Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

Al-Hasani, Ream, McCall, Jordan G., Shin, Gunchul, Gomez, Adrian M., Schmitz, Gavin P., Bernardi, Julio M., Pyo, Chang-O., Park, Sung Il, Marcinkiewcz, Catherine M., Crowley, Nicole A., Krashes, Michael J., Lowell, Bradford B., Kash, Thomas L., Rogers, John A., Bruchas, Michael R.·2015·Neuron

DOI 10.1016/j.neuron.2015.08.019

Cited by (343)

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Kazuo Nakamoto, Ayaka Taniguchi, Shogo Tokuyama · 2020 · European Journal of Pharmacology
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Sebastiano Bariselli, Nanami L. Miyazaki, Meaghan C. Creed, Alexxai V. Kravitz · 2020 · Nature Communications
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Douglas R. Funk, Kathleen M. Coen, Sahar Tamadon, Anh Dzung Lê · 2019 · Neuropharmacology
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Yan Zhou, Mary Jeanne Kreek · 2018 · Journal of Pharmacology and Experimental Therapeutics
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Mark M. Gergues, Christine N. Yohn, Anusha P. Bharadia, Marjorie R. Levinstein, Benjamin A. Samuels · 2021 · Translational Psychiatry
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Israelashvili, Michal, Yael, Dorin, Vinner, Esther, Belelovsky, Katya, Bar-Gad, Izhar · 2020 · Cortex
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Yue Zhang, Jingwen Gao, Na Li, Peng Xu, Shimeng Qu, Jinqian Cheng, Mingrui Wang, Xueru Li, Yaheng Song, Fan Xiao et al. · 2023 · Acta Pharmaceutica Sinica B
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Ehsan Shokri Kojori, Mika Naganawa, Vijay A. Ramchandani, Dean Foster Wong, Gene‐Jack Wang, Nora D. Volkow · 2021 · Human Brain Mapping
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Rachel I. Anderson, David E. Moorman, Howard C. Becker · 2018 · Handbook of experimental pharmacology
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Guilian Tian, Katrina Bartas, May Hui, Lingxuan Chen, Jose J Vasquez, Ghalia Azouz, Pieter Derdeyn, Rían W. Manville, Erick L. Ho, Amanda S. Fang et al. · 2024 · Neuron
Animal models of alcohol use disorder and the brain: From casual drinking to dependence.
Nicole A. Crowley, Nigel C. Dao, Sarah N. Magee, Alexandre Jose Bourcier, Emily G. Lowery‐Gionta · 2019 · Translational Issues in Psychological Science
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Barbara Juarez, Yutong Liu, Lu Zhang, Ming‐Hu Han · 2018 · Alcohol
An intein-split transactivator for intersectional neural imaging and optogenetic manipulation
Hao-Shan Chen, Xiaolong Zhang, Rongrong Yang, Guang-Ling Wang, Xinyue Zhu, Yuanfang Xu, Dan‐Yang Wang, Na Zhang, Shou Qiu, Lijie Zhan et al. · 2022 · Nature Communications
The neurobiology of abstinence-induced reward-seeking in males and females
Yanaira Alonso‐Caraballo, Suman K. Guha, Elena H. Chartoff · 2020 · Pharmacology Biochemistry and Behavior
Dichotomous regulation of striatal plasticity by dynorphin
Renzhi Yang, Rupa R. Lalchandani, Fuu-Jiun Hwang, Daniel W. Bloodgood, Dong Kong, Jun Ding · 2022 · Molecular Psychiatry
Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential
Stephanie C. Gantz, Maria M. Ortiz-Juza, Andrew J. Belilos, Khaled Moussawi · 2021 · eLife
Accurate inference of genome-wide spatial expression with iSpatial
Chao Zhang, Renchao Chen, Yi Zhang · 2022 · Science Advances