Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

Guillot-Sestier, Marie-Victoire, Doty, Kevin R., Gate, David, Rodriguez, Javier, Leung, Brian P., Rezai-Zadeh, Kavon, Town, Terrence·2015·Neuron

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Items 101–200 of 363

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  5. Immunization with Bacillus Calmette-Guérin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the recruitment of inflammation-resolving monocytes to the brain
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  7. Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming
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  11. IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
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  12. Interleukin-10 deficiency exacerbates inflammation-induced tau pathology
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  13. Innate immune activation in Alzheimer’s disease
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  14. The neuroinflammatory role of microglia in Alzheimer's disease and their associated therapeutic targets
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  15. Brain interference: Revisiting the role of IFNγ in the central nervous system
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  16. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease
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  17. Maresin 1 Improves Cognitive Decline and Ameliorates Inflammation in a Mouse Model of Alzheimer’s Disease
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  18. Targeting Microglia in Alzheimer’s Disease: Pathogenesis and Potential Therapeutic Strategies
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  19. CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis
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  20. Actin-mediated Microglial Chemotaxis via G-Protein Coupled Purinergic Receptor in Alzheimer’s Disease
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  21. Administrations of human adult ischemia-tolerant mesenchymal stem cells and factors reduce amyloid beta pathology in a mouse model of Alzheimer's disease
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  22. Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice
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  23. Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells
    Yunjie Yang, Zitian He, Zhiwei Xing, Zejie Zuo, Lifang Yuan, Yingying Wu, Mei Hua Jiang, Fangfang Qi, Zhibin Yao · 2020 · Journal of Neuroinflammation
  24. Anti-inflammatory Signaling in Microglia Exacerbates Alzheimer’s Disease-Related Pathology
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  25. A fresh perspective from immunologists and vaccine researchers: Active vaccination strategies to prevent and reverse Alzheimer's disease
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  26. Activation of STAT3 Regulates Reactive Astrogliosis and Neuronal Death Induced by AβO Neurotoxicity
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  27. Mapping of Variable DNA Methylation Across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome
    Junchen Gu, Michael W. Stevens, Xiaoyun Xing, Daofeng Li, Bo Zhang, Jacqueline E. Payton, Eugene M. Oltz, James N. Jarvis, Kaiyu Jiang, Theodore J. Cicero et al. · 2016 · G3 Genes Genomes Genetics
  28. Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis
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  29. AF710B, an M1/sigma‐1 receptor agonist with long‐lasting disease‐modifying properties in a transgenic rat model of Alzheimer's disease
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  30. Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer’s disease pathophysiology
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  32. Alzheimer’s disease and cytokine IL-10 gene polymorphisms: is there an association?
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  33. Cognitive impairment after long COVID-19: current evidence and perspectives
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  35. N , N ′-Diacetyl- p -phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice
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  36. Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer’s Disease Immunotherapy
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  37. Serum Interleukin-10 Levels Correlate with Cerebrospinal Fluid Amyloid Beta Deposition in Alzheimer Disease Patients
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  39. An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
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  40. Increased tauopathy drives microglia-mediated clearance of beta-amyloid
    Wesley Chen, Edsel Abud, Stephen T. Yeung, Anita Lakatos, Trevor Nassi, Jane Wang, David L Blum, Luc Buée, Wayne W. Poon, Mathew M. Blurton-Jones · 2016 · Acta Neuropathologica Communications
  41. Resistance Exercise Decreases Amyloid Load and Modulates Inflammatory Responses in the APP/PS1 Mouse Model for Alzheimer’s Disease
    Debora Hashiguchi, Henrique Correia Campos, Raphael Wuo‐Silva, Jean Faber, Sérgio Gomes da Silva, Antônio Augusto Coppi Maciel Ribeiro, Ricardo Mário Arida, Beatriz M. Longo · 2020 · Journal of Alzheimer s Disease
  42. Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease
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  45. Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice
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  53. Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles
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  73. Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease
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