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Cited by 105Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchTranscranial Magnetic Stimulation Studies

Neural circuitry of PTSD with or without mild traumatic brain injury: a meta-analysis

Simmons, Alan N., Matthews, Scott C.·2012·Neuropharmacology
DOI 10.1016/j.neuropharm.2011.03.016
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Abstract

Posttraumatic Stress Disorder (PTSD) and mild traumatic brain injury (mTBI) often occur together. Parsing out the unique and overlapping effects of these conditions on the brain, can inform the selection of appropriate treatments. Although recent studies indicate that warfighters in Operations Enduring and Iraqi Freedom are at a high risk for PTSD and mTBI, there is a dearth of research directly comparing their neural correlates. In this paper, we briefly discuss these conditions and supply two meta-analyses of the relevant functional magnetic resonance imaging studies conducted to date. By looking at the overlap in these analyses, we suggest that the middle frontal gyrus may be an appropriate area for future investigations aimed at disentangling PTSD and mTBI. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.

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Crossref · 10.1016/j.neuropharm.2011.03.016

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  • Animal models of fear learning have led to the supposition that dysfunction in amygdala activity, the key structure in the regulation of fear and stress, is common to various anxiety disorders.

    “Animal models of fear learning have led to the supposition that dysfunction in amygdala activity, the key structure in the regulation of fear and stress (Simmons and Matthews, 2012), is common to various anxiety disorders.”

    From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Simmons and Matthews, 2012

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Authors
Simmons, A. N., & Matthews, S. C.
Affiliations
University of California San Diego (US)
Corresponding author
Simmons, Alan N.
ORCID
Simmons, Alan N.
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2012-02
Volume
62
Issue
2
Pages
598-606
ISSN
0028-3908 (ISSN-L)
DOI
10.1016/j.neuropharm.2011.03.016
OpenAlex
W1965697904
Cited by
105
References
17
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 13 · 2013: 9 · 2012: 9
FWCI
1.60
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Veterans Affairs (I01-CX000292)
  • Center of Excellence for Stress and Mental Health
  • University of California, San Diego
  • Clinical Science Research and Development
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords
post-traumatic stress disorder, mild traumatic brain injury, neural correlates, functional MRI, middle frontal gyrus, warfighters, combat exposure
MeSH terms
Brain, Brain Injuries, Humans, Life Change Events, Military Personnel, Nerve Net, Stress Disorders, Post-Traumatic, Veterans, Iraq War, 2003-2011, Afghan Campaign 2001-

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