Cited by 32Neuroinflammation and Neurodegeneration MechanismsAnesthesia and Neurotoxicity ResearchNeurogenesis and neuroplasticity mechanisms

Normal aging of offspring mice of mothers with induced inflammation during pregnancy

Golan, H., Stilman, M., Lev, V., Huleihel, M.·2006·Neuroscience

Abstract

Intrauterine inflammation is a major risk for offspring neurodevelopmental brain damage and may result in cognitive limitations and poor cognitive and perceptual outcomes. In the present study we tested the possibility that prenatal exposure to a high level of inflammatory factors may increase the risk for neurodegeneration in aging. The effect of systemic maternal inflammation (MI), induced by lipopolysaccharide (LPS) on offspring brain aging, was examined in 8 month old (adult) and 20 month old (aged) offspring mice. A significant effect of age was found in the distance and velocity of exploration in the open field in both groups. In addition, MI aged offspring covered longer distances and enter frequently to the center of the field compared with the aged control group. Although only little difference was found in the aged MI offspring compared with the control offspring, the overall profile of behavior of these mice differs from that of the control group, as detected by clustering analysis. The expression of the death-associated protein FAS-ligand and the amount of apoptotic cell death were examined in the brains of aged offspring. Similar levels of FAS-ligand expression and parallel density of apoptotic cells were detected in the brains of aged mice of control and MI groups. Altogether, moderate systemic MI was not found to increase the risk for cell death in the aged offspring; limited effect was found in mice profile of behavior.

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Crossref · 10.1016/j.neuroscience.2006.05.045

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Authors
Golan, H., Stilman, M., Lev, V., & Huleihel, M.
Affiliations
Ben-Gurion University of the Negev (IL)
Corresponding author
Golan, H.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2006
Volume
141
Issue
4
Pages
1909-1918
ISSN
0306-4522 (ISSN-L)
OpenAlex
W2074075153
Cited by
32
References
39
Citations by year
2025: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 2
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
prenatal inflammation, brain aging, neurodegeneration, offspring behavior, open field exploration, Fas ligand, apoptosis, cognitive aging
MeSH terms
Age Factors, Aging, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Brain, Exploratory Behavior, Female, Gestational Age, Immunohistochemistry, Inflammation, Learning, Lipopolysaccharides, Motor Activity, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Cytokines, Cell Death, Mice, Fas Ligand Protein

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