Retinal output changes qualitatively with every change in ambient illuminance
Open accessAbstract
The collective activity pattern of retinal ganglion cells, the retinal code, underlies higher visual processing. How does the ambient illuminance of the visual scene influence this retinal output? We recorded from isolated mouse and pig retina and from mouse dorsal lateral geniculate nucleus in vivo at up to seven ambient light levels covering the scotopic to photopic regimes. Across each luminance transition, most ganglion cells exhibited qualitative response changes, whereas they maintained stable responses within each luminance. We commonly observed the appearance and disappearance of ON responses in OFF cells and vice versa. Such qualitative response changes occurred for a variety of stimuli, including full-field and localized contrast steps and naturalistic movies. Our results suggest that the retinal code is not fixed but varies with every change of ambient luminance. This finding raises questions about signal processing within the retina and has implications for visual processing in higher brain areas.
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The observation that the 300 s preconditioning stimulus produced a dopaminergic response at light offset is consistent with rebound excitation exhibited by light-adapted OFF and ON-OFF retinal ganglion cells when a prolonged light stimulus is discontinued.
“This observation is consistent with rebound excitation exhibited by light-adapted OFF and ON-OFF retinal ganglion cells when a prolonged light stimulus is discontinued (Tikidji-Hamburyan et al., 2015; Drinnenberg et al., 2018).”
From Ventral striatum dopamine release encodes unique properties of visual stimuli in mice (2023) · cites this paper as Tikidji-Hamburyan et al., 2015
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- Authors
- Tikidji-Hamburyan, A., Reinhard, K., Seitter, H., Hovhannisyan, A., Procyk, C. A., Allen, A. E., Schenk, M., Lucas, R. J., & Münch, T. A.
- Affiliations
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- University of Manchester (GB)
- Universitätsklinikum Tübingen (DE)
- Corresponding author
- Münch, Thomas A
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2014-12-08
- Volume
- 18
- Issue
- 1
- Pages
- 66-74
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4338531
- OpenAlex
- W2018243434
- Cited by
- 134
- References
- 59
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 10 · 2023: 11 · 2022: 11 · 2021: 16 · 2020: 11 · 2019: 9 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 9 · 2014: 1
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- SDL (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/I007296/1, BBSRC BB/1007296/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- retinal ganglion cells, ON and OFF responses, ambient illuminance, dorsal lateral geniculate nucleus, luminance adaptation, mouse retina, pig retina
- MeSH terms
- Animals, Environment, gamma-Aminobutyric Acid, Lighting, Mice, Inbred C57BL, Retina, Retinal Ganglion Cells, Swine, Mice, Knockout, GABA Antagonists, Photoreceptor Cells, Vertebrate, Mice, Cyclic Nucleotide-Gated Cation Channels, Electrophysiological Phenomena
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