The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Injury mechanisms in acute intracerebral hemorrhage
Open accessAbstract
ABSTRACT Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled ‘Cerebral Ischemia’. HighlightsIntracerebral hemorrhage remains a deadly hemorrhagic stroke subtype.Trials of interventional strategies have failed to show a beneficial effect.Multiple trials of minimally invasive clot removal strategies are underway.Studies of hematoma clearance mechanisms may reveal pharmacologic targets.
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Hemphill, J. C., Greenberg, S. M., Anderson, C. S., Becker, K., Bendok, B. R., Cushman, M., Fung, G. L., Goldstein, J. N., Macdonald, R. L., Mitchell, P. H., et al. (2015) · Stroke · doi:10.1161/str.0000000000000069 · Cited by 3,994
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Mendelow, A. D., GREGSON, B. A., Fernandes, H. M., Murray, G. D., Teasdale, G. M., Hope, D., Karimi, A., Shaw, M. D. M., & Barer, D. H. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17826-x · Cited by 1,996
Cerebral microbleeds: a guide to detection and interpretation
Greenberg, S. M., Vernooij, M. W., Cordonnier, C., Viswanathan, A., Al-Shahi Salman, R., Warach, S., Launer, L. J., Van Buchem, M. A., & Breteler, M. M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70013-4 · Cited by 1,798
Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R., Cohen, J. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121623109 · Cited by 1,666
Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage
Anderson, C. S., Heeley, E., Huang, Y., Wang, J., Stapf, C., Delcourt, C., Lindley, R., Robinson, T., Lavados, P., Neal, B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214609 · Cited by 1,614
Qureshi, A. I., Mendelow, A. D., & Hanley, D. F. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60371-8 · Cited by 1,526
Early Hemorrhage Growth in Patients With Intracerebral Hemorrhage
Brott, T., Broderick, J., Kothari, R., Barsan, W., Tomsick, T., Sauerbeck, L., Spilker, J., Duldner, J., & Khoury, J. (1997) · Stroke · doi:10.1161/01.str.28.1.1 · Cited by 1,477
Mendelow, A. D., Gregson, B. A., Rowan, E. N., Murray, G. D., Gholkar, A., & Mitchell, P. M. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60986-1 · Cited by 1,420
Intracerebral haemorrhage: mechanisms of injury and therapeutic targets
Keep, R. F., Hua, Y., & Xi, G. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70104-7 · Cited by 1,308
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Cited by
Greenberg, S. M., Ziai, W. C., Cordonnier, C., Dowlatshahi, D., Francis, B., Goldstein, J. N., Hemphill, J. C., Johnson, R., Keigher, K. M., Mack, W. J., et al. (2022) · Stroke · doi:10.1161/str.0000000000000407 · Cited by 1,639
Chen, S., Zhao, L., Sherchan, P., Ding, Y., Yu, J., Nowrangi, D., Tang, J., Xia, Y., & Zhang, J. H. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1140-6 · Cited by 122
Kong, Y., Li, S., Zhang, M., Xu, W., Chen, Q., Zheng, L., Liu, P., & Zou, W. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01770-x · Cited by 55
Metadata
- Authors
- Wilkinson, D. A., Pandey, A. S., Thompson, B. G., Keep, R. F., Hua, Y., & Xi, G.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 134
- Issue
- Pt B
- Pages
- 240-248
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2757856543
- Cited by
- 258
- References
- 78
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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