Gliotransmitters Travel in Time and Space
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The identification of the presence of active signaling between astrocytes and neurons in a process termed gliotransmission has caused a paradigm shift in our thinking about brain function. However, we are still in the early days of the conceptualization of how astrocytes influence synapses, neurons, networks, and ultimately behavior. In this Perspective, our goal is to identify emerging principles governing gliotransmission and consider the specific properties of this process that endow the astrocyte with unique functions in brain signal integration. We develop and present hypotheses aimed at reconciling confounding reports and define open questions to provide a conceptual framework for future studies. We propose that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons.
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Astrocyte interactions with synaptic circuits are multimodal and multiscale, occur under physiological conditions, and contribute to behavior.
“astrocyte interactions with synaptic circuits are multimodal and multiscale, occur under physiological conditions 2-5 and contribute to behavior 6-8 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [2]
Astrocytes contribute to synaptic plasticity by releasing fast mediators that directly modify synaptic function.
“Astrocytes contribute to synaptic plasticity by releasing fast mediators that directly modify synaptic function 2, 4 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [2]
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Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex
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Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses
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GABA release by hippocampal astrocytes
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Self-citationBell-Shaped D-Serine Actions on Hippocampal Long-Term Depression and Spatial Memory Retrieval
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Self-citationLocally Synchronized Astrocytes
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The endocannabinoid system in guarding against fear, anxiety and stress
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The structure and dynamics of networks with higher order interactions
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Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior
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Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling
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Self-citationAstrocyte regulation of synaptic behavior
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Self-citationCB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity
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Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue
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Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism
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Self-citationDopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity
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<i>Drosophila</i> Central Nervous System Glia
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The glia of the adult D rosophila nervous system
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Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes
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Functional Oxygen Sensitivity of Astrocytes
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Specialized astrocytes mediate glutamatergic gliotransmission in the CNS
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Self-citationStructural and Functional Plasticity of Astrocyte Processes and Dendritic Spine Interactions
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Self-citationQuestions and (some) answers on reactive astrocytes
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Glucose metabolism links astroglial mitochondria to cannabinoid effects
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Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse
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- Authors
- Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A.
- Affiliations
- University of Minnesota (US)
- University of Padua (IT)
- Tufts University (US)
- Université de Bordeaux (FR)
- Université de Montréal (CA)
- University of Lausanne (CH)
- Corresponding author
- Carmignoto, Giorgio
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 81
- Issue
- 4
- Pages
- 728-739
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4107238
- OpenAlex
- W2042681276
- Cited by
- 1,308
- References
- 134
- Citations by year
- 2026: 73 · 2025: 101 · 2024: 115 · 2023: 125 · 2022: 116 · 2021: 153 · 2020: 116 · 2019: 95 · 2018: 105 · 2017: 84 · 2016: 86 · 2015: 105 · 2014: 32 · 2013: 1
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- HAL (submittedVersion)
- Funders
- National Science Foundation
- Sbarro Health Research Organization
- European Commission (202167, 340368)
- Institut National de la Santé et de la Recherche Médicale
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (140999, 31003A, 203729)
- LabEx BRAIN
- National Institutes of Health
- Canadian Institutes of Health Research (MOP‐14137, MOP‐111070)
- National Institute on Alcohol Abuse and Alcoholism (R01AA020183)
- National Institute of Mental Health (R01MH095385)
- National Institute on Drug Abuse (R01DA025967)
- National Institute of Neurological Disorders and Stroke (R01NS037585)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- gliotransmission, astrocytes, astrocyte-neuron communication, high-affinity receptor, spatiotemporal signaling, astrocyte function
- MeSH terms
- Animals, Astrocytes, Cell Communication, Humans, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses
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