An animal model of female adolescent cannabinoid exposure elicits a long-lasting deficit in presynaptic long-term plasticity
Open accessAbstract
Cannabis continues to be the most accessible and popular illicit recreational drug. Whereas current data link adolescence cannabinoid exposure to increased risk for dependence on other drugs, depression, anxiety disorders and psychosis, the mechanism(s) underlying these adverse effects remains controversial. Here we show in a mouse model of female adolescent cannabinoid exposure deficient endocannabinoid (eCB)-mediated signaling and presynaptic forms of long-term depression at adult central glutamatergic synapses in the prefrontal cortex. Increasing endocannabinoid levels by blockade of monoacylglycerol lipase, the primary enzyme responsible for degrading the endocannabinoid 2-arachidonoylglycerol (2-AG), with the specific inhibitor JZL 184 ameliorates eCB-LTD deficits. The observed deficit in cortical presynaptic signaling may represent a neural maladaptation underlying network instability and abnormal cognitive functioning. Our study suggests that adolescent cannabinoid exposure may permanently impair brain functions, including the brain's intrinsic ability to appropriately adapt to external influences.
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Persistent cognitive deficits following adolescent exposure to a CB1 agonist may be mediated by downstream systems such as glutamate and GABA and not the endocannabinoid system.
“Interestingly, total FC CB1 receptors remain unchanged in adult female rodents following adolescent exposure to a CB1 receptor agonist (Lovelace et al. 2015), suggesting that persistent cognitive deficits in FC-mediated tasks produced by adolescent exposure to a CB1 agonist may be mediated by downstream systems such as glutamate and GABA and not the endocannabinoid system.”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Lovelace et al. 2015
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Dynamic mapping of human cortical development during childhood through early adulthood
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BackgroundThe molecular logic of endocannabinoid signalling
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Persistent cannabis users show neuropsychological decline from childhood to midlife
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“…that chronic adolescent, but not adult, exposure to cannabinoids produces permanent cognitive impairments in animal models (O'Shea et al., 2004; Quinn et al., 2008; Raver et al., 2013; Schneider et al., 2005; Schneider and Koch, 2003) and in humans (Meier et al., 2012; Solowij et al., 2002).”
BackgroundZamberletti, E., Beggiato, S., Steardo, L., Prini, P., Antonelli, T., Ferraro, L., Rubino, T., & Parolaro, D. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.028 · Cited by 147 · see citing works
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Disentangling the lasting effects of adolescent cannabinoid exposure
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Le, A. A., Quintanilla, J., Amani, M., Piomelli, D., Lynch, G., & Gall, C. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105565 · Cited by 22 · see citing works
- Authors
- Lovelace, J. W., Corches, A., Vieira, P. A., Hiroto, A. S., Mackie, K., & Korzus, E.
- Affiliations
- University of California, Riverside (US)
- Indiana University Bloomington (US)
- Corresponding author
- Korzus, Edward
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 99
- Pages
- 242-255
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC4644105
- OpenAlex
- W226968899
- Cited by
- 43
- References
- 6
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 1 · 2015: 2
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- UCR Collaborative Research Seed Grant
- NIH/NIMH (MH086078)
- NIH/NIDA (DA011322, DA021696)
- Ford Fellowship
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Keywords
- endocannabinoid signaling, monoacylglycerol lipase, 2-arachidonoylglycerol, prefrontal cortex, glutamatergic synapses, female mice, cognitive impairment, cannabis adverse effects
- MeSH terms
- Animals, Marijuana Abuse, Cognition Disorders, Disease Models, Animal, Female, Mice, Inbred C57BL, Morpholines, Naphthalenes, Prefrontal Cortex, Presynaptic Terminals, Long-Term Potentiation, Receptors, Metabotropic Glutamate, Recognition, Psychology, Receptor, Cannabinoid, CB1, Tissue Culture Techniques, Benzoxazines, Cannabinoid Receptor Agonists, Endocannabinoids
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