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Cited by 215Neural dynamics and brain functionCognitive Abilities and TestingMemory and Neural Mechanisms

The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.

Variability in neuronal activity in primate cortex during working memory tasks

Shafi, M., Zhou, Y., Quintana, J., Chow, C., Fuster, J., Bodner, M.·2007·Neuroscience
DOI 10.1016/j.neuroscience.2006.12.072
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Abstract

Persistent elevated neuronal activity has been identified as the neuronal correlate of working memory. It is generally assumed in the literature and in computational and theoretical models of working memory that memory-cell activity is stable and replicable; however, this assumption may be an artifact of the averaging of data collected across trials, and needs experimental verification. In this study, we introduce a classification scheme to characterize the firing frequency trends of cells recorded from the cortex of monkeys during performance of working memory tasks. We examine the frequency statistics and variability of firing during baseline and memory periods. We also study the behavior of cells on individual trials and across trials, and explore the stability of cellular firing during the memory period. We find that cells from different firing-trend classes possess markedly different statistics. We also find that individual cells show substantial variability in their firing behavior across trials, and that firing frequency also varies markedly over the course of a single trial. Finally, the average frequency distribution is wider, the magnitude of the frequency increases from baseline to memory smaller, and the magnitude of frequency decreases larger than is generally assumed. These results may serve as a guide in the evaluation of current theories of the cortical mechanisms of working memory.

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Metadata

Authors
Shafi, M., Zhou, Y., Quintana, J., Chow, C., Fuster, J., & Bodner, M.
Affiliations
  • University of California, Los Angeles (US)
  • Johns Hopkins University (US)
  • University of Pittsburgh (US)
Corresponding author
  • Fuster, J.
  • Bodner, M.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2007-05
Volume
146
Issue
3
Pages
1082-1108
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2006.12.072
OpenAlex
W1963850213
Cited by
215
References
105
Citations by year
2026: 2 · 2025: 15 · 2024: 9 · 2023: 14 · 2022: 16 · 2021: 20 · 2020: 15 · 2019: 10 · 2018: 22 · 2017: 20 · 2016: 12 · 2015: 10 · 2014: 9 · 2013: 11 · 2012: 7
FWCI
2.83
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Whitehall Foundation
  • Mind and Life Institute (MH-01508)
  • National Institute of Mental Health (MH-25082, MH-51697)
  • Alfred P. Sloan Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
working memory, firing rate, persistent neuronal activity, primate cortex, single-unit recording, trial-to-trial variability, baseline activity
MeSH terms
Algorithms, Animals, Haplorhini, Cerebral Cortex, Data Interpretation, Statistical, Electrophysiology, Extracellular Space, Memory, Short-Term, Nerve Net, Neurons, Parietal Lobe, Prefrontal Cortex

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