Cited by 249Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchNeural and Behavioral Psychology Studies

The neural networks of inhibitory control in posttraumatic stress disorder

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Falconer, Erin, Bryant, Richard, Felmingham, Kim L., Kemp, Andrew H., Gordon, Evian, Peduto, Anthony, Olivieri, Gloria, Williams, Leanne M.·2008·Journal of Psychiatry and Neuroscience

Abstract

OBJECTIVE: Posttraumatic stress disorder (PTSD) involves deficits in information processing that may reflect hypervigilence and deficient inhibitory control. To date, however, no PTSD neuroimaging study has directly examined PTSD-related changes in executive inhibition. Our objective was to investigate the hypothesis that executive inhibitory control networks are compromised in PTSD. METHODS: Functional magnetic resonance imaging (fMRI) was used during a Go/No-Go inhibition task completed by a sample of patients with PTSD (n = 23), a matched sample of healthy (i.e. without trauma exposure) control participants (n = 23) and a sample of control participants with trauma exposure who did not meet criteria for PTSD (n = 17). RESULTS: Participants with PTSD showed more inhibition-related errors than did individuals without trauma exposure. During inhibition, control participants activated a right-lateralized cortical inhibitory network, whereas patients with PTSD activated only the left lateral frontal cortex. PTSD was associated with a reduction in right cortical activation and increased activation of striatal and somatosensory regions. CONCLUSION: The increased inhibitory error and reduced right frontal cortical activation are consistent with compromised inhibitory control in PTSD, while the increased activation of brain regions associated with sensory processing and a greater demand on inhibitory control may reflect enhanced stimulus processing in PTSD, which may undermine cortical control mechanisms.

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Authors
Falconer, E., Bryant, R., Felmingham, K. L., Kemp, A. H., Gordon, E., Peduto, A., Olivieri, G., & Williams, L. M.
Affiliations
  • Westmead Hospital (AU)
  • The University of Sydney (AU)
  • The Brain Resource International Database, Brain Resource Company, Ultimo
Venue
Journal of Psychiatry and Neuroscience
Published
2008-09
Volume
33
Issue
5
Pages
413-422
ISSN
  • 1180-4882 (ISSN-L)
  • 1488-2434
OpenAlex
W2099636654
Cited by
249
References
51
Citations by year
2026: 4 · 2025: 6 · 2024: 15 · 2023: 16 · 2022: 10 · 2021: 13 · 2020: 21 · 2019: 22 · 2018: 20 · 2017: 17 · 2016: 23 · 2015: 19 · 2014: 11 · 2013: 11 · 2012: 13
FWCI
10.37
Type
journal article
Language
en
Open access
Locations
  • Journal of Psychiatry and Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • PubMed
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
post-traumatic stress disorder, inhibitory control, executive function, go/no-go task, right frontal cortex, striatum, somatosensory cortex, hypervigilance, trauma exposure, artificial neural networks
MeSH terms
Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neural Inhibition, Stress Disorders, Post-Traumatic, Diagnostic and Statistical Manual of Mental Disorders, Young Adult

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