Tripartite synapses: astrocytes process and control synaptic information
Abstract
The term 'tripartite synapse' refers to a concept in synaptic physiology based on the demonstration of the existence of bidirectional communication between astrocytes and neurons. Consistent with this concept, in addition to the classic 'bipartite' information flow between the pre- and postsynaptic neurons, astrocytes exchange information with the synaptic neuronal elements, responding to synaptic activity and, in turn, regulating synaptic transmission. Because recent evidence has demonstrated that astrocytes integrate and process synaptic information and control synaptic transmission and plasticity, astrocytes, being active partners in synaptic function, are cellular elements involved in the processing, transfer and storage of information by the nervous system. Consequently, in contrast to the classically accepted paradigm that brain function results exclusively from neuronal activity, there is an emerging view, which we review herein, in which brain function actually arises from the coordinated activity of a network comprising both neurons and glia.
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Dysregulated communication with neurons can impair synaptic plasticity.
“For astrocytes in particular, dysregulated communication with neurons can impair synaptic plasticity (31, 32).”
From Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease (2020) · cites this paper as [32]
Interactions with glial cells also play a role in neural signaling and neuromodulation, leading to the concept of tripartite synapses that include a glial contribution.
“Interactions with glial cells also play a role in neural signaling and neuromodulation, leading to the concept of “tripartite” synapses that include a glial contribution (Perea et al., 2009).”
From Toward an integration of deep learning and neuroscience (2016) · cites this paper as Perea et al., 2009
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- Authors
- Perea, G., Navarrete, M., & Araque, A.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Araque, Alfonso
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 32
- Issue
- 8
- Pages
- 421-431
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2147372806
- Cited by
- 1,820
- References
- 109
- Citations by year
- 2026: 89 · 2025: 124 · 2024: 133 · 2023: 140 · 2022: 126 · 2021: 128 · 2020: 107 · 2019: 108 · 2018: 112 · 2017: 80 · 2016: 112 · 2015: 106 · 2014: 102 · 2013: 90 · 2012: 107
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- tripartite synapse, astrocytes, astrocyte-neuron communication, synaptic transmission, synaptic plasticity, neuron-glia interactions
- MeSH terms
- Animals, Astrocytes, Calcium, Synaptic Transmission, Neurons, Synapses, Neurotransmitter Agents
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