Sex Differences in Risk and Resilience: Stress Effects on the Neural Substrates of Emotion and Motivation

Wellman, Cara L.; Bangasser, Debra A.; Bollinger, Justin L.; Coutellier, Laurence; Logrip, Marian L.; Moench, Kelly M.; Urban, Kimberly R.

doi:10.1523/jneurosci.1673-18.2018

Cited by 88Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Sex Differences in Risk and Resilience: Stress Effects on the Neural Substrates of Emotion and Motivation

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Wellman, Cara L., Bangasser, Debra A., Bollinger, Justin L., Coutellier, Laurence, Logrip, Marian L., Moench, Kelly M., Urban, Kimberly R.·2018·The Journal of Neuroscience

DOI 10.1523/jneurosci.1673-18.2018PMC PMC6209838

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Abstract

Risk for stress-sensitive psychopathologies differs in men and women, yet little is known about sex-dependent effects of stress on cellular structure and function in corticolimbic regions implicated in these disorders. Determining how stress influences these regions in males and females will deepen our understanding of the mechanisms underlying sex-biased psychopathology. Here, we discuss sex differences in CRF regulation of arousal and cognition, glucocorticoid modulation of amygdalar physiology and alcohol consumption, the age-dependent impact of social stress on prefrontal pyramidal cell excitability, stress effects on the prefrontal parvalbumin system in relation to emotional behaviors, contributions of stress and gonadal hormones to stress effects on prefrontal glia, and alterations in corticolimbic structure and function after cessation of chronic stress. These studies demonstrate that, while sex differences in stress effects may be nuanced, nonuniform, and nonlinear, investigations of these differences are nonetheless critical for developing effective, sex-specific treatments for psychological disorders.

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Sex differences in stress responses are thought to contribute to sex differences in anxiety risk.
“Sex differences in stress responses are thought to contribute to sex differences in the anxiety risk (3–5), as anxiety rates are higher in women vs. men (6–11).”
From Sexual differentiation of neural mechanisms of stress sensitivity during puberty (2023) · cites this paper as [4]
The section “Sensitivity of the parvalbumin (PV) system to stress” reports that stress increased anxiety-like behavior in female but not male mice. The Introduction links sex-dependent stress effects to sex-biased psychopathology, but the copy does not specifically establish that these differences contribute to human anxiety risk. (LLM, conf=0.82)
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Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244 · see citing works
Twelve‐month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States
Kessler, R. C., Petukhova, M., Sampson, N. A., Zaslavsky, A. M., & Wittchen, H. (2012) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1359 · Cited by 2,947 · cited 2× · see citing works
“Women are at increased risk for disorders such as depression and post-traumatic stress disorder (PTSD) (Breslau, 2009; Kessler et al., 2012), and often display more severe symptoms (de Graaf et al., 2002; Schoevers et al., 2003).”
Background
From circuits to behaviour in the amygdala
Janak, P. H., & Tye, K. M. (2015) · Nature · doi:10.1038/nature14188 · Cited by 2,011 · cited 1× · see citing works
“The CeA synthesizes inputs from amygdala subdivisions to regulate stress- and rewardrelated behavioral responses (Janak and Tye, 2015); thus, changes in the CeA and associated circuitry have a unique capacity to alter behavior.”
Background
Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging
Lenroot, R. K., & Giedd, J. N. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.06.001 · Cited by 1,863 · see citing works
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works
Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat
Birrell, J. M., & Brown, V. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04320.2000 · Cited by 1,421 · see citing works
The cognitive neuroscience of sustained attention: where top-down meets bottom-up.
Sarter, M., Givens, B., & Bruno, J. P. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00044-3 · Cited by 1,194 · see citing works
The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive
Goldman-Rakic, P. S. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0129 · Cited by 1,072 · see citing works
Neurobiology of Executive Functions: Catecholamine Influences on Prefrontal Cortical Functions
Arnsten, A. F. T., & Li, B.-M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.019 · Cited by 948 · see citing works
Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes
Setiawan, E., Wilson, A. A., Mizrahi, R., Rusjan, P. M., Miler, L., Rajkowska, G., Suridjan, I., Kennedy, J. L., Rekkas, P. V., Houle, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2427 · Cited by 939 · see citing works
The Epidemiology of Trauma, PTSD, and Other Posttrauma Disorders
Breslau, N. (2009) · Trauma, Violence, & Abuse · doi:10.1177/1524838009334448 · Cited by 810 · see citing works
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Weinhard, L., di Bartolomei, G., Bolasco, G., Machado, P., Schieber, N. L., Neniskyte, U., Exiga, M., Vadisiute, A., Raggioli, A., Schertel, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03566-5 · Cited by 790 · see citing works
Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement
Sousa, N., Lukoyanov, N. V., Madeira, M. D., Almeida, O. F. X., & Paula-Barbosa, M. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00050-6 · Cited by 758 · see citing works
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.5.624 · Cited by 721 · see citing works
Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro
Smith, S. H., & Stillman, B. (1989) · Cell · doi:10.1016/0092-8674(89)90398-x · Cited by 699 · see citing works
Sex differences in microglial colonization of the developing rat brain
Schwarz, J. M., Sholar, P. W., & Bilbo, S. D. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07630.x · Cited by 672 · see citing works
Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy
Conrad, C. D., Magariños, A. M., LeDoux, J. E., & McEwen, B. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.902 · Cited by 664 · see citing works
Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy.
Conrad, C. D., Magariños, A. M., LeDoux, J. E., & McEwen, B. S. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.5.902 · Cited by 663 · see citing works
Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663 · see citing works
Interneuron Diversity series: Rhythm and mood in perisomatic inhibition
Freund, T. F. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00227-3 · Cited by 641 · see citing works
Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors
Banasr, M., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.008 · Cited by 606 · see citing works
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works
Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
Torres-Platas, S. G., Cruceanu, C., Chen, G. G., Turecki, G., & Mechawar, N. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.05.007 · Cited by 545 · see citing works
Sublime Microglia: Expanding Roles for the Guardians of the CNS
Salter, M. W., & Beggs, S. (2014) · Cell · doi:10.1016/j.cell.2014.06.008 · Cited by 531 · see citing works
Sex and Age Differences in Attention-Deficit/Hyperactivity Disorder Symptoms and Diagnoses: Implications for DSM-V and ICD-11
Ramtekkar, U. P., Reiersen, A. M., Todorov, A. A., & Todd, R. D. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2009.11.011 · Cited by 480 · see citing works
Stress-induced prefrontal reorganization and executive dysfunction in rodents
Holmes, A., & Wellman, C. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.11.005 · Cited by 469 · see citing works
Self-citation
The dark side of emotion: the addiction perspective
Koob, G. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.044 · Cited by 433 · see citing works
Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex
Hinwood, M., Morandini, J., Day, T. A., & Walker, F. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr229 · Cited by 420 · see citing works
Stress and Fear Extinction
Maren, S., & Holmes, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.180 · Cited by 412 · see citing works
Risk factors for 12-month comorbidity of mood, anxiety, and substance use disorders: findings from the Netherlands Mental Health Survey and Incidence Study.
de Graaf, R., Bijl, R., Smit, F., Vollebergh, W., & Spijker, J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.620 · Cited by 406 · see citing works
Steroid hormone receptor expression and function in microglia
Sierra, A., Gottfried‐Blackmore, A., Milner, T. A., McEwen, B. S., & Bulloch, K. (2008) · Glia · doi:10.1002/glia.20644 · Cited by 405 · see citing works
Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology
Bangasser, D. A., Curtis, A., Reyes, B. A. S., Bethea, T. T., Parastatidis, I., Ischiropoulos, H., Van Bockstaele, E. J., & Valentino, R. J. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.66 · Cited by 401 · see citing works
Self-citation
Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress
Hodes, G. E., Pfau, M. L., Purushothaman, I., Ahn, H. F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1392-15.2015 · Cited by 395 · see citing works
Development of the prefrontal cortex during adolescence: Insights into vulnerable neural circuits in schizophrenia
Lewis, D. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00277-1 · Cited by 388 · see citing works
Converging patterns of alcohol use and related outcomes among females and males in the United States, 2002 to 2012
White, A., Castle, I. P., Chen, C. M., Shirley, M., Roach, D., & Hingson, R. (2015) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12815 · Cited by 378 · see citing works
Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons
Roberto, M., Madamba, S. G., Moore, S. D., Tallent, M. K., & Siggins, G. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437926100 · Cited by 360 · see citing works
Elevated translocator protein in anterior cingulate in major depression and a role for inflammation in suicidal thinking: A positron emission tomography study
Holmes, S. E., Hinz, R., Conen, S., Gregory, C. J., Matthews, J. C., Anton-Rodriguez, J. M., Gerhard, A., & Talbot, P. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.005 · Cited by 346 · see citing works
Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder
Miguel-Hidalgo, J. J., Baucom, C. C., Dilley, G. E., Overholser, J. C., Meltzer, H. Y., Stockmeier, C. A., & Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00999-9 · Cited by 337 · see citing works
Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives
Fee, C., Banasr, M., & Sibille, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.024 · Cited by 329 · see citing works
Chronic Stress Induced Remodeling of the Prefrontal Cortex: Structural Re-Organization of Microglia and the Inhibitory Effect of Minocycline
Hinwood, M., Tynan, R. J., Charnley, J. L., Beynon, S. B., Day, T. A., & Walker, F. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs151 · Cited by 325 · see citing works
Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress
RADLEY, J., ROCHER, A., JANSSEN, W., HOF, P., MCEWEN, B., & MORRISON, J. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.008 · Cited by 323 · see citing works
Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats
Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0069-12.2012 · Cited by 319 · see citing works
Self-citation
Acute and Chronic Ethanol Alter Glutamatergic Transmission in Rat Central Amygdala: an<i>In Vitro</i>and<i>In Vivo</i>Analysis
Roberto, M., Schweitzer, P., Madamba, S. G., Stouffer, D. G., Parsons, L. H., & Siggins, G. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5077-03.2004 · Cited by 312 · see citing works
Increased GABA Release in the Central Amygdala of Ethanol-Dependent Rats
Roberto, M., Madamba, S. G., Stouffer, D. G., Parsons, L. H., & Siggins, G. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3004-04.2004 · Cited by 299 · see citing works
Chronic stress effects on memory: sex differences in performance and monoaminergic activity
Bowman, R. E., Beck, K. D., & Luine, V. N. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00022-3 · Cited by 290 · see citing works
Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior
Wohleb, E. S., Terwilliger, R., Duman, C. H., & Duman, R. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.026 · Cited by 288 · see citing works
Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of ΔFosB
Vialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1787-13.2014 · Cited by 283 · cited 2× · see citing works
“Evidence suggest that resilience or vulnerability to stressinduced emotional dysregulation may be modulated by prefrontal neuronal activity (Vialou et al., 2014; Labonté et al., 2017).”
Background
Opposite Molecular Signatures of Depression in Men and Women
Seney, M. L., Huo, Z., Cahill, K., French, L., Puralewski, R., Zhang, J., Logan, R. W., Tseng, G., Lewis, D. A., & Sibille, E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.017 · Cited by 272 · see citing works
Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions
Fuchikami, M., Thomas, A., Liu, R., Wohleb, E. S., Land, B. B., DiLeone, R. J., Aghajanian, G. K., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414728112 · Cited by 265 · see citing works
Comorbidity and risk‐patterns of depression, generalised anxiety disorder and mixed anxiety‐depression in later life: results from the AMSTEL study
Schoevers, R. A., Beekman, A. T. F., Deeg, D. J. H., Jonker, C., & van Tilburg, W. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1001 · Cited by 265 · see citing works
Sex/gender differences in the brain and cognition in schizophrenia
Mendrek, A., & Mancini-Marı̈e, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.013 · Cited by 265 · see citing works
The clinical neurobiology of drug craving
Sinha, R. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.05.001 · Cited by 262 · see citing works
CXCR3-Dependent Microglial Recruitment Is Essential for Dendrite Loss after Brain Lesion
Rappert, A., Bechmann, I., Pivneva, T., Mahlo, J., Biber, K., Nolte, C., Kovac, A. D., Gerard, C., Boddeke, H. W. G. M., Nitsch, R., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2451-04.2004 · Cited by 259 · see citing works
Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders
Blaine, S. K., & Sinha, R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.037 · Cited by 257 · cited 4× · see citing works
“Importantly, women with AUD experience greater craving to drink following exposure to stressful images (Hartwell and Ray, 2013) and stronger relationships between past trauma severity and craving (Heffner et al., 2011), relative to men.”
BackgroundInfluential
Stress Impairs GABAergic Network Function in the Hippocampus by Activating Nongenomic Glucocorticoid Receptors and Affecting the Integrity of the Parvalbumin-Expressing Neuronal Network
Hu, W., Zhang, M., Czéh, B., Flügge, G., & Zhang, W. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.31 · Cited by 246 · see citing works
Dendritic remodeling in the adolescent medial prefrontal cortex and the basolateral amygdala of male and female rats
Koss, W. A., Belden, C. E., Hristov, A. D., & Juraska, J. M. (2014) · Synapse · doi:10.1002/syn.21716 · Cited by 228 · see citing works
Chronic stress increases prefrontal inhibition: a mechanism for stress-induced prefrontal dysfunction
McKlveen, J. M., Morano, R. L., Fitzgerald, M., Zoubovsky, S., Cassella, S. N., Scheimann, J. R., Ghosal, S., Mahbod, P., Packard, B. A., Myers, B., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.03.2101 · Cited by 224 · see citing works
Sexually Dimorphic Responses of the Brain Norepinephrine System to Stress and Corticotropin-Releasing Factor
Curtis, A. L., Bethea, T., & Valentino, R. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300875 · Cited by 222 · see citing works
Localization of estrogen receptor ?-immunoreactivity in astrocytes of the adult rat brain
Azcoitia, Í., Sierra, A., & García‐Segura, L. M. (1999) · Glia · doi:10.1002/(sici)1098-1136(199905)26:3 · Cited by 222 · see citing works
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79828 · Cited by 218 · see citing works
Self-citation
Differential effects of stress on microglial cell activation in male and female medial prefrontal cortex
Bollinger, J. L., Burns, C. M. B., & Wellman, C. L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.003 · Cited by 216 · see citing works
Self-citation
Chronic stress effects on dendritic morphology in medial prefrontal cortex: sex differences and estrogen dependence
Garrett, J., & Wellman, C. L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.057 · Cited by 215 · see citing works
Self-citation
Sex differences in spatial and non-spatial Y-maze performance after chronic stress
Conrad, C. D., Grote, K. A., Hobbs, R. J., & Ferayorni, A. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(02)00018-7 · Cited by 215 · see citing works
Acute stress impairs spatial memory in male but not female rats: influence of estrous cycle
Conrad, C. D., Jackson, J. L., Wieczorek, L., Baran, S. E., Harman, J. S., Wright, R. L., & Korol, D. L. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.04.025 · Cited by 211 · see citing works
A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex
Wang, H., Stradtman, G. G., Wang, X.-J., & Gao, W.-J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804318105 · Cited by 199 · see citing works
Chronic stress-induced disruption of the astrocyte network is driven by structural atrophy and not loss of astrocytes
Tynan, R. J., Beynon, S. B., Hinwood, M., Johnson, S. J., Nilsson, M., Woods, J. J., & Walker, F. R. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1102-0 · Cited by 199 · see citing works
Sex‐specific mechanisms for responding to stress
Bangasser, D. A., & Wicks, B. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23812 · Cited by 198 · see citing works
Self-citation
Estrogen Promotes Stress Sensitivity in a Prefrontal Cortex-Amygdala Pathway
Shansky, R. M., Hamo, C., Hof, P. R., Lou, W., McEwen, B. S., & Morrison, J. H. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq003 · Cited by 191 · see citing works
Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment
Singhal, G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00097 · Cited by 186 · see citing works
Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death
Rossi, D. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.04.003 · Cited by 178 · see citing works
Prefrontal cortex executive processes affected by stress in health and disease
Girotti, M., Adler, S. M., Bulin, S. E., Fucich, E. A., Paredes, D., & Morilak, D. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.004 · Cited by 176 · see citing works
Corticotropin-Releasing Hormone Directly Activates Noradrenergic Neurons of the Locus Ceruleus RecordedIn Vitro
Jedema, H. P., & Grace, A. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2830-04.2004 · Cited by 176 · see citing works
Hypoactivity of the Hypothalamo-Pituitary-Adrenocortical Axis during Recovery from Chronic Variable Stress
Ostrander, M. M., Ulrich‐Lai, Y. M., Choi, D. C., Richtand, N. M., & Herman, J. P. (2006) · Endocrinology · doi:10.1210/en.2005-1041 · Cited by 168 · see citing works
Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition
Wei, J., Yuen, E., Liu, W., Li, X., Zhong, P., Karatsoreos, I., Mcewen, B. S., & Yan, Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.83 · Cited by 162 · see citing works
Chronic Stress- and Sex-Specific Neuromorphological and Functional Changes in Limbic Structures
McLaughlin, K. J., Baran, S. E., & Conrad, C. D. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8079-7 · Cited by 152 · see citing works
Rat cerebral cortex corticotropin‐releasing hormone receptors: evidence for receptor coupling to multiple G‐proteins
Grammatopoulos, D. K., Randeva, H. S., Levine, M. A., Kanellopoulou, K. A., & Hillhouse, E. W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00067.x · Cited by 143 · see citing works
Sex differences in stress regulation of arousal and cognition
Bangasser, D. A., Eck, S. R., Telenson, A. M., & Salvatore, M. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.025 · Cited by 133 · see citing works
Self-citation
High self-perceived stress and many stressors, but normal diurnal cortisol rhythm, in adults with ADHD (attention-deficit/hyperactivity disorder)
Hirvikoski, T., Lindholm, T., Nordenström, A., Nordström, A.-L., & Lajic, S. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.12.004 · Cited by 123 · see citing works
Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders
Shepard, R., Page, C. E., & Coutellier, L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.038 · Cited by 118 · see citing works
Self-citation
Neuroinflammatory priming to stress is differentially regulated in male and female rats
Fonken, L. K., Frank, M. G., Gaudet, A. D., D’Angelo, H. M., Daut, R. A., Hampson, E. C., Ayala, M. T., Watkins, L. R., & Maier, S. F. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.005 · Cited by 115 · see citing works
Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression
Bangasser, D. A., Reyes, B. A. S., Piel, D., Garachh, V., Zhang, X.-Y., Plona, Z., Bockstaele, E. J. V., Beck, S. G., & Valentino, R. J. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.24 · Cited by 106 · see citing works
Self-citation
Stress-induced plasticity of GABAergic inhibition
Maguire, J. L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00157 · Cited by 103 · see citing works
Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor
Bryce, C. A., & Floresco, S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.15 · Cited by 102 · see citing works
Behavioral stress alters corticolimbic microglia in a sex- and brain region-specific manner
Bollinger, J. L., Collins, K. E., Patel, R., & Wellman, C. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187631 · Cited by 100 · see citing works
Self-citation
Changes in the Prefrontal Glutamatergic and Parvalbumin Systems of Mice Exposed to Unpredictable Chronic Stress
Shepard, R., & Coutellier, L. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0528-0 · Cited by 97 · see citing works
Self-citation
Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking
Simms, J. A., Haass-Koffler, C. L., Bito-Onon, J., Li, R., & Bartlett, S. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.268 · Cited by 97 · see citing works
Sex differences in reinstatement of alcohol seeking in response to cues and yohimbine in rats with and without a history of adolescent corticosterone exposure
Bertholomey, M. L., Nagarajan, V., & Torregrossa, M. M. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4278-x · Cited by 94 · see citing works
Restraint Stress Alters Nociceptin/Orphanin FQ and CRF Systems in the Rat Central Amygdala: Significance for Anxiety-Like Behaviors
Ciccocioppo, R., de Guglielmo, G., Hansson, A. C., Ubaldi, M., Kallupi, M., Cruz, M. T., Oleata, C. S., Heilig, M. A., & Roberto, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2400-13.2014 · Cited by 92 · see citing works
Corticotropin-releasing hormone receptors in the medial prefrontal cortex regulate hypothalamic–pituitary–adrenal activity and anxiety-related behavior regardless of prior stress experience
Jaferi, A., & Bhatnagar, S. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.100 · Cited by 84 · see citing works
Gender Differences in Trauma History and Symptoms as Predictors of Relapse to Alcohol and Drug Use
Heffner, J. L., Blom, T. J., & Anthenelli, R. M. (2011) · American Journal on Addictions · doi:10.1111/j.1521-0391.2011.00141.x · Cited by 79 · see citing works
The effects of restraint stress on voluntary ethanol consumption in rats.
Lynch, W. J., Kushner, M. G., Rawleigh, J. M., Fiszdon, J. M., & Carroll, M. E. (1999) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.7.4.318 · Cited by 76 · see citing works
Environmental stressors influence limited-access ethanol consumption by C57BL/6J mice in a sex-dependent manner
Cozzoli, D. K., Tanchuck-Nipper, M. A., Kaufman, M. N., Horowitz, C. B., & Finn, D. A. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.07.015 · Cited by 75 · see citing works
Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-Induced Neuropsychiatric Disorders
Negrón-Oyarzo, I., Aboitiz, F., & Fuentealba, P. (2016) · Neural Plasticity · doi:10.1155/2016/7539065 · Cited by 75 · see citing works
The Effect of Stress on the Consumption of Alcohol and Reserpine
Casey, A. (1960) · Quarterly Journal of Studies on Alcohol · doi:10.15288/qjsa.1960.21.208 · Cited by 75 · see citing works
The prefrontal–limbic network in depression: A core pathology of synapse regression
Bennett, M. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.001 · Cited by 74 · see citing works
Cellular Adaptations of Dorsal Raphe Serotonin Neurons Associated with the Development of Active Coping in Response to Social Stress
Wood, S. K., Zhang, X., Reyes, B. A. S., Lee, C. S., Bockstaele, E. J. V., & Valentino, R. J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.026 · Cited by 72 · see citing works
Life events and the 1-year prevalence of major depressive episode, generalized anxiety disorder, and panic disorder in a community sample
Newman, S. C., & Bland, R. C. (1994) · Comprehensive Psychiatry · doi:10.1016/0010-440x(94)90173-2 · Cited by 71 · see citing works
The impact from the aftermath of chronic stress on hippocampal structure and function: Is there a recovery?
Ortiz, J. B., & Conrad, C. D. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.02.005 · Cited by 70 · see citing works
Sex differences and chronic stress effects on the neural circuitry underlying fear conditioning and extinction
Farrell, M. R., Sengelaub, D. R., & Wellman, C. L. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.04.002 · Cited by 69 · see citing works
Self-citation
The effects of restraint stress on voluntary ethanol consumption in rats.
Lynch, W. J., Kushner, M. G., Rawleigh, J. M., et al. (1999) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.7.4.318 · Cited by 65 · see citing works
Differential dendritic remodeling in prelimbic cortex of male and female rats during recovery from chronic stress
Moench, K. M., & Wellman, C. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.049 · Cited by 63 · see citing works
Self-citation
DIFFERENT EFFECTS OF STRESS ON ALCOHOL DRINKING BEHAVIOUR IN MALE AND FEMALE MICE SELECTIVELY BRED FOR HIGH ALCOHOL PREFERENCE
Chester, J. A., Barrenha, G. D., DeMARIA, A., & FINEGAN, A. (2005) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh242 · Cited by 57 · see citing works
Sex differences in responses of the basolateral-central amygdala circuit to alcohol, corticosterone and their interaction
Logrip, M. L., Oleata, C., & Roberto, M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.11.021 · Cited by 56 · cited 3× · see citing works
“Conversely, corticosterone treatment reduced BLA-EPSP amplitudes in CeL, but not CeM, in females, occluding the effects of alcohol coapplication in both subdivisions (Logrip et al., 2017).”
BackgroundSelf-citation
Restraint stress enhances alcohol intake in adolescent female rats but reduces alcohol intake in adolescent male and adult female rats
Wille‐Bille, A., Ferreyra, A., Sciangula, M., Chiner, F., Nizhnikov, M. E., & Pautassi, R. M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.004 · Cited by 55 · see citing works
Astrocytes in the rat medial amygdala are responsive to adult androgens
Johnson, R. T., Schneider, A., DonCarlos, L. L., Breedlove, S. M., & Jordan, C. L. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23061 · Cited by 54 · see citing works
Phosphodiesterase 10A Regulates Alcohol and Saccharin Self-Administration in Rats
Logrip, M. L., Vendruscolo, L. F., Schlosburg, J. E., Koob, G. F., & Zorrilla, E. P. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.20 · Cited by 53 · see citing works
Self-citation
Cognitive impact of social stress and coping strategy throughout development
Snyder, K. P., Barry, M. E., & Valentino, R. J. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3654-7 · Cited by 51 · see citing works
Shifting priorities: highly conserved behavioral and brain network adaptations to chronic stress across species
Nikolova, Y. S., Misquitta, K. A., Rocco, B. R., Prévot, T. D., Knodt, A. R., Ellegood, J., Voineskos, A. N., Lerch, J. P., Hariri, A. R., Sibille, E. L., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0083-5 · Cited by 51 · see citing works
Stress history increases alcohol intake in relapse: relation to phosphodiesterase 10A
Logrip, M. L., & Zorrilla, E. P. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00460.x · Cited by 48 · see citing works
Self-citation
Working Memory Impairing Actions of Corticotropin-Releasing Factor (CRF) Neurotransmission in the Prefrontal Cortex
Hupalo, S., & Berridge, C. W. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.85 · Cited by 48 · see citing works
Adolescent social defeat decreases spatial working memory performance in adulthood
Novick, A. M., Miiller, L. C., Forster, G. L., & Watt, M. J. (2013) · Behavioral and Brain Functions · doi:10.1186/1744-9081-9-39 · Cited by 47 · see citing works
Chronic stress produces enduring decreases in novel stress-evoked c-fosmRNA expression in discrete brain regions of the rat
Ostrander, M. M., Ulrich‐Lai, Y. M., Choi, D. C., Flak, J. N., Richtand, N. M., & Herman, J. P. (2009) · Stress · doi:10.3109/10253890802641966 · Cited by 45 · see citing works
Stress-induced alterations in prefrontal dendritic spines: Implications for post-traumatic stress disorder
Moench, K. M., & Wellman, C. L. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.12.035 · Cited by 41 · see citing works
Self-citation
Gonadal hormones affect alcohol drinking, but not cue + yohimbine-induced alcohol seeking, in male and female rats
Bertholomey, M. L., & Torregrossa, M. M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.10.025 · Cited by 40 · see citing works
Ketamine prevents stress-induced cognitive inflexibility in rats
Nikiforuk, A., & Popik, P. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.009 · Cited by 39 · see citing works
Sex moderates stress reactivity in heavy drinkers
Hartwell, E. E., & Ray, L. A. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.06.016 · Cited by 36 · see citing works
Age- and Sex-Dependent Impact of Repeated Social Stress on Intrinsic and Synaptic Excitability of the Rat Prefrontal Cortex
Urban, K. R., & Valentino, R. J. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw388 · Cited by 36 · see citing works
Self-citation
CB 1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats
Kirson, D., Oleata, C. S., Parsons, L. H., Ciccocioppo, R., & Roberto, M. (2017) · Addiction Biology · doi:10.1111/adb.12525 · Cited by 34 · see citing works
Corticotropin releasing factor impairs sustained attention in male and female rats
Cole, R. D., Kawasumi, Y., Parikh, V., & Bangasser, D. A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.08.023 · Cited by 33 · see citing works
Self-citation
Adolescent social defeat alters N-methyl-d-aspartic acid receptor expression and impairs fear learning in adulthood
Novick, A. M., Mears, M., Forster, G. L., Lei, Y., Tejani‐Butt, S. M., & Watt, M. J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.02.013 · Cited by 33 · see citing works
The impact of social stress during adolescence or adulthood and coping strategy on cognitive function of female rats
Snyder, K., Barry, M. E., Plona, Z., Ho, A., Zhang, X., & Valentino, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.047 · Cited by 25 · see citing works
Functional interactions between stress neuromediators and the locus coeruleus–norepinephrine system
Valentino, R. J., & Bockstaele, E. J. V. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80026-4 · Cited by 14 · see citing works
Reduced Somatostatin Expression or Somatostatin-Positive Gamma-Aminobutyric Acid Neurons: A Shared Pathology Across Brain Disorders
Sibille, E. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.002 · Cited by 11 · see citing works
511. Stress-Induced Neuronal CSF1 Provokes Microglia-Mediated Dendritic Remodeling and Depressive-Like Behavior
Wohleb, E. S., Terwilliger, R. Z., Duman, C. H., & Duman, R. S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1119 · Cited by 9 · see citing works
ACNP 55th Annual Meeting: Poster Session II
Valenza, M., Butelman, E. R., & Kreek, M. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.241 · Cited by 9 · see citing works
SOCIAL EXCLUSION AND SENSITIZATION OF THE DOPAMINE SYSTEM: A [123I]IBZM-SPECT STUDY IN YOUNG ADULTS WITH SERIOUS HEARING IMPAIRMENT
Gevonden, M. J., Booij, J., van den Brink, W., van Os, J., & Selten, J. P. (2014) · Schizophrenia Research · doi:10.1016/s0920-9964(14)70098-2 · Cited by 1 · see citing works
154. Behavioral and Brain Network Adaptations to Chronic Stress, A Translational Study
Banasr, M., Nikolova, Y. S., Misquitta, K. A., Rocco, B. R., Prevot, T. D., Knodt, A. R., Hariri, A. R., Voineskos, A. N., Ellegood, J., Lerch, J. P., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.167 · Cited by 1 · see citing works
Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment
Heuser, I., Bissette, G., Dettling, M., Schweiger, U., Gotthardt, U., Schmider, J., Lammers, C.-H., Nemeroff, C. B., & Holsboer, F. (1998) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1998)8:2

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Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 226 · see citing works
Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition
Page, C. E., & Coutellier, L. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.024 · Cited by 213 · see citing works
Self-citation
The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197 · see citing works
Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
Maitra, M., Mitsuhashi, H., Rahimian, R., Chawla, A., Yang, J., Fiori, L. M., Davoli, M. A., Perlman, K., Aouabed, Z., Mash, D. C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38530-5 · Cited by 164 · see citing works
The cortisol switch between vulnerability and resilience
de Kloet, E. R., & Joëls, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01934-8 · Cited by 153 · see citing works
Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress
Tan, T., Wang, W., Liu, T., Zhong, P., Conrow‐Graham, M., Tian, X., & Yan, Z. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108874 · Cited by 103 · see citing works
Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings
Walsh, M. J. M., Wallace, G. L., Gallegos, S. M., & Braden, B. B. (2021) · NeuroImage: Clinical · doi:10.1016/j.nicl.2021.102719 · Cited by 97 · see citing works
The extent to which childhood adversity and recent stress influence all-cause mortality risk in older adults
Johnson, J., Chaudieu, I., Ritchie, K., Scali, J., Ancelin, M.-L., & Ryan, J. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104492 · Cited by 92 · see citing works
Sex Differences in the Development of the Rodent Corticolimbic System
Premachandran, H., Zhao, M., & Arruda-Carvalho, M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.583477 · Cited by 89 · see citing works
Sex, stress and steroids
Sze, Y., & Brunton, P. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14615 · Cited by 85 · see citing works
Child abuse associates with increased recruitment of perineuronal nets in the ventromedial prefrontal cortex: a possible implication of oligodendrocyte progenitor cells
Tanti, A., Belliveau, C., Nagy, C., Maitra, M., Denux, F., Perlman, K., Chen, F. Y., Mpai, R., Canonne, C., Théberge, S., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01372-y · Cited by 65 · see citing works
Sex differences in the neurochemistry of frontal cortex: Impact of early life stress
Perry, C. J., Campbell, E. J., Drummond, K. D., Lum, J. S., & Kim, J. H. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15208 · Cited by 58 · see citing works
How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders
Kaul, D., Schwab, S. G., Mechawar, N., & Matosin, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.025 · Cited by 56 · see citing works
Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides
Tanti, A., Lutz, P.-É., Kim, J., O’Leary, L. A., Théroux, J., Turecki, G., & Mechawar, N. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0471-z · Cited by 56 · see citing works
Neurobiological Links between Stress, Brain Injury, and Disease
Guo, H., Zheng, L., Xu, H., Pang, Q., Ren, Z., Gao, Y. Z., & Wang, T. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8111022 · Cited by 53 · see citing works
Susceptibility and resilience to chronic social defeat stress in adolescent male mice: No correlation between social avoidance and sucrose preference
Alves-dos-Santos, L., Resende, L. D. S., & Chiavegatto, S. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100221 · Cited by 51 · see citing works
Sex Differences in Acute Alcohol Sensitivity of Naïve and Alcohol Dependent Central Amygdala GABA Synapses
Kirson, D., Khom, S., Rodriguez, L., Wolfe, S. A., Varodayan, F. P., Gandhi, P. J., Patel, R. R., Vlkolinský, R., Bajo, M., & Roberto, M. (2021) · Alcohol and Alcoholism · doi:10.1093/alcalc/agab034 · Cited by 43 · see citing works
Do different types of stress differentially alter behavioural and neurobiological outcomes associated with depression in rodent models? A systematic review
Preez, A. D., Eum, J., Eiben, I., Eiben, P., Zunszain, P. A., Pariante, C. M., Thuret, S., & Fernandes, C. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100896 · Cited by 46 · see citing works
The stress of losing sleep: Sex-specific neurobiological outcomes
Wright, C. J., Milosavljevic, S., & Pocivavsek, A. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100543 · Cited by 45 · see citing works
Resilience, pain, and the brain: Relationships differ by sociodemographics
Tanner, J. J., Johnson, A. J., Terry, E. L., Cardoso, J. S., GARVAN, C. W., Staud, R. M., DEUTSCH, G., Deshpande, H., Lai, S., Addison, A., et al. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24790 · Cited by 42 · see citing works
The association between psychological resilience and cognitive function in longitudinal data: Results from the community follow-up survey
Yang, J. S., Jeon, Y. J., Lee, G. B., Kim, H. C., & Jung, S. J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.04.062 · Cited by 41 · see citing works
Bundling the haystack to find the needle: Challenges and opportunities in modeling risk and resilience following early life stress
Brenhouse, H. C., & Bath, K. G. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100768 · Cited by 40 · see citing works
Resilience to the effects of social stress on vulnerability to developing drug addiction
Calpe-López, C., Martínez-Caballero, M. Á., García-Pardo, M. P., & Aguilar, M. A. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i1.24 · Cited by 38 · see citing works
Stress, associative learning, and decision-making
Giovanniello, J. R., Bravo-Rivera, C., Rosenkranz, J. A., & Lattal, K. M. (2023) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2023.107812 · Cited by 38 · see citing works
The impact of confinement in the psychosocial behaviour due COVID-19 among members of a Brazilian university
Prado, H. M. D. A., Borghi, F., de Mello, T. M. V. F., & Kassisse, D. M. G. (2020) · International Journal of Social Psychiatry · doi:10.1177/0020764020971318 · Cited by 38 · see citing works
Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders
Steinman, M. Q., Kirson, D., Wolfe, S. A., Khom, S., D’Ambrosio, S. R., Bagsic, S. R. S., Bajo, M., Vlkolinský, R., Hoang, N. K., Singhal, A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00920-2 · Cited by 36 · see citing works
Progressive increase in the complexity and translatability of rodent testing to assess space-radiation induced cognitive impairment
Britten, R. A., Wellman, L. L., & Sanford, L. D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.027 · Cited by 36 · see citing works
Sexual differentiation of neural mechanisms of stress sensitivity during puberty
Wright, E. C., Luo, P. X., Zakharenkov, H. C., Serna Godoy, A., Lake, A. A., Prince, Z. D., Sekar, S., Culkin, H. I., Ramirez, A. V., Dwyer, T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306475120 · Cited by 34 · see citing works
A systematic review and multilevel meta-analysis of the prenatal and early life stress effects on rodent microglia, astrocyte, and oligodendrocyte density and morphology
Orso, R., Creutzberg, K. C., Lumertz, F. S., Kestering-Ferreira, É., Stocchero, B. A., Perrone, M. K., Begni, V., Grassi‐Oliveira, R., Riva, M. A., & Viola, T. W. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105202 · Cited by 33 · see citing works
Role of the locus coeruleus-noradrenergic system in stress-related psychopathology and resilience: Clinical and pre-clinical evidences
Slavova, D., Ortiz, V., Blaise, M., Bairachnaya, M., Giros, B., & Isingrini, E. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105925 · Cited by 36 · see citing works
Sex-dependent astrocyte reactivity: Unveiling chronic stress-induced morphological changes across multiple brain regions
Zhang, A. Y., Elias, E., & Manners, M. T. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106610 · Cited by 29 · see citing works
Medication adherence is influenced by resilience in patients with systemic lupus erythematosus
Pinto, C. M., García‐Carrasco, M., Campos-Rivera, S., Munguía‐Realpozo, P., Etchegaray‐Morales, I., Ayón-Aguilar, J., Alonso-García, N. E., & Méndez‐Martínez, S. (2021) · Lupus · doi:10.1177/09612033211004722 · Cited by 29 · see citing works
Structural brain alterations in older adults exposed to early-life adversity
Ancelin, M., Carrière, I., Artéro, S., Maller, J. J., Meslin, C., Dupuy, A., Ritchie, K. A., Ryan, J. L., & Chaudieu, I. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105272 · Cited by 28 · see citing works
Social instability in adolescence differentially alters dendritic morphology in the medial prefrontal cortex and its response to stress in adult male and female rats
Breach, M. R., Moench, K. M., & Wellman, C. L. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22723 · Cited by 26 · see citing works
Self-citation
The missing sex
Seydel, C. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00844-4 · Cited by 26 · see citing works
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Rodriguez, L., Kirson, D., Wolfe, S. A., Patel, R. R., Varodayan, F. P., Snyder, A. E., Gandhi, P. J., Khom, S., Vlkolinský, R., Bajo, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147842 · Cited by 22 · see citing works
Synaptic inhibition in the neocortex: Orchestration and computation through canonical circuits and variations on the theme
Lourenço, J., Koukouli, F., & Bacci, A. (2020) · Cortex · doi:10.1016/j.cortex.2020.08.015 · Cited by 22 · see citing works
Modulation of the NOP receptor signaling affects resilience to acute stress
Holanda, V. A. D., Pacifico, S., Neto, J. A., Finetti, L., Soares, B. L., Calò, G., Gavioli, E. C., & Ruzza, C. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119864942 · Cited by 24 · see citing works
Volume and Connectivity Differences in Brain Networks Associated with Cognitive Constructs of Binge Eating
Hartogsveld, B., Quaedflieg, C. W. E. M., van Ruitenbeek, P., & Smeets, T. (2022) · eNeuro · doi:10.1523/eneuro.0080-21.2021 · Cited by 25 · see citing works
Resilience to social defeat stress in adolescent male mice
Reguilón, M. D., Ballestín, R., Miñarro, J., & Rodríguez‐Arias, M. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110591 · Cited by 21 · see citing works
Patterns of Depression and Resilience in Children and Adolescents Exposed to an Earthquake: A Latent Profile Analysis
Wang, Y., Ge, F., Wan, M., & Zhang, J. (2021) · Psychiatry Investigation · doi:10.30773/pi.2020.0330 · Cited by 19 · see citing works
Corticotropin releasing factor and drug seeking in substance use disorders: Preclinical evidence and translational limitations
Mantsch, J. R. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100038 · Cited by 19 · see citing works
Wistar Kyoto Rats Display Anhedonia In Consumption but Retain Some Sensitivity to the Anticipation of Palatable Solutions
Wright, R. L., Gilmour, G., & Dwyer, D. M. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00070 · Cited by 19 · see citing works
Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders
Tobinski, A.-M., & Rappeneau, V. (2021) · Pharmaceuticals · doi:10.3390/ph14080780 · Cited by 18 · see citing works
Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective
Chavez, C. L. J., Coelho, M. A., Brewin, L. W., Swauncy, I., Tran, T., Albanese, T., Laguna, A., Gabriela, I., & Szumlinski, K. K. (2020) · Brain Sciences · doi:10.3390/brainsci10060405 · Cited by 18 · see citing works
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Nguyen, R., Rahyab, R., Deshpande, A., Legge, E., Almeida, J. F., Herz, S. M., Zylko, A. L., Damaj, M. I., & Lasek, A. W. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110641 · Cited by 17 · see citing works
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Ruisoto, P., Guerra, V., López-Núñez, C., Sánchez-Puertas, R. N., Paladines-Costa, M. B., & Pineda-Cabrera, N. J. (2022) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2022.100322 · Cited by 19 · see citing works
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Fudge, J. L., Kelly, E. A., & Hackett, T. A. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1453-22.2022 · Cited by 13 · see citing works
Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions
Bertocchi, I., Oberto, A., Longo, A., Palanza, P., & Eva, C. E. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104824 · Cited by 14 · see citing works
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Bendrath, S. C., Méndez, H. G., Dankert, A. M., Lerma-Cabrera, J. M., Carvajal, F., Dornellas, A. P. S., Lee, S., Neira, S., Haun, H. L., Delpire, E. J., et al. (2024) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2024.100405 · Cited by 12 · see citing works
Riluzole prevents stress-induced spine plasticity in the hippocampus but mimics it in the amygdala
Naskar, S., Datta, S., & Chattarji, S. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100442 · Cited by 9 · see citing works
Prefrontal Regulation of Safety Learning during Ethologically Relevant Thermal Threat
Felix‐Ortiz, A. C., Terrell, J. M., Gonzalez, C., Msengi, H. D., Boggan, M. B., Ramos, A. R., Magalhães, G., & Burgos-Robles, A. (2024) · eNeuro · doi:10.1523/eneuro.0140-23.2024 · Cited by 7 · see citing works
Early life adversities are associated with lower expected value signaling in the adult brain.
Sacu, S., Dubois, M., Hezemans, F., Aggensteiner, P., Monninger, M., Brandeis, D., Banaschewski, T., Hauser, T. U., & Holz, N. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.04.005 · Cited by 7 · see citing works
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Li, P., & Yan, Z. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100601 · Cited by 8 · see citing works
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Canto‐de‐Souza, L., Baptista‐de‐Souza, D., Thiele, M., Garcia, V. L., Silva, K. C., de Souza, F. V., Crestani, C. C., & Nunes‐de‐Souza, R. L. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111313 · Cited by 8 · see citing works
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Favoretto, C. A., Pagliusi, M., & Morais‐Silva, G. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1175514 · Cited by 8 · see citing works
Microglial responses to inflammatory challenge in adult rats altered by developmental exposure to polychlorinated biphenyls in a sex-specific manner
Walker, K. A., Rhodes, S. T., Liberman, D. A., Gore, A. C., & Bell, M. R. (2024) · NeuroToxicology · doi:10.1016/j.neuro.2024.07.009 · Cited by 7 · see citing works
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Asch, R., Pothula, S., Toyonaga, T., Fowles, K., Groman, S. M., García-Milian, R., Dileone, R., Taylor, J. R., & Esterlis, I. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01441-y · Cited by 6 · see citing works
Time-dependent changes in cognitive flexibility performance during intermittent social stress: Relevance for motivation and reward-seeking behavior
Sullivan, L. J., Shaffer, H., Hill, C., & Arco, A. D. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111972 · Cited by 6 · see citing works
Parental hostility predicts reduced cortical thickness in males
Chad‐Friedman, E., Botdorf, M., Riggins, T., & Dougherty, L. R. (2020) · Developmental Science · doi:10.1111/desc.13052 · Cited by 6 · see citing works
Paeonol facilitates the repair of neuronal damage in the mPFC caused by chronic stress via the Rho GTPases-cofilin1 signaling pathway
Zhu, X., Zhang, Y., Yan, X., Zhao, Y., Shi, L., Sun, Z., Kang, M. H., Zong, Y., Li, Q., & Xu, Z. (2025) · Neuroscience Letters · doi:10.1016/j.neulet.2025.138329 · Cited by 5 · see citing works
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Mohammadi, M. R., Zarafshan, H., Bashi, S. K., & Khaleghi, A. (2020) · Iranian Journal of Psychiatry · doi:10.18502/ijps.v15i4.4293 · Cited by 5 · see citing works
Neural Correlates of Opioid-Induced Risk-Taking Behavior in the Prelimbic Prefrontal Cortex
Quave, C. B., Vasquez, A. M., Aquino-Miranda, G., Marín, M., Bora, E. P., Chidomere, C. L., Zhang, X. O., Engelke, D. S., & Monte, F. H. D. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.2422-24.2025 · Cited by 4 · see citing works
Chronic unpredictable stress produces hyperalgesia and promotes inhibitory drive in medial prefrontal cortex
Maile, L., Mercado, K., Baig, L., & Davidson, S. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105452 · Cited by 4 · see citing works
Impact of change in psychological resilience on subsequent all-cause and cause-specific mortality in community-dwelling older adults: a nationwide cohort study
Zhang, C., Bai, A., Li, W., Wang, Q., Liu, S., & Miao, M. (2025) · Public Health · doi:10.1016/j.puhe.2025.105833 · Cited by 4 · see citing works
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Iryanidar, I., Kadar, K., & Irwan, A. M. (2023) · Frontiers of Nursing · doi:10.2478/fon-2023-0032 · Cited by 4 · see citing works
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Krolick, K. N., Cao, J., Gulla, E. M., Bhardwaj, M., Marshall, S. J., Zhou, E. Y., Kiss, A. J., Choueiry, F., Zhu, J., & Shi, H. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.002 · Cited by 4 · see citing works
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Li, Q., Yan, X., Zhao, Y., Xu, Z., & Zhu, X.-L. (2025) · Neuroreport · doi:10.1097/wnr.0000000000002188 · Cited by 3 · see citing works
Age- and sex-dependent effects of stressors on activity of the nucleus reuniens of the thalamus
Uliana, D. L., & Grace, A. A. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.09.018 · Cited by 3 · see citing works
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Balboa, J. G., Colapietro, A. A., Cantarelli, V. I., Ponzio, M. F., Retamal, M. N. C., Pallarés, M. E., Antonelli, M. C., & Chertoff, M. (2025) · Neurotoxicity Research · doi:10.1007/s12640-025-00731-9 · Cited by 4 · see citing works
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Буткевич, И. П., Михайленко, В. А., & Vershinina, E. A. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0307 · Cited by 3 · see citing works
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Nadifi, Y., Popa, I. A., Brochu, L., Girard, G., & Maziade, M. (2026) · The Canadian Journal of Psychiatry · doi:10.1177/07067437251412627 · Cited by 1 · see citing works
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Santos‐Silva, T., Godoy, L. D., Guimarães, F. S., & Gomes, F. V. (2026) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyag043 · Cited by 1 · see citing works
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Beichi, O. A. A. (2021) · Psychology and Education Journal · doi:10.17762/pae.v58i2.1066 · Cited by 1 · see citing works
Oestrogens: Structure, Mechanisms of Action and Role in Mood and Cognition
Almeida, O. F. X., & Patchev, V. K. (2020) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0029144
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de Souza, A. D. J. (2021) · doi:10.11606/d.17.2021.tde-11062021-080616
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Filipi, H., & Rasyida, A. (2022) · Surabaya Biomedical Journal · doi:10.30649/sbj.v2i1.36
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Chandler, B. (2022) · doi:10.17760/d20467311
Stress in utero: effects on gliovascular integrity in female infant offspringPreprint
Rodrigues, M., Sousa, I., Baptista, F. I., & Coelho‐Santos, V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.17.589633
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Franklin, T., Bitarafan, S., King, A. T., Goodson, M. C., Rutledge, C., Gajelli, T., Prichard, A., Zepeda-López, H. M., Kye, N., Sloan, S. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.12.664223
Sex-Specific Insights in Neuroscience: From Brain Structure to Mental Health Interventions
Kim, H., & Lee, H. (2026) · Springer eBooks · doi:10.1007/978-981-95-2070-1_4
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Biasin, J. M., Yarenko, D., Willoughby, T., & Heffer, T. (2026) · Journal of Youth and Adolescence · doi:10.1007/s10964-026-02368-z
Modeling the Exposome in Murine Cardiovascular Disease
Sulaman, B. A., Zhu, J., Xiong, T., Ireland, T. E., Downey, J., Świrski, F. K., Robbins, C. S., Leeper, N. J., Poller, W. C., & McAlpine, C. S. (2026) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2026.101690
Maternal Immune Activation Leads to Lasting Sex-Specific Changes in Behavior and Hippocampal Morphological and Molecular Features in 12-Month-Old Rat Offspring
Sentyabreva, A. V., Lyamtsev, A. S., Melnikova, E. A., Aliper, G. M., & Kosyreva, A. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188222
Myelin as an emerging dimension of neuroendocrine brain plasticity: lifelong neuroactive steroid regulation and sex-specific mechanisms
Schumacher, M., & Ghoumari, A. M. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101293

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Storsved, H., & Wellman, C. L. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.08.013
Self-citation
Chapter 1: Introduction
(1990) · Regulatory Toxicology and Pharmacology · doi:10.1016/s0273-2300(05)80077-7 · Cited by 15 · see citing works
Effects of stress on the structure and function of the medial prefrontal cortex: Insights from animal models
Wellman, C. L., Bollinger, J. L., & Moench, K. M. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.11.007 · Cited by 53 · see citing works
Self-citation
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Farrell, M. R., Sengelaub, D. R., & Wellman, C. L. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.04.002 · Cited by 69 · see citing works
Self-citation
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Henze, G., Konzok, J., Kreuzpointner, L., Bärtl, C., Giglberger, M., Peter, H. L., Streit, F., Kudielka, B. M., Kirsch, P., & Wüst, S. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab062 · Cited by 28 · see citing works

Authors: Wellman, C. L., Bangasser, D. A., Bollinger, J. L., Coutellier, L., Logrip, M. L., Moench, K. M., & Urban, K. R.
Affiliations: Indiana University Bloomington (US)
Temple University (US)
University of Cincinnati (US)
The Ohio State University (US)
Indiana University – Purdue University Indianapolis (US)
Children's Hospital of Philadelphia (US)
ORCID: Wellman, Cara L.
Bangasser, Debra A.
Bollinger, Justin L.
Coutellier, Laurence
Logrip, Marian L.
Moench, Kelly M.
Urban, Kimberly R.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2018-10-31
Volume: 38
Issue: 44
Pages: 9423-9432
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1673-18.2018
PMC: PMC6209838
OpenAlex: W2899474391
Cited by: 88
References: 129
Citations by year: 2026: 9 · 2025: 11 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 16 · 2020: 14 · 2019: 9
FWCI: 5.60
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IUScholarWorks Open (Indiana University) (submittedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
PMC
Funders: National Science Foundation (1552416, T32MH103213, T32HD049336)
Pennsylvania Department of Health (420792)
National Institutes of Health (UL1TR001108, AA021802)
National Institute on Alcohol Abuse and Alcoholism (R00AA021802, K99AA021802)
National Institute of Mental Health (R01MH093981, T32MH103213)
National Institute of Neurological Disorders and Stroke (T32NS007413)
National Center for Advancing Translational Sciences
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD049336)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: sex differences, stress, resilience, corticolimbic system, corticotropin-releasing factor, glucocorticoids, amygdala, alcohol consumption, social stress, prefrontal cortex, pyramidal neurons, parvalbumin interneurons, glia, gonadal hormones, chronic stress, emotions, motivation
MeSH terms: Animals, Mental Disorders, Brain, Corticotropin-Releasing Hormone, Emotions, Female, Humans, Male, Motivation, Neuroglia, Neurons, Risk Factors, Sex Characteristics, Stress, Psychological, Resilience, Psychological

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Sex Differences in Risk and Resilience: Stress Effects on the Neural Substrates of Emotion and Motivation

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