The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma
Open accessAbstract
Oncogenic TACC-tics: Human cancers exhibit many types of genomic rearrangements—including some that juxtapose sequences from two unrelated genes—thereby creating fusion proteins with oncogenic activity. Functional analysis of these fusion genes can provide mechanistic insights into tumorigenesis and potentially lead to effective drugs, as famously illustrated by the BCR-ABL gene in chronic myelogenous leukemia. Singh et al. (p. 1231 , published online 26 July) identify and characterize a fusion gene present in 3% of human glioblastomas, a deadly brain cancer. In the resultant fusion protein, the tyrosine kinase region of the fibroblast growth factor receptor (FGFR) is joined to a domain from a transforming acidic coiled-coil (TACC) protein. The TACC-FGFR protein is oncogenic, shows unregulated kinase activity, localizes to the mitotic spindle, and disrupts chromosome segregation. In mice, FGFR inhibitors slowed the growth of tumors driven by the TACC-FGFR gene, suggesting that a subset of glioblastoma patients may benefit from these types of drugs.
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Cites
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735
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Cited by
The Somatic Genomic Landscape of Glioblastoma
Brennan, C. W., Verhaak, R. G. W., McKenna, A., Campos, B., Noushmehr, H., Salama, S. R., Zheng, S., Chakravarty, D., Sanborn, J. Z., Berman, S. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.034 · Cited by 5,016
“, 2011a), and FGFR1/FGFR2/FGFR3 (Singh et al., 2012), demonstrating the potential clinical impact of this TCGA data set.”
BackgroundInfluentialSelf-citationComprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
The Cancer Genome Atlas Research Network (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1402121 · Cited by 3,148
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
The landscape of kinase fusions in cancer
Stransky, N., Cerami, E., Schalm, S., Kim, J. L., & Lengauer, C. (2014) · Nature Communications · doi:10.1038/ncomms5846 · Cited by 968
Challenges to curing primary brain tumours
Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., Gottardo, N., Gutmann, D. H., Hargrave, D., Holland, E. C., et al. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0177-5 · Cited by 959
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Metadata
- Authors
- Singh, D., Chan, J. M., Zoppoli, P., Niola, F., Sullivan, R., Castano, A., Liu, E. M., Reichel, J., Porrati, P., Pellegatta, S., Qiu, K., Gao, Z., Ceccarelli, M., Riccardi, R., Brat, D. J., Guha, A., Aldape, K., Golfinos, J. G., Zagzag, D., Mikkelsen, T., Finocchiaro, G., Lasorella, A., Rabadan, R., & Iavarone, A.
- Venue
- Science
- Published
- 2012-09-07
- Volume
- 337
- Issue
- 6099
- Pages
- 1231-1235
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005036868
- Cited by
- 789
- References
- 4
- FWCI
- 29.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Singh, D., Chan, J. M., Zoppoli, P., Niola, F., Sullivan, R., Castano, A., Liu, E. M., Reichel, J., Porrati, P., Pellegatta, S., Qiu, K., Gao, Z., Ceccarelli, M., Riccardi, R., Brat, D. J., Guha, A., Aldape, K., Golfinos, J. G., Zagzag, D., . . . Iavarone, A. (2012). Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma. Science. https://doi.org/10.1126/science.1220834
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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