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Cited by 357

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

Open access
Pan, Bifeng, Akyuz, Nurunisa, Liu, Xiao-Ping, Asai, Yukako, Nist-Lund, Carl, Kurima, Kiyoto, Derfler, Bruce H., György, Bence, Limapichat, Walrati, Walujkar, Sanket, Wimalasena, Lahiru N., Sotomayor, Marcos, Corey, David P., Holt, Jeffrey R.·2018·Neuron
DOI 10.1016/j.neuron.2018.07.033
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Abstract

SUMMARY The proteins that form the permeation pathway of mechanosensory transduction channels in inner-ear hair cells have not been definitively identified. Genetic, anatomical, and physiological evidence support a role for transmembrane channel-like protein (TMC) 1 in hair cell sensory transduction, yet the molecular function of TMC proteins remains unclear. Here, we provide biochemical evidence suggesting TMC1 assembles as a dimer, along with structural and sequence analyses suggesting similarity to dimeric TMEM16 channels. To identify the pore region of TMC1, we used cysteine mutagenesis and expressed mutant TMC1 in hair cells of Tmc1/2-null mice. Cysteine-modification reagents rapidly and irreversibly altered permeation properties of mechanosensory transduction. We propose that TMC1 is structurally similar to TMEM16 channels and includes ten transmembrane domains with four domains, S4–S7, that line the channel pore. The data provide compelling evidence that TMC1 is a pore-forming component of sensory transduction channels in auditory and vestibular hair cells.

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Metadata

Authors
Pan, B., Akyuz, N., Liu, X.-P., Asai, Y., Nist-Lund, C., Kurima, K., Derfler, B. H., György, B., Limapichat, W., Walujkar, S., Wimalasena, L. N., Sotomayor, M., Corey, D. P., & Holt, J. R.
Venue
Neuron
Publisher
Elsevier BV
Published
2018-08
Volume
99
Issue
4
Pages
736-753.e6
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2018.07.033
OpenAlex
W2888583750
Cited by
357
References
82
FWCI
23.96
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. https://app.cochat.ai/papers/10.1016/j.neuron.2018.07.033
The paper
Pan, B., Akyuz, N., Liu, X.-P., Asai, Y., Nist-Lund, C., Kurima, K., Derfler, B. H., György, B., Limapichat, W., Walujkar, S., Wimalasena, L. N., Sotomayor, M., Corey, D. P., & Holt, J. R. (2018). TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. https://doi.org/10.1016/j.neuron.2018.07.033

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.