Cited by 345Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

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Al-Hasani, Ream, McCall, Jordan G., Shin, Gunchul, Gomez, Adrian M., Schmitz, Gavin P., Bernardi, Julio M., Pyo, Chang-O., Park, Sung Il, Marcinkiewcz, Catherine M., Crowley, Nicole A., Krashes, Michael J., Lowell, Bradford B., Kash, Thomas L., Rogers, John A., Bruchas, Michael R.·2015·Neuron

DOI 10.1016/j.neuron.2015.08.019PMC PMC4625385

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Abstract

The nucleus accumbens (NAc) and the dynorphinergic system are widely implicated in motivated behaviors. Prior studies have shown that activation of the dynorphin-kappa opioid receptor (KOR) system leads to aversive, dysphoria-like behavior. However, the endogenous sources of dynorphin in these circuits remain unknown. We investigated whether dynorphinergic neuronal firing in the NAc is sufficient to induce aversive behaviors. We found that photostimulation of dynorphinergic cells in the ventral NAc shell elicits robust conditioned and real-time aversive behavior via KOR activation, and in contrast, photostimulation of dorsal NAc shell dynorphin cells induced a KOR-mediated place preference and was positively reinforcing. These results show previously unknown discrete subregions of dynorphin-containing cells in the NAc shell that selectively drive opposing behaviors. Understanding the discrete regional specificity by which NAc dynorphinerigic cells regulate preference and aversion provides insight into motivated behaviors that are dysregulated in stress, reward, and psychiatric disease.

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Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Untitled work
(2012) · doi:10.1016/j.jmoldx.2011.08.002 · Cited by 2,567
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
The Basal Ganglia and Adaptive Motor Control
Graybiel, A. M., Aosaki, T., Flaherty, A. W., & Kimura, M. (1994) · Science · doi:10.1126/science.8091209 · Cited by 1,324
A functional anatomical study of unipolar depression
Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266
Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics
Kim, T.-I., McCall, J. G., Jung, Y. H., Huang, X., Siuda, E. R., Li, Y., Song, J., Song, Y. M., Pao, H. A., Kim, R.-H., et al. (2013) · Science · doi:10.1126/science.1232437 · Cited by 1,174
Self-citation
Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor
Chavkin, C., James, I. F., & D, A. G. M. (1982) · Science · doi:10.1126/science.6120570 · Cited by 1,171
Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response
Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115

Show all 65 references

Research works printed but not linked: 2

Al-Hasani, 2013, Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism, Neuropsychopharmacology, 38, 2484, 10.1038/npp.2013.151 · DOI
Siuda, 2015, Spatiotemporal control of opioid signaling and behavior, Neuron, 86, 923, 10.1016/j.neuron.2015.03.066 · DOI

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Self-citation
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Self-citation
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Saddoris, M. P., Siletti, K. A., Stansfield, K. J., & Bercum, F. M. (2018) · Learning & Memory · doi:10.1101/lm.047019.117 · Cited by 8
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Self-citation
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Go, Y. (2025) · Neuroscience Research · doi:10.1016/j.neures.2025.03.004 · Cited by 3
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Authors: Al-Hasani, R., McCall, J. G., Shin, G., Gomez, A. M., Schmitz, G. P., Bernardi, J. M., Pyo, C.-O., Park, S. I., Marcinkiewcz, C. M., Crowley, N. A., Krashes, M. J., Lowell, B. B., Kash, T. L., Rogers, J. A., & Bruchas, M. R.
Affiliations: Washington University in St. Louis (US)
University of Illinois Urbana-Champaign (US)
University of North Carolina at Chapel Hill (US)
National Institutes of Health (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Bruchas, Michael R.
ORCID: McCall, Jordan G.
Shin, Gunchul
Gomez, Adrian M.
Park, Sung Il
Crowley, Nicole A.
Krashes, Michael J.
Lowell, Bradford B.
Kash, Thomas L.
Rogers, John A.
Bruchas, Michael R.
Venue: Neuron
Publisher: Elsevier BV
Published: 2015-09
Volume: 87
Issue: 5
Pages: 1063-1077
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2015.08.019
PMC: PMC4625385
OpenAlex: W1919448202
Cited by: 345
References: 65
Citations by year: 2026: 16 · 2025: 33 · 2024: 28 · 2023: 30 · 2022: 32 · 2021: 36 · 2020: 42 · 2019: 40 · 2018: 34 · 2017: 25 · 2016: 26 · 2015: 3
FWCI: 13.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: Hope Center for Neurological Disorders
National Institutes of Health (K99-R00, DA033396)
National Institute on Alcohol Abuse and Alcoholism (P60AA011605)
National Institute of Mental Health (K99/R00, F31MH101956)
National Institute on Drug Abuse (R01DA033396, DA033396, K99DA038725, R01DA037152, DA038725, R00DA038725)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK075632, R01DK089044, R01DK071051, P30DK046200, R01DK096010, R37DK053477)
National Institute of Neurological Disorders and Stroke (TR01NS081707, P30NS057105, R01NS081707, K99/R00)
National Center for Research Resources (S10RR027552)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens shell, kappa opioid receptor, aversive behavior, place preference, reward, photostimulation, regional specificity, motivated behavior, dysphoria
MeSH terms: Action Potentials, Animals, Avoidance Learning, Conditioning, Operant, Dynorphins, Electric Stimulation, Gene Expression Regulation, Luminescent Proteins, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Nucleus Accumbens, Photic Stimulation, Protein Precursors, Reward, Self Stimulation, Time Factors, Receptors, Dopamine D2, Maze Learning, Mice, Wireless Technology, In Vitro Techniques

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Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

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