Cited by 39Pain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice

Open access
Bagdas, Deniz, Muldoon, Pretal P., AlSharari, Shakir, Carroll, F. Ivy, Negus, S. Stevens, Damaj, M. Imad·2016·Neuropharmacology

Abstract

Pain encompasses both a sensory as well as an affective dimension and these are differentially processed in the brain and periphery. It is therefore important to develop animal models to reflect the non-reflexive assays in pain. In this study, we compared effects of the mu opioid receptor agonist morphine, the nonsteroidal anti-inflammatory drug ketoprofen and the kappa receptor opioid agonist U50,488H and antagonist JDTic on acetic acid-induced stretching and acetic acid-induced aversion in the condition place aversion (CPA) test in male ICR mice. Intraperitoneal administration of acetic acid (0.32-1%) was equipotent in stimulating stretching and CPA. Ketoprofen, morphine and U50,488H all inhibited the acid-induced stretching. Ketoprofen and morphine also blocked the acid-induced CPA but U50,488H failed to do so. The reversal ability of ketoprofen and morphine on acid-induced CPA is unique to pain-stimulated place aversion since these drugs failed to reduce non-noxious LiCl-induced CPA. Overall, this study characterized and validated a preclinical mouse model of pain-related aversive behavior that can be used to assess genetic and biological mechanisms of pain as well as improving the predictive validity of preclinical studies on candidate analgesics.

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Crossref · 10.1016/j.neuropharm.2015.11.024

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  • Systemic JDtic fails to block conditioned place aversion produced by visceral and acid-induced pain in mice.

    “However, systemic doses of the k-opioid receptor antagonist (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (JDtic) failed to block conditioned place aversion that was produced by visceral and acid-induced pain in mice (Bagdas et al., 2016).”

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Research works printed but not linked: 1

  1. Rivière PJM Junien JL 2000 Opioid receptors, targets for new gastrointestinal drug development Drug Development Molecular Targets for GI Diseases Totowa, NJ Humana Press 203 238 Gaginella TS Guglietta A

Cited by

Authors
Bagdas, D., Muldoon, P. P., AlSharari, S., Carroll, F. I., Negus, S. S., & Damaj, M. I.
Affiliations
  • Virginia Commonwealth University (US)
  • RTI International (US)
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2016-03
Volume
102
Pages
236-243
ISSN
0028-3908 (ISSN-L)
OpenAlex
W2173038123
Cited by
39
References
46
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 1
FWCI
1.23
Type
journal article
Language
en
Open access
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Bursa Uludag University - AVESIS (submittedVersion)
Funders
NIH (R01DA-019377, R01NS070715, R01DA030404)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
visceral pain, conditioned place aversion, acetic acid-induced pain, morphine, ketoprofen, U50,488H, JDTic, mu-opioid receptor, kappa opioid receptor, nonsteroidal anti-inflammatory drugs
MeSH terms
Analgesics, Opioid, Animals, Anti-Inflammatory Agents, Non-Steroidal, Avoidance Learning, Behavior, Animal, Ketoprofen, Male, Mice, Inbred ICR, Morphine, Piperidines, Receptors, Opioid, mu, Receptors, Opioid, kappa, 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Tetrahydroisoquinolines, Mice, Visceral Pain

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