The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The mechanosensitive Piezo1 channel is required for bone formation
Open accessAbstract
Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer that is critical for various biological processes, plays a critical role in bone formation. Knockout of Piezo1 in osteoblast lineage cells disrupts the osteogenesis of osteoblasts and severely impairs bone structure and strength. Bone loss that is induced by mechanical unloading is blunted in knockout mice. Intriguingly, simulated microgravity treatment reduced the function of osteoblasts by suppressing the expression of Piezo1. Furthermore, osteoporosis patients show reduced expression of Piezo1, which is closely correlated with osteoblast dysfunction. These data collectively suggest that Piezo1 functions as a key mechanotransducer for conferring mechanosensitivity to osteoblasts and determining mechanical-load-dependent bone formation, and represents a novel therapeutic target for treating osteoporosis or mechanical unloading-induced severe bone loss.
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Citations
Cites
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., & Patapoutian, A. (2010) · Science · doi:10.1126/science.1193270 · Cited by 3,316
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350
Piezo1 integration of vascular architecture with physiological force
Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A., Ludlow, M. J., Sedo, A., Hyman, A. J., McKeown, L., Young, R. S., et al. (2014) · Nature · doi:10.1038/nature13701 · Cited by 1,223
Self-citationPiezo proteins are pore-forming subunits of mechanically activated channels
Coste, B., Xiao, B., Santos, J. S., Syeda, R., Grandl, J., Spencer, K. S., Kim, S. E., Schmidt, M., Mathur, J., Dubin, A. E., et al. (2012) · Nature · doi:10.1038/nature10812 · Cited by 1,167
Self-citationPiezo1, a mechanically activated ion channel, is required for vascular development in mice
Ranade, S. S., Qiu, Z., Woo, S.-H., Hur, S. S., Murthy, S. E., Cahalan, S. M., Xu, J., Mathur, J., Bandell, M., Coste, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409233111 · Cited by 901
Self-citationCrowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
Eisenhoffer, G. T., Loftus, P. D., Yoshigi, M., Otsuna, H., Chien, C.-B., Morcos, P. A., & Rosenblatt, J. (2012) · Nature · doi:10.1038/nature10999 · Cited by 875
Mechanical stretch triggers rapid epithelial cell division through Piezo1
Gudipaty, S. A., Lindblom, J., Loftus, P. D., Redd, M. J., Edes, K., Davey, C. F., Krishnegowda, V., & Rosenblatt, J. (2017) · Nature · doi:10.1038/nature21407 · Cited by 803
Chemical activation of the mechanotransduction channel Piezo1
Syeda, R., Xu, J., Dubin, A. E., Coste, B., Mathur, J., Huynh, T., Matzen, J., Lao, J., Tully, D. C., Engels, I. H., et al. (2015) · eLife · doi:10.7554/elife.07369 · Cited by 737
Zhang, M., Xuan, S., Bouxsein, M. L., von Stechow, D., Akeno, N., Faugere, M. C., Malluche, H., Zhao, G., Rosen, C. J., Efstratiadis, A., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208265200 · Cited by 696
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
Pathak, M. M., Nourse, J. L., Tran, T., Hwe, J., Arulmoli, J., Le, D. T. T., Bernardis, E., Flanagan, L. A., & Tombola, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409802111 · Cited by 657
Cited by
Mechanical regulation of bone remodeling
Wang, L., You, X., Zhang, L., Zhang, C., & Zou, W. (2022) · Bone Research · doi:10.1038/s41413-022-00190-4 · Cited by 641
Molecular mechanosensors in osteocytes
Qin, L., Liu, W., Cao, H., & Xiao, G. (2020) · Bone Research · doi:10.1038/s41413-020-0099-y · Cited by 484
Zhou, T., Gao, B., Fan, Y., Liu, Y., Feng, S., Cong, Q., Zhang, X., Zhou, Y., Yadav, P. S., Lin, J., et al. (2020) · eLife · doi:10.7554/elife.52779 · Cited by 392
A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis
Shen, B., Tasdogan, A., Ubellacker, J. M., Zhang, J., Nosyreva, E. D., Du, L., Murphy, M. M., Hu, S., Yi, Y., Kara, N., et al. (2021) · Nature · doi:10.1038/s41586-021-03298-5 · Cited by 310
Structure deformation and curvature sensing of PIEZO1 in lipid membranes
Yang, X., Lin, C., Chen, X., Li, S., Li, X., & Xiao, B. (2022) · Nature · doi:10.1038/s41586-022-04574-8 · Cited by 305
Self-citation
Metadata
- Authors
- Sun, W., Chi, S., Li, Y., Ling, S., Tan, Y., Xu, Y., Jiang, F., Li, J., Liu, C., Zhong, G., Cao, D., Jin, X., Zhao, D., Gao, X., Liu, Z., Xiao, B., & Li, Y.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2019-07-10
- Volume
- 8
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2956354975
- Cited by
- 429
- References
- 46
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sun, W., Chi, S., Li, Y., Ling, S., Tan, Y., Xu, Y., Jiang, F., Li, J., Liu, C., Zhong, G., Cao, D., Jin, X., Zhao, D., Gao, X., Liu, Z., Xiao, B., & Li, Y. (2019). The mechanosensitive Piezo1 channel is required for bone formation. eLife. https://doi.org/10.7554/elife.47454
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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