Cited by 1,308Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsNeural dynamics and brain function

Gliotransmitters Travel in Time and Space

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Araque, Alfonso, Carmignoto, Giorgio, Haydon, Philip G., Oliet, Stéphane H.R., Robitaille, Richard, Volterra, Andrea·2014·Neuron

Abstract

The identification of the presence of active signaling between astrocytes and neurons in a process termed gliotransmission has caused a paradigm shift in our thinking about brain function. However, we are still in the early days of the conceptualization of how astrocytes influence synapses, neurons, networks, and ultimately behavior. In this Perspective, our goal is to identify emerging principles governing gliotransmission and consider the specific properties of this process that endow the astrocyte with unique functions in brain signal integration. We develop and present hypotheses aimed at reconciling confounding reports and define open questions to provide a conceptual framework for future studies. We propose that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons.

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Crossref · 10.1016/j.neuron.2014.02.007

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Authors
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A.
Affiliations
  • University of Minnesota (US)
  • University of Padua (IT)
  • Tufts University (US)
  • Université de Bordeaux (FR)
  • Université de Montréal (CA)
  • University of Lausanne (CH)
Corresponding author
Carmignoto, Giorgio
Venue
Neuron
Publisher
Elsevier BV
Published
2014-02
Volume
81
Issue
4
Pages
728-739
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2042681276
Cited by
1,308
References
134
Citations by year
2026: 73 · 2025: 101 · 2024: 115 · 2023: 125 · 2022: 116 · 2021: 153 · 2020: 116 · 2019: 95 · 2018: 105 · 2017: 84 · 2016: 86 · 2015: 105 · 2014: 32 · 2013: 1
FWCI
11.69
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
  • IRIS (submittedVersion)
  • HAL (submittedVersion)
Funders
  • National Science Foundation
  • Sbarro Health Research Organization
  • European Commission (202167, 340368)
  • Institut National de la Santé et de la Recherche Médicale
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (140999, 31003A, 203729)
  • LabEx BRAIN
  • National Institutes of Health
  • Canadian Institutes of Health Research (MOP‐14137, MOP‐111070)
  • National Institute on Alcohol Abuse and Alcoholism (R01AA020183)
  • National Institute of Mental Health (R01MH095385)
  • National Institute on Drug Abuse (R01DA025967)
  • National Institute of Neurological Disorders and Stroke (R01NS037585)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
gliotransmission, astrocytes, astrocyte-neuron communication, high-affinity receptor, spatiotemporal signaling, astrocyte function
MeSH terms
Animals, Astrocytes, Cell Communication, Humans, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses

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