Decreased GABA receptor in the cerebral cortex of epileptic rats: Effect of Bacopa monnieri and Bacoside-A
Open accessAbstract
BACKGROUND: Gamma amino butyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tones that counter balances neuronal excitation. When this balance is perturbed, seizures may ensue. METHODS: In the present study, alterations of the general GABA, GABAA and GABAB receptors in the cerebral cortex of the epileptic rat and the therapeutic application of Bacopa monnieri were investigated. RESULTS: Scatchard analysis of [3H]GABA, [3H]bicuculline and [3H]baclofen in the cerebral cortex of the epileptic rat showed significant decrease in Bmax (P < 0.001) compared to control. Real Time PCR amplification of GABA receptor subunits such as GABAAά1, GABAAγ, GABAAδ, GABAB and GAD where down regulated (P < 0.001) in epileptic rats. GABAAά5 subunit and Cyclic AMP responsible element binding protein were up regulated. Confocal imaging study confirmed the decreased GABA receptors in epileptic rats. Epileptic rats have deficit in radial arm and Y maze performance. CONCLUSIONS: Bacopa monnieri and Bacoside-A treatment reverses epilepsy associated changes to near control suggesting that decreased GABA receptors in the cerebral cortex have an important role in epileptic occurrence; Bacopa monnieri and Bacoside-A have therapeutic application in epilepsy management.
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Studies have elucidated evidence for the role of Bacopa monnieri in epilepsy, dementia, and Parkinson's disease attenuation.
“There have been studies that have elucidated evidence for the role of B. monnieri in epilepsy, dementia, and Parkinson’s disease attenuation [96,97].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [96]
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- Authors
- Mathew, J., Balakrishnan, S., Antony, S., Abraham, P. M., & Paulose, C.
- Affiliations
- Cochin University of Science and Technology (IN)
- Venue
- Journal of Biomedical Science
- Published
- 2012-02-24
- Volume
- 19
- Issue
- 1
- Pages
- 25-25
- ISSN
- 1021-7770 (ISSN-L)
- 1423-0127
- PMC
- PMC3306740
- OpenAlex
- W2110097195
- Cited by
- 65
- References
- 61
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Journal of Biomedical Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- Kerala State Council for Science, Technology and Environment
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- GABA receptors, GABAA receptor, GABAB receptors, epilepsy, Bacopa monnieri, bacoside A, cerebral cortex, GABA receptor subunits, GAD, cyclic AMP response element binding protein, spatial learning deficits, rat model of epilepsy, anticonvulsant therapy
- MeSH terms
- Animals, Cerebral Cortex, Disease Models, Animal, Epilepsy, gamma-Aminobutyric Acid, Gene Expression Regulation, Humans, Pilocarpine, Plant Extracts, Receptors, GABA-A, Saponins, Triterpenes, Rats, Wistar, Receptors, GABA-B, Maze Learning, Bacopa, Rats
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