Cited by 69Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchMedicinal Plants and Neuroprotection

Decreased GABA receptor in the cerebral cortex of epileptic rats: Effect of Bacopa monnieri and Bacoside-A

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Mathew, Jobin, Balakrishnan, Savitha, Antony, Sherin, Abraham, Pretty Mary, Paulose, CS·2012·Journal of Biomedical Science

Abstract

BACKGROUND: Gamma amino butyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tones that counter balances neuronal excitation. When this balance is perturbed, seizures may ensue. METHODS: In the present study, alterations of the general GABA, GABAA and GABAB receptors in the cerebral cortex of the epileptic rat and the therapeutic application of Bacopa monnieri were investigated. RESULTS: Scatchard analysis of [3H]GABA, [3H]bicuculline and [3H]baclofen in the cerebral cortex of the epileptic rat showed significant decrease in Bmax (P < 0.001) compared to control. Real Time PCR amplification of GABA receptor subunits such as GABAAά1, GABAAγ, GABAAδ, GABAB and GAD where down regulated (P < 0.001) in epileptic rats. GABAAά5 subunit and Cyclic AMP responsible element binding protein were up regulated. Confocal imaging study confirmed the decreased GABA receptors in epileptic rats. Epileptic rats have deficit in radial arm and Y maze performance. CONCLUSIONS: Bacopa monnieri and Bacoside-A treatment reverses epilepsy associated changes to near control suggesting that decreased GABA receptors in the cerebral cortex have an important role in epileptic occurrence; Bacopa monnieri and Bacoside-A have therapeutic application in epilepsy management.

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Crossref · 10.1186/1423-0127-19-25

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  • Studies have elucidated evidence for the role of Bacopa monnieri in epilepsy, dementia, and Parkinson's disease attenuation.

    “There have been studies that have elucidated evidence for the role of B. monnieri in epilepsy, dementia, and Parkinson’s disease attenuation [96,97].”

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  1. Singh HK Dhawan BN Tandon PN, Bijiani V, Wadhwa S Drugs affecting learning and memory Lectures in neurobiology 1992 1 New Delhi:Wiley Eastern 189 207
  2. Lloyd KG Munari C Bossi L Stoeffels C Talairach J Morselli PL Morselli PL Biochemical evidence for the alterations of GABA- mediated synaptic transmission in pathological brain tissue (stereo EEG or morphological definition) from epileptic patients Neuro- transmitters, Seizures, and Epilepsy 1981 Raven press 325 338
  3. Reas SK Amee K Paulose CS Decreased glutamate receptor binding and NMDA R1 gene expression in the hippocampus of pilocarpine induced epileptic rats: neuroprotective role of Bacopa monnieri extract Epilepsy and Behavior 2008 12 54 60 10.1016/j.yebeh.2007.09.021 18086456 · DOI
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Authors
Mathew, J., Balakrishnan, S., Antony, S., Abraham, P. M., & Paulose, C.
Affiliations
Cochin University of Science and Technology (IN)
Venue
Journal of Biomedical Science
Published
2012-02-24
Volume
19
Issue
1
Pages
25-25
ISSN
  • 1021-7770 (ISSN-L)
  • 1423-0127
OpenAlex
W2110097195
Cited by
65
References
61
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 1
FWCI
1.80
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Biomedical Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Department of Biotechnology, Ministry of Science and Technology, India
  • Department of Science and Technology, Ministry of Science and Technology, India
  • Indian Council of Medical Research
  • Kerala State Council for Science, Technology and Environment
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
GABA receptors, GABAA receptor, GABAB receptors, epilepsy, Bacopa monnieri, bacoside A, cerebral cortex, GABA receptor subunits, GAD, cyclic AMP response element binding protein, spatial learning deficits, rat model of epilepsy, anticonvulsant therapy
MeSH terms
Animals, Cerebral Cortex, Disease Models, Animal, Epilepsy, gamma-Aminobutyric Acid, Gene Expression Regulation, Humans, Pilocarpine, Plant Extracts, Receptors, GABA-A, Saponins, Triterpenes, Rats, Wistar, Receptors, GABA-B, Maze Learning, Bacopa, Rats

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