Cited by 201Posttraumatic Stress Disorder ResearchNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

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Altered reward processing in the nucleus accumbens and mesial prefrontal cortex of patients with posttraumatic stress disorder

Sailer, Uta, Robinson, Simon, Fischmeister, Florian Ph.S., König, Dorothea, Oppenauer, Claudia, Lueger-Schuster, Brigitte, Moser, Ewald, Kryspin-Exner, Ilse, Bauer, Herbert·2008·Neuropsychologia

DOI 10.1016/j.neuropsychologia.2008.05.022

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Abstract

Posttraumatic stress disorder (PTSD) is known to be associated with altered medial prefrontal activation in response to threatening stimuli and with behavioural deficits in prefrontal functions such as working memory and attention. Given the importance of these areas and processes for decision-making, this functional magnetic resonance imaging study investigated whether decision-making is altered in patients with PTSD. In particular, the neural response to gain and loss feedback was evaluated in a decision-making task in which subjects could maximise their number of points total by learning a particular response pattern. Behaviourally, controls learned the correct response pattern faster than patients. Functionally, patients and controls differed in their neural response to gains, but not in their response to losses. During the processing of gains in the late phase of learning, PTSD patients as compared to controls showed lower activation in the nucleus accumbens and the mesial PFC, critical structures in the reward pathway. This reduced activation was not due to different rates of learning, since it was similarly present in patients with unimpaired learning performance. These findings suggest that positive outcome information lost its salience for patients with PTSD. This may reflect decreasing motivation as the task progressed.

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Authors: Sailer, U., Robinson, S., Fischmeister, F. P. S., König, D., Oppenauer, C., Lueger-Schuster, B., Moser, E., Kryspin-Exner, I., & Bauer, H.
Affiliations: University of Vienna (AT)
Medical University of Vienna (AT)
Corresponding author: Sailer, Uta
ORCID: Sailer, Uta
Robinson, Simon
Fischmeister, Florian Ph.S.
König, Dorothea
Oppenauer, Claudia
Moser, Ewald
Venue: Neuropsychologia
Publisher: Elsevier BV
Published: 2008-09
Volume: 46
Issue: 11
Pages: 2836-2844
ISSN: 0028-3932 (ISSN-L)
DOI: 10.1016/j.neuropsychologia.2008.05.022
OpenAlex: W1981443966
Cited by: 201
References: 65
Citations by year: 2026: 7 · 2025: 10 · 2024: 6 · 2023: 14 · 2022: 10 · 2021: 12 · 2020: 14 · 2019: 14 · 2018: 17 · 2017: 12 · 2016: 18 · 2015: 12 · 2014: 5 · 2013: 11 · 2012: 14
FWCI: 8.94
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropsychologia (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Oesterreichische Nationalbank
Schuhfried
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: post-traumatic stress disorder, reward processing, nucleus accumbens, decision-making, learning, motivation, reward salience, reward pathways
MeSH terms: Adult, Decision Making, Feedback, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Processes, Neuropsychological Tests, Nucleus Accumbens, Oxygen, Psychomotor Performance, Reward, Stress Disorders, Post-Traumatic, Case-Control Studies, Prefrontal Cortex, Statistics, Nonparametric

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Altered reward processing in the nucleus accumbens and mesial prefrontal cortex of patients with posttraumatic stress disorder

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