Sex differences in responses of the basolateral-central amygdala circuit to alcohol, corticosterone and their interaction
Open accessAbstract
Alcohol use disorders are chronically relapsing conditions that pose significant health challenges for our society. Stress is a prevalent trigger of relapse, particularly for women, yet the mechanisms by which alcohol and stress interact, and how this differs between males and females, remain poorly understood. The glutamatergic circuit connecting the basolateral (BLA) and central (CeA) nuclei of the amygdala is a likely locus for such adaptations, yet the impact of alcohol, corticosterone and their interaction on this circuit has been understudied. In particular, no studies have addressed sex differences in these effects or potential differential responses between the lateral and medial subdivisions of the central nucleus. Thus, we assessed the effects of alcohol and corticosterone treatments on BLA-evoked compound glutamatergic responses in medial and lateral CeA neurons from male and female rats. We observed minimal differences between medial and lateral CeA responses to alcohol and corticosterone in male rats, which were primarily sensitive to alcohol-induced inhibition of glutamatergic postsynaptic potentials. Unlike male neurons, cells from female rats displayed reduced sensitivity to alcohol's inhibitory effects. In addition, female neurons diverged in their sensitivity to corticosterone, with lateral CeA neuronal responses significantly blunted following corticosterone treatment and medial CeA neurons largely unchanged by corticosterone or subsequent co-application of alcohol. Together these data highlight striking differences in how male and female amygdala respond to alcohol and the stress hormone corticosterone, factors which may impact differential susceptibility of the sexes to alcohol- and stress-related disorders.
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Application of the GR-agonist corticosterone alone does not alter evoked CeA glutamate transmission, but when applied in combination with ethanol it markedly reduces evoked glutamate transmission.
“a previous study found that application of the GR-agonist corticosterone alone does not alter evoked CeA glutamate transmission but when applied in combination with ethanol markedly reduced evoked glutamate transmission (Logrip et al., 2017)”
From Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats (2022) · cites this paper as Logrip et al., 2017
Prior ethanol exposure may prime GR at CeA synapses to enhance glucocorticoid regulation of evoked neurotransmitter release.
“suggesting that prior ethanol exposure may prime GR at CeA synapses to enhance glucocorticoid regulation of evoked neurotransmitter release.”
From Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats (2022) · cites this paper as Logrip et al., 2017
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Effects of DRD2 splicing-regulatory polymorphism and DRD4 48 bp VNTR on crack cocaine addiction
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Sex- and age-specific effects on the development of addiction and compulsive-like drinking in rats
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“On the other hand, it is suggested that there are sexdependent effects of ethanol on neuronal activity [43, 44], adaptations in diverse brain regions [45], underlying neuroimmune transcriptional signatures and related signaling pathways [46], as well as genetic effects [47] which contribute to differences in alcohol-r…”
BackgroundMaternal Separation Stress Affects Voluntary Ethanol Intake in a Sex Dependent Manner
Bertagna, N. B., Favoretto, C. A., Rodolpho, B. T., Palombo, P., Yokoyama, T. S., Righi, T., Loss, C. M., Leão, R. M., Miguel, T. T., & Cruz, F. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.775404 · Cited by 17 · see citing works
Rangel‐Barajas, C., Boehm, S. L., & Logrip, M. L. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108564 · Cited by 14 · see citing works
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Self-citationSex differences in the microglial response to stress and chronic alcohol exposure in mice
Soares, A. R., Garcia‐Rivas, V., Fai, C., Thomas, M. A., Zheng, X., Picciotto, M. R., & Mineur, Y. S. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00701-y · Cited by 15 · see citing works
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“13], but the triple interaction between Categories × Conditions × Treatments was found significant [F(2,72) = 4.”
BackgroundResultInfluentialNoradrenaline Modulates Central Amygdala GABA Transmission and Alcohol Drinking in Female Rats
Anjos-Santos, A., Erikson, C. M., Flores‐Ramirez, F. J., Rodriguez, L., Barchiesi, R., Vozella, V., Borgonetti, V., Cruz, B., Zalfa, C., Hughes, K. J., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.03.024 · Cited by 11 · see citing works
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“We found an overall increase in freezing behavior induced by CORT in females, which aligns with previous research indicating that females tend to be more responsive to CORT (Logrip et al., 2017).”
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Self-citationSubregional Differences in Alcohol Modulation of Central Amygdala Neurocircuitry
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GABAergic Neurons in the Central Amygdala Promote Emergence from Isoflurane Anesthesia in Mice
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“53,54 Whether sex differences play a role in the effect of the GABAergic central amygdala or central amygdala–basal forebrain pathway on anesthetic emergence needs to be further explored.”
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Sex differences in neural response to an acute stressor in individuals with an alcohol use disorder
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“Alcohol may be used to self-medicate anxiety disorders, which can lead to alcohol abuse (Gilpin et al., 2015; Logrip et al., 2017; Nentwig et al., 2019).”
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“Rodent studies have shown that there are sex differences in CeA neuronal fi ring in response to stress and alcohol as male neurons show a greater inhibition by acute ethanol, while female neurons are more responsive to the stress hormone corticosterone [51].”
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Role of microglia in stress-induced alcohol intake in female and male micePreprint
Soares, A. R., Garcia‐Rivas, V., Fai, C., Thomas, M. A., Zheng, X., Picciotto, M. R., & Mineur, Y. S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.05.597614 · Cited by 2 · see citing works
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Sex, Stress, and Neuropeptides Interact to Influence Alcohol Consumption
Nentwig, T. B., & Grisel, J. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813125-1.00033-7 · Cited by 1 · see citing works
ENDURANCE AND INTOXICATION INDICATORS OF RAT BRAIN WITH CHRONIC ALCOHOLIZATION
Макаренко, О. А., Karabadzhak, L. I., & Kika, V. V. (2022) · Odesa National University Herald Biology · doi:10.18524/2077-1746.2022.1(50).259843
Sex-dependent effects of chronic intermittent ethanol treatment in Wistar rats
Dorofeikova, M., Antonova, I., Gromova, �. G., Veraksa, A. E., Филатова, Е. В., & Egorov, A. Y. (2023) · Biological Communications · doi:10.21638/spbu03.2023.304
“…there are sex differences in the response of amygdala subnuclei to corticosterone which may promote sex differences in stress-induced alcohol intake (Logrip, Oleata, and Roberto, 2017) Many researchers have focused on the basics of cognitive flexibility, but few have used in vivo methods to assess…”
MethodChaloux-Pinette, E., Mirelez-Prince, M. V., Soto, S., Ananth, K., Tong, X. J., Silva, V., Rodriguez, D., & Janak, P. H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.10.622812
The Impacts of Binge Drinking and Hangover on the Social Brain: An Integrative Narrative Review
Bagosi, Z., Karasz, G., Thury, A. Á., Simon, B., Földesi, I., & Csabafi, K. (2025) · Biomedicines · doi:10.3390/biomedicines13112802
“…brains of men are more vulnerable to the impact of binge drinking compared to women, and that adolescents are more sensitive to both the positive, rewarding properties and the negative, adverse effects of alcohol, and therefore, more susceptible to developing alcohol addiction, than adults [55–66].”
Moss, E. M., Batsaikhan, E., Amsden, S., & Kirson, D. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70290
Sizer, S. E., Brown, A. R., Anderson, J. K., Summerlin, A. E., Girgis, I., Yang, S. Y., Bedard, M. L., Olson, S. H., Slosky, L. M., Leinninger, G. M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.722083
Sizer, S. E., Brown, A. R., Anderson, J. K., Summerlin, A. E., Girgis, I., Yang, S. Y., Bedard, M. L., Olson, S. H., Slosky, L. M., Leinninger, G. M., et al. (2026) · Addiction Neuroscience · doi:10.1016/j.addicn.2026.100285
- Authors
- Logrip, M. L., Oleata, C., & Roberto, M.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Logrip, Marian L.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 114
- Pages
- 123-134
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC5372203
- OpenAlex
- W2557488033
- Cited by
- 56
- References
- 40
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 2 · 2019: 6 · 2018: 8 · 2017: 2
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Funders
- National Institutes of Health (K99/R00 AA021802)
- National Institute on Alcohol Abuse and Alcoholism (P60 AA006420, AA015566, U01 AA013498, AA017447)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- sex differences, alcohol, corticosterone, stress, alcoholism, relapse, basolateral amygdala, central amygdala, glutamatergic synapses, postsynaptic inhibition
- MeSH terms
- Ethanol, Animals, Corticosterone, Female, Male, Neurons, Sex Characteristics, Rats, Wistar, Excitatory Postsynaptic Potentials, Rats, Basolateral Nuclear Complex, Central Amygdaloid Nucleus
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