The DOI matches its Crossref record; 79 of the 80 references it cites were found in a registry or an index.
Short-Term Plasticity at Hippocampal Mossy Fiber Synapses Is Induced by Natural Activity Patterns and Associated with Vesicle Pool Engram Formation
Open accessAbstract
Post-tetanic potentiation (PTP) is an attractive candidate mechanism for hippocampus-dependent short-term memory. Although PTP has a uniquely large magnitude at hippocampal mossy fiber-CA3 pyramidal neuron synapses, it is unclear whether it can be induced by natural activity and whether its lifetime is sufficient to support short-term memory. We combined in vivo recordings from granule cells (GCs), in vitro paired recordings from mossy fiber terminals and postsynaptic CA3 neurons, and "flash and freeze" electron microscopy. PTP was induced at single synapses and showed a low induction threshold adapted to sparse GC activity in vivo. PTP was mainly generated by enlargement of the readily releasable pool of synaptic vesicles, allowing multiplicative interaction with other plasticity forms. PTP was associated with an increase in the docked vesicle pool, suggesting formation of structural "pool engrams." Absence of presynaptic activity extended the lifetime of the potentiation, enabling prolonged information storage in the hippocampal network.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For example, high-frequency stimulation (HFS) induces several cyclic adenosine monophosphate (cAMP)-dependent forms of presynaptic plasticity [21,28–33].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [21]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Thus, both short- and long-term mechanisms may involve the formation of vesicle pool engrams [21].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [21]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Previous work showed that facilitation and PTP may lead to conditional detonation or plasticity-dependent detonation at this synapse [21,51].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [21]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Thus, chemical potentiation primarily involved an increase in pool size but also an increase in Pr, reminiscent of hippocampal mossy fiber PTP [21].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [21]
The cited source says what the claim attributes to it.
In the citing paper
“Second, it has a unique extent of presynaptic plasticity, including facilitation, post-tetanic potentiation (PTP) [21], and long-term potentiation (LTP) [27].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [21]
The cited source says what the claim attributes to it.
In the citing paper
“This is consistent with a decrease in strength of synaptic transmission after H-89 application [21].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [21]
The cited source says what the claim attributes to it.
In the citing paper
“Moreover, our results revealed that baseline activity of cAMP-PKA signaling pathway is important for coupling distance, basal synaptic transmission, and the induction of presynaptic potentiation, as the application of PKA antagonists led to “uncoupling” of Munc13-1 and CaV2.1 (Figs 5 and S9) and a decrease in synaptic strength [21].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [21]
The cited source says what the claim attributes to it.
In the citing paper
“Changes in both RRP and Pr have been also reported during PTP [21].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. (1995) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.2307/2983304 · Cited by 22,453
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663
Abbott, L. F., & Regehr, W. G. (2004) · Nature · doi:10.1038/nature03010 · Cited by 1,684
Optogenetic stimulation of a hippocampal engram activates fear memory recall
Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K. A., & Tonegawa, S. (2012) · Nature · doi:10.1038/nature11028 · Cited by 1,669
Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
Klausberger, T., Magill, P. J., Márton, L. F., Roberts, J. D. B., Cobden, P. M., Buzsáki, G., & Somogyi, P. (2003) · Nature · doi:10.1038/nature01374 · Cited by 1,345
Geiger, J. R. P., Melcher, T., Koh, D.-S., Sakmann, B., Seeburg, P. H., Jonas, P., & Monyer, H. (1995) · Neuron · doi:10.1016/0896-6273(95)90076-4 · Cited by 1,260
Synaptic theory of working memory
Mongillo, G., Barak, O., & Tsodyks, M. (2008) · Science · doi:10.1126/science.1150769 · Cited by 1,253
Flagged first, then by citations
1 of the 80 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis
Lee, J.-H., Kim, J. S., Noh, S., Lee, H., Lee, S. Y., Mun, J. Y., Park, H., & Chung, W. (2020) · Nature · doi:10.1038/s41586-020-03060-3 · Cited by 407
Calcium-dependent docking of synaptic vesicles
Silva, M., Tran, V., & Marty, A. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.04.003 · Cited by 87
Synapsins and the Synaptic Vesicle Reserve Pool: Floats or Anchors?
Zhang, M., & Augustine, G. J. (2021) · Cells · doi:10.3390/cells10030658 · Cited by 66
Guzman, S. J., Schlögl, A., Espinoza, C., Zhang, X., Suter, B. A., & Jónás, P. (2021) · Nature Computational Science · doi:10.1038/s43588-021-00157-1 · Cited by 58
Self-citationCalcium dependence of neurotransmitter release at a high fidelity synapse
Eshra, A., Schmidt, H., Eilers, J., & Hallermann, S. (2021) · eLife · doi:10.7554/elife.70408 · Cited by 56
Metadata
- Authors
- Vandael, D., Borges-Merjane, C., Zhang, X., & Jonas, P.
- Affiliations
- Institute of Science and Technology Austria (AT)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 107
- Issue
- 3
- Pages
- 509-521.e7
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7427323
- OpenAlex
- W3032084133
- Cited by
- 114
- References
- 80
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 17 · 2023: 24 · 2022: 15 · 2021: 23 · 2020: 6
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Horizon 2020 (692692)
- European Research Council
- Austrian Science Fund (V 739-B27, Z 312-B27)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- post-tetanic potentiation, short-term plasticity, mossy fiber synapses, hippocampus, CA3 pyramidal cells, granule cells, synaptic vesicle pools, readily releasable pool, docked vesicles, short-term memory, synaptic plasticity, presynaptic activity
- MeSH terms
- Action Potentials, Animals, Memory, Short-Term, Microscopy, Electron, Neuronal Plasticity, Synapses, Synaptic Vesicles, Pyramidal Cells, Patch-Clamp Techniques, Dentate Gyrus, Mossy Fibers, Hippocampal, Mice, Rats, Synaptic Potentials, CA3 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
