Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats.
Abstract
Preclinical data support the long-term adverse effects on cognition, emotionality, and psychotic-like behaviors of adolescent exposure to natural and synthetic cannabinoids. To investigate whether the long-lasting adverse effects induced by cannabinoids in adolescence are influenced by early-life stress, female and male rats were subjected to 24-h maternal deprivation at postnatal day (PND) 9 and treated with tetrahydrocannabinol (THC) during adolescence (PND 35-45) according to our previously reported protocol. At adulthood, rats were tested in the novel object recognition, social interaction, and forced swim tests, to evaluate possible alterations in recognition memory, social behavior, and coping strategy. Moreover, cannabinoid CB1 receptor density and functionality, as well as NMDA and dopamine D1 and D2 receptor densities were measured through autoradiographic binding studies. In female maternally deprived rats, THC failed to impair recognition memory, counteracted aggressiveness induced by maternal deprivation, whereas no interaction was observed in the passive coping behavior. In males, the association of the two events increased passive coping response without affecting other behaviors. This behavioral picture was accompanied by gender-dependent and region-specific alterations in NMDA, D1 and D2 receptors. In conclusion, this study demonstrates that adolescent THC exposure might have different behavioral outcomes in animals previously exposed to early-life stress comp…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
24 h maternal deprivation on PND 9 did not affect male or female social exploration in rats.
“while 24 h MD on PND 9 did not affect male or female social exploration (Zamberletti et al., 2012).”
From Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood (2018) · cites this paper as Zamberletti et al., 2012
Early life stress is known to increase aggression in rodents.
“ELS is known to increase aggression in rodents (Veenema et al., 2006, 2007; Zamberletti et al., 2012; Yu et al., 2013; Kohl et al., 2015)”
From Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood (2018) · cites this paper as Zamberletti et al., 2012
Cites
Risk Taking and Novelty Seeking in Adolescence: Introduction to Part I
KELLEY, A. E., SCHOCHET, T., & LANDRY, C. F. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.003 · Cited by 325 · see citing works
Mateos, B., Borcel, E., Loriga, R., Luesu, W., Bini, V, Llorente, R., Castelli, M., & Viveros, M.-P. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110370503 · Cited by 108 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cannabis use during adolescent development: Susceptibility to psychiatric illness
Chadwick, B., Miller, M. L., & Hurd, Y. L. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00129 · Cited by 210 · see citing works
The Impact of Exposure to Cannabinoids in Adolescence: Insights From Animal Models
Rubino, T., & Parolaro, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.024 · Cited by 183 · see citing works
Self-citationZamberletti, E., Beggiato, S., Steardo, L., Prini, P., Antonelli, T., Ferraro, L., Rubino, T., & Parolaro, D. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.028 · Cited by 147 · see citing works
Self-citationEffects of early-life stress on cognitive function and hippocampal structure in female rodents.
Loi, M., Mossink, J. C. L., Meerhoff, G. F., Den Blaauwen, J. L., Lucassen, P. J., & Joëls, M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.024 · Cited by 109 · see citing works
Kentrop, J., Smid, C. R., Achterberg, E. J. M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00193 · Cited by 41 · see citing works
Prini, P., Penna, F., Sciuccati, E., Alberio, T., & Rubino, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102094 · Cited by 37 · see citing works
Self-citationDisentangling the lasting effects of adolescent cannabinoid exposure
Stringfield, S. J., & Torregrossa, M. M. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110067 · Cited by 32 · see citing works
- Authors
- Zamberletti, E., Prini, P., Speziali, S., Gabaglio, M., Solinas, M., Parolaro, D., & Rubino, T.
- Affiliations
- University of Insubria (IT)
- Corresponding author
- Parolaro, D.
- Rubino, T.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 204
- Pages
- 245-257
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2084070896
- Cited by
- 107
- References
- 2
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 10 · 2019: 3 · 2018: 16 · 2017: 9 · 2016: 9 · 2015: 8 · 2014: 2 · 2013: 7 · 2012: 5
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- maternal deprivation, early life stress, sex differences, CB1 receptor, NMDA receptor, dopamine D1 receptor, dopamine D2 receptor, recognition memory, social behavior, passive coping, aggression
- MeSH terms
- Animals, Behavior, Animal, Female, Male, Maternal Deprivation, Memory, Sex Factors, Social Behavior, Dronabinol, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
