ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

Kanekiyo, Takahisa, Xu, Huaxi, Bu, Guojun·2014·Neuron

DOI 10.1016/j.neuron.2014.01.045

Cited by (626)

Items 301–400 of 626

Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome
Mark E. Mapstone, Thomas J Gross, Fabio M. Macciardi, Amrita K. Cheema, Melissa E. Petersen, Elizabeth Head, Benjamin L. Handen, William Edward Klunk, Bradley T. Christian, Wayne P. Silverman et al. · 2020 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
Cell type-specific functions of Alzheimer's disease endocytic risk genes
Johanna‐Katharina Maninger, Karolina Nowak, Srilakshmi Goberdhan, Rachel O’Donoghue, Natalie Connor‐Robson · 2024 · Philosophical Transactions of the Royal Society B Biological Sciences
iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta
Yunfeng Ding, Sean P. Palecek, Eric V. Shusta · 2024 · Fluids and Barriers of the CNS
Remyelination: A Potential Therapeutic Strategy for Alzheimer’s Disease?
Junjun Sun, Hong Zhou, Feng Bai, Zhijun Zhang, Qingguo Ren · 2017 · Journal of Alzheimer s Disease
Population pharmacokinetics and standard uptake value ratio of aducanumab, an amyloid plaque–removing agent, in patients with Alzheimer’s disease
Kumar Kandadi Muralidharan, Xiao Tong, Kenneth G. Kowalski, Raj Rajagovindan, Lin Lin, Samantha Budd Haberlain, Ivan A. Nestorov · 2021 · CPT Pharmacometrics & Systems Pharmacology
Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4
Xianglong Hou, Xuexin Zhang, Huan Zou, Mingfeng Guan, Chaoying Fu, Wenyuan Wang, Zai-Rong Zhang, Yang Geng, Yelin Chen · 2023 · Neuron
Protein structures in Alzheimer's disease: The basis for rationale therapeutic design
Laia Montoliu‐Gaya, Sandra Villegas · 2015 · Archives of Biochemistry and Biophysics
Regional analysis and genetic association of nigrostriatal degeneration in Lewy body disease
Koji Kasanuki, Michael G. Heckman, Nancy N. Diehl, Melissa Erin Murray, Shunsuke Koga, Alexandra I. Soto, Owen A. Ross, Dennis W. Dickson · 2017 · Movement Disorders
The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study
Ningwei Hu, Ling Gao, Yu Jiang, Shan Wei, Suhang Shang, Chen Chen, Liangjun Dang, Jin Wang, Kang Huo, Meiying Deng et al. · 2020 · Lipids in Health and Disease
APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention
Xiaopu Zhou, Amy K.Y. Fu, Nancy Y. Ip · 2021 · Current Opinion in Neurobiology
Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders
Carl Eckerström, Johan Svensson, Petronella Kettunen, Michael A. G. Jonsson, Marie Eckerström · 2021 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
Effects of Gender and Apolipoprotein E on Novelty MMN and P3a in Healthy Elderly and Amnestic Mild Cognitive Impairment
Gao, Lijuan, Chen, Jiu, Gu, Lihua, Shu, Hao, Wang, Zan, Liu, Duan, Yan, Yanna, Zhang, Zhijun · 2018 · Frontiers in Aging Neuroscience
Substances of abuse and the blood brain barrier: Interactions with physical exercise
Marta A. Małkiewicz, Andrzej Małecki, Michal J. Toborek, Arkadiusz Szarmach, Paweł Jan Winklewski · 2020 · Neuroscience & Biobehavioral Reviews
Molecular Pathobiology of the Cerebrovasculature in Aging and in Alzheimers Disease Cases With Cerebral Amyloid Angiopathy
Joseph O. Ojo, Jon M. Reed, Gogce C. Crynen, Prashanthi Vallabhaneni, James Evans, Benjamin Shackleton, Maxwell Eisenbaum, Charis Ringland, Anastasia Edsell, MICHAEL J. MULLAN et al. · 2021 · Frontiers in Aging Neuroscience
Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids
Emily Lewkowicz, Mari N. Nakamura, Michael J. Rynkiewicz, Olga Gursky · 2023 · Cellular and Molecular Life Sciences
The Single Toxin Origin of Alzheimer’s Disease and Other Neurodegenerative Disorders Enables Targeted Approach to Treatment and Prevention
Martin Tolar, John A. Hey, Aidan Power, Susan R. Abushakra · 2024 · International Journal of Molecular Sciences
A polipoprotein E Levels in Pediatric Patients Undergoing Cardiopulmonary Bypass
Mehmet Ali Ağırbaşlı, Jianxun Jim Song, Fengyang Lei, Shigang Wang, Allen R. Kunselman, Joseph Brian Clark, John L. Myers, Akif Ündar · 2015 · Artificial Organs
Cooperation between neurovascular dysfunction and Aβ in Alzheimer’s disease
Niya Wang, Xiang Yang, Zhong Zhao, Da Liu, Xiaoyan Wang, Hao Tang, Chuyu Zhong, Xinzhang Chen, Wenli Kelly Chen, Qiang Meng · 2023 · Frontiers in Molecular Neuroscience
Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer’s Disease
Yomna S. Momen, Jayshree Mishra, Narendra Kumar · 2024 · Nutrients
Current Management and Therapeutic Strategies for Cerebral Amyloid Angiopathy
Yasuteru Inoue, Yukio Ando, Yohei Misumi, Mitsuharu Ueda · 2021 · International Journal of Molecular Sciences
Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals
Yuqing Sun, Yuxin Zhao, Ke Hu, Meng Wang, Yong Liu, Bing Liu, Alzheimer’s Disease Neuroimaging Initiative · 2023 · Translational Psychiatry
The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population
Jiaqiang Zheng, Huacheng Yan, Lei Shi, Yanying Kong, Yongpan Zhao, Li Xie, Jian Li, Mukun Huang, Jin Li, Shujin Zhao · 2016 · Medicine
A flow cytometry–based in vitro assay reveals that formation of apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform and cell type
Kara, Eleanna, Marks, Jordan D., Roe, Allyson D., Commins, Caitlin, Fan, Zhanyun, Calvo-Rodriguez, Maria, Wegmann, Susanne, Hudry, Eloise, Hyman, Bradley T. · 2018 · Journal of Biological Chemistry
Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease
Uzma Azam, Muhammad Moazzam Naseer, Christophe Rochais · 2025 · European Journal of Medicinal Chemistry
The evolution of microglia replacement: A new paradigm for CNS disease therapy
Yanxia Rao, Yunfei Bai, Xiaoyu Li, Bingying Du, Bo Peng · 2025 · Cell stem cell
Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer’s disease patients
Matthew Paul Lennol, Irene Sánchez-Domínguez, Inmaculada Cuchillo‐Ibáñez, Elena Camporesi, Gunnar Brinkmalm, Daniel Andres Alcolea, Juan Fortea, Alberto Lleó, Guadalupe Sòria, Fernando Aguado et al. · 2022 · Alzheimer s Research & Therapy
Blood Pressure Variability, Central Autonomic Network Dysfunction, and Cerebral Small‐Vessel Disease in APOE4 Carriers
Trevor Lohman, Isabel J. Sible, Arunima Kapoor, Allison C Engstrom, Fatemah Shenasa, John Paul M Alitin, Aimée Gaubert, Kathleen E. Rodgers, David Robert Bradford, Mara Mather et al. · 2024 · Journal of the American Heart Association
Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer’s disease?
Maowen Ba, Min Kong, Xiaofeng Li, Kok Pin Ng, Pedro Rosa‐Neto, Serge G. Gauthier · 2016 · Translational Neurodegeneration
Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before
Liying Corinne Lee, Michele Q. L. Goh, Edward H. Koo · 2017 · BioEssays
Differential Effect of APOE Alleles on Brain Glucose Metabolism in Targeted Replacement Mice: An [<sup>18</sup>F]FDG-μPET Study
Venzi, Marcello, Tóth, Miklós, Häggkvist, Jenny, Bogstedt, Anna, Rachalski, Adeline, Mattsson, Anna, Frumento, Paolo, Farde, Lars · 2017 · Journal of Alzheimer's Disease Reports
An Analysis of the Neurological and Molecular Alterations Underlying the Pathogenesis of Alzheimer’s Disease
Chantal Vidal, Zhang Li · 2021 · Cells
Infliximab and/or MESNA alleviate doxorubicin-induced Alzheimer's disease-like pathology in rats: A new insight into TNF-α/Wnt/β-catenin signaling pathway
Hoda E. Mohamad, Dina Mohamed Abo–Elmatty, Nehal S. Wahba, Mohamed A. Shaheen, Rowan Sakr, Alaa S. Wahba · 2022 · Life Sciences
Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study
Mélina Régy, Aline Dugravot, Sèverine Sabia, Aurore Fayossé, Jean‐François Mangin, Marie Chupin A, Clara Fischer, Vincent Bouteloup, Carole Dufouil, Geneviève Chêne et al. · 2022 · NeuroImage
APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice
Terri‐Leigh Stephen, Bayla M Breningstall, Sharanya Suresh, Cassandra Joan McGill, Christian J. Pike · 2022 · Journal of Neuroinflammation
Molecular mechanisms implicated in protein changes in the Alzheimer’s disease human hippocampus
Hai Duc Nguyen, Woong-Ki Kim, Giang Huong Vu · 2024 · Mechanisms of Ageing and Development
Study of Exosomes Shed New Light on Physiology of Amyloidogenesis
Guillaume van Niel · 2016 · Cellular and Molecular Neurobiology
Cerebrospinal Fluid Proteins as Regulators of Beta‐amyloid Aggregation and Toxicity
Kayla M. Pate, Regina M. Murphy · 2017 · Israel Journal of Chemistry
An Intracellular Amyloid-β/AβPP Epitope Correlates with Neurodegeneration in those Neuronal Populations Early Involved in Alzheimer’s Disease
Gisela Esquerda-Canals, Joaquı́n Martı́, Alejandro R. Roda, Sandra Villegas · 2017 · Journal of Alzheimer s Disease
Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain
Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Milica Koprivica, Arianna Cembran, MICHAEL J. MULLAN, Fiona Crawford, Joseph O. Ojo, Corbin J. Bachmeier · 2024 · Experimental Neurology
Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer’s disease: a potential early sign of AD
Julen Goikolea, Gorka Gereñu, Makrina Daniilidou, Francesca Mangialasche, Patrizia Mecocci, Tiia Ngandu, Juha O. Rinne, Alina Solomon, Miia Kivipelto, Ángel Cedazo-Mı́nguez et al. · 2022 · Alzheimer s Research & Therapy
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
Jordy Sepulveda, Jennifer Yejean Kim, Joseph Binder, Stefano Vicini, George William Rebeck · 2024 · Molecular Neurodegeneration
Early Activation of Astrocytes does not Affect Amyloid Plaque Load in an Animal Model of Alzheimer’s Disease
Dongpi Wang, Xiaoqin Zhang, Mingkai Wang, Dongming Zhou, Hongyu Pan, Qiang Shu, Binggui Sun · 2018 · Neuroscience Bulletin
A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases
Jia Zhao, Mengxia Zhu, Mukesh Kumar, Fung Yin Ngo, Yinghui Li, Lixing Lao, Jianhui Rong · 2018 · CNS & Neurological Disorders - Drug Targets
Daily rhythms of cognition-related factors are modified in an experimental model of Alzheimer’s disease
Lorena Navigatore-Fonzo, Andrea Castro, Verónica Pignataro, Marisa Hilda Garraza, Marilina Casais, Ana Cecilia Anzulovich · 2017 · Brain Research
Trends in glycolipid biomarker discovery in neurodegenerative disorders by mass spectrometry
Dehelean, Liana, Sarbu, Mirela, Petrut, Alina, Zamfir, Alina D. · 2019 · Advances in experimental medicine and biology
Relationships of <i>APOE</i> Genotypes With Small RNA and Protein Cargo of Brain Tissue Extracellular Vesicles From Patients With Late-Stage AD
Huang, Yiyao, Driedonks, Tom A.P., Cheng, Lesley, Rajapaksha, Harinda, Turchinovich, Andrey, Routenberg, David A., Nagaraj, Rajini, Redding-Ochoa, Javier, Arab, Tanina, Powell, Bonita H. et al. · 2022 · Neurology Genetics
A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
Ana Carolina Valencia‐Olvera, Deebika Balu, Shreya Bellur, Thomas P. McNally, Yaseen Saleh, Don Pham, Shivesh Ghura, Jason M. York, Jan O. Johansson, Mary Jo LaDu et al. · 2023 · Alzheimer s Research & Therapy
Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans
Yingjie Wu, Yining Chen, Xiaochun Yu, Minxing Zhang, Zhaoyu Li · 2023 · International Journal of Molecular Sciences
RETRACTED ARTICLE: Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis
Ava Rashtchian, Mohammad Hossein Etemadi, Elham Asadi, Sara Binaei, Mina Abbasi, Maedeh Bayani, Erfan Izadi, Sayedeh-Fatemeh Sadatmadani, Mahdyieh Naziri, Sahar Khoshravesh et al. · 2024 · BMC Neuroscience · Retracted
Overview and Current Status of Alzheimer’s Disease in Bangladesh
Md. Rashidur Rahman, Afsana Tajmim, Mohammad Ali, Mostakim Sharif · 2017 · Journal of Alzheimer s Disease Reports
APOE genotype, hypertension severity and outcomes after intracerebral haemorrhage
Alessandro Biffi, Meredith P. Murphy, Patryk P Kubiszewski, Christina E. Kourkoulis, Kristin M. Schwab, M. Edip Gurol, Steven Mark Greenberg, Anand Viswanathan, Christopher D. Anderson, Jonathan M. Rosand · 2019 · Brain Communications
Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses
Allison Ann Dilliott, Kelly M. Sunderland, Paula M. McLaughlin, Angela Roberts, Emily C. Evans, Agessandro Abrahão, Malcolm A. Binns, Sandra E. Black, MICHAEL J. BORRIE, Leanne K. Casaubon et al. · 2021 · Neurobiology of Aging
Islet adaptation to obesity and insulin resistance in WNIN/GR-Ob rats
Himadri Singh, Sireesha Ganneru, Venkata Malakapalli, Maniprabha Chalasani, Giridharan Nappanveettil, Ramesh Ramachandra Bhonde, Vijayalakshmi Venkatesan · 2014 · Islets
Peripheral TREM2 mRNA levels in early and late-onset Alzheimer disease’s patients
Gamze Güven, Başar Bılgıç, Bedia Samancı, Hakan I. Gurvit, Haşmet Ayhan Hanağası, Çağla Dönmez, Rukiye Aslan, Ebba Lohmann, Nihan Erginel‐Ünaltuna · 2020 · Molecular Biology Reports
Contributions of sex and genotype to exploratory behavior differences in an aged humanized APOE mouse model of late-onset Alzheimer's disease
John W. McLean, Avnish Bhattrai, Francesca Vitali, Adam C. Raikes, Jean‐Paul L. Wiegand, Roberta Dı́az Brinton · 2022 · Learning & Memory
Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases
Morteza Abyadeh, Vivek Gupta, João A. Paulo, Samran Sheriff, Sina Shadfar, Matthew J. Fitzhenry, Ardeshir Amirkhani, Veer Bala Gupta, Ghasem Hosseini Salekdeh, Paul A. Haynes et al. · 2023 · Aging and Disease
A computational model of Alzheimer's disease at the nano, micro, and macroscales
Éléonore Chamberland, Seyedadel Moravveji, Nicolas Doyon, Simon Duchesne · 2024 · Frontiers in Neuroinformatics
Detecting Shared Genetic Architecture Among Multiple Phenotypes by Hierarchical Clustering of Gene-Level Association Statistics
Melissa R. McGuirl, Samuel Pattillo Smith, Björn Sandstede, Sohini Ramachandran · 2020 · Genetics
Joint trajectories of episodic memory and odor identification in older adults: patterns and predictors
Christina S. Dintica, Miriam L. Haaksma, Jonas Olofsson, David Alan Bennett, Weili Xu · 2021 · Aging
APOE4 Allele, Sex, and Dementia Risk in Parkinson’s Disease: Lessons From a Longitudinal Cohort
Chizoba C. Umeh, Abhimanyu Mahajan, Aleksandra Mihailović, Gregory M. Pontone · 2021 · Journal of Geriatric Psychiatry and Neurology
Complement Activation in the Central Nervous System: A Biophysical Model for Immune Dysregulation in the Disease State
Nicholas Peoples, Candace J. Strang · 2021 · Frontiers in Molecular Neuroscience
Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype Are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
Supasitthumrong, Thitiporn, Tunvirachaisakul, Chavit, Aniwattanapong, Daruj, Tangwongchai, Sookjaroen, Chuchuen, Phenphichcha, Tawankanjanachot, Itthipol, Snabboon, Thiti, Hemrungrojn, Solaphat, Carvalho, Andre F., Maes, Michael · 2019 · Journal of Alzheimer’s Disease
Immunometabolism Reframes Alzheimer’s Disease: From Systemic Dysmetabolism to Glial Rewiring
Duc‐Hiep Bach, Long L Nguyen · 2026 · Cellular and Molecular Neurobiology
Neurogenetic and Neuroepigenetic Mechanisms in Cognitive Health and Disease
Davide Martino Coda, Johannes Gräff · 2020 · Frontiers in Molecular Neuroscience
Exploring the Role of Lipid-Binding Proteins and Oxidative Stress in Neurodegenerative Disorders: A Focus on the Neuroprotective Effects of Nutraceutical Supplementation and Physical Exercise
Giorgia Scarfò, Rebecca Piccarducci, Simona Daniele, Ferdinando Franzoni, Claudia Martini · 2022 · Antioxidants
Structural insights into human ABCA7-mediated lipid transport
Shucheng Fang, Liang Wang, Meng‐Ting Cheng, Da Xu, Zhipeng Chen, Jie Wang, Wenli Liao, Yanyan Li, Cong‐Zhao Zhou, Wen‐Tao Hou et al. · 2025 · Structure
Amyloid Signature Proteins in Feline Amyloidosis
S. Miyazaki, Ayumi Kadota, Ikki Mitsui, Tomoaki Murakami · 2020 · Journal of Comparative Pathology
The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology
Anett Hudák, Katalin Jósvay, Ildikó Domonkos, Annamária Letoha, László Szilák, Tamás Letoha · 2021 · International Journal of Molecular Sciences
Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction
Steve Zaldua, Frederick C. Damen, Rohan Pisharody, Riya Thomas, Kelly D. Fan, Giri K. Ekkurthi, Sarah B. Scheinman, Sami Alahmadi, Felecia M. Marottoli, Simon T. Alford et al. · 2020 · Heliyon
Differences in Recycling of Apolipoprotein E3 and E4—LDL Receptor Complexes—A Mechanistic Hypothesis
Meewhi Kim, Безпрозванный Илья Борисович · 2021 · International Journal of Molecular Sciences
Association of the top 20 Alzheimer's disease risk genes with [18F]flortaucipir PET
Eddie Stage, Shannon L. Risacher, Kathleen A. Lane, Sujuan Gao, Kwangsik T. Nho, Andrew J. Saykin, Liana G. Apostolova, Alzheimer’s Disease Neuroimaging Initiative · 2022 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
An in-silico insight into the predictive interaction of Apolipoprotein-E with Epstein-Barr virus proteins and their probable role in mediating Alzheimer’s disease
Deeksha Tiwari, Gaurava Srivastava, Omkar Indari, Vijay Shankar Tripathi, Mohammad Imran Siddiqi, Hem Chandra Jha · 2022 · Journal of Biomolecular Structure and Dynamics
Genetic Interaction of APOE and FGF1 is Associated with Memory Impairment and Hippocampal Atrophy in Alzheimer’s Disease
Ya‐Ting Chang, Hiroaki Kazui, Manabu Ikeda, Chi‐Wei Huang, Shu-Hua Huang, Shih‐Wei Hsu, Wen‐Neng Chang, Chiung‐Chih Chang · 2018 · Aging and Disease
A Concise Overview of Biosensing Technologies for the Detection of Alzheimer's Disease Biomarkers
Marjan Talebi, Hadi Esmaeeli, Mohsen Talebi, Tahereh Farkhondeh, Saeed Samarghandian · 2021 · Current Pharmaceutical Biotechnology
Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females
Tian Wang, Zisu Mao, Yuan Shang, Simona Merlini, Francesca Vitali, Jean‐Paul L. Wiegand, Roberta Dı́az Brinton · 2025 · Frontiers in Aging Neuroscience
Mechanisms of Astrocyte Action in the Blood Brain Barrier: From Structural Support to Dynamic Regulation
Di null Feng, Lili null Wang, Aoyu null Hu, Shanshan Zhang · 2025 · Journal of Integrative Neuroscience
Genetic interaction is associated with lower metabolic connectivity and memory impairment in clinically mild Alzheimer's disease
Young‐Tae Chang, Cheng‐Wei Huang, Shu‐Hua Huang, Shih Wei Hsu, W.‐N. Chang, J.‐J. Lee, Chiung‐Chih Chang · 2018 · Genes Brain & Behavior
A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease
Haimeng Bai, Adam Christian Naj, Penelope H. Benchek, Logan C. Dumitrescu, Timothy J. Hohman, Kara L. Hamilton‐Nelson, Asha R. Kallianpur, Anthony J. Griswold, Badri Narayan Vardarajan, Eden R. Martin et al. · 2023 · Alzheimer s & Dementia
Trans‐ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study
Patrick M. Abou‐Sleiman, Hui‐Qi Qu, John J. Connolly, Frank D. Mentch, Alexandre C. Pereira, Paulo A. Lotufo, Stephen M. Tollman, Ananyo Choudhury, Michèle Ramsay, Norihiro Kato et al. · 2023 · Alzheimer s & Dementia
CRISPR/Cas9 Gene Editing: A Novel Approach Towards Alzheimer's Disease Treatment
Siddhant Tripathi, Yashika Sharma, Rajesh A. Rane, Dileep Kumar · 2024 · CNS & Neurological Disorders - Drug Targets
When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age
Teal S. Eich, Angeliki Tsapanou, Yaakov Stern · 2019 · Neuropsychologia
Regulation of Alzheimer's disease-associated proteins during epileptogenesis
Eva‐Lotta von Rüden, Christina Zellinger, Julia Gedon, Andreas Walker, Vera Bierling, Cornelia A. Deeg, Stefanie M. Hauck, Heidrun Potschka · 2019 · Neuroscience
Approaches for Increasing Cerebral Efflux of Amyloid-β in Experimental Systems
David A. Loeffler · 2024 · Journal of Alzheimer s Disease
Maximally asymmetric transbilayer distribution of anionic lipids alters the structure and interaction with lipids of an amyloidogenic protein dimer bound to the membrane surface
Sara Y. Cheng, George Chou, Creighton Buie, Mark W. Vaughn, Campbell Compton, Kwan Hon Cheng · 2016 · Chemistry and Physics of Lipids
Structural Switch from Hairpin to Duplex/Antiparallel G-Quadruplex at Single-Nucleotide Polymorphism (SNP) Site of Human Apolipoprotein E ( APOE ) Gene Coding Region
Swati Chaudhary, Mahima Kaushik, Saami Ahmed, Ritushree Kukreti, Shrikant Kukreti · 2018 · ACS Omega
Targeting Neuroplasticity, Cardiovascular, and Cognitive-Associated Genomic Variants in Familial Alzheimer’s Disease
Jorge Ivan Velez, Francisco Javier Lopera, Penelope K. Creagh, Laura B. Piñeros-Hernández, Debjani Das, Martha Lucía Cervantes-Henríquez, Johan E. Acosta-López, Mario A. Isaza-Ruget, Lady G. Espinosa, Simon Easteal et al. · 2018 · Molecular Neurobiology
Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOE ɛ 4 Carriers
Chelsea C. Hays, Zvinka Z. Zlatar, Mary J. Meloy, J Osuna, Thomas T. Liu, Douglas R Galasko, Christina E. Wierenga · 2019 · Journal of Alzheimer s Disease
A Review of Brain-Targeted Nonviral Gene-Based Therapies for the Treatment of Alzheimer’s Disease
Sanjay Arora, Divya Sharma, Buddhadev Layek, Jagdish Singh · 2021 · Molecular Pharmaceutics
Map kinase and PKC signaling pathways modulate NGF-mediated apoE transcription
Megan Rae Strachan-Whaley, Kate Reilly, James Dobson, Bettina E. Kalisch · 2015 · Neuroscience Letters
LRP1 at the crossroads of Aβ clearance and therapeutic targeting in Alzheimer’s disease
Yuepeng Deng, Haolin Yin, Zihao Lu, Huan Lan, Wenxiong Liu, Chao Zuo, Nanfang Pan, Xiaohe Tian, Q. Gong · 2026 · Frontiers in Aging Neuroscience
Effects of DHA (omega-3 fatty acid) and estradiol on amyloid β-peptide regulation in the brain
Didier Majou, Anne-Lise Dermenghem · 2023 · Brain Research
The role of Apolipoprotein E4 on cognitive impairment in Parkinson’s disease and Parkinsonisms
Angenelle Eve Rosal, Sarah L. Martin, Antonio P. Strafella · 2025 · Frontiers in Neuroscience
Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy
Ana Pacheco de Oliveira, Divya Baghel, Brooke Holcombe, William Chase, Tyler Ward, Shih‐Hsiu J. Wang, Ayanjeet Ghosh · 2025 · Acta Neuropathologica
APOE ɛ4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults
Simone Hollands, Yen Ying Lim, Simon Matthew Laws, Victor L. Villemagne, Robert H. Pietrzak, Karra Harrington, Tenielle Porter, Peter Jeffrey Snyder, David J. Ames, Christopher James Fowler et al. · 2017 · Journal of Alzheimer s Disease
Liver-Brain Axis in Sporadic Alzheimer’s Disease: Role of Ten Signature Genes in a Mouse Model
Ruchi Jakhmola-Mani, Anam Islam, Deepshikha Pande Katare · 2020 · CNS & Neurological Disorders - Drug Targets
CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer’s Disease Encephalic Samples
Bruno Mari Fredi, Roger Willian de Lábio, Lucas Trevizani Rasmussen, Eduardo Federighi Baisi Chagas, Elizabeth Chen, Gustavo Turecki, Marı́lia de Arruda Cardoso Smith, Spencer Luíz Marques Payão · 2023 · Cellular and Molecular Neurobiology
Selective microRNA expression of exosomes from retinal pigment epithelial cells by oxidative stress
Zhengyu Zhang, Qinyuan Gu, Lu Chen, Dongqing Yuan, Xunyi Gu, Huiming Qian, Ping Xie, Qinghuai Liu, Zizhong Hu · 2024 · Vision Research
Impaired hypoxic tolerance in APP 23 mice: a dysregulation of neuroprotective globin levels
Zoë P. Van Acker, Evi Luyckx, Wendy Van Leuven, Eva Geuens, Peter Paul De Deyn, Debby Van Dam, Sylvia Dewilde · 2017 · FEBS Letters
Effects of Six-Month Aerobic Exercise Intervention on Sleep in Healthy Older Adults in the Brain in Motion Study: A Pilot Study
Veronica Guadagni, Cameron M. Clark, Amanda V. Tyndall, Jill K. Raneri, Jillian S. Parboosingh, David B. Hogan, Patrick J. Hanly, Marc J. Poulin · 2018 · Journal of Alzheimer s Disease Reports
Plasma levels of Interleukin 18 but not amyloid-β or Tau are elevated in female depressive patients
Farong Liu, Luyin Yang, Huifei Sophia Zheng, Yunqiang Zhou, Bin-bin Chen, Huaxi Xu, Yun‐wu Zhang, Dong‐Yan Shen · 2020 · Comprehensive Psychiatry