The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Magnetoelectric Materials for Miniature, Wireless Neural Stimulation at Therapeutic Frequencies
Open accessPublished version of a preprint
Abstract
A major challenge for miniature bioelectronics is wireless power delivery deep inside the body. Electromagnetic or ultrasound waves suffer from absorption and impedance mismatches at biological interfaces. On the other hand, magnetic fields do not suffer these losses, which has led to magnetically powered bioelectronic implants based on induction or magnetothermal effects. However, these approaches have yet to produce a miniature stimulator that operates at clinically relevant high frequencies. Here, we show that an alternative wireless power method based on magnetoelectric (ME) materials enables miniature magnetically powered neural stimulators that operate up to clinically relevant frequencies in excess of 100 Hz. We demonstrate that wireless ME stimulators provide therapeutic deep brain stimulation in a freely moving rodent model for Parkinson's disease and that these devices can be miniaturized to millimeter-scale and fully implanted. These results suggest that ME materials are an excellent candidate to enable miniature bioelectronics for clinical and research applications.
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“Upon reaching the transducer, the magnetic field causes the magnetostrictive material to undergo a deformation. This mechanical deformation is then converted into an electrical voltage by the piezoelectric component, effectively transferring energy from the external source to the implant (Dong et al., 2003; Zhai et al., 2006; Singer et al., 2020).”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Singer et al., 2020
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Using DeepLabCut for 3D markerless pose estimation across species and behaviors
Nath, T., Mathis, A., Chen, A. C., Patel, A., Bethge, M., & Mathis, M. W. (2019) · Nature Protocols · doi:10.1038/s41596-019-0176-0 · Cited by 1,536
A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves
Chen, J., Kan, P. T. M., Yu, Z., Alrashdan, F. T., Garcia, R., Singer, A. L., Lai, C. S. E., Avants, B., Crosby, S., Li, Z., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00873-7 · Cited by 237
Self-citationZaeimbashi, M., Nasrollahpour, M., Khalifa, A., Romano, A., Liang, X., Chen, H., Sun, N., Matyushov, A. D., Lin, H., Dong, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23256-z · Cited by 205
Magnetoelectric effect: principles and applications in biology and medicine– a review
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Metadata
- Authors
- Singer, A., Dutta, S., Lewis, E., Chen, Z., Chen, J. C., Verma, N., Avants, B., Feldman, A. K., O’Malley, J., Beierlein, M., Kemere, C., & Robinson, J. T.
- Affiliations
- Rice University (US)
- The University of Texas Health Science Center at Houston (US)
- Baylor College of Medicine (US)
- Corresponding author
- Robinson, Jacob T.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 107
- Issue
- 4
- Pages
- 631-643.e5
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7818389
- OpenAlex
- W3033085681
- Cited by
- 202
- References
- 59
- Citations by year
- 2026: 31 · 2025: 29 · 2024: 39 · 2023: 20 · 2022: 33 · 2021: 35 · 2020: 11
- FWCI
- 11.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (CBET-1351692, GRFP 1842494, IGERT 1250104)
- National Institutes of Health (1U18EB029353-01, R21EY028397A)
- Rice University
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Wireless Power Transfer Systems
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Multiferroics and related materials
- Keywords
- magnetoelectric materials, wireless neural stimulation, deep brain stimulation, Parkinson's disease, high-frequency stimulation
- MeSH terms
- Animals, Equipment Design, Humans, Deep Brain Stimulation, Implantable Neurostimulators, Wireless Technology
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