Distinct subpopulations of nucleus accumbens dynorphin neurons drive aversion and reward

Al-Hasani, Ream, McCall, Jordan G., Shin, Gunchul, Gomez, Adrian M., Schmitz, Gavin P., Bernardi, Julio M., Pyo, Chang-O., Park, Sung Il +7 more·2015·Neuron

Cited by (344)

Items 301–344 of 344

  1. The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
    A Marinescu, Eshita Kamal, Peter Leary, Keila Navarro I Batista, Manuel Klug, Nataša Savić, Christelle Le Foll, Marie A. Labouesse · 2025 · eLife
  2. Local control of dopamine release in nucleus accumbens gates opioid withdrawal aversion
    Matthew B. Pomrenze, Jason Tucciarone, Gavin C. Touponse, Nicholas Denomme, BaDoi N. Phan, Robyn St. Laurent, Julia A Galiza Soares, Daniel F. Cardozo Pinto, Michaela Y. Guo, Jinhee Baek et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  3. A conserved population of genetically defined striatal neurons gates opioid reward
    Olivia R. Drake, Caroline M. Fiore, Emily T. Jorgensen, Catherine E. Newman, Luke Potter, Austyn Trull, Aditya Pradeep, Lara Ianov, Jamie Peters, Jasper A. Heinsbroek et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Liquid Chromatography-Mass Spectrometry Strategies for in vivo Neurochemical Monitoring with Microdialysis.
    Jenny‐Marie T. Wong · 2016 · Deep Blue (University of Michigan)
  5. The Neural Encoding of Reward in the Striatal-Pallidal Circuitry
    Chung Lung Chan · 2017 · e-Publications@Marquette (Marquette University)
  6. The Role of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in the Neurobiology of Stress-Related Behaviors
    Rachel J. Donahue · 2016 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
  7. A Molecular Code for Imprinting Drug-Cue Associations
    Adrian M. Gomez, Michael R. Bruchas · 2017 · Neuron
  8. Kappa counterconditioning of cocaine cues
    John R. Mantsch, Robert C. Twining · 2018 · Neuropsychopharmacology
  9. Role of Stress-Associated Signaling in Addiction
    Elizabeth M. Doncheck, John R. Mantsch · 2018 · Elsevier eBooks
  10. ALCOHOL ABOLISHES POST-STRESSOR AVERSION IN MALE RATS (POTENTIAL ROLE OF к-OPIOID RECEPTORS)
    Valery N. Mukhin, Andrey P. Kozlov, Irina N. Abdurasulova, Konstantin I. Pavlov, Vadim V. Sizov, Anna V. Matsulevich, В. М. Клименко · 2018 · Medical academic journal
  11. Exploring the side effect profile of 16-Ethynyl Salvinorin A
    Stephen George Mathew · 2019
  12. Investigating the anti-cocaine, anti-nociceptive properties and side effects of MP1104, a novel mixed opioid receptor agonist
    Diana Vivian Atigari · 2019
  13. Nucleus accumbens n-methyl-d-aspartate receptor function and reward learning: implications for cocaine use disorders
    Max E. Joffe · 2016
  14. The Kappa Opioid Receptor is required for some intermittent alcohol drinking induced changes in stress and threat responding in male C57BL/6J mice
    Lara S. Hwa, Morgan Bowling, Rachel Calloway, Thomas L. Kash · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Chronic Pain in a Mouse Model of Multiple Sclerosis: Contributions of the Kappa Opioid System
    Caylin I. Chadwick · 2021 · ERA: Education and Research Archive (University of Alberta)
  16. Dichotomic Regulation of Striatal Plasticity by Dynorphin
    Renzhi Yang, Rupa R. Lalchandani, Fuu-Jiun Hwang, Daniel W. Bloodgood, Dong Kong, Jun Ding · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Faculty Opinions recommendation of A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system.
    Kent C. Berridge · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  18. Faculty Opinions recommendation of Optogenetic activation of amygdala projections to nucleus accumbens can arrest conditioned and unconditioned alcohol consummatory behavior.
    Kent C. Berridge · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  19. Faculty Opinions recommendation of Affective valence in the brain: modules or modes?
    Geoffrey M. Schoenbaum, Kauê Machado Costa · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  20. Pre-clinical Anti-Addictive and Side-Effect profiles of Novel Kappa-opioid Agonists
    David Young · 2015
  21. Faculty Opinions recommendation of Nucleus accumbens modulation in reward and aversion.
    Marina E. Wolf · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  22. Exploring the side effect profile of 16-Ethynyl Salvinorin A
    Stephen George Mathew · 2019
  23. Faculty Opinions recommendation of A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system.
    Wolfram Schultz · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  24. An arbiter model of motivational selection
    Gavan P. McNally · 2019
  25. Dorsal Hippocampus To Nucleus Accumbens Projections Drive Reinforcement Via Activation of Accumbal Dynorphin Neurons
    Nicolas Massaly, Khairunisa Mohamad Ibrahim, Hye Jean Yoon, Rossana Sandoval, Sidney B. Williams, Hannah E. Frye, William Post, Waylin Yu, Olayinka Idowu, Azra Zec et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  26. Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
    Nathan R. Kerr · 2023
  27. Dopamine transporter threonine-53 phosphorylation dictates kappa opioid receptor mediated locomotor suppression and conditioned place aversion via transporter upregulation
    Durairaj Ragu Varman, Lankupalle Damodara Jayanthi, Sammanda Ramamoorthy · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Dynorphin modulates motivation through a pallido-amygdala cholinergic circuit
    Qingtao Sun, Mingzhe Liu, Wuqiang Guan, Xiong Xiao, Chunyang Dong, Michael R. Bruchas, Larry S. Zweifel, Yulong Li, Lin Tian, Bo Li · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  29. A striosomal accumbens pathway drives compulsive seeking behaviors through an aversive Esr1+ hypothalamic-habenula circuit
    Thomas Contesse, Buse Yel Bektash, Marta Graziano, Chiara Forastieri, Alessandro Contestabile, Salomé Hahne, Felix Jung, Ifigeneia Nikolakopoulou, Xiao Cao, Vasiliki Skara et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  30. Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress
    Marwa O. Mikati, Petra Erdmann-Gilmore, Rose Connors, Sineadh M. Conway, Jim Malone, Justin Woods, Robert W. Sprung, R. Reid Townsend, Ream Al‐Hasani · 2025 · eLife
  31. The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
    A Marinescu, Eshita Kamal, Peter Leary, Keila Navarro I Batista, Manuel Klug, Nataša Savić, Christelle Le Foll, Marie A. Labouesse · 2026 · eLife
  32. Alcohol consumption drives sex- and region- specific disruption of somatostatin signaling in mice
    Dakota F. Brockway, Keith R. Griffith, Andrew J. Kacala, Lauren Bellfy, Laurel R. Seemiller, Matthew Ulrich, Joseph M. Ricotta, Md Shakhawat Hossain, Janine L. Kwapis, Patrick J. Drew et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Linking Depression, Alcohol Use Disorder, and DYN/KOR System Genes
    Selin Özkan-Kotiloğlu · 2025 · Springer eBooks
  34. The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot
    A Marinescu, Eshita Kamal, Peter Leary, Keila Navarro I Batista, Manuel Klug, Nataša Savić, Christelle Le Foll, Marie A. Labouesse · 2025 · eLife
  35. VGF in the Nucleus Accumbens Regulates Synaptic and Opioid-Evoked Plasticity
    Anisha P. Adke, Lydia B Cunitz, Rachel M. Dick, Tuba H. Ali, Carmen Julia Salvatierra Rocha, Ying Zhang, Lucy Vulchanova, Patrick E. Rothwell · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  36. Linking Depression, Alcohol Use Disorder, and DYN/KOR System Genes
    Selin Özkan-Kotiloğlu · 2024 · Springer eBooks
  37. C57 and DBA mouse strains express distinct cocaine avoidance phenotypes in an operant runway independent of differences in striatal dynorphin-enkephalin balance
    Bailey C. Remmers, In Bae Choi, Kanako Matsumura, Amélia Nicot, Sydney Cox, Lauren K. Dobbs · 2026 · Psychopharmacology
  38. Mu-opioid and nociceptin receptors show divergent, cell-type-specific actions in the mesocorticolimbic reward system in opioid use disorder
    Marie‐Charlotte Allichon, Jeanne Espinosa, Rebecca H. Cole, Mei-Chuan Ko, Peter Vanhoutte, Max E. Joffe · 2026 · Frontiers in Cellular Neuroscience
  39. Multisystem regulation of reward and addiction: beyond the dopaminergic system
    Óscar Arias-Carrión, Emmanuel Ortega‐Robles, Mario Treviño, Magdalena Guerra‐Crespo, Elı́as Manjarrez, Ernst Pöppel · 2026 · Frontiers in Pharmacology
  40. Social Novelty Recruits a Dysfunctional Nucleus Accumbens Ensemble That Drives Social Avoidance in a Shank3 −/− Autism Model
    Oakleigh M. Folkes, Meaghan Donahue, Rafael E. Perez, Angelica M. Minier-Toribio, Paola N. Negrón-Moreno, Marina R. Picciotto, Yong-Hui Jiang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Nucleus accumbens medial shell D1 and D2 medium spiny neurons signal the valence of conditioned stimuli in a sex-dependent manner
    Gabrielle Siemonsmeier, Eshaan S Iyer, Heike Schuler, Ariel Mandel Weinbaum, Kristine Huang, Joëlle Lopez, Rosemary C. Bagot · 2026 · Neuropsychopharmacology
  42. Kappa opioid receptors mediate aversion—and it matters
    Rainer Spanagel, Filipe Reis Teodoro Andrade · 2026 · Neuropsychopharmacology
  43. Peripheral kappa opioid receptors modulate cold hypersensitivity in a mouse model of chemotherapy-induced neuropathy
    Manish K. Madasu, Loc V. Thang, Christian C. Ohazurume, Sriya Chebrolu, Richard A. Houghten, Sravanthi Bandla, Tayler D. Sheahan, Audra M. Foshage, Jay P. McLaughlin, Jordan G. McCall et al. · 2026 · Pain
  44. Endocannabinoids facilitate reward engagement through retrograde gain control
    David J. Marcus, Anthony E. English, Gunn Chun, Emmaline F. Seth, Rachel Oommen, Sabrina Hwang, Bailey A Wells, Sean C. Piantadosi, Azra Vajzovic Suko, Sayaka J. Kenmochi et al. · 2026 · Nature