The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury
Open accessAbstract
Epidural electrical stimulation of lumbar segments facilitates standing and walking in animal models and humans with spinal cord injury. However, the mechanisms through which this neuromodulation therapy engages spinal circuits remain enigmatic. Using computer simulations and behavioral experiments, we provide evidence that epidural electrical stimulation interacts with muscle spindle feedback circuits to modulate muscle activity during locomotion. Hypothesis-driven strategies emerging from simulations steered the design of stimulation protocols that adjust bilateral hindlimb kinematics throughout gait execution. These stimulation strategies corrected subject-specific gait and balance deficits in rats with incomplete and complete spinal cord injury. The conservation of muscle spindle feedback circuits across mammals suggests that the same mechanisms may facilitate motor control in humans. These results provide a conceptual framework to improve stimulation protocols for clinical applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We previously showed that epidural electrical stimulation targeting the individual dorsal root entry zones of the lumbosacral spinal cord enables the modulation of specific leg motor pools9–12.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [12]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
OpenSim: Open-Source Software to Create and Analyze Dynamic Simulations of Movement
Delp, S. L., Anderson, F. C., Arnold, A. S., Loan, P., Habib, A., John, C. T., Guendelman, E., & Thelen, D. G. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.901024 · Cited by 4,951
The NEURON Simulation Environment
Hines, M. L., & Carnevale, N. T. (1997) · Neural Computation · doi:10.1162/neco.1997.9.6.1179 · Cited by 2,630
Flexion‐reflex of the limb, crossed extension‐reflex, and reflex stepping and standing
Sherrington, C. (1910) · The Journal of Physiology · doi:10.1113/jphysiol.1910.sp001362 · Cited by 1,336
Dynamic Sensorimotor Interactions in Locomotion
Rossignol, S., Dubuc, R., & Gossard, J.-P. (2006) · Physiological Reviews · doi:10.1152/physrev.00028.2005 · Cited by 1,096
Electronic dura mater for long-term multimodal neural interfaces
Minev, I. R., Musienko, P., Hirsch, A., Barraud, Q., Wenger, N., Moraud, E. M., Gandar, J., Capogrosso, M., Milekovic, T., Asboth, L., et al. (2015) · Science · doi:10.1126/science.1260318 · Cited by 1,082
Self-citationInterneuronal relay in spinal pathways from proprioceptors
Jankowska, E. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90024-9 · Cited by 931
LOCOMOTOR CIRCUITS IN THE MAMMALIAN SPINAL CORD
Kiehn, O. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112910 · Cited by 868
Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury
van den Brand, R., Heutschi, J., Barraud, Q., DiGiovanna, J., Bartholdi, K., Huerlimann, M., Friedli, L., Vollenweider, I., Moraud, E. M., Duis, S., et al. (2012) · Science · doi:10.1126/science.1217416 · Cited by 767
Self-citationMcIntyre, C. C., Richardson, A. G., & Grill, W. M. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00353.2001 · Cited by 764
Angeli, C. A., Edgerton, V. R., Gerasimenko, Y. P., & Harkema, S. J. (2014) · Brain · doi:10.1093/brain/awu038 · Cited by 750
Flagged first, then by citations
Cited by
Sorted by citations
Seth, A., Hicks, J. L., Uchida, T. K., Habib, A., Dembia, C. L., Dunne, J. J., Ong, C. F., DeMers, M. S., Rajagopal, A., Millard, M., et al. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006223 · Cited by 1,338
Targeted neurotechnology restores walking in humans with spinal cord injury
Wagner, F. B., Mignardot, J.-B., Le Goff-Mignardot, C. G., Demesmaeker, R., Komi, S., Capogrosso, M., Rowald, A., Seáñez, I., Caban, M., Pirondini, E., et al. (2018) · Nature · doi:10.1038/s41586-018-0649-2 · Cited by 1,087
Self-citationWalking naturally after spinal cord injury using a brain–spine interface
Lorach, H., Galvez, A., Spagnolo, V., Martel, F., Karakas, S., Intering, N., Vat, M., Faivre, O., Harte, C., Komi, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06094-5 · Cited by 631
“We previously showed that epidural electrical stimulation targeting the individual dorsal root entry zones of the lumbosacral spinal cord enables the modulation of specific leg motor pools 9–12 .”
BackgroundSelf-citationA brain–spine interface alleviating gait deficits after spinal cord injury in primates
Capogrosso, M., Milekovic, T., Borton, D., Wagner, F., Moraud, E. M., Mignardot, J.-B., Buse, N., Gandar, J., Barraud, Q., Xing, D., et al. (2016) · Nature · doi:10.1038/nature20118 · Cited by 635
Self-citationSpinal cord repair: advances in biology and technology
Courtine, G., & Sofroniew, M. V. (2019) · Nature Medicine · doi:10.1038/s41591-019-0475-6 · Cited by 508
Self-citationRowald, A., Komi, S., Demesmaeker, R., Baaklini, E., Hernandez-Charpak, S. D., Paoles, E., Montanaro, H., Cassara, A., Becce, F., Lloyd, B., et al. (2022) · Nature Medicine · doi:10.1038/s41591-021-01663-5 · Cited by 455
Self-citationFormento, E., Minassian, K., Wagner, F., Mignardot, J. B., Le Goff-Mignardot, C. G., Rowald, A., Bloch, J., Micera, S., Capogrosso, M., & Courtine, G. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0262-6 · Cited by 370
Self-citationThe translational landscape in spinal cord injury: focus on neuroplasticity and regeneration
Hutson, T. H., & Giovanni, S. D. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0280-3 · Cited by 311
Greiner, N., Barra, B., Schiavone, G., Lorach, H., James, N., Conti, S., Kaeser, M., Fallegger, F., Borgognon, S., Lacour, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20703-1 · Cited by 199
Self-citationEpidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis
Powell, M. P., Verma, N., Sorensen, E., Carranza, E., Boos, A., Fields, D. P., Roy, S., Ensel, S., Barra, B., Balzer, J. R., et al. (2023) · Nature Medicine · doi:10.1038/s41591-022-02202-6 · Cited by 220
Self-citationNeuromodulation in the restoration of function after spinal cord injury
James, N. D., McMahon, S. B., Field-Fote, E. C., & Bradbury, E. J. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30287-4 · Cited by 192
Neurohybrid Memristive CMOS-Integrated Systems for Biosensors and Neuroprosthetics
Mikhaylov, A. N., Pimashkin, A. S., Pigareva, Y., Gerasimova, S. A., Gryaznov, E. G., Shchanikov, S., Zuev, A. D., Talanov, M. O., Lavrov, I. A., Demin, V. A., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00358 · Cited by 189
Hofstoetter, U. S., Freundl, B., Danner, S. M., Krenn, M. J., Mayr, W., Binder, H., & Minassian, K. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6588 · Cited by 150
Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury
Bonizzato, M., Pidpruzhnykova, G., DiGiovanna, J., Shkorbatova, P., Pavlova, N., Micera, S., & Courtine, G. (2018) · Nature Communications · doi:10.1038/s41467-018-05282-6 · Cited by 149
Self-citationRejc, E., Angeli, C., Bryant, N., & Harkema, S. J. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4516 · Cited by 140
Cho, Y., Park, S., Lee, J., & Yu, K. J. (2021) · Advanced Materials · doi:10.1002/adma.202005786 · Cited by 142
Hutson, T. H., Kathe, C., Palmisano, I., Bartholdi, K., Hervera, A., Virgiliis, F. D., McLachlan, E., Zhou, L., Kong, G., Barraud, Q., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw2064 · Cited by 126
Self-citationConfiguration of electrical spinal cord stimulation through real-time processing of gait kinematics
Capogrosso, M., Wagner, F. B., Gandar, J., Moraud, E. M., Wenger, N., Milekovic, T., Shkorbatova, P. Y., Pavlova, N., Евгеньевич, М. П., Bézard, E., et al. (2018) · Nature Protocols · doi:10.1038/s41596-018-0030-9 · Cited by 125
Self-citationNatural and targeted circuit reorganization after spinal cord injury
Anderson, M. A., Squair, J. W., Gautier, M., Hutson, T. H., Kathe, C., Barraud, Q., Bloch, J., & Courtine, G. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01196-1 · Cited by 126
Self-citationPhillips, A. A., Squair, J. W., Sayenko, D. G., Edgerton, V. R., Gerasimenko, Y., & Krassioukov, A. V. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5082 · Cited by 120
Barra, B., Conti, S., Perich, M. G., Zhuang, K., Schiavone, G., Fallegger, F., Galan, K., James, N. D., Barraud, Q., Delacombaz, M., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01106-5 · Cited by 114
Self-citationPukos, N., Goodus, M. T., Sahinkaya, F. R., & McTigue, D. M. (2019) · Glia · doi:10.1002/glia.23702 · Cited by 95
Refining rodent models of spinal cord injury
Lilley, E. J., Andrews, M. R., Bradbury, E. J., Elliott, H., Hawkins, P., Ichiyama, R. M., Keeley, J., Michael-Titus, A. T., Moon, L. D. F., Pluchino, S., et al. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113273 · Cited by 90
A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease
Milekovic, T., Moraud, E. M., Macellari, N., Moerman, C., Raschellà, F., Sun, S., Perich, M. G., Varescon, C., Demesmaeker, R., Bruel, A., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02584-1 · Cited by 86
Self-citationRaspopović, S., Petrini, F. M., Żelechowski, M., & Valle, G. (2016) · Proceedings of the IEEE · doi:10.1109/jproc.2016.2600560 · Cited by 84
Control of Mammalian Locomotion by Somatosensory Feedback
Frigon, A., Akay, T., & Prilutsky, B. I. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210020 · Cited by 95
Hachmann, J. T., Yousak, A., Wallner, J. J., Gad, P. N., Edgerton, V. R., & Gorgey, A. S. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00020.2021 · Cited by 82
Laliberté, A. M., Goltash, S., Lalonde, N. R., & Bui, T. V. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00512 · Cited by 83
Eisdorfer, J. T., Smit, R. D., Keefe, K. M., Lemay, M. A., Smith, G. M., & Spence, A. J. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00163 · Cited by 65
Electrical Stimulation as a Tool to Promote Plasticity of the Injured Spinal Cord
Jack, A. S., Hurd, C., Martin, J. H., & Fouad, K. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7033 · Cited by 58
Seáñez, I., & Capogrosso, M. (2021) · Bioelectronic Medicine · doi:10.1186/s42234-021-00077-5 · Cited by 58
Self-citationTherapeutic Stimulation for Restoration of Function After Spinal Cord Injury
Ievins, A., & Moritz, C. T. (2017) · Physiology · doi:10.1152/physiol.00010.2017 · Cited by 58
A biomimetic electrical stimulation strategy to induce asynchronous stochastic neural activity
Formento, E., D’Anna, E., Gribi, S., Lacour, S. P., & Micera, S. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/aba4fc · Cited by 57
Self-citationMayr, W., Krenn, M. J., & Dimitrijevic, M. R. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000382 · Cited by 53
Evaluation of a Neuromechanical Walking Control Model Using Disturbance Experiments
Song, S., & Geyer, H. (2017) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2017.00015 · Cited by 53
The Role of Functional Neuroanatomy of the Lumbar Spinal Cord in Effect of Epidural Stimulation
Cuellar, C. A., Mendez, A. A., Islam, R., Calvert, J. S., Grahn, P. J., Knudsen, B. E., Pham, T. D., Lee, K. H., & Lavrov, I. A. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00082 · Cited by 48
Balance, gait, and falls in spinal cord injury
Wirz, M., & van Hedel, H. J. A. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63916-5.00024-0 · Cited by 51
Mechanisms of Stem Cell Therapy in Spinal Cord Injuries
Shinozaki, M., Nagoshi, N., Nakamura, M., & Okano, H. (2021) · Cells · doi:10.3390/cells10102676 · Cited by 58
Capogrosso, M., Gandar, J., Greiner, N., Moraud, E. M., Wenger, N., Shkorbatova, P. Y., Евгеньевич, М. П., Minev, I. R., Lacour, S. P., & Courtine, G. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aaa87a · Cited by 48
Self-citationRejc, E., & Angeli, C. (2019) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2018.12.009 · Cited by 45
Motor cortical dynamics are shaped by multiple distinct subspaces during naturalistic behaviorPreprint
Perich, M. G., Conti, S., Badi, M., Bogaard, A. R., Barra, B., Rajan, K., Bloch, J., Courtine, G., Micera, S., Capogrosso, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.30.228767 · Cited by 58
Self-citationRomeni, S., Losanno, E., Emedoli, D., Albano, L., Agnesi, F., Mandelli, C., Barzaghi, L. R., Pompeo, E., Mura, C., Alemanno, F., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adp9607 · Cited by 45
Self-citationSamejima, S., Henderson, R. P., Pradarelli, J. J., Mondello, S. E., & Moritz, C. T. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114178 · Cited by 42
Moraud, E. M., Zitzewitz, J. V., Miehlbradt, J., Wurth, S. M., Formento, E., DiGiovanna, J., Capogrosso, M., Courtine, G., & Micera, S. (2018) · Scientific Reports · doi:10.1038/s41598-017-18293-y · Cited by 39
Self-citationTinkhauser, G., & Moraud, E. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.734186 · Cited by 39
Self-citationPoststroke arm and hand paresis: should we target the cervical spinal cord?
Pirondini, E., Carranza, E., Balaguer, J.-M., Sorensen, E., Weber, D. J., Krakauer, J. W., & Capogrosso, M. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.05.002 · Cited by 42
Self-citationXinwang, L. V., Liang, J., & Zhipu, W. A. N. G. (2021) · Panminerva Medica · doi:10.23736/s0031-0808.20.03974-9 · Cited by 40
Spinal Epidural Stimulation Strategies: Clinical Implications of Locomotor Studies in Spinal Rats
Shah, P. K., & Lavrov, I. A. (2017) · The Neuroscientist · doi:10.1177/1073858417699554 · Cited by 37
A Whole-Body Musculoskeletal Model of the Mouse
Tata Ramalingasetty, S., Danner, S. M., Arreguit, J., Markin, S. N., Rodarie, D., Kathe, C., Courtine, G., Rybak, I. A., & Ijspeert, A. J. (2021) · IEEE Access · doi:10.1109/access.2021.3133078 · Cited by 35
Self-citationFirst-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy
Prat-Ortega, G., Ensel, S., Donadio, S., Borda, L., Boos, A., Yadav, P., Verma, N., Ho, J. C., Carranza, E., Frazier-Kim, S., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03484-8 · Cited by 43
Self-citationLearning to promote recovery after spinal cord injury
Grau, J. W., Baine, R. E., Bean, P. A., Davis, J. A., Fauss, G. N. K., Henwood, M. K., Hudson, K. E., Johnston, D. T., Tarbet, M. M., & Strain, M. M. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113334 · Cited by 36
A computational outlook on neurostimulation
Capogrosso, M., & Lempka, S. F. (2020) · Bioelectronic Medicine · doi:10.1186/s42234-020-00047-3 · Cited by 32
Self-citationSpinal cord stimulation for the restoration of bladder function after spinal cord injury
Steadman, C. J., & Grill, W. M. (2020) · Healthcare Technology Letters · doi:10.1049/htl.2020.0026 · Cited by 31
Mesbah, S., Gonnelli, F., Angeli, C., El-Baz, A. S., Harkema, S. J., & Rejc, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-50938-y · Cited by 32
Gradwell, M. A., Ozeri-Engelhard, N., Eisdorfer, J. T., Laflamme, O. D., Gonzalez, M., Upadhyay, A., Medlock, L., Shrier, T., Patel, K., Aoki, A., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.027 · Cited by 32
Neurorestorative interventions involving bioelectronic implants after spinal cord injury
Cho, N., Squair, J. W., Bloch, J., & Courtine, G. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0027-x · Cited by 32
Self-citationMascaro, A. L. A., Falotico, E., Petkoski, S., Pasquini, M., Vannucci, L., Tort‐Colet, N., Conti, E., Resta, F., Spalletti, C., Ramalingasetty, S. T., et al. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.00031 · Cited by 32
Self-citationNeuroplasticity and regeneration after spinal cord injury
Punjani, N., Deska‐Gauthier, D., Hachem, L. D., Abramian, M., & Fehlings, M. G. (2023) · North American Spine Society Journal (NASSJ) · doi:10.1016/j.xnsj.2023.100235 · Cited by 35
Liang, L., Damiani, A., Brocco, M. D., Rogers, E. R., Jantz, M., Fisher, L. E., Gaunt, R. A., Capogrosso, M., Lempka, S. F., & Pirondini, E. (2022) · The Journal of Physiology · doi:10.1113/jp282884 · Cited by 30
Self-citationIntrathecal Therapeutics: Device Design, Access Methods, and Complication Mitigation
Nagel, S. J., Reddy, C. G., Frizon, L. A., Holland, M. T., Machado, A. G., Gillies, G. T., & Howard, M. A. (2017) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12693 · Cited by 29
Zhang, H., Liu, Y., Zhou, K., Wei, W., & Liu, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.749465 · Cited by 32
Intrinsic Axonal Growth and the Drive for Regeneration
O’Donovan, K. J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00486 · Cited by 27
Ibáñez, J., Angeli, C., Harkema, S. J., Farina, D., & Rejc, E. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00293.2021 · Cited by 25
Physiological effects of cathodal electrode configuration for transspinal stimulation in humans
Σκιαδόπουλος, Α., Pulverenti, T. S., & Knikou, M. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00342.2022 · Cited by 26
Mao, G., Zhou, Z., Su, H., Chen, Y., Zhang, J., Zhang, C., Wang, Z., & Lü, X. (2023) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2023.3234580 · Cited by 24
Jack, A. S., Hurd, C., Forero, J. P., Nataraj, A., Fenrich, K. K., Blesch, A., & Fouad, K. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24209 · Cited by 23
Derungs, A., & Amft, O. (2020) · Scientific Reports · doi:10.1038/s41598-020-68225-6 · Cited by 23
A wireless spinal stimulation system for ventral activation of the rat cervical spinal cord
Hogan, M., Barber, S. M., Rao, Z., Kondiles, B. R., Huang, M., Steele, W. J., Yu, C., & Horner, P. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-94047-1 · Cited by 22
Preclinical upper limb neurorobotic platform to assess, rehabilitate, and develop therapies
Pasquini, M., James, N. D., Dewany, I., Coen, F.-V., Cho, N., Lai, S., Anil, S., Carpaneto, J., Barraud, Q., Lacour, S. P., et al. (2022) · Science Robotics · doi:10.1126/scirobotics.abk2378 · Cited by 21
Self-citationPowell, M. P., Verma, N., Sorensen, E., Carranza, E., Boos, A., Fields, D. P., Roy, S., Ensel, S., Barra, B., Balzer, J. R., et al. (2022) · medRxiv · doi:10.1101/2022.04.11.22273635 · Cited by 21
Self-citationAugmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept
Hankov, N., Caban, M., Demesmaeker, R., Roulet, M., Komi, S., Xiloyannis, M., Gehrig, A., Varescon, C., Spiess, M. R., Maggioni, S., et al. (2025) · Science Robotics · doi:10.1126/scirobotics.adn5564 · Cited by 25
Self-citationIn vivoelectrophysiological mechanisms underlying cervical epidural stimulation in adult rats
Sharma, P., & Shah, P. K. (2021) · The Journal of Physiology · doi:10.1113/jp281146 · Cited by 19
Alashram, A. R., Padua, E., Raju, M., Romagnoli, C., & Annino, G. (2021) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2021.2000200 · Cited by 18
Mansour, N. M., Pino, I. P., Freeman, D., Carrabre, K., Venkatesh, S., Darrow, D., Samadani, U., & Parr, A. M. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0007 · Cited by 18
Shackleton, C., Hodgkiss, D. D., Samejima, S., Miller, T., Pérez, M. A., Nightingale, T. E., Sachdeva, R., & Krassioukov, A. V. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00367.2022 · Cited by 18
Romeni, S., Losanno, E., Koert, E., Pierantoni, L., Delgado-Martínez, I., Navarro, X., & Micera, S. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/ace219 · Cited by 18
Self-citationSpinal maps of motoneuron activity during human locomotion: neuromechanical considerations
Avaltroni, P., Cappellini, G., Labini, F. S., Ivanenko, Y. P., & Lacquaniti, F. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1389436 · Cited by 18
Coherent, time-shifted patterns of microstructural plasticity during motor-skill learning
Azzarito, M., Emmenegger, T. M., Ziegler, G., Huber, E., Grabher, P., Callaghan, M. F., Thompson, A. J., Friston, K. J., Weiskopf, N., Killeen, T., et al. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120128 · Cited by 20
Balaguer, J.-M., Prat-Ortega, G., Ostrowski, J., Borda, L., Verma, N., Yadav, P., Sorensen, E., de Freitas, R., Ensel, S., Donadio, S., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.023 · Cited by 17
Self-citationMolecular Determinants of Mechanical Itch Sensitization in Chronic Itch
Lee, H. K., Graham, R., Melikyan, D., Smith, B., Mirzakhalili, E., Lempka, S. F., & Duan, B. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.937890 · Cited by 16
Spinal stimulation for motor rehabilitation immediately modulates nociceptive transmission
Bandres, M. F., Gomes, J. D. F., & McPherson, J. G. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac9a00 · Cited by 16
Electronic Dura Mater Meddling in the Central Nervous System
Bloch, J., Lacour, S. P., & Courtine, G. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.5767 · Cited by 16
Self-citationCurated Model Development Using NEUROiD: A Web-Based NEUROmotor Integration and Design Platform
Iyengar, R. S., Pithapuram, M. V., Singh, A. K., & Raghavan, M. (2019) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2019.00056 · Cited by 15
Barra, B., Roux, C., Kaeser, M., Schiavone, G., Lacour, S. P., Bloch, J., Courtine, G., Rouiller, E. M., Schmidlin, E., & Capogrosso, M. (2018) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2018.8512554 · Cited by 14
Self-citationYang, D., Yang, W. M., Li, L., Zhou, K., Hao, M., Feng, X., Zhang, T., & Liu, Y. (2019) · Sensors · doi:10.3390/s19214673 · Cited by 14
Eisdorfer, J. T., Sobotka-Briner, H., Schramfield, S., Moukarzel, G., Chen, J., Campion, T. J., III, Smit, R. D., Rauscher, B. C., Lemay, M. A., Smith, G. M., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.872634 · Cited by 14
Harnessing spinal circuit reorganization for targeted functional recovery after spinal cord injury
Sun, X., Li, L., Huang, L., Li, Y., Wang, L., & Wei, Q. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106854 · Cited by 16
Linking cortex and contraction—Integrating models along the corticomuscular pathway
Haggie, L., Schmid, L., Röhrle, O., Besier, T. F., McMorland, A. J. C., & Saini, H. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1095260 · Cited by 14
Regeneration and Plasticity Induced by Epidural Stimulation in a Rodent Model of Spinal Cord Injury
Angelin, L. G., Carreño, M. N. P., Otoch, J. P., de Resende, J. C. F., Arévalo, A. L., Motta‐Teixeira, L. C., Seelaender, M. C. L., & Lepski, G. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169043 · Cited by 14
Lalonde, N. R., & Bui, T. V. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.10.001 · Cited by 14
Supraspinal control of motoneurons after paralysis enabled by spinal cord stimulationPreprint
Balaguer, J.-M., Prat-Ortega, G., Verma, N., Yadav, P., Sorensen, E., de Freitas, R., Ensel, S., Borda, L., Donadio, S., Liang, L., et al. (2023) · medRxiv · doi:10.1101/2023.11.29.23298779 · Cited by 13
Self-citationSpinal cord stimulation for spinal cord injury – Where do we stand? A narrative review
Mundra, A., Kalidindi, K. K. V., Chhabra, H. S., & Manghwani, J. (2023) · Journal of Clinical Orthopaedics and Trauma · doi:10.1016/j.jcot.2023.102210 · Cited by 14
Hvingelby, V. S., Carra, R. B., Terkelsen, M. H., Hamani, C., Capato, T., Košutzká, Z., Krauss, J. K., Moro, E., Pavese, N., & Cury, R. G. (2024) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.14143 · Cited by 12
Kibleur, P., Ramalingasetty, S. T., Greiner, N., Conti, S., Barra, B., Zhuang, K., Kaeser, M., Ijspeert, A. J., & Capogrosso, M. (2020) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2020.2986491 · Cited by 14
Self-citationMallampalli, K., Pithapuram, M. V., Rangayyan, Y. M., Iyengar, R. S., Singh, A. K., Sripada, S., & Raghavan, M. (2022) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2022.106804 · Cited by 12
High-density spinal cord stimulation selectively activates lower urinary tract nerves
Jantz, M., Gopinath, C., Kumar, R., Chin, C., Wong, L., Ogren, J. I., Fisher, L. E., McLaughlin, B. L., & Gaunt, R. A. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/aca0c2 · Cited by 11
Chen, Q., Zhao, Z., Yin, G., Yang, C., Wang, D., Feng, Z., & Ta, N. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-340 · Cited by 11
Spinal sensory circuits in motion
Böhm, U. L., & Wyart, C. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.07.007 · Cited by 10
Dalrymple, A. N., & Mushahwar, V. K. (2020) · Journal of Medical Robotics Research · doi:10.1142/s2424905x20410032 · Cited by 9
Yao, Q., Guan, J., Ma, L., Cheng, L., Duan, F., Xu, F., Zhao, W., Duan, W., Wu, H., Chen, Z., et al. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13344 · Cited by 10
Metadata
- Authors
- Moraud, E. M., Capogrosso, M., Formento, E., Wenger, N., DiGiovanna, J., Courtine, G., & Micera, S.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Scuola Superiore Sant'Anna (IT)
- Corresponding author
- Courtine, Grégoire
- Micera, Silvestro
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 89
- Issue
- 4
- Pages
- 814-828
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2255557036
- Cited by
- 220
- References
- 56
- Citations by year
- 2026: 19 · 2025: 30 · 2024: 29 · 2023: 18 · 2022: 26 · 2021: 28 · 2020: 21 · 2019: 15 · 2018: 14 · 2017: 12 · 2016: 8
- FWCI
- 14.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Funders
- Fondation Bertarelli
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (269921)
- Berlin Institute of Health
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- epidural stimulation, spinal cord injury, gait rehabilitation, balance deficits, spinal cord circuits, locomotion, hindlimb kinematics, incomplete spinal cord injury, complete spinal cord injury
- MeSH terms
- Analysis of Variance, Animals, Biomechanical Phenomena, Computer Simulation, Electromyography, Electric Stimulation Therapy, Postural Balance, Female, Hindlimb, Locomotion, Models, Neurological, Motor Neurons, Nerve Net, Rats, Inbred Lew, Sensation Disorders, Spinal Cord Injuries, Gait Disorders, Neurologic, Feedback, Physiological, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
