The neuroinflammatory role of microglia in Alzheimer's disease and their associated therapeutic targets

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

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Inflammation and cancer: triggers, mechanisms, and consequences

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The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation

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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

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Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

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Inflammation and tumor progression: signaling pathways and targeted intervention

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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Macrophage M1/M2 polarization

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Microglial <scp>M1/M2</scp> polarization and metabolic states

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The ageing systemic milieu negatively regulates neurogenesis and cognitive function

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High performance plasma amyloid-β biomarkers for Alzheimer's disease

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A polarizing question: do M1 and M2 microglia exist?

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CSF markers for incipient Alzheimer's disease

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The P2X7 Receptor in Infection and Inflammation

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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

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A Meta-Analysis of Cytokines in Alzheimer's Disease

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Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

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Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

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Clinical trial of indomethacin in Alzheimer's disease

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Alzheimer’s disease: risk factors and potentially protective measures

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Blood-brain barrier dysfunction and recovery after ischemic stroke

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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

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Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

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Emerging roles of PPARS in inflammation and immunity

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Microglia polarization from M1 to M2 in neurodegenerative diseases

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

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Diagnosis of Early Alzheimer's Disease: Clinical Practice in 2021

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Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies

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Regulation of Tau Pathology by the Microglial Fractalkine Receptor

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A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

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Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

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IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

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Immune proteins in brain development and synaptic plasticity

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Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

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CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

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Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

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Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease

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Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

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Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

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Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

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IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline

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The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease

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Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

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The China Alzheimer Report 2022

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APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics

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β-amyloid Peptides and Amyloid Plaques in Alzheimer's Disease

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Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury

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NLRP3 Inflammasome and Inflammatory Diseases

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The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ

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Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity

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Role of tau protein in Alzheimer’s disease: The prime pathological player

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CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease

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CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

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Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases

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IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

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APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease

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Cytokine Signaling Modulates Blood-Brain Barrier Function

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NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

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Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in <i>ApoE4</i> Carriers

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Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

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Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling

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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

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Anti-Inflammatory Drugs and Risk of Alzheimer's Disease: An Updated Systematic Review and Meta-Analysis

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The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

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A Randomized Pilot Clinical Trial of the Safety of Pioglitazone in Treatment of Patients With Alzheimer Disease

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The Role of NLRP3 Inflammasome in Alzheimer’s Disease and Potential Therapeutic Targets

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TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy

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Increased Serum IL-1β Level in Alzheimer’s Disease and Mild Cognitive Impairment

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Serum IgG Antibody Levels to Periodontal Microbiota Are Associated with Incident Alzheimer Disease

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Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

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Alzheimer’s Disease And Inflammation: A Review Of Cellular And Therapeutic Mechanisms

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Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease

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Fractalkine‐induced activation of the phosphatidylinositol‐3 kinase pathway attentuates microglial activation <i>in vivo</i> and <i>in vitro</i>

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Non-Steroidal Anti-Inflammatory Drugs as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Treatment Effect

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The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives

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Purification of Apolipoprotein E Attenuates Isoform-specific Binding to β-Amyloid

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NF-κB as a Key Mediator of Brain Inflammation in Alzheimer’s Disease

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NSAID Exposure and Risk of Alzheimer's Disease: An Updated Meta-Analysis From Cohort Studies

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Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

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Li, X., Li, Z., Chen, H., Guo, H., Ge, Y., Dong, F., Zhang, F., & Zhang, F. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115199 · Cited by 6 · see citing works

TREM2 and LAG-3 in cancer and Alzheimer’s disease immunotherapy

Yuan, S., Fuchs, N. S., Abdel‐Rahman, S. A., Kaur, B., & Gabr, M. T. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2025.06.010 · Cited by 6 · see citing works

Inflammation in Obstructive Sleep Apnea: A Global Bibliometric Perspective

Fan, H., Niu, H., ‍Zhao, B., & Gao, X. (2025) · Nature and Science of Sleep · doi:10.2147/nss.s554362 · Cited by 6 · see citing works

Inhibitory Potential of the Drimane Sesquiterpenoids Isotadeonal and Polygodial in the NF-kB Pathway

Marín, V., Villegas, C., Ogundele, A. V., Cabrera‐Pardo, J. R., Schmidt, B., Paz, C., & Burgos, V. (2025) · Molecules · doi:10.3390/molecules30071555 · Cited by 5 · see citing works

Chemical Profiling of Polyphenolic Fraction of Cannabis sativa L. vr. Kompolti Industrial Inflorescences: Insights into Cannabidiol Neuroprotective Effects in a Cellular Model of Parkinson’s Disease

Fantasma, F., D’Urso, G., Martella, N., Capuano, A., Boccia, E., Samukha, V., Felice, V. D., Saviano, G., Trombetta, F., Lauro, G., et al. (2025) · Plants · doi:10.3390/plants14101473 · Cited by 4 · see citing works

Direct and indirect role of non-coding RNAs in company with amyloid and tau protein in promoting neuroinflammation in post-ischemic brain neurodegeneration

Pluta, R. M. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1670462 · Cited by 4 · see citing works

A role for INPP5D in aerobic exercise-mediated attenuation of microglial activation and neuroinflammation in Alzheimer's disease

Jiang, T., Zhuang, Y., Jian, J., Wang, J., Ding, Z., Liu, W., Wu, T., & Yang, M. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111633 · Cited by 4 · see citing works

Research progress on microglial pyroptosis and inflammasomes: a comprehensive analysis

Wang, X., Li, Z., Ma, B., & Jia, Q. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1582579 · Cited by 3 · see citing works

Silencing SOX2-OT alleviates A β -induced damage to neurons and microglial cells by targeting miR-143-3p in Alzheimer’s disease

Huang, T., Wang, X., & Liu, Y. (2025) · Toxicology Research · doi:10.1093/toxres/tfaf159 · Cited by 3 · see citing works

Isoliensinine confers neuroprotection and alleviates LPS-induced neuroinflammation in microglia by regulating the MAPK/NF-κB signaling

Yuan, M., Hu, J., Gao, L., Long, W., Wang, S., Tan, X., & Hu, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1675865 · Cited by 3 · see citing works

Antibody drug conjugates in Alzheimer’s disease: emerging strategies and future directions

AmeliMojarad, M., & AmeliMojarad, M. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.12.053 · Cited by 3 · see citing works

Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer’s disease-like pathology in mice

Li, Y., Wang, H., Zhang, D., Wang, S., Li, Z., Li, J.-J., Tai, S., Tong, D.-D., Wang, B., Lu, D., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68937-9 · Cited by 4 · see citing works

Targeting of neuroinflammation, oxidative stress, and synaptic dysfunction by vinpocetine in alzheimer’s disease: a comprehensive appraisal

Al‐kuraishy, H. M., Jabir, M., Rafeeq, M. F., Sulaiman, G. M., Albuhadily, A. K., & Al-Gareeb, A. I. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01829-5 · Cited by 3 · see citing works

Neuroinflammation in neurodegenerative diseases: pathogenic pathways and emerging pharmacotherapeutic targets in Alzheimer’s and Parkinson’s disease

Kumar, R. R., Kamaljeet, & Kosey, S. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02325-z · Cited by 3 · see citing works

Enzymes and Alzheimer's Disease: Pioneering Drug Development Strategies

Godwa, T., Dubey, S., & Tiwari, P. K. (2025) · Current Psychopharmacologye · doi:10.2174/0122115560340307250106065419 · Cited by 3 · see citing works

Carvacrol/thymol derivatives as highly selective BuChE inhibitors with anti-inflammatory activities: Discovery and bio-evaluation

Zhang, Y.-L., Yang, H.-Y., Gou, J., Qi, X., Qiao, Y.-B., & Li, Q. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108430 · Cited by 3 · see citing works

miR-132 and Its Exosomal Form in Alzheimer’s Disease: Linking Epigenetic Regulation to Neurodegeneration

Oriquat, G. A., Abdulsahib, W. K., Jyothi, S. R., Nayak, P. P., Chauhan, A. S., Singla, S., Sead, F. F., & Polatova, D. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05513-0 · Cited by 3 · see citing works

From omics to function: role of DNAJC13, RIN3, SERPINB9, SLC11A1, and TGFBR1 in Parkinson's disease-associated microglia

Liu, Z., Liu, S., Chang, Y., & Rong, J. (2026) · European journal of medical research · doi:10.1186/s40001-026-04151-z · Cited by 2 · see citing works

Antioxidant and Anti-Inflammatory Activity of N-acylethanolamines of Omega-3 Polyunsaturated Fatty Acids in Vitro

Manzhulo, I., Gromova, E., Ivashkevich, D., Egoraeva, A. A., Sultanov, R. M., & Ponomarenko, A. I. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01942-9 · Cited by 2 · see citing works

Neuroinflammation and Its Impact on Autophagy in Neurodegeneration

Bhattacharya, K., Chanu, N. R., Das, D., & Kumpakha, R. (2025) · Springer eBooks · doi:10.1007/978-981-95-3945-1_1 · Cited by 1 · see citing works

Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 expression in microglia during Alzheimer’s disease progression

Xu, Z., Chen, M., Liang, F., Song, S., Lei, J., Huang, X., Hu, D., Tang, L., Xu, P., & Lu, L. Z.-B. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-025-07621-w · Cited by 1 · see citing works

CTAD 2025: Key trends redefining therapeutic and diagnostic strategies in Alzheimer's disease

Yuan, M., & Zhou, H.-Y. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261430764 · Cited by 1 · see citing works

Natural Chiral Scaffolds in Alzheimer′s Disease: Therapeutic Potential, Mechanism, and Clinical Aspects

Singh, A., Sahu, S. K., & Sah, A. K. (2026) · BioMed Research International · doi:10.1155/bmri/5968529 · Cited by 1 · see citing works

New Oligophenalenone Dimers from Talaromyces stipitatus with Potential Anti-Neuroinflammatory Activity

Liu, Q., Gao, Y., Wang, B., Du, K., Zhu, S., Yuan, Y., Gao, Y., & Yue, T. (2026) · Molecules · doi:10.3390/molecules31081308 · Cited by 1 · see citing works

Neuroinflammation-centered pathophysiology and therapeutic strategy design in Alzheimer's disease: Cutting-edge developments

Li, D., Zhang, Z., Lei, L. U., Liu, J., Cai, W., Hou, J., Lu, Y., & Yu, G. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112689 · Cited by 4 · see citing works

A brain-targeted biomimetic iron-porphyrin covalent organic framework nanoplatform for Alzheimer's disease: synergistic intervention via antioxidant, Aβ-regulating and immunomodulatory effects

Yan, Y., Tian, D., Yang, F., Zhao, R., Deng, L., Wang, Q., & Xie, M. (2026) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2026.141264 · Cited by 1 · see citing works

Emerging diagnostic biomarkers and therapeutic targets in Alzheimer's disease

Dineshbhai, T. K., Rafaliya, D., Singh, A., Maheshwari, S., Lalan, M. S., & Chakraborthy, G. S. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02341-z · Cited by 1 · see citing works

Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis?

Chmiel, J., Gawełczyk, W., Soczyńska, J., & Leszek, J. (2026) · Cells · doi:10.3390/cells15131151

Development of an AAV Vector System for Highly Specific and Efficient Gene Expression in MicrogliaPreprint

Aoki, R., Konno, A., Hosoi, N., Kawabata, H., & Hirai, H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.05.622037

Hyperintensity of the left piriform cortex and amygdala on T2-weighted FLAIR images in patients with probable Alzheimer’s disease correlates with cerebral cortical atrophy

Ishizaka, H., Sekine, A., Naka, M., Nakano, S., Nagase, H., & Tsushima, Y. (2025) · Acta Radiologica Open · doi:10.1177/20584601251317629

Daidzein Ameliorates Alzheimer's Disease-Like Cognitive Decline and Neuroinflammation by Modulating Rtn4bPreprint

Wang, X., Wang, X., Yin, Z., Meng, X., Yang, X., Han, J., Yang, W., Chen, D., Zhao, F., Yun, J., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5339597

Targeting Microglial Phagocytosis for Alzheimer's Disease Management: Natural, Pharmacological, Nanoparticle, and Gene Therapy Approaches

Raghuvanshi, S., Mazumder, A., & Das, S. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273378092250623064748

CSF1R inhibitors pexidartinib and sotuletinib induce rapid glial ablation despite their limited brain penetrabilityPreprint

van Tellingen, O., Tolboom, Z. J., Leter, Y. M., Tsouri, E., Burylo, A. M., Heijningen, C. L. V., Schagen, S. B., de Gooijer, M. C., & Kuil, L. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.11.681780

Traditional Chinese Medicine and Ferroptosis in Alzheimer’s Disease: A Potential Therapeutic Approach

Liu, A., Xing, L., Li, J., Yao, M., Song, J., Guo, W., Duan, P., & Li, H. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s590868

Life Cycle and Circadian Rhythms in Central Resident Immunity and Neuropsychiatric Pathology

Lim, Z., Nguyen, H. L., Zeng, Y., Qu, Q., Le, Y., Sun, M., Wang, X., Zhu, H., Qian, Y., Saeed, S., et al. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01612-7

Aging effects on emotionality, cognition and brain mononuclear cells in Sprague-Dawley rats of both sexes

Djuretić, J., Ivanović, J., Jezdić, K., Todorović, V., Bufan, B., Santrač, A., & Aranđelović, J. (2026) · npj Aging · doi:10.1038/s41514-026-00364-y

Natural Product Rengyolone Attenuates LPS‐Induced Microglia Inflammation via Suppression of the TLR4/NF‐κB Pathway

Li, Z., Sun, Q., Yang, X., Zu, X., Chen, X., Xu, X., Wang, J., Li, X., & Shen, Y.-H. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.71314

L-ornithine liposomal nanoparticles as a potent candidate for hepatic encephalopathy therapy via inhibiting Δ1-pyrroline-5-carboxylate dehydrogenase

Atta, A., Mohamed, T. M., & Salem, M. M. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110001

Research Progress on Neuroinflammatory Activity and Mechanisms of Natural Products in the Treatment of Alzheimer’s Disease

Liu, Q., Miao, D., Ge, X., Yan, S., Zhang, T., & Li, H. (2026) · Natural Product Communications · doi:10.1177/1934578x261456969

Fukinolic acid facilitates toxic amyloid-β oligomerization and exacerbates synaptic dysfunction

Chae, H. J., Kwon, H., Son, S.-R., Moon, S., Park, A. Y., Bae, H. J., Jang, D. S., & Kim, D. H. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119619

Ershiwuwei Shanhu Pill ameliorates cognitive impairment in Alzheimer’s disease mice by remodeling gut microbiota and host serum metabolites

Li, N., Jiang, K., Peng, X., Yang, C., Xiong, W., & Wang, W. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1820691

Wine polyphenols and potential uses in alzheimer’s disease: A new narrative

Raja, T. R. W., Pillay, M., Thenmozhi, J., Diana, M., & Duraipandiyan, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29192-0.00048-0

PGK1 Drives Glial Glycolytic Reprogramming to Mediate Isoflurane‐Induced Cognitive Impairment in Aged Mice

Ren, Z., Hu, H., Guo, J., Liu, Y., Qiu, C., Yuan, K., Ma, Y., Jiao, S., Guo, R., Zhao, D., et al. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71276

A nose-to-brain drug delivery system targeting mitochondrial dysfunction: application potential and future prospects of chitosan nanogels in Alzheimer's disease

Huang, Q., Zuo, Y., Xie, Y., Liu, Z., Wang, L., Xu, H., Yu, M., & Liu, C. (2026) · Biomaterials Science · doi:10.1039/d6bm00624h

Regulatory Effects of the PDE8B Inhibitor PF-04957325 on Cognitive Impairment and Neuroinflammation in Aβ-Induced Alzheimer’s Disease Mouse Models

Liu, Y., Li, M., Yu, H., Liu, H., Xu, Q., & Li, F. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04830-7

Nanomedicine targeting neuroinflammatory pathways in Alzheimer’s disease: a new frontier in inflammopharmacology

Kaushik, S., Fatima, J. E., Raheem, A., Barbhuiya, M. A., Thirupathi, A. T., Singh, L. P., Khan, P. A., Aparna, T. N., Pramanik, S., & Shahid, M. A. A. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02329-9

Calycosin attenuates LPS-induced microglia inflammatory responses and microglia-mediated synaptic impairment via modulation of TLR4/MyD88/NF-κB signaling pathway

Gao, X., Wang, R., Chen, H., Chen, X., & Wang, X. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1817366

The role of microglia glucose metabolism reprogramming in Alzheimer's disease treatment

Cao, Q., Shen, M., Liu, Y., Li, C., Liu, L., Zhou, J., Yue, R., Niu, D., Ren, Y., Pan, L., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261478594

Targeting amyloid and Tau: Antibody therapies for Alzheimer’s disease

Upadhyay, R., Sangitha, & Sevanan, M. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.08.011

Palmitic Acid Amplifies Microglial Inflammatory Activation Involving C5aR1-Sensitive Inflammatory Signaling and JMJD3/H3K27me3-Related Epigenetic Changes

Chen, L., Xu, S., Liu, Y., & Luo, X. (2026) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-026-10308-8

Lipid Metabolism in Central Nervous System Diseases: Pathological Mechanisms and Therapeutic Advances

Yuan, J., Huang, S., Jiao, K., Yang, S., Ge, X., Liu, W., Wang, W., Shu, H., & Zhou, X. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71109

Precision medicine: personalizing treatments for improved outcomes

Papadopoulou, P., & Stratakis, C. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40572-3.00015-0

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Cartas‐Cejudo, P., Miguel, M. D., Extramiana, L., Lachén‐Montes, M., Romero-Murillo, S., Gveric, D. O., Fernández‐Irigoyen, J., & Santamaría, E. (2026) · Brain Pathology · doi:10.1111/bpa.70140

Metal Ions and Protein Aggregation: Unraveling Molecular Interactions and Theranostic Prospects in Proteinopathies

Milardi, D., Han, J., Lee, H. J., Ding, F., Miller, Y., Faller, P., Bush, A. I., Crouch, P. J., Finkelstein, D. I., Double, K. L., et al. (2026) · Chemical Reviews · doi:10.1021/acs.chemrev.5c00420

Substituent Effects on Electronic Properties and Acetylcholinesterase Inhibitory Potential of Donepezil Analogues: A DFT, Molecular Docking, and ADMET Study with Dynamics Validation of the Lead CandidatePreprint

Ejaz, M. M., Iftikhar, H., Al-Namshah, K. S., Khan, S., Ashraf, S., Meer, N., Riaz, M., Saleem, M., & Khan, M. S. J. (2026) · Research Square · doi:10.21203/rs.3.rs-11082767/v1

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases

Tian, Q., Tong, Y., Yu, F., & Hu, X. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71118

Fucosylated chondroitin sulfate modulates microglia-associated responses and reduces Aβ burden with ERK1/2-related signaling changes

Xiao, X., Gao, F., Xie, J., Lu, Y., Lv, K., Mo, H., Chen, J., Liu, J., 蒙琪光, Guan, Y., et al. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106278

Sodium oligomannate remodels gut redox adaptation and promotes microbiota-derived indole-3-propionic acid production to alleviate Alzheimer’s disease

Zhang, D., Chu, H., Zhang, Y., Wang, Y., Zhang, Y., Guo, Y., Wan, P., Yue, H., Sun, G., Chao, Y., et al. (2026) · Gut · doi:10.1136/gutjnl-2026-339603

Engineering human brain microphysiological systems for alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE) modeling and drug testing: translational promise, limitations, and future directions

Yun, Y., Jena, S., Egido-Betancourt, H., Uzoechi, S., Kim, D. Y., Lee, J.-M., & Nguyen, J. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115982

Microglia in the Neuroinflammatory Pathogenesis of Alzheimer’s Disease and Related Therapeutic Targets

Cai, Y., Liu, J., Wang, B., Sun, M., & Yang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.856376 · Cited by 351 · see citing works

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

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Brain resident microglia in Alzheimer’s disease: foe or friends

Kaur, S., Malleshwari, K., Sharma, A., Giridharan, V. V., & Dandekar, M. P. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01550-8 · Cited by 23 · see citing works

Microglia-Associated Neuroinflammation in Alzheimer’s Disease and Its Therapeutic Potential

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Microglial Dysregulation Underlying Neuroinflammatory Pathogenesis in Alzheimer’s Disease and Related DementiasPreprint

Singh, A. S., Naqvi, A., & Chanu, M. T. (2026) · Preprints.org · doi:10.20944/preprints202606.0446.v1