The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The human amygdala is involved in general behavioral relevance detection: Evidence from an event-related functional magnetic resonance imaging Go-NoGo task
Open accessAbstract
The amygdala is classically regarded as a detector of potential threat and as a critical component of the neural circuitry mediating conditioned fear responses. However, it has been reported that the human amygdala responds to multiple expressions of emotions as well as emotionally neutral stimuli of a novel, uncertain or ambiguous nature. Thus, it has been proposed that the function of the amygdala may be of a more general art, i.e. as a detector of behaviorally relevant stimuli [Sander D, Grafman J, Zalla T (2003) The human amygdala: an evolved system for relevance detection. Rev Neurosci 14:303-316]. To investigate this putative function of the amygdala, we used event related functional magnetic resonance imaging (fMRI) and a modified Go-NoGo task composed of behaviorally relevant and irrelevant letter and number stimuli. Analyses revealed bilateral amygdala activation in response to letter stimuli that were behaviorally relevant as compared with letters with less behavioral relevance. Similar results were obtained for relatively infrequent NoGo relevant stimuli as compared with more frequent Go stimuli. Our findings support a role for the human amygdala in general detection of behaviorally relevant stimuli.
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“Converging evidence from this field suggests the amygdalaa key brain region for emotion regulation (LeDoux, 2003), processing (Seeley et al., 2007), detection (Ousdal et al., 2008), and vigilance for social cues across sensory modalities (Whalen, 2007) is an important target of OT administration.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Ousdal et al., 2008
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Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Eickhoff, S. B., Stephan, K. E., Mohlberg, H., Grefkes, C., Fink, G. R., Amunts, K., & Zilles, K. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.034 · Cited by 4,033 · cited 2×
“Small volume corrections for multiple comparisons were applied for our regions of interest (ROIs) (bilateral amygdala) based on anatomically defined ROIs using the SPM Anatomy toolbox developed by Eickhoff et al. (2005).”
MethodFears, phobias, and preparedness: toward an evolved module of fear and fear learning
Öhman, A., & Mineka, S. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.483 · Cited by 3,147
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · cited 2×
“…has efferent connections with cortical and subcortical areas engaged in attentional and motivational processes (Holland and Gallagher, 1999; Davis and Whalen, 2001), allowing it to mediate vigilance and redirect attention as a function of shifting behavioral relevance of environmental…”
BackgroundAnalysis of fMRI Time-Series Revisited
Friston, K. J., Holmes, A. P., Poline, J., Grasby, P. M., Williams, S., Frackowiak, R. S. J., & Turner, R. (1995) · NeuroImage · doi:10.1006/nimg.1995.1007 · Cited by 2,504 · cited 2×
“The images were spatially normalized (Friston et al., 1995), resampled at 2×2×2 mm and smoothed using a 6 mm full width-half maximum (FWHM) isotropic kernel.”
MethodAdolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360 · cited 4×
“…fax: +47-23-02-73-33. o.a.andreassen@medisin.uio.no (O. A. Andreassen).. -PA Author M anuscript N IH -PA Author M anuscript recognizing fearful facial expressions (Adolphs et al., 1994), and tended to judge unknown individuals as more trustworthy and approachable (Adolphs et al., 1998).”
BackgroundInfluentialA differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013 · cited 2×
“During the past several years the classical view of the amygdala as a threat detector/fear-module has been expanded following multiple reports linking the amygdala to non-fearful emotional facial expressions including happiness (Breiter et al., 1996; Morris et al., 1996; Canli et al., 2002), sadness (Blair et al.”
BackgroundResponse and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711 · cited 2×
“During the past several years the classical view of the amygdala as a threat detector/fear-module has been expanded following multiple reports linking the amygdala to non-fearful emotional facial expressions including happiness (Breiter et al., 1996; Morris et al., 1996; Canli et al., 2002), sadness (Blair et al.”
BackgroundLaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80475-4 · Cited by 1,402 · cited 1×
“Several research groups have shown that the amygdala contributes to acquisition and expression of conditioned fear responses, both in animals (LeDoux, 2000) and humans (LaBar et al., 1998).”
BackgroundDissociable neural responses to facial expressions of sadness and anger
Blair, R. J. R., Morris, J. S., Frith, C. D., Perrett, D. I., & Dolan, R. J. (1999) · Brain · doi:10.1093/brain/122.5.883 · Cited by 1,212 · cited 2×
“, 2002), sadness (Blair et al., 1999), contempt (Sambataro et al.”
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Giacometti, C. (2023) · theses.fr (ABES) · doi:10.70675/a9788477z9d8ez4b11zb5b1zf5f523ba492c
Colin, L., Iglói, K., Montagrin, A., Kumar, S., Hofmeister, J., Gschwind, M., Schwartz, S., & Virginie Sterpenich, A. (2026) · Journal of Sleep Research · doi:10.1111/jsr.70386
Metadata
- Authors
- Ousdal, O. T., Jensen, J., Server, A., Hariri, A. R., Nakstad, P. H., & Andreassen, O. A.
- Affiliations
- Oslo University Hospital (NO)
- University of Oslo (NO)
- University of Pittsburgh (US)
- Corresponding author
- Andreassen, O.A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 156
- Issue
- 3
- Pages
- 450-455
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2755288
- OpenAlex
- W2004180312
- Cited by
- 102
- References
- 45
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 5 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 15
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Universitetet i Oslo
- Norges Forskningsråd (#167153/V50, #163070/V50, 167153)
- National Institute of Mental Health (K01MH072837)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- amygdala, go/no-go task, emotional salience, threat detection, stimulation frequency
- MeSH terms
- Adult, Amygdala, Decision Making, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Signal Detection, Psychological, Young Adult
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