The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity
Open accessAbstract
Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson's disease and addiction. In contrast to the extensive studies on neurons, astrocyte involvement in dopaminergic signaling remains largely unknown. Using transgenic mice, optogenetics, and pharmacogenetics, we studied the role of astrocytes on the dopaminergic system. We show that in freely behaving mice, astrocytes in the nucleus accumbens (NAc), a key reward center in the brain, respond with Ca 2+ elevations to synaptically released dopamine, a phenomenon enhanced by amphetamine. In brain slices, synaptically released dopamine increases astrocyte Ca 2+, stimulates ATP/adenosine release, and depresses excitatory synaptic transmission through activation of presynaptic A 1 receptors. Amphetamine depresses neurotransmission through stimulation of astrocytes and the consequent A 1 receptor activation. Furthermore, astrocytes modulate the acute behavioral psychomotor effects of amphetamine. Therefore, astrocytes mediate the dopamine- and amphetamine-induced synaptic regulation, revealing a novel cellular pathway in the brain reward system.
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“DA signaling is considered to play a key role in astrocyte-neuron crosstalk in the striatum. 79”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [79]
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Cites
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Tripartite synapses: glia, the unacknowledged partner
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Self-citationIndependent optical excitation of distinct neural populations
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Astrocytes, from brain glue to communication elements: the revolution continues
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Tripartite synapses: astrocytes process and control synaptic information
Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820
Self-citationLong-term potentiation depends on release of d-serine from astrocytes
Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389
Astrocyte Control of Synaptic Transmission and Neurovascular Coupling
Haydon, P. G., & Carmignoto, G. (2006) · Physiological Reviews · doi:10.1152/physrev.00049.2005 · Cited by 1,371
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308
Self-citationAstrocytic Purinergic Signaling Coordinates Synaptic Networks
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Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,244
“79 Sulpiride is an antidepressant that blocks the ability of the GLT-1 inhibitor TFB-TBOA to induce synaptic depression 80 and partly attenuates the impact of fl uorocitrate (a metabolic uncoupler that blocks aconitase in the tricarboxylic acid (TCA) cycle) on synaptic output.”
BackgroundNegative feedback control of neuronal activity by microglia
Badimon, A., Strasburger, H. J., Ayata, P., Chen, X., Nair, A., Ikegami, A., Hwang, P., Chan, A. T., Graves, S. M., Uweru, J. O., et al. (2020) · Nature · doi:10.1038/s41586-020-2777-8 · Cited by 979
Behaviorally consequential astrocytic regulation of neural circuits
Nagai, J., Yu, X., Papouin, T., Cheong, E., Freeman, M. R., Monk, K. R., Hastings, M. H., Haydon, P. G., Rowitch, D. H., Shaham, S., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.12.008 · Cited by 315
Making sense of astrocytic calcium signals — from acquisition to interpretation
Semyanov, A., Henneberger, C., & Agarwal, A. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0361-8 · Cited by 269
G-Protein-Coupled Receptors in Astrocyte–Neuron Communication
Kofuji, P., & Araque, A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.025 · Cited by 249
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Metadata
- Authors
- Corkrum, M., Covelo, A., Lines, J., Bellocchio, L., Pisansky, M., Loke, K., Quintana, R., Rothwell, P. E., Lujan, R., Marsicano, G., Martin, E. D., Thomas, M. J., Kofuji, P., & Araque, A.
- Affiliations
- University of Minnesota (US)
- Université de Bordeaux (FR)
- Corresponding author
- Araque, Alfonso
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 105
- Issue
- 6
- Pages
- 1036-1047.e5
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7322729
- OpenAlex
- W2999291880
- Cited by
- 327
- References
- 67
- Citations by year
- 2026: 27 · 2025: 63 · 2024: 62 · 2023: 52 · 2022: 54 · 2021: 48 · 2020: 21
- FWCI
- 20.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- RUIdeRA - Institutional University Repository (University of Castilla-La Mancha) (submittedVersion, other-oa)
- Funders
- University of Minnesota
- European Research Council (ERC-2017-AdG-786467, RGP0036/2014)
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Human Frontier Science Program
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- astrocytes, dopamine, nucleus accumbens, synaptic regulation, astrocyte calcium signaling, adenosine A1 receptor, amphetamine, psychomotor effects, reward systems, dopaminergic signaling
- MeSH terms
- Adenosine, Adenosine Triphosphate, Amphetamine, Animals, Astrocytes, Calcium, Clozapine, Dopamine, Female, Male, Mice, Transgenic, Motor Activity, Synaptic Transmission, Nucleus Accumbens, Reward, Receptors, Dopamine D1, Mice, Knockout, Excitatory Postsynaptic Potentials, Mice, Optogenetics
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