The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression
Open accessAbstract
Alteration of tissue mechanical properties is a physical hallmark of solid tumors including gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here, we show that mechanosensitive ion channel Piezo regulates mitosis and tissue stiffness of Drosophila gliomas, but not non-transformed brains. PIEZO1 is overexpressed in aggressive human gliomas and its expression inversely correlates with patient survival. Deleting PIEZO1 suppresses the growth of glioblastoma stem cells, inhibits tumor development, and prolongs mouse survival. Focal mechanical force activates prominent PIEZO1-dependent currents from glioma cell processes, but not soma. PIEZO1 localizes at focal adhesions to activate integrin-FAK signaling, regulate extracellular matrix, and reinforce tissue stiffening. In turn, a stiffer mechanical microenvironment elevates PIEZO1 expression to promote glioma aggression. Therefore, glioma cells are mechanosensory in a PIEZO1-dependent manner, and targeting PIEZO1 represents a strategy to break the reciprocal, disease-aggravating feedforward circuit between tumor cell mechanotransduction and the aberrant tissue mechanics. VIDEO ABSTRACT.
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Piezo1 integration of vascular architecture with physiological force
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Self-citationPiezo2 is the major transducer of mechanical forces for touch sensation in mice
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Piezo1, a mechanically activated ion channel, is required for vascular development in mice
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Mechanical stretch triggers rapid epithelial cell division through Piezo1
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Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma
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Cited by
Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
Atcha, H., Jairaman, A., Holt, J. R., Meli, V. S., Nagalla, R. R., Veerasubramanian, P. K., Brumm, K. T., Lim, H. E., Othy, S., Cahalan, M. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23482-5 · Cited by 644
The mechanosensitive Piezo1 channel is required for bone formation
Sun, W., Chi, S., Li, Y., Ling, S., Tan, Y., Xu, Y., Jiang, F., Li, J., Liu, C., Zhong, G., et al. (2019) · eLife · doi:10.7554/elife.47454 · Cited by 429
Zhou, T., Gao, B., Fan, Y., Liu, Y., Feng, S., Cong, Q., Zhang, X., Zhou, Y., Yadav, P. S., Lin, J., et al. (2020) · eLife · doi:10.7554/elife.52779 · Cited by 392
The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
Jiang, F., Yin, K., Wu, K., Zhang, M., Wang, S., Cheng, H., Zhou, Z., & Xiao, B. (2021) · Nature Communications · doi:10.1038/s41467-021-21178-4 · Cited by 283
Extracellular matrix stiffness: Mechanisms in tumor progression and therapeutic potential in cancer
Zhang, M., & Zhang, B. (2025) · Experimental Hematology & Oncology · doi:10.1186/s40164-025-00647-2 · Cited by 269
“In addition, TAGLN was identified as a potent mechanosensitive gene that mediates ovarian cancer cell migration and invasion in response to stiffness by regulating the RhoA/ROCK pathway in a feedback loop through binding to Src activation [42].”
Metadata
- Authors
- Chen, X., Wanggou, S., Bodalia, A., Zhu, M., Dong, W., Fan, J. J., Yin, W. C., Min, H.-K., Hu, M., Draghici, D., Dou, W., Li, F., Coutinho, F. J., Whetstone, H., Kushida, M. M., Dirks, P. B., Song, Y., Hui, C.-C., Sun, Y., Wang, L.-Y., Li, X., & Huang, X.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 100
- Issue
- 4
- Pages
- 799-815.e7
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2896032894
- Cited by
- 401
- References
- 56
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Chen, X., Wanggou, S., Bodalia, A., Zhu, M., Dong, W., Fan, J. J., Yin, W. C., Min, H.-K., Hu, M., Draghici, D., Dou, W., Li, F., Coutinho, F. J., Whetstone, H., Kushida, M. M., Dirks, P. B., Song, Y., Hui, C.-C., Sun, Y., . . . Huang, X. (2018). A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression. Neuron. https://doi.org/10.1016/j.neuron.2018.09.046
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