Cited by 391Memory and Neural MechanismsMemory Processes and InfluencesCognitive Functions and Memory

A two-trial memory task with automated recording: study in young and aged rats

Dellu, F., Mayo, W., Cherkaoui, J., Le Moal, M., Simon, H.·1992·Brain Research

Abstract

A two-trial recognition task, based on place or object exploration in a Y-maze, was developed to study memory in adult and aged rats. This paradigm avoids the use of electric shocks or deprivation that may have non-specific influences on the responses, and the task does not require learning of a rule. A number of behavioral parameters in several animals could be recorded automatically. These behavioral parameters were found to be differently influenced both by the type of recognition (place vs. object) and by the inter-trial interval (recognition retention time). Impaired recognition was also detected in 18-months-old rats. This recognition task which combines simplicity, sensitivity and high specificity may thus be a useful adjunct to our current battery of memory tasks.

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Crossref · 10.1016/0006-8993(92)91352-f

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Authors
Dellu, F., Mayo, W., Cherkaoui, J., Le Moal, M., & Simon, H.
Affiliations
Université de Bordeaux (FR)
Corresponding author
Simon, H.
Venue
Brain Research
Publisher
Elsevier BV
Published
1992-08
Volume
588
Issue
1
Pages
132-139
ISSN
0006-8993 (ISSN-L)
OpenAlex
W1984139645
Cited by
390
References
20
Citations by year
2026: 17 · 2025: 14 · 2024: 13 · 2023: 17 · 2022: 16 · 2021: 14 · 2020: 15 · 2019: 15 · 2018: 19 · 2017: 17 · 2016: 21 · 2015: 17 · 2014: 24 · 2013: 22 · 2012: 12
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
recognition memory, Y-maze, place recognition, object recognition, aging, aged rats, memory impairment, intertrial interval
MeSH terms
Aging, Animals, Discrimination, Psychological, Exploratory Behavior, Male, Memory, Rats, Sprague-Dawley, Rats

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