The neural networks of inhibitory control in posttraumatic stress disorder
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OBJECTIVE: Posttraumatic stress disorder (PTSD) involves deficits in information processing that may reflect hypervigilence and deficient inhibitory control. To date, however, no PTSD neuroimaging study has directly examined PTSD-related changes in executive inhibition. Our objective was to investigate the hypothesis that executive inhibitory control networks are compromised in PTSD. METHODS: Functional magnetic resonance imaging (fMRI) was used during a Go/No-Go inhibition task completed by a sample of patients with PTSD (n = 23), a matched sample of healthy (i.e. without trauma exposure) control participants (n = 23) and a sample of control participants with trauma exposure who did not meet criteria for PTSD (n = 17). RESULTS: Participants with PTSD showed more inhibition-related errors than did individuals without trauma exposure. During inhibition, control participants activated a right-lateralized cortical inhibitory network, whereas patients with PTSD activated only the left lateral frontal cortex. PTSD was associated with a reduction in right cortical activation and increased activation of striatal and somatosensory regions. CONCLUSION: The increased inhibitory error and reduced right frontal cortical activation are consistent with compromised inhibitory control in PTSD, while the increased activation of brain regions associated with sensory processing and a greater demand on inhibitory control may reflect enhanced stimulus processing in PTSD, which may undermine cortical control mechanisms.
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PTSD has been linked to impaired attention regulation and inhibitory control.
“PTSD has been linked to impaired attention regulation and inhibitory control [[13], [14], [15], [16]].”
From A randomized controlled trial of yoga vs nonaerobic exercise for veterans with PTSD: Understanding efficacy, mechanisms of change, and mode of delivery (2021) · cites this paper as [14]
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- Authors
- Falconer, E., Bryant, R., Felmingham, K. L., Kemp, A. H., Gordon, E., Peduto, A., Olivieri, G., & Williams, L. M.
- Affiliations
- Westmead Hospital (AU)
- The University of Sydney (AU)
- The Brain Resource International Database, Brain Resource Company, Ultimo
- Venue
- Journal of Psychiatry and Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2008-09
- Volume
- 33
- Issue
- 5
- Pages
- 413-422
- ISSN
- 1180-4882 (ISSN-L)
- 1488-2434
- PMC
- PMC2527717
- OpenAlex
- W2099636654
- Cited by
- 249
- References
- 51
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 15 · 2023: 16 · 2022: 10 · 2021: 13 · 2020: 21 · 2019: 22 · 2018: 20 · 2017: 17 · 2016: 23 · 2015: 19 · 2014: 11 · 2013: 11 · 2012: 13
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatry and Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- PubMed
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- post-traumatic stress disorder, inhibitory control, executive function, go/no-go task, right frontal cortex, striatum, somatosensory cortex, hypervigilance, trauma exposure, artificial neural networks
- MeSH terms
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neural Inhibition, Stress Disorders, Post-Traumatic, Diagnostic and Statistical Manual of Mental Disorders, Young Adult
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