The Genetic Basis of Alzheimer’s Disease
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  45. Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels
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  46. Association of rare APOE missense variants with Alzheimer's disease in the Japanese population
    Miyashita, Akinori, Obinata, Ai, Hara, Norikazu, Mitsumori, Risa, Kaneda, Daita, Hashizume, Yoshio, Sano, Terunori, Takao, Masaki, Gabdulkhaev, Ramil, Tada, Mari et al. · 2025 · Journal of Alzheimer’s Disease
  47. Structural changes to the basal forebrain cholinergic system in the continuum of Alzheimer disease
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  48. Navigation Between Alzheimer’s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology—Genetics and Neuroinflammation
    Abdalla Bowirrat, Albert Pinhasov, Aia Bowirrat, Rajendra Dhar Badgaiyan · 2025 · International Journal of Molecular Sciences
  49. Apolipoprotein E (APOE) regulates the transport of monosialotetrahexosylganglioside (GM1)
    Dong Yan Zhang, Jian Wang, Gangtong Huang, Martin Dokholyan, Smaranda Willcox, Jack D. Griffith, Feng Ding, Nikolay V. Dokholyan · 2025 · Journal of Biological Chemistry
  50. Retrospective analysis of Braak stage– and APOE4 allele–dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly
    Anna M. Chen, Martin Gajdošík, Wajiha Ahmed, Sinyeob Ahn, James S. Babb, Esther Blessing, Allal Boutajangout, Mony J. de Leon, Ludovic Debure, Naomi Love Gaggi et al. · 2024 · NeuroImage
  51. An overview in interactions and biosensors of multiple biomarkers of Alzheimer’s disease
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  52. Levels of Thyroid Hormones and Indices of Energy Metabolism in the Cerebral Cortex of Rats with Experimental Alzheimer’s Disease
    Tatyana V. Gorbach, Оксана Анатоліївна Наконечна, Anton S. Tkachenko, Tetiana Shcholok, A. O. Onikova · 2018 · Neurophysiology
  53. APOE ɛ4-TOMM40L Haplotype Increases the Risk of Mild Cognitive Impairment Conversion to Alzheimer’s Disease
    Rèmy Cardoso, Carolina Lemos, Bárbara Oliveiros, Maria Rosário Almeida, Inês Baldeiras, Cláudia Pereira, ANA CAROLINA DA SILVA SANTOS, Diana Duro, Daniela Vieira, Isabel J. Santana et al. · 2020 · Journal of Alzheimer s Disease
  54. Nanobiosensors for Non-Amyloidbeta-Tau Biomarkers as Advanced Reporters of Alzheimer’s Disease
    Le Minh Tu Phan; Phan Le Minh Tu, Thi Xoan Hoang, Vo Thuy Anh Thu, Jae Young Kim, Sang-Myung Lee, Won Woo Cho, Young Hyo Kim, Seong Hye Choi, Sungbo Cho · 2020 · Diagnostics
  55. Development of a Low-Molecular-Weight Aβ42 Detection System Using a Enzyme-Linked Peptide Assay
    Sang‐Heon Kim, Eun-Hye Lee, Hyung‐Ji Kim, A-Ru Kim, Ye-Eun Kim, Jae‐Hong Lee, Moon‐Young Yoon, Seong‐Ho Koh · 2021 · Biomolecules
  56. A closer look at pathogenic amyloid-β in Alzheimer’s disease using cryo-electron microscopy: a narrative review
    Yang Gao, Sophia Schedin‐Weiss, Lars O. Tjernberg · 2024 · Advanced technology in neuroscience .
  57. Apolipoprotein E genotypes and amyloid burden associated with cognitive decline in non-demented Parkinson's disease patients: A preliminary analysis
    Clara Trompeta, Carmen Gasca‐Salas, Rafael Rodríguez‐Rojas, Beatriz Fernández‐Rodríguez, Jordi Clarimón, Lina García‐Cañamaque, Pasqualina Guida, Frida Hernández‐Fernández, Pascual Sánchez‐Juan, Javier Olazarán et al. · 2025 · Journal of the Neurological Sciences
  58. Apolipoprotein E4 inhibits γ‐secretase activity via binding to the γ‐secretase complex
    Yang Sun, Sadequl Islam, Yuan Gao, Tomohisa Nakamura, Kun Zou, Makoto Michikawa · 2022 · Journal of Neurochemistry
  59. Enhanced Cerebral Hemodynamics and Cognitive Function Via Knockout of Dual-Specificity Protein Phosphatase 5
    Huawei Zhang, Jane J. Border, Xing Fang, Yedan Liu, Chengyun Tang · 2023 · Journal of Pharmacy and Pharmacology Research
  60. Lipids and Lipoproteins in Alzheimer’s Disease
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  61. Regarding long-term statin therapy: Are we trading stronger hearts for weaker brains?
    Mark R. Goldstein, Luca Mascitelli · 2014 · Medical Hypotheses
  62. The Diagnostic Use of the Plasma Quantification of 24S-Hydroxycholesterol and Other Oxysterols in Neurodegenerative Disease
    Domenico Tripodi, Federica Vitarelli, Simona Spiti, Valerio Leoni · 2023 · Advances in experimental medicine and biology
  63. CRISPR/Cas9 gene editing: A new hope for Alzheimer's disease
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  64. Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies
    Siddhant Tripathi, Yashika Sharma, Dileep Kumar · 2024 · Current Protein and Peptide Science
  65. Endocytic Pathways Unveil the Role of Syndecans in the Seeding and Spreading of Pathological Protein Aggregates: Insights into Neurodegenerative Disorders
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  66. Sphingolipids in Cerebrospinal Fluid and Plasma Lipoproteins of APOE4 Homozygotes and Non- APOE4 Carriers with Mild Cognitive Impairment versus Subjective Cognitive Decline
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  67. Inhibition of Sirt2 Decreases ApoE Secretion in Astrocytes and Microglial Cells
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  68. Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease
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  71. Brain Network Functional Connectivity in Alzheimer’s Disease and Frontotemporal Dementia
    Juan Helen Zhou, Kwun Kei Ng, Siwei Liu · 2020 · Springer eBooks
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  73. Association of Plasma Oligomerized Amyloid-β and Cerebral White Matter Lesions in a Health Screening Population
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  74. Daily oscillation of cognitive factors is modified in the temporal cortex of an amyloid β(1-42)-induced rat model of Alzheimer’s disease
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  75. Effect of Apolipoprotein E isoforms on the Abundance and Function of P-glycoprotein in Human Brain Microvascular Endothelial Cells
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  76. Multi-omic analysis of meningeal cerebral amyloid angiopathy reveals enrichment of unsubstituted glucosamine and extracellular proteins
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  77. Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neurons
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  89. Deletion of neuronal Idol ameliorates Alzheimer's disease–related pathologies via APOE receptors
    Karahan, Hande, Hartigan, Kelly, Al‐Amin, Md Mamun, John, Sutha K., McCord, Brianne, Wijeratne, H. R. Sagara, Acri, Dominic J., Smith, Daniel C., Dabin, Luke C., Cordero, Hannah M. Rondon et al. · 2025 · Alzheimer's & Dementia
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  94. Obesity-related brain atrophy is independent of Alzheimer's disease protein pathways
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  95. Spatiotemporal profiling reveals the impact of caloric restriction in the aging mammalian brain
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