Cited by 1,684Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Synaptic computation

Abbott, L. F., Regehr, Wade G.·2004·Nature

Abstract

Neurons are often considered to be the computational engines of the brain, with synapses acting solely as conveyers of information. But the diverse types of synaptic plasticity and the range of timescales over which they operate suggest that synapses have a more active role in information processing. Long-term changes in the transmission properties of synapses provide a physiological substrate for learning and memory, whereas short-term changes support a variety of computations. By expressing several forms of synaptic plasticity, a single neuron can convey an array of different signals to the neural circuit in which it operates.

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Crossref · 10.1038/nature03010

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Authors
Abbott, L. F., & Regehr, W. G.
Affiliations
  • Brandeis University (US)
  • Harvard University (US)
Venue
Nature
Published
2004-10
Volume
431
Issue
7010
Pages
796-803
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W4247763225
Cited by
1,684
References
4
Citations by year
2026: 100 · 2025: 140 · 2024: 148 · 2023: 126 · 2022: 138 · 2021: 134 · 2020: 121 · 2019: 92 · 2018: 106 · 2017: 69 · 2016: 65 · 2015: 58 · 2014: 53 · 2013: 49 · 2012: 45
FWCI
2.24
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
synaptic plasticity, short-term plasticity, long-term synaptic plasticity, learning and memory, neural information processing, synaptic transmission, neural circuits
MeSH terms
Animals, Synaptic Transmission, Neuronal Plasticity, Neurons, Sound Localization, Synapses

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