Apoptotic cell: linkage of inflammation and wound healing
Open accessAbstract
We consider that from the wound to the healing process, the physiology point key to linkage of the process is still unclear. The process from inflammation to the wound healing is divided into three phases: (1) inflammation process, (2) tissue formation, and (3) tissue remodeling. The inflammation program includes cell produced related factors and immune cells infiltration. We thought the inflammation factors that may be also involved in the followed healing process. But the question is "what kind of factor is the major key involved in the end of the inflammation then to initiate the healing." We suspect that the apoptosis of immune cell may be the major key to end of inflammation and to initiate the healing.
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Neutrophils intensify the inflammatory reaction by releasing proinflammatory cytokines IL-1 and TNF-α.
“The cells in question intensify the inflammatory reaction by releasing proinflammatory cytokines—IL-1 and TNF-α [37].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [37]
After two- or three-day presence in the wound area, neutrophils are depleted by apoptosis and replaced by monocytes.
“After two- or three-day presence in the wound area, the neutrophils are depleted in the process of apoptosis and are replaced by monocytes [36, 37].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [37]
TGF-β is the only growth factor that accelerates maturation of epithelial cell layers.
“TGF-β is the only growth factor which accelerates “maturation” of epithelial cell layers [37].”
From The role of the extracellular matrix components in cutaneous wound healing (2014) · cites this paper as [37]
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- Authors
- Wu, Y.-S., & Chen, S.-N.
- Affiliations
- National Taiwan University (TW)
- Corresponding author
- Chen, Shiu-Nan
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 5
- Pages
- 1-1
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC3896898
- OpenAlex
- W2103828946
- Cited by
- 500
- References
- 70
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 10 · 2023: 14 · 2022: 7 · 2021: 68 · 2020: 51 · 2019: 58 · 2018: 58 · 2017: 69 · 2016: 77 · 2015: 60 · 2014: 17
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- apoptosis, immune cell apoptosis, inflammation, wound healing, tissue remodeling, tissue formation, immune cell infiltration, inflammation resolution
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