How diverse retinal functions arise from feedback at the first visual synapse
Open accessAbstract
Many brain regions contain local interneurons of distinct types. How does an interneuron type contribute to the input-output transformations of a given brain region? We addressed this question in the mouse retina by chemogenetically perturbing horizontal cells, an interneuron type providing feedback at the first visual synapse, while monitoring the light-driven spiking activity in thousands of ganglion cells, the retinal output neurons. We uncovered six reversible perturbation-induced effects in the response dynamics and response range of ganglion cells. The effects were enhancing or suppressive, occurred in different response epochs, and depended on the ganglion cell type. A computational model of the retinal circuitry reproduced all perturbation-induced effects and led us to assign specific functions to horizontal cells with respect to different ganglion cell types. Our combined experimental and theoretical work reveals how a single interneuron type can differentially shape the dynamical properties of distinct output channels of a brain region.
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The observation that the 300 s preconditioning stimulus produced a dopaminergic response at light offset is consistent with rebound excitation exhibited by light-adapted OFF and ON-OFF retinal ganglion cells when a prolonged light stimulus is discontinued.
“This observation is consistent with rebound excitation exhibited by light-adapted OFF and ON-OFF retinal ganglion cells when a prolonged light stimulus is discontinued (Tikidji-Hamburyan et al., 2015; Drinnenberg et al., 2018).”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Drinnenberg et al., 2018
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- Authors
- Drinnenberg, A., Franke, F., Morikawa, R. K., Jüttner, J., Hillier, D., Hantz, P., Hierlemann, A., Azeredo da Silveira, R., & Roska, B.
- Affiliations
- University of Basel (CH)
- ETH Zurich (CH)
- Institute of Molecular and Clinical Ophthalmology Basel (CH)
- Corresponding author
- Roska, Botond
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 99
- Issue
- 1
- Pages
- 117-134.e11
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC6101199
- OpenAlex
- W2809379800
- Cited by
- 61
- References
- 31
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 4 · 2022: 14 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 4
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- Boehringer Ingelheim Fonds
- Swiss National Science Foundation (CRSII3_141801)
- Ambizione (PZ00P3_167989)
- NCCR “Molecular Systems Engineering”
- CNRS (UMR8559)
- ERC (267351, 694829, 669157)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- horizontal cells, retinal ganglion cells, feedback, response dynamics, ganglion cell types, retinal circuitry, computational model, input-output transformation
- MeSH terms
- Animals, Calcium, Feedback, Interneurons, Models, Neurological, Retinal Ganglion Cells, Synapses, Vision, Ocular, Photoreceptor Cells, Vertebrate, Retinal Bipolar Cells, Retinal Horizontal Cells, Mice
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