Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice
Abstract
Unlabelled Effects of morphine on acquisition and retrieval of memory have been proven in the avoidance paradigms. In present study, we used a two-trial recognition Y-maze to test the effects of acute morphine and morphine withdrawal on spatial recognition memory. The Y-maze is based on the innate tendency of rodents to explore novel environments and therefore avoid punishment and reward. Results 1) Pre-training morphine 10 mg/kg impaired the recognition spatial memory of acquisition after a 1 h inter-trial interval (ITI), whereas morphine 2.5, 5 and 10 mg/kg showed impairment after 2 h ITI. 2) Pre-retention morphine 5, 10 mg/kg disrupted the retrieval of memory after 1 h ITI. 3) Morphine 5 and 10 mg/kg caused hyper-locomotor activity depending on the state. 4) Mice withdrawn from morphine 40 mg/kg but not 10 mg/kg for 3 days showed amnesia in Y-maze. Our data suggested that acute morphine impaired the acquisition and retrieval of spatial recognition memory and increased the locomotor activity in the Y-maze depending on the dose and state. Moreover, withdrawal from chronic morphine also impaired acquisition in the Y-maze depending on the dose and state.
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Chronic administration and withdrawal of amphetamine and morphine have been shown to cause severe spatial recognition memory and executive impairment in rodents and humans.
“Chronic administration and withdrawal of amphetamine and morphine have been shown to cause severe spatial recognition memory and executive impairment in rodents and humans (49–51).”
Cites
A two-trial memory task with automated recording: study in young and aged rats
Dellu, F., Mayo, W., Cherkaoui, J., Le Moal, M., & Simon, H. (1992) · Brain Research · doi:10.1016/0006-8993(92)91352-f · Cited by 390 · see citing works
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The effect of pain on cognitive function: A review of clinical and preclinical research
Moriarty, O., McGuire, B. E., & Finn, D. P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.002 · Cited by 1,122 · see citing works
Memory systems and the addicted brain
Goodman, J., & Packard, M. G. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00024 · Cited by 140 · see citing works
McKinnon, M. C., Boyd, J. E., Frewen, P. A., Lanius, U. F., Jetly, R., Richardson, J. D., & Lanius, R. A. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.07.017 · Cited by 94 · see citing works
“…(Spain and Newsom, 1991; Zhu et al., 2011) and retrieval (Zhu et al., 2011) of spatial memories, and to disrupt working memory (Itoh et al., 1994), avoidance learning (Aguilar et al., 1998; Ukai et al., 1997; Zarrindast and Rezayof, 2004), and spatial recognition memory (Ma et al., 2007).”
InfluentialJiang, Y., Liu, Y., Gao, M., Xue, M., Wang, Z., & Liang, H. (2020) · Food & Function · doi:10.1039/c9fo01780a · Cited by 88 · see citing works
Mathew, J., Balakrishnan, S., Antony, S., Abraham, P. M., & Paulose, C. (2012) · Journal of Biomedical Science · doi:10.1186/1423-0127-19-25 · Cited by 65 · see citing works
Kouémou, N. E., Taiwe, G. S., Moto, F. C. O., Pale, S., Ngoupaye, G. T., Njapdounke, J. S. K., Nkantchoua, G. C. N., Pahaye, D. B., & Bum, E. N. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00847 · Cited by 55 · see citing works
Ravichandran, V. A., Kim, M., Han, S. K., & Cha, Y. S. (2018) · Nutrients · doi:10.3390/nu10070917 · Cited by 28 · see citing works
Jian-min, C., Zhi-yuan, W., Shi-xuan, W., Rui, S., Ning, W., & Jin, L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.885574 · Cited by 7 · see citing works
Addressing altered anticipation as a transdiagnostic target through computational psychiatry
Sepúlveda, P., Aitsahalia, I., Kumar, K., Atkin, T., & Iigaya, K. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.02.014 · Cited by 3 · see citing works
- Authors
- Ma, M. X., Chen, Y. M., He, J., Zeng, T., & Wang, J. H.
- Affiliations
- Jilin University (CN)
- Kunming Institute of Zoology (CN)
- Corresponding author
- Wang, J.H.
- ORCID
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 147
- Issue
- 4
- Pages
- 1059-1065
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1971649598
- Cited by
- 168
- References
- 1
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 11 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 10 · 2012: 10
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- morphine, morphine withdrawal, spatial recognition memory, Y-maze, memory acquisition, memory retrieval, locomotor activity
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Dose-Response Relationship, Drug, Drug Administration Schedule, Male, Mice, Inbred ICR, Morphine, Morphine Dependence, Narcotics, Spatial Behavior, Time Factors, Maze Learning, Recognition, Psychology, Mice
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