CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

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  1. Additional file 3 of An integrated toolkit for human microglia functional genomics
    Imdadul Haq, Jason C. Ngo, Nainika Roy, Renshun Pan, Nadiya Nawsheen, Rebecca Chiu, Zhang, Ya, Fujita, Masashi, Soni, Rajesh K., Xuebing Wu et al. · 2024 · Figshare
  2. Additional file 1 of An integrated toolkit for human microglia functional genomics
    Imdadul Haq, Jason C. Ngo, Nainika Roy, Renshun Pan, Nadiya Nawsheen, Rebecca Chiu, Zhang, Ya, Fujita, Masashi, Soni, Rajesh K., Xuebing Wu et al. · 2024 · Figshare
  3. Additional file 2 of Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist
    Hong Mei, Zhao Zha, Wei Wang, Yusang Xie, Yuege Huang, Wenping Li, Wei, Dong, Xinxin Zhang, Qu, Jieming, Liu, Jia · 2021 · Figshare
  4. Additional file 4 of Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening
    Xing Li, Shiyu Sun, Zhang, Wansong, Liang, Ziwei, Yitong Fang, Sun, Tianhu, Wan, Yong, Ma, Xingcong, Zhang, Shuqun, Xu, Yang et al. · 2024 · Figshare
  5. Additional file 2 of mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
    Kun Leng, Rooney, Brendan, Frank McCarthy, Wenlong Xia, Indigo V.L. Rose, Sophie Bax, Marcus Y. Chin, Saeed Fathi, Kari A. Herrington, Manuel D. Leonetti et al. · 2024 · Figshare
  6. Additional file 5 of Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening
    Xing Li, Shiyu Sun, Zhang, Wansong, Liang, Ziwei, Yitong Fang, Sun, Tianhu, Wan, Yong, Ma, Xingcong, Zhang, Shuqun, Xu, Yang et al. · 2024 · Figshare
  7. Additional file 6 of mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
    Kun Leng, Rooney, Brendan, Frank McCarthy, Wenlong Xia, Indigo V.L. Rose, Sophie Bax, Marcus Y. Chin, Fathi, Saeed, Kari A. Herrington, Manuel D. Leonetti et al. · 2024 · Figshare
  8. Additional file 2 of Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening
    Xing Li, Shiyu Sun, Zhang, Wansong, Liang, Ziwei, Yitong Fang, Sun, Tianhu, Wan, Yong, Ma, Xingcong, Zhang, Shuqun, Xu, Yang et al. · 2024 · Figshare
  9. Additional file 11 of An integrated toolkit for human microglia functional genomics
    Imdadul Haq, Jason C. Ngo, Nainika Roy, Renshun Pan, Nadiya Nawsheen, Rebecca Chiu, Zhang, Ya, Fujita, Masashi, Soni, Rajesh K., Xuebing Wu et al. · 2024 · Figshare
  10. Additional file 9 of An integrated toolkit for human microglia functional genomics
    Imdadul Haq, Jason C. Ngo, Nainika Roy, Renshun Pan, Nadiya Nawsheen, Rebecca Chiu, Zhang, Ya, Fujita, Masashi, Soni, Rajesh K., Xuebing Wu et al. · 2024 · Figshare
  11. Additional file 2 of Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathways
    Daniel C. Xu, Hanna Sas‐Nowosielska, Greg Donahue, Hua Huang, Naemeh Pourshafie, Charly Ryan Good, Shelley L. Berger · 2024 · Figshare
  12. Additional file 3 of mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
    Kun Leng, Rooney, Brendan, Frank McCarthy, Wenlong Xia, Indigo V.L. Rose, Sophie Bax, Marcus Y. Chin, Saeed Fathi, Kari A. Herrington, Manuel D. Leonetti et al. · 2024 · Figshare
  13. Additional file 2 of Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1
    Restuadi Restuadi, Frederik J. Steyn, Edor Kabashi, Shyuan Thieu Ngo, Feifei Cheng, Marta F. Nabais, Thompson, Mike J., Ting Qi, Yang Wu, Anjali K. Henders et al. · 2022 · Figshare
  14. Additional file 4 of mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
    Kun Leng, Rooney, Brendan, Frank McCarthy, Wenlong Xia, Indigo V.L. Rose, Sophie Bax, Marcus Y. Chin, Fathi, Saeed, Kari A. Herrington, Manuel D. Leonetti et al. · 2024 · Figshare
  15. Additional file 5 of An integrated toolkit for human microglia functional genomics
    Imdadul Haq, Jason C. Ngo, Nainika Roy, Renshun Pan, Nadiya Nawsheen, Rebecca Chiu, Zhang, Ya, Fujita, Masashi, Soni, Rajesh K., Xuebing Wu et al. · 2024 · Figshare
  16. Additional file 3 of Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening
    Xing Li, Shiyu Sun, Zhang, Wansong, Liang, Ziwei, Yitong Fang, Sun, Tianhu, Wan, Yong, Ma, Xingcong, Zhang, Shuqun, Xu, Yang et al. · 2024 · Figshare
  17. Additional file 1 of Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist
    Hong Mei, Zhao Zha, Wei Wang, Yusang Xie, Yuege Huang, Li, Wenping, Wei, Dong, Zhang, Xinxin, Qu, Jieming, Liu, Jia · 2021 · Figshare
  18. Additional file 7 of An integrated toolkit for human microglia functional genomics
    Imdadul Haq, Jason C. Ngo, Nainika Roy, Renshun Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Fujita, Masashi, Soni, Rajesh K., Xuebing Wu et al. · 2024 · Figshare
  19. Additional file 2 of An integrated toolkit for human microglia functional genomics
    Imdadul Haq, Jason C. Ngo, Nainika Roy, Renshun Pan, Nadiya Nawsheen, Rebecca Chiu, Zhang, Ya, Fujita, Masashi, Soni, Rajesh K., Xuebing Wu et al. · 2024 · Figshare
  20. Additional file 13 of Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist
    Hong Mei, Zhao Zha, Wei Wang, Yusang Xie, Yuege Huang, Wenping Li, Wei, Dong, Zhang, Xinxin, Qu, Jieming, Liu, Jia · 2021 · Figshare
  21. Additional file 1 of mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
    Kun Leng, Rooney, Brendan, Frank McCarthy, Wenlong Xia, Indigo V.L. Rose, Sophie Bax, Marcus Y. Chin, Saeed Fathi, Kari A. Herrington, Manuel D. Leonetti et al. · 2024 · Figshare
  22. Additional file 6 of Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening
    Xing Li, Shiyu Sun, Zhang, Wansong, Liang, Ziwei, Yitong Fang, Sun, Tianhu, Wan, Yong, Ma, Xingcong, Zhang, Shuqun, Xu, Yang et al. · 2024 · Figshare
  23. Cell-type-specific adaptations to mitochondrial stress underly the neurological presentations of MTRFR mutations
    Mariana Zarate-Mendez, Kaela O’Connor, Natalia Malig, Oliver Podmanicky, Julia Kleniuk, Sally Spendiff, Evan Reid, Hanns Lochmüller, Denisa Hathazi, Rita Horváth · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Lost in translation: absence of KIAA1324/ELAPOR1 protein in pathological TDP-43-affected neurons in ALS/FTD
    Maize C. Cao, Molly E. V. Swanson, Indranil Basak, Kirstin McDonald, Frederick J. Arnold, Cameron M. Stockford, George Guo, Maurice A. Curtis, Richard L. M. Faull, Stephanie M. Hughes et al. · 2026 · Acta Neuropathologica Communications
  25. Single Cell Transcriptomics and Surface Protein Expression Reveal Distinct Cellular and Molecular Phenotypes in Human RPESC-RPE and PSC-RPE
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    Boxun Li, Kevin T. Hagy, Alexias Safi, M Beer, Alejandro Barrera, Sara Geraghty, Ruhi Rai, Alyssa N. Pederson, Samuel J. Reisman, Michael I Love et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
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    Lisa Rousselot · 2023 · theses.fr (ABES)
  28. Mosaic: Single-Cell Atlas of Stress
    Edward Siler Monk, Bianca M. Shieu, Dhruvita Kumbhani, Liang Fu, Albert Lin, Josephine Amalia Taverna, Carrie Jo Braden, C. Jeff Uribe-Lacy, Wensheng Zhang, Casey M. Sabbag et al. · 2026 · Cells
  29. Engineered dCas12f1-SAM enables robust transcriptional activation and gain-of-function screening in primary human cells
    Jiaxuan Cao, Zhirui Liu, Xinwen Chen, Zilin Lan, Li Liu, Yixin Zhai, Wentian Wang, Chaoyou Xue, Hui Cheng, Yao Yao et al. · 2026 · Nature Communications
  30. A class of deep intronic IGHMBP2 variants activate a shared cryptic splice donor, enabling correction of select variants with a single antisense oligonucleotide
    Sarah Silverstein, Andrew D. Nguyen, Rotem Orbach, Sandra C. Donkervoort, Thomas A. Cassini, Mary E. Koziura, Véronique Bolduc, Audrey M. Winkelsas, Ester Masati, Shreya Nandi et al. · 2026 · medRxiv
  31. C9orf72-associated G4C2 hexanucleotide repeat expression in Drosophila mushroom bodies causes age-dependent TDP-43 pathology and dementia relevant phenotypes mediated in part by the glypican Dlp/GPC6
    Brijesh Singh Chauhan, Megan Alexandria Brennan, Peter C. Forstmeier, Yifu Han, R. Keating Godfrey, Kendall R. Van Keuren‐Jensen, Rita Sattler, Justin K. Ichida, Daniela C. Zarnescu · 2026 · Acta Neuropathologica Communications
  32. Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cells
    William P. Marinello, Mark J. Zylka · 2026 · Frontiers in Toxicology
  33. Combinatorial and Inducible CRISPRa/i Enables Canalized hiPSC Forward Programming and Iterative Refinement via Single-Cell Genomics
    Federica Sozza, Alberto Romano, Nicole D'Elia, Martina Terenzi, Maria Luisa Ratto, Emily R. Cliff, Gabrielle Nattenberg, S D Bianchi, Silvia Becca, Heather Klug et al. · 2026 · SSRN Electronic Journal
  34. POCKET-seq enables genome-wide profiling of on- and off-target transcriptional regulation events by dCas9-KRAB during CRISPR interference experiments
    Christine M. Joyce, Griffin D Kramer, Jonathan T. Vu, Katherine U. Tavasoli, Brooke M. Gardner, Chris D. Richardson · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Glucose concentration of neuronal media formulations influences PINK1-dependent mitophagy in human iNeurons
    Benjamin O’Callaghan, Daniela Melandri, Darija Šoltić, Katharina Cosker, Marc P. M. Soutar, James R. Evans, Hannah Clarke, Joe Robin, Sonia Gandhi, Nicol Birsa et al. · 2026 · Autophagy Reports
  36. Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migration
    Stephanie L. Sarbanes, Jakub Žiak, Dylan C. Sacks, Yue Andy Qi, Alex L. Kolodkin, Antonina Roll‐Mecak · 2026 · Current Biology
  37. A pooled CRISPR-based neuronal activity screen links TMEM50A-dependent MVB function to synaptic integrity and remote memory
    Jianhui Wang, Meiqi Liu, Yiming Chen, Jiancheng Chen, Xin Zhong, Zilong Wang, Xian Jiang, Ruilin Tian · 2026 · Cell Reports
  38. Pharmacogenetics and Pharmacogenomics in Psychiatry: Challenges and Opportunities
    2026 · Frontiers research topics
  39. ARID5A RNA-binding coordinates microglial defense and ferroptosis in iPSC-derived models
    Danielle M. Schafer, Steven M. Blue, Shuhao Xu, Orel Mizrahi, Maya L. Gosztyla, Lena Street, Katherine L. Rothamel, Hema Kopalle, Samuel B. Landry, Elijah K.F. Rosales et al. · 2026 · Nature Communications
  40. Mapping cell-type- and age-dependent neuronal vulnerability through genome-wide in vivo CRISPRi screens in the mouse brain
    Risheng Lin, Zeting Ke, Jianhui Wang, Tianzi Wei, Lifu Zhang, Yitong Fang, Ruilin Tian · 2026 · Neuron
  41. Systematic Dissection of Key Driver Perturbation Signatures in Single Cells via ECCITE-seq
    Jinglong Zhang, Kristen Brennand, Bin Zhang, Minghui Wang, Aiqun Li · 2026 · Methods in molecular biology
  42. Integration of cell-specific gene expression and chromatin accessibility facilitates localization of neurodegenerative risk in microglia
    Xylena Reed, Dominic J. Acri, Alexandra G. Beilina, Jinhui Ding, Sara Sáez-Atiénzar, Mary Kaileh, Sarah Bromberek, Fangle Hu, Grigory Lerner, Daniel M. Ramos et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases
    Chengzhang Zhu, Zhiyan Zhao, Bojun Song, Yan-Ming Chen, Yu Xiao, Zhe Zhang, Yingzhi Ye, Niannian Xu, Ruijia Zhang, Yongxin Huang et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  44. CRISPR screening in neurodegeneration and lysosomal biology: Uncovering disease mechanisms and genetic modifiers
    Hamid Esmaeili, Supta Das, Krystyna Rytel, Ellen Sidransky, Yu Chen · 2026 · Molecular Genetics and Metabolism
  45. Failure to release from the ER translocon induces 60S ribosome degradation
    Zebulon G. Levine, Stuti Khandwala, Christina J. Zhang, Kelsey L. Hickey, Julia Joung, Jingjie Hu, Yi Hua Chen, Jingchuan Luo, Anders S. Hansen, J. Wade Harper et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  46. 151st Annual Meeting of the American Neurological Association
    2026 · Annals of Neurology
  47. Transcriptomic and phenotypic characterization of Alzheimer’s disease risk genes in neurons and astrocytes highlights shared and cell type specific cellular mechanisms
    Caia S. Dominicus, Diego Peretti, Geraldine Rodschinka, Samuel Ogden, Juliette Steer, Melissa Leija‐Salazar, Adib Miraki Feriz, Claudia Feng, Shikha Kataria, Jing Su et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Emerging frontiers for AI in single-cell genomics
    Sneha Mitra, Jiaxin Li, Christina S. Leslie · 2026 · Molecular Cell
  49. Programming brain endothelial identity: Transcription factor and genome engineering approaches to improve iPSC-derived BBB models
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  50. Human Induced Pluripotent Stem Cells in Rare Neurological Disorders: Opportunities and Challenges for Disease Modeling and Drug Discovery
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  51. SNX13 and SNX14 interorganelle tethers suppress lysosome membrane damage and neurodegeneration
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  52. Brain-informed helper lipid selection enhances intracranial mRNA delivery
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  53. "GiRAFR improves gRNA detection and annotation in single cell CRISPR screens" source data
    Qian Yu, Bernard Thienpont · 2023 · Figshare
  54. Key Resource Table: Dynamic convergence of neurodevelopmental disorder risk genes across neurodevelopment
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  55. Parkin deficiency rewires the genetic dependencies that govern neuronal survival
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  56. Cross-modal transfer enables zero-shot prediction of drug responses across cell types
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