The Impact of Exposure to Cannabinoids in Adolescence: Insights From Animal Models

Neuronal Oscillations in Cortical Networks

Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576 · see citing works

Dynamic mapping of human cortical development during childhood through early adulthood

Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604 · cited 1× · see citing works

Brain development during childhood and adolescence: a longitudinal MRI study

Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., Paus, T., Evans, A. C., & Rapoport, J. L. (1999) · Nature Neuroscience · doi:10.1038/13158 · Cited by 5,552 · see citing works

Abnormal neural oscillations and synchrony in schizophrenia

Uhlhaas, P. J., & Singer, W. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2774 · Cited by 2,120 · see citing works

Neurophysiological and Computational Principles of Cortical Rhythms in Cognition

Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939 · see citing works

In vivo evidence for post-adolescent brain maturation in frontal and striatal regions

Sowell, E. R., Thompson, P. M., Holmes, C. J., Jernigan, T. L., & Toga, A. W. (1999) · Nature Neuroscience · doi:10.1038/13154 · Cited by 1,439 · see citing works

Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction

Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409 · see citing works

Morphometric study of human cerebral cortex development

Huttenlocher, P. R. (1990) · Neuropsychologia · doi:10.1016/0028-3932(90)90031-i · Cited by 1,239 · see citing works

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030 · see citing works

Cannabis use and psychosis: A longitudinal population-based study

van Os, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf043 · Cited by 928 · see citing works

Synaptogenesis in the Prefrontal Cortex of Rhesus Monkeys

Bourgeois, J.-P., Goldman-Rakic, P. S., & Rakic, P. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.1.78 · Cited by 687 · see citing works

Mapping Changes in the Human Cortex throughout the Span of Life

Sowell, E. R., Thompson, P. M., & Toga, A. W. (2004) · The Neuroscientist · doi:10.1177/1073858404263960 · Cited by 572 · see citing works

Localizing Age-Related Changes in Brain Structure between Childhood and Adolescence Using Statistical Parametric Mapping

Sowell, E. R., Thompson, P. M., Holmes, C. J., Batth, R., Jernigan, T. L., & Toga, A. W. (1999) · NeuroImage · doi:10.1006/nimg.1999.0436 · Cited by 554 · see citing works

White matter development in adolescence: A DTI study

Asato, M. R., Terwilliger, R., Woo, J., & Luna, B. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp282 · Cited by 512 · see citing works

Amygdalo-cortical sprouting continues into early adulthood: implications for the development of normal and abnormal function during adolescence

Cunningham, M. G., Bhattacharyya, S., & Benes, F. M. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10376 · Cited by 474 · see citing works

A role for synaptic plasticity in the adolescent development of executive function

Selemon, L. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.7 · Cited by 439 · cited 1× · see citing works

Chronic Pubertal, but not Adult Chronic Cannabinoid Treatment Impairs Sensorimotor Gating, Recognition Memory, and the Performance in a Progressive Ratio Task in Adult Rats

Schneider, M., & Koch, M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300225 · Cited by 425 · see citing works

Growth of white matter in the adolescent brain: Myelin or axon?

Paus, T. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.002 · Cited by 424 · see citing works

Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia

Maynard, T. M., Sikich, L., Lieberman, J. A., & LaMantia, A.-S. (2001) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006887 · Cited by 383 · see citing works

The development of neural synchrony reflects late maturation and restructuring of functional networks in humans

Uhlhaas, P. J., Roux, F., Singer, W., Haenschel, C., Sireteanu, R., & Rodriguez, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900390106 · Cited by 356 · see citing works

Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the “Two hit hypothesis.”

Bayer, T. A., Falkai, P., & Maier, W. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00039-4 · Cited by 346 · see citing works

Chronic Δ9-Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in Adult Rats: Behavioral and Biochemical Correlates

Rubino, T., Vigano', D., Realini, N., Guidali, C., Braida, D., Capurro, V., Castiglioni, C., Cherubino, F., Romualdi, P., Candeletti, S., et al. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301664 · Cited by 345 · see citing works

The neurobiology of adolescence: Changes in brain architecture, functional dynamics, and behavioral tendencies

Sturman, D. A., & Moghaddam, B. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.003 · Cited by 341 · see citing works

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

Maccarrone, M., Guzmán, M., Mackie, K., Doherty, P., & Harkany, T. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3846 · Cited by 298 · see citing works

Adolescent Rats Find Repeated Δ9-THC Less Aversive Than Adult Rats but Display Greater Residual Cognitive Deficits and Changes in Hippocampal Protein Expression Following Exposure

Quinn, H. R., Matsumoto, I., Callaghan, P. D., Long, L. E., Arnold, J. C., Gunasekaran, N., Thompson, M. R., Dawson, B., Mallet, P. E., Kashem, M. A., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301475 · Cited by 293 · see citing works

Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats

O’Shea, M., Singh, M. E., McGregor, I. S., & Mallet, P. E. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104047277 · Cited by 292 · see citing works

Estradiol Acutely Suppresses Inhibition in the Hippocampus through a Sex-Specific Endocannabinoid and mGluR-Dependent Mechanism

Huang, G. Z., & Woolley, C. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.035 · Cited by 288 · see citing works

Role in Anxiety Behavior of the Endocannabinoid System in the Prefrontal Cortex

Rubino, T., Realini, N., Castiglioni, C., Guidali, C., Viganò, D., Marras, E., Petrosino, S., Perletti, G., Maccarrone, M., Marzo, V. D., et al. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm161 · Cited by 283 · see citing works

Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood

Rubino, T., Realini, N., Braida, D., Guidi, S., Capurro, V., Viganò, D., Guidali, C., Pinter, M., Sala, M., Bartesaghi, R., et al. (2009) · Hippocampus · doi:10.1002/hipo.20554 · Cited by 282 · see citing works

Age matters

McCutcheon, J. E., & Marinelli, M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06648.x · Cited by 279 · see citing works

GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia

González‐Burgos, G., Fish, K. N., & Lewis, D. A. (2011) · Neural Plasticity · doi:10.1155/2011/723184 · Cited by 244 · see citing works

Gene-Environment Interplay Between Cannabis and Psychosis

Henquet, C., Forti, M. D., Morrison, P., Kuepper, R., & Murray, R. M. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn108 · Cited by 241 · see citing works

The endocannabinoid system in anxiety, fear memory and habituation

Ruehle, S., Rey, A. A., Remmers, F., & Lutz, B. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408958 · Cited by 236 · see citing works

Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats

O’Shea, M., McGregor, I. S., & Mallet, P. E. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106065188 · Cited by 230 · see citing works

Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects

Ellgren, M., Artmann, A., Tkalych, O., Gupta, A., Hansen, H. S., Hansen, S. H., Devi, L. A., & Hurd, Y. L. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.06.009 · Cited by 228 · see citing works

Cell Type-Specific Development of NMDA Receptors in the Interneurons of Rat Prefrontal Cortex

Wang, H.-X., & Gao, W. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.20 · Cited by 198 · see citing works

Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex

Rubino, T., Prini, P., Piscitelli, F., Zamberletti, E., Trusel, M., Melis, M., Sagheddu, C., Ligresti, A., Tonini, R., Marzo, V. D., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.09.015 · Cited by 191 · see citing works

Development of the GABAergic System from Birth to Adolescence

Kilb, W. (2012) · The Neuroscientist · doi:10.1177/1073858411422114 · Cited by 190 · see citing works

CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex

Cass, D. K., Flores-Barrera, E., Thomases, D. R., Vital, W. F., Caballero, A. C., & Tseng, K. Y. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.14 · Cited by 181 · see citing works

Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients

Chong, V. Z., Thompson, M., Beltaifa, S., Webster, M. J., Law, A. J., & Weickert, C. S. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.12.474 · Cited by 177 · see citing works

The neurodevelopmental hypothesis of schizophrenia: a review of recent developments

McGrath, J. J., Feron, F. P., Burne, T. H. J., Mackay‐Sim, A., & Eyles, D. W. (2003) · Annals of Medicine · doi:10.1080/07853890310010005 · Cited by 176 · see citing works

Regional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated Δ9‐tetrahydrocannabinol exposure

Burston, J. J., Wiley, J. L., Craig, A. A., Selley, D. E., & Sim‐Selley, L. J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00870.x · Cited by 164 · see citing works

Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission.

Bambico, F. R., Nguyen, N.-T., Katz, N., & Gobbi, G. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.020 · Cited by 161 · see citing works

Adolescent brain development in normality and psychopathology

Luciana, M. M. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000643 · Cited by 157 · see citing works

The ontogeny of cannabinoid receptors in the brain of postnatal and aging rats

Belue, R. C., Howlett, A. C., Westlake, T. M., & Hutchings, D. E. (1995) · Neurotoxicology and Teratology · doi:10.1016/0892-0362(94)00053-g · Cited by 154 · see citing works

Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats

Zamberletti, E., Beggiato, S., Steardo, L., Prini, P., Antonelli, T., Ferraro, L., Rubino, T., & Parolaro, D. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.028 · Cited by 147 · see citing works

Postnatal development of dopamine D4-like receptors in rat forebrain regions: comparison with D2-like receptors

Tarazi, F. I., Tomasini, E. C., & Baldessarini, R. J. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00111-4 · Cited by 141 · see citing works

Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood

Fernández, J. M. B., Marín, S., Fernández, B., Marco, E. M., Rubio, M., Guaza, C., Ambrosio, E., & Viveros, M. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1550-7 · Cited by 137 · see citing works

The Depressive Phenotype Induced in Adult Female Rats by Adolescent Exposure to THC is Associated with Cognitive Impairment and Altered Neuroplasticity in the Prefrontal Cortex

Rubino, T., Realini, N., Braida, D., Alberio, T., Capurro, V., Viganò, D., Guidali, C., Sala, M., Fasano, M., & Parolaro, D. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9031-3 · Cited by 131 · see citing works

Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats

Realini, N., Viganò, D., Guidali, C., Zamberletti, E., Rubino, T., & Parolaro, D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.003 · Cited by 130 · see citing works

Postnatal Developmental Trajectories of Neural Circuits in the Primate Prefrontal Cortex: Identifying Sensitive Periods for Vulnerability to Schizophrenia

Hoftman, G. D., & Lewis, D. A. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr029 · Cited by 128 · see citing works

Estrogenic regulation of limbic cannabinoid receptor binding

Riebe, C. J. N., Hill, M. N., Lee, T. T. Y., Hillard, C. J., & Gorzalka, B. B. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.02.008 · Cited by 128 · see citing works

New understanding of adolescent brain development: relevance to transitional healthcare for young people with long term conditions

Colver, A. F., & Longwell, S. (2013) · Archives of Disease in Childhood · doi:10.1136/archdischild-2013-303945 · Cited by 123 · see citing works

Short- and Long-Term Cognitive Effects of Chronic Cannabinoids Administration in Late-Adolescence Rats

Abush, H., & Akirav, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031731 · Cited by 114 · see citing works

Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB ₁ cannabinoid receptors

Mateos, B., Borcel, E., Loriga, R., Luesu, W., Bini, V, Llorente, R., Castelli, M., & Viveros, M.-P. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110370503 · Cited by 108 · see citing works

Sex differences in the effects of Δ9-tetrahydrocannabinol on spatial learning in adolescent and adult rats

Cha, Y. M., Jones, K. H., Kuhn, C. M., Wilson, W. A., & Swartzwelder, S. H. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee7b7e · Cited by 108 · see citing works

Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats.

Zamberletti, E., Prini, P., Speziali, S., Gabaglio, M., Solinas, M., Parolaro, D., & Rubino, T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.038 · Cited by 107 · see citing works

Sexually Dimorphic Effects of Cannabinoid Compounds on Emotion and Cognition

Rubino, T., & Parolaro, D. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00064 · Cited by 106 · see citing works

Chronic Adolescent Exposure to Δ-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes

O’Tuathaigh, C. M. P., Hryniewiecka, M., Behan, Á. T., Tighe, O., Coughlan, C. A., Desbonnet, L., Cannon, M. D., Karayiorgou, M., Gogos, J. A., Cotter, D., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.100 · Cited by 103 · see citing works

Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia

Viganò, D., Guidali, C., Petrosino, S., Realini, N., Rubino, T., Marzo, V. D., & Parolaro, D. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009371 · Cited by 99 · see citing works

Endocannabinoids via CB 1 receptors act as neurogenic niche cues during cortical development

Díaz-Alonso, J., Guzmán, M., & Galve‐Roperh, I. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0385 · Cited by 94 · see citing works

Sex Differences in Δ9-Tetrahydrocannabinol Metabolism and In Vivo Pharmacology Following Acute and Repeated Dosing in Adolescent Rats

Wiley, J., & Burston, J. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.05.057 · Cited by 93 · see citing works

Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment

Wegener, N., & Koch, M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.081 · Cited by 90 · see citing works

Periadolescent Exposure to the NMDA Receptor Antagonist MK-801 Impairs the Functional Maturation of Local GABAergic Circuits in the Adult Prefrontal Cortex

Thomases, D. R., Cass, D. K., & Tseng, K. Y. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4147-12.2013 · Cited by 89 · see citing works

Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence

Long, L. E., Chesworth, R., Huang, X., McGregor, I. S., Arnold, J. C., & Karl, T. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001854 · Cited by 89 · see citing works

Sex‐dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour

Llorente‐Berzal, A., Fuentes, S., Gagliano, H., López‐Gallardo, M., Armario, A., Viveros, M., & Nadal, R. A. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00318.x · Cited by 88 · see citing works

Developing translational animal models for symptoms of schizophrenia or bipolar mania

Geyer, M. A. (2008) · Neurotoxicity Research · doi:10.1007/bf03033576 · Cited by 88 · see citing works

Long-term cognitive impairments induced by chronic cannabinoid exposure during adolescence in rats: a strain comparison

Renard, J., Krebs, M., Jay, T. M., & Pen, G. L. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2865-z · Cited by 81 · see citing works

The effect of Δ9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats

Malone, D. T., & TAYLOR, D. A. H. B. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.009 · Cited by 77 · see citing works

Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia

Gleason, K. A., Birnbaum, S. G., Shukla, A., & Ghose, S. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.122 · Cited by 77 · see citing works

The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesion

SCHNEIDER, M., & Koch, M. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.03.009 · Cited by 71 · see citing works

Temporal changes in N‐acylethanolamine content and metabolism throughout the peri‐adolescent period

Lee, T. T. ‐., Hill, M. N., Hillard, C. J., & Gorzalka, B. B. (2012) · Synapse · doi:10.1002/syn.21609 · Cited by 68 · see citing works

Effects of Pubertal Cannabinoid Administration on Attentional Set-Shifting and Dopaminergic Hyper-Responsivity in a Developmental Disruption Model of Schizophrenia

Gomes, F. V., Guimarães, F. S., & Grace, A. A. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu018 · Cited by 68 · see citing works

Development of Cannabinoid 1 Receptor Protein and Messenger RNA in Monkey Dorsolateral Prefrontal Cortex

Eggan, S. M., Mizoguchi, Y., Stoyak, S. R., & Lewis, D. A. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp179 · Cited by 64 · see citing works

Age at onset of psychotic disorder: Cannabis, BDNF Val66Met, and sex‐specific models of gene–environment interaction

Decoster, J., van Os, J., Kenis, G., Henquet, C., Peuskens, J., Binder, M. D., & van Winkel, R. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31174 · Cited by 64 · see citing works

Adolescent Cannabinoid Exposure Permanently Suppresses Cortical Oscillations in Adult Mice

Raver, S. M., Haughwout, S. P., & Keller, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.164 · Cited by 62 · see citing works

The Influence of Schizophrenia-Related Neuregulin-1 Polymorphisms on Sensorimotor Gating in Healthy Males

Roussos, P., Giakoumaki, S. G., Adamaki, E., & Bitsios, P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.009 · Cited by 61 · see citing works

Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes

O’Tuathaigh, C. M. P., Clarke, G. A., Walsh, J., Desbonnet, L., Petit, E., O’Leary, C., Tighe, O., Clarke, N. E., Karayiorgou, M., Gogos, J. A., et al. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001581 · Cited by 61 · see citing works

Neural processing of reward in adolescent rodents

Simon, N. W., & Moghaddam, B. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.11.001 · Cited by 59 · see citing works

Strain dependence of adolescent Cannabis influence on heroin reward and mesolimbic dopamine transmission in adult Lewis and Fischer 344 rats

Cadoni, C., Simola, N., Espa, E., Fenu, S., & Chiara, G. D. (2013) · Addiction Biology · doi:10.1111/adb.12085 · Cited by 57 · see citing works

Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory

Higuera‐Matas, A., Botreau, F., Miguéns, M., Olmo, N. D., Borcel, É., Pérez-Álvarez, L., Garcı́a-Lecumberri, C., & Ambrosio, E. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.06.013 · Cited by 56 · see citing works

Repeated Δ⁹-Tetrahydrocannabinol Exposure in Adolescent Monkeys: Persistent Effects Selective for Spatial Working Memory

Verrico, C. D., Gu, H., Peterson, M. L., Sampson, A. R., & Lewis, D. A. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13030335 · Cited by 56 · see citing works

Sex-specific disturbances of the glutamate/GABA balance in the hippocampus of adult rats subjected to adolescent cannabinoid exposure

Higuera‐Matas, A., Miguéns, M., Coria, S. M., Assis, M. A., Borcel, É., Olmo, N. D., & Ambrosio, E. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.028 · Cited by 52 · see citing works

Reading skill and structural brain development

Houston, S. M., Lebel, C. A., Katzir, T., Manis, F. R., Kan, E., Rodriguez, G., & Sowell, E. R. (2014) · Neuroreport · doi:10.1097/wnr.0000000000000121 · Cited by 52 · see citing works

Drugs of abuse and increased risk of psychosis development

Gururajan, A., Manning, E. E., Klug, M., & van den Buuse, M. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412455232 · Cited by 50 · see citing works

Sex-Dependent Psychoneuroendocrine Effects of THC and MDMA in an Animal Model of Adolescent Drug Consumption

Llorente‐Berzal, A., Puighermanal, E., Burokas, A., Ozaita, A., Maldonado, R. J., Marco, E. M., & Viveros, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078386 · Cited by 44 · see citing works

Comparison of Cannabinoid CB1Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK-9470

Verdurand, M., Nguyen, V., Stark, D., Zahra, D., Grégoire, M., Greguric, I. D., & Zavitsanou, K. (2011) · International Journal of Molecular Imaging · doi:10.1155/2011/548123 · Cited by 41 · see citing works

Chronic pubertal cannabinoid treatment as a behavioural model for aspects of schizophrenia: effects of the atypical antipsychotic quetiapine

Leweke, F. M., & Schneider, M. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000842 · Cited by 37 · see citing works

Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice

Spencer, J. R., Darbyshire, K. M. E., Boucher, A. A., Kashem, M. A., Long, L. E., McGregor, I. S., Karl, T., & Arnold, J. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00015 · Cited by 35 · see citing works

Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: Receptor mechanisms

Raver, S. M., & Keller, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.07.006 · Cited by 34 · see citing works

Chronic cannabinoid treatment during young adulthood induces sex-specific behavioural deficits in maternally separated rats

Klug, M., & van den Buuse, M. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.019 · Cited by 34 · see citing works

Central GABA mechanisms during postnatal development in the rat: Neurochemical characteristics

Hedner, T., Iversen, K., & Lundborg, P. G. (1984) · Journal of Neural Transmission · doi:10.1007/bf01255409 · Cited by 32 · see citing works

Juvenile cannabinoid treatment induces frontostriatal gliogenesis in Lewis rats

Bortolato, M., Bini, V., Frau, R., Devoto, P., Pardu, A., Fan, Y., & Solbrig, M. V. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.12.011 · Cited by 32 · see citing works

Repeated administration of a synthetic cannabinoid receptor agonist differentially affects cortical and accumbal neuronal morphology in adolescent and adult rats

Carvalho, A. F., Reyes, B. A. S., Ramalhosa, F., Sousa, N., & Bockstaele, E. J. V. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0914-6 · Cited by 32 · see citing works

An investigation into “two hit” effects of BDNF deficiency and young-adult cannabinoid receptor stimulation on prepulse inhibition regulation and memory in mice

Klug, M., & van den Buuse, M. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00149 · Cited by 25 · see citing works

Adolescent cannabinoid exposure attenuates adult female sexual motivation but does not alter adulthood CB1R expression or estrous cyclicity

Chadwick, B. J., Saylor, A. J., & López, H. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.07.006 · Cited by 19 · see citing works

Untitled work

Andersen (2000) · doi:10.1002/1098-2396(200008)37:2

Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood

Gobbi, G., Atkin, T., Zytynski, T., Wang, S., Askari, S., Boruff, J., Ware, M., Marmorstein, N., Cipriani, A., Dendukuri, N., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.4500 · Cited by 914 · see citing works

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

Ligresti, A., PETROCELLIS, L. D., & Marzo, V. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2016 · Cited by 482 · see citing works

The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development

Meyer, H. C., Lee, F. S., & Gee, D. G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.143 · Cited by 222 · see citing works

The Trouble with CBD Oil

Hazekamp, A. (2018) · Medical Cannabis and Cannabinoids · doi:10.1159/000489287 · Cited by 190 · see citing works

Association of Cannabis Use During Adolescence With Neurodevelopment

Albaugh, M. D., Ottino-Gonzalez, J., Sidwell, A., Lepage, C., Juliano, A., Owens, M. M., Chaarani, B., Spechler, P., Fontaine, N., Rioux, P., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.1258 · Cited by 176 · see citing works

Experience during adolescence shapes brain development: From synapses and networks to normal and pathological behavior

Dow-Edwards, D. L., MacMaster, F. P., Peterson, B. S., Niesink, R. J. M., Andersen, S. L., & Braams, B. R. (2019) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2019.106834 · Cited by 146 · see citing works

Cannabinoid Receptors: An Update on Cell Signaling, Pathophysiological Roles and Therapeutic Opportunities in Neurological, Cardiovascular, and Inflammatory Diseases

Haspula, D., & Clark, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207693 · Cited by 137 · see citing works

Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons

Miller, M. L., Chadwick, B., Dickstein, D. L., Purushothaman, I., Egervari, G., Rahman, T., Tessereau, C., Hof, P. R., Roussos, P., Shen, L., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0243-x · Cited by 134 · see citing works

High times for cannabis: Epigenetic imprint and its legacy on brain and behavior

Szutorisz, H., & Hurd, Y. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.011 · Cited by 129 · see citing works

Cannabidiol as a suggested candidate for treatment of autism spectrum disorder

Poleg, S., Golubchik, P., Offen, D., & Weizman, A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.030 · Cited by 123 · see citing works

Endocannabinoid Signaling in the Control of Social Behavior

Don, W., Allsop, S. A., Tye, K. M., & Piomelli, D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.005 · Cited by 111 · see citing works

Are adolescents more vulnerable to the harmful effects of cannabis than adults? A placebo-controlled study in human males

Mokrysz, C., Freeman, T. P., Korkki, S. M., Griffiths, K., & Curran, H. V. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.225 · Cited by 107 · see citing works

Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z

Febo, M., Blum, K., Badgaiyan, R. D., Pérez, P. D., Colón-Pérez, L. M., Thanos, P. K., Ferris, C. F., Kulkarni, P. P., Giordano, J., Baron, D. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174774 · Cited by 105 · see citing works

Cannabidiol as a Potential New Type of an Antipsychotic. A Critical Review of the Evidence

Rohleder, C., Müller, J. K., Lange, B., & Leweke, F. M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00422 · Cited by 94 · see citing works

Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Male Mice

Torrens, A., Vozella, V., Huff, H., McNeil, B., Ahmed, F., Ghidini, A., Mahler, S. V., Huestis, M. A., Das, A., & Piomelli, D. (2020) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.265892 · Cited by 88 · see citing works

Adolescent cannabis use, change in neurocognitive function, and high-school graduation: A longitudinal study from early adolescence to young adulthood

Castellanos-Ryan, N., Pingault, J.-B., Parent, S., Vitaro, F., Tremblay, R. E., & Séguin, J. R. (2017) · Development and Psychopathology · doi:10.1017/s0954579416001280 · Cited by 111 · see citing works

Cannabis: A Treasure Trove or Pandora's Box?

Solymosi, K., & Köfalvi, A. (2016) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557516666161004162133 · Cited by 88 · see citing works

Consensus paper of the WFSBP task force on cannabis, cannabinoids and psychosis

D’Souza, D. C., Forti, M. D., Ganesh, S., George, T. P., Hall, W., Hjorthøj, C. R., Howes, O. D., Keshavan, M. S., Murray, R. M., Nguyen, T. B., et al. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2038797 · Cited by 87 · see citing works

Is the Adolescent Brain at Greater Vulnerability to the Effects of Cannabis? A Narrative Review of the Evidence

Blest‐Hopley, G., Colizzi, M., Giampietro, V., & Bhattacharyya, S. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00859 · Cited by 85 · see citing works

Cannabis and development of dual diagnoses: A literature review

Hanna, R. C., Perez, J. M., & Ghose, S. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1213273 · Cited by 86 · see citing works

Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure

de Salas-Quiroga, A., García-Rincón, D., Gómez-Domínguez, D., Valero, M., Simón-Sánchez, S., Paraíso‐Luna, J., Aguareles, J., Pujadas, M., Muguruza, C., Callado, L. F., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0621-3 · Cited by 84 · see citing works

Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice

Busquets-García, A., Gómez, E. S., Redon, B., Mackenbach, Y., Vallée, M., Chaouloff, F., Varilh, M., Ferreira, G., Piazza, P.-V., & Marsicano, G. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.4 · Cited by 78 · see citing works

Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway

Ibarra‐Lecue, I., Mollinedo-Gajate, I., Meana, J. J., Callado, L. F., Dı́ez-Alarcia, R., & Urigüen, L. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0076-y · Cited by 77 · see citing works

Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex

Dı́ez-Alarcia, R., Ibarra‐Lecue, I., López‐Cardona, A. P., Meana, J. J., Gutiérrez‐Adán, A., Callado, L. F., Agirregoitia, E., & Urigüen, L. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00415 · Cited by 73 · see citing works

The Psychiatric Consequences of Cannabinoids

Aquino, J. P. D., Sherif, M. A., Radhakrishnan, R., Cahill, J. D., Ranganathan, M., & D’Souza, D. C. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.03.013 · Cited by 66 · see citing works

Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthoodPreprint

Alteba, S., Korem, N., & Akirav, I. (2016) · Learning & Memory · doi:10.1101/lm.041608.116 · Cited by 63 · see citing works

Advancing the science on cannabis concentrates and behavioural health

Bidwell, L. C., Martin‐Willett, R., & Karoly, H. C. (2021) · Drug and Alcohol Review · doi:10.1111/dar.13281 · Cited by 60 · see citing works

The Behavioral Sequelae of Cannabis Use in Healthy People: A Systematic Review

Sorkhou, M., Bedder, R. H., & George, T. P. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.630247 · Cited by 61 · see citing works

Exposure to cannabinoids can lead to persistent cognitive and psychiatric disorders

Krebs, M., Kébir, O., & Jay, T. M. (2019) · European Journal of Pain · doi:10.1002/ejp.1377 · Cited by 60 · see citing works

Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder

D’Souza, D. C., Radhakrishnan, R., Naganawa, M., Ganesh, S., Nabulsi, N., Najafzadeh, S., Ropchan, J., Ranganathan, M., Cortes-Briones, J., Huang, Y., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00891-4 · Cited by 55 · see citing works

Pharmacokinetic and pharmacodynamic properties of aerosolized (“vaped”) THC in adolescent male and female rats

Ruiz, C. M., Torrens, A., Lallai, V., Castillo, E., Manca, L., Martinez, M. X., Justeson, D. N., Fowler, C. D., Piomelli, D., & Mahler, S. V. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05976-8 · Cited by 56 · see citing works

Adolescent Δ9-Tetrahydrocannabinol Exposure and Astrocyte-Specific Genetic Vulnerability Converge on Nuclear Factor-κB–Cyclooxygenase-2 Signaling to Impair Memory in Adulthood

Jouroukhin, Y., Zhu, X., Shevelkin, A. V., Hasegawa, Y., Abazyan, B. N., Saito, A., Pevsner, J., Kamiya, A., & Pletnikov, M. V. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.07.024 · Cited by 54 · see citing works

Cannabis use among youth in the United States, 2004–2016: Faster rate of increase among youth with depression

Weinberger, A. H., Zhu, J., Lee, J., Anastasiou, E., Copeland, J., & Goodwin, R. D. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.107894 · Cited by 55 · see citing works

Clinical characteristics of synthetic cannabinoid-induced psychosis in relation to schizophrenia: a single-center cross-sectional analysis of concurrently hospitalized patients

Altıntaş, M., İnanç, L., Oruç, G. A., Arpacıoğlu, S., & Güleç, H. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s107622 · Cited by 50 · see citing works

Exploring Cannabis and Alcohol Co-Use in Adolescents: A Narrative Review of the Evidence

Karoly, H. C., Ross, J. M., Ellingson, J. M., & Feldstein Ewing, S. W. (2020) · Journal of Dual Diagnosis · doi:10.1080/15504263.2019.1660020 · Cited by 46 · see citing works

Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine

Scherma, M., Qvist, J. S., Asok, A., Huang, S. C., Masia, P., Deidda, M. L., Wei, Y. B., Soni, R. K., Fratta, W., Fadda, P., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920866117 · Cited by 47 · see citing works

Current state of evidence of cannabis utilization for treatment of autism spectrum disorders

Agarwal, R., Burke, S. L., & Maddux, M. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2259-4 · Cited by 46 · see citing works

Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology

Rodrigues, R. S., Lourenço, D. M., Paulo, S. L., Mateus, J. M., Ferreira, M. F., Mouro, F. M., Moreira, J. B., Ribeiro, F. F., Sebastião, A. M., & Xapelli, S. (2019) · Molecules · doi:10.3390/molecules24071350 · Cited by 45 · see citing works

Intravenous self-administration of delta-9-THC in adolescent rats produces long-lasting alterations in behavior and receptor protein expression

Stringfield, S. J., & Torregrossa, M. M. (2021) · Psychopharmacology · doi:10.1007/s00213-020-05684-9 · Cited by 41 · see citing works

Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood

Lichenstein, S. D., Musselman, S. C., Shaw, D. S., Sitnick, S. L., & Forbes, E. E. (2017) · Addiction · doi:10.1111/add.13882 · Cited by 43 · see citing works

The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity

Struik, D., Sanna, F., & Fattore, L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00249 · Cited by 42 · see citing works

Effects of cannabis exposure in the prenatal and adolescent periods: Preclinical and clinical studies in both sexes

Tirado-Muñoz, J., López-Rodríguez, A. B., Fonseca, F., Farré, M., Torrens, M., & Viveros, M. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100841 · Cited by 42 · see citing works

Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and Adulthood

Borsoï, M., Manduca, A., Bara, A., Lassalle, O., Pélissier‐Alicot, A., & Manzoni, O. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00023 · Cited by 39 · see citing works

Adolescence versus adulthood: differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse

Corongiu, S., Dessì, C., & Cadoni, C. (2020) · Addiction Biology · doi:10.1111/adb.12721 · Cited by 36 · see citing works

Δ 9 -Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adult

Leishman, E., Murphy, M., Mackie, K., & Bradshaw, H. B. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.02.001 · Cited by 42 · see citing works

Frequent Low-Dose Δ9-Tetrahydrocannabinol in Adolescence Disrupts Microglia Homeostasis and Disables Responses to Microbial Infection and Social Stress in Young Adulthood

Lee, H.-L., Jung, K.-M., Fotio, Y., Squire, E., Palese, F., Lin, L., Torrens, A., Ahmed, F., Mabou Tagne, A., Ramirez, J., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.04.017 · Cited by 38 · see citing works

Uso da Cannabis medicinal e autismo

Lima, M. C. M., Valênça, M. M., Machado, C. E., Pereira, M. E. D. M., & Brant, P. K. (2020) · Jornal Memorial da Medicina · doi:10.37085/jmmv2.n1.2020.pp.5-14 · Cited by 37 · see citing works

Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence

Rodrigues, R. J., Marques, J. M., & Köfalvi, A. (2024) · Cells · doi:10.3390/cells13221875 · Cited by 37 · see citing works

Effects of Marijuana Use on Brain Structure and Function

Brumback, T., Castro, N., Jacobus, J., & Tapert, S. F. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.06.004 · Cited by 38 · see citing works

New vistas on cannabis use disorder

Melis, M., Frau, R., Kalivas, P. W., Spencer, S. M., Chioma, V. C., Zamberletti, E., Rubino, T., & Parolaro, D. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.033 · Cited by 38 · see citing works

Chronic Δ9-THC Exposure Differently Affects Histone Modifications in the Adolescent and Adult Rat Brain

Prini, P., Penna, F., Sciuccati, E., Alberio, T., & Rubino, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102094 · Cited by 37 · see citing works

Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats

Schoch, H., Huerta, M. Y., Ruiz, C. M., Farrell, M. R., Jung, K., Huang, J. J., Campbell, R. R., Piomelli, D., & Mahler, S. V. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4749-8 · Cited by 36 · see citing works

Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood

Saravia, R., Ten-Blanco, M., Julià‐Hernández, M., Gagliano, H., Andero, R., Armario, A., Maldonado, R. J., & Berrendero, F. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.016 · Cited by 37 · see citing works

Escalating low‐dose Δ 9 ‐tetrahydrocannabinol exposure during adolescence induces differential behavioral and neurochemical effects in male and female adult rats

Poulia, N., Delis, F., Brakatselos, C., Lekkas, P., Kokras, N., Dalla, C., & Antoniou, K. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14598 · Cited by 34 · see citing works

A Systematic Review of Human Neuroimaging Evidence of Memory-Related Functional Alterations Associated with Cannabis Use Complemented with Preclinical and Human Evidence of Memory Performance Alterations

Blest-Hopley, G., Giampietro, V., & Bhattacharyya, S. (2020) · Brain Science · doi:10.3390/brainsci10020102 · Cited by 27 · see citing works

Long-Term Consequences of Adolescent Exposure to THC-Rich/CBD-Poor and CBD-Rich/THC-Poor Combinations: A Comparison with Pure THC Treatment in Female Rats

Gabaglio, M., Zamberletti, E., Manenti, C., Parolaro, D., & Rubino, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168899 · Cited by 34 · see citing works

Familial factors may not explain the effect of moderate‐to‐heavy cannabis use on cognitive functioning in adolescents: a sibling‐comparison study

Ellingson, J. M., Ross, J. M., Winiger, E. A., Stallings, M. C., Corley, R. P., Friedman, N. P., Hewitt, J. K., Tapert, S. F., Brown, S. A., Wall, T. L., et al. (2020) · Addiction · doi:10.1111/add.15207 · Cited by 32 · see citing works

Adolescent alcohol and cannabis use in Iceland 1995–2015

Arnarsson, Á. M., Kristofersson, G. K., & Bjarnason, Þ. (2017) · Drug and Alcohol Review · doi:10.1111/dar.12587 · Cited by 33 · see citing works

Emerging Mechanisms Underlying Dynamics of GABAergic Synapses

Maffei, A., Charrier, C., Caiati, M. D., Barberis, A., Mahadevan, V., Woodin, M. A., & Tyagarajan, S. K. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1824-17.2017 · Cited by 33 · see citing works

Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling

Cuccurazzu, B., Zamberletti, E., Nazzaro, C., Prini, P., Trusel, M., Grilli, M., Parolaro, D., Tonini, R., & Rubino, T. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy057 · Cited by 32 · see citing works

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism

Mouro, F. M., Köfalvi, A., André, L., Baqi, Y., Müller, C. E., Ribeiro, J. A., & Sebastião, A. M. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.003 · Cited by 31 · see citing works

Cannabis Use, Anxiety, and Perceptions of Risk among Canadian Undergraduates: The Moderating Role of Gender

Hellemans, K. G. C., Wilcox, J., Nino, J. N., Young, M. M., & McQuaid, R. J. (2019) · The Canadian Journal of Addiction · doi:10.1097/cxa.0000000000000059 · Cited by 31 · see citing works

Neurobiological mechanisms underlying cannabis-induced memory impairment

Prini, P., Zamberletti, E., Manenti, C., Gabaglio, M., Parolaro, D., & Rubino, T. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.02.002 · Cited by 31 · see citing works

Δ9-Tetrahydrocannabinol During Adolescence Attenuates Disruption of Dopamine Function Induced in Rats by Maternal Immune Activation

Lecca, S., Luchicchi, A., Scherma, M., Fadda, P., Muntoni, A., & Pistis, M. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00202 · Cited by 28 · see citing works

Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

Berthoux, C., Hamieh, A. M., Rogliardo, A., Doucet, E. L., Coudert, C., Ango, F., Grychowska, K., Chaumont‐Dubel, S., Zajdel, P., Maldonado, R. J., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201910605 · Cited by 29 · see citing works

Dos(e)Age: Role of Dose and Age in the Long-Term Effect of Cannabinoids on Cognition

Zamberletti, E., & Rubino, T. (2022) · Molecules · doi:10.3390/molecules27041411 · Cited by 30 · see citing works

Associations between adolescent cannabis use and brain structure in psychosis

Abush, H., Ghose, S., Enkevort, E. A. V., Clementz, B. A., Pearlson, G. D., Sweeney, J. A., Keshavan, M. S., Tamminga, C. A., & Ivleva, E. I. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.03.008 · Cited by 27 · see citing works

l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry

Felice, M. D., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J. G., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1050-20.2020 · Cited by 26 · see citing works

The CannTeen study: verbal episodic memory, spatial working memory, and response inhibition in adolescent and adult cannabis users and age-matched controls

Lawn, W., Fernandez‐Vinson, N., Mokrysz, C., Hogg, G., Lees, R., Trinci, K., Petrilli, K., Borissova, A., Ofori, S., Waters, S., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06143-3 · Cited by 28 · see citing works

Comparative Pharmacokinetics of Δ 9 -Tetrahydrocannabinol in Adolescent and Adult Male and Female Rats

Torrens, A., Roy, P., Lin, L., Vu, C., Grimes, D., Inshishian, V. C., Montesinos, J. S., Ahmed, F., Mahler, S. V., Huestis, M. A., et al. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2021.0205 · Cited by 25 · see citing works

Exposure to cannabinoid agonist WIN 55,212-2 during early adolescence increases alcohol preference and anxiety in CD1 mice

Frontera, J. L., Pini, V. M. G., Messore, F., & Brusco, A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.05.018 · Cited by 24 · see citing works

Acute effects of cannabis on speech illusions and psychotic-like symptoms: two studies testing the moderating effects of cannabidiol and adolescence

Mokrysz, C., Shaban, N. D. C., Freeman, T. P., Lawn, W., Pope, R. A., Hindocha, C., Freeman, A. M., Wall, M. B., Bloomfield, M., Morgan, C. J. A., et al. (2020) · Psychological Medicine · doi:10.1017/s0033291720001038 · Cited by 24 · see citing works

Δ 9-Tetrahydrocannabinol During Adolescence Reprograms the Nucleus Accumbens Transcriptome, Affecting Reward Processing, Impulsivity, and Specific Aspects of Cocaine Addiction-Like Behavior in a Sex-Dependent Manner

Orihuel, J., Capellán, R., Roura-Martínez, D., Ucha, M., Ambrosio, E., & Higuera-Matas, A. (2021) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab058 · Cited by 23 · see citing works

This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence

Kwan, L. Y., Eaton, D. L., Andersen, S. L., Dow-Edwards, D. L., Levin, E. D., Talpos, J. C., Vorhees, C. V., & Li, A. A. (2020) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2020.106916 · Cited by 22 · see citing works

Inhibition of Fatty Acid Amide Hydrolase (FAAH) During Adolescence and Exposure to Early Life Stress may Exacerbate Depression-like Behaviors in Male and Female Rats

Alteba, S., Portugalov, A., Hillard, C. J., & Akirav, I. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.022 · Cited by 22 · see citing works

Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice

Iemolo, A., Montilla‐Perez, P., Nguyen, J. D., Risbrough, V. B., Taffe, M. A., & Telese, F. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108495 · Cited by 18 · see citing works

Cannabinoid CB1 receptor-sensitive neurodevelopmental processes and trajectories

Tseng, K. Y., & Molla, H. M. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03057-2 · Cited by 19 · see citing works

Nasal Accumulation and Metabolism of Δ9-Tetrahydrocannabinol Following Aerosol (‘Vaping’) Administration in Adolescent Rats

Torrens, A., Ruiz, C., Martinez, M. X., Tagne, A. M., Roy, P., Grimes, D., Ahmed, F., Lallai, V., Inshishian, V., Bautista, M., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106600 · Cited by 14 · see citing works

Marijuana and Madness: Associations Between Cannabinoids and Psychosis

Ranganathan, M., Skosnik, P. D., & D’Souza, D. C. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.007 · Cited by 18 · see citing works

Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective

Santoso, A. D., & Ridder, D. J. M. K. D. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2021.0237 · Cited by 18 · see citing works

Cortical thickness, cortical surface area and subcortical volumes in schizophrenia and bipolar disorder patients with cannabis use

Hartberg, C. B., Lange, E. H., Lagerberg, T. V., Haukvik, U. K., Andreassen, O. A., Melle, I. S., & Agartz, I. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.11.019 · Cited by 18 · see citing works

Alterations in rat prefrontal cortex kynurenic acid levels are involved in the enduring cognitive dysfunctions induced by tetrahydrocannabinol exposure during the adolescence

Beggiato, S., Ieraci, A., Zuccarini, M., Iorio, P. D., Schwarcz, R. M., & Ferraro, L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.996406 · Cited by 17 · see citing works

Multiple Cerebral Infarcts in a Young Patient Associated With Marijuana Use

Volpon, L. C., Sousa, C. L. M. D. M., Moreira, S. K. K., Teixeira, S. R., & Carlotti, A. P. D. C. P. (2017) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000326 · Cited by 17 · see citing works

Adolescent cannabinoid exposure interacts with other risk factors in schizophrenia: A review of the evidence from animal models

Dunn, A. L., Michie, P. T., Hodgson, D. M., & Harms, L. R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.028 · Cited by 15 · see citing works

Adolescence effortful control as a mediator between family ecology and problematic substance use in early adulthood: A 16-year prospective study

Mun, C. J., Dishion, T. J., Tein, J., & Otten, R. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001742 · Cited by 17 · see citing works

Impact of Endocannabinoid System Manipulation on Neurodevelopmental Processes Relevant to Schizophrenia

Zamberletti, E., & Rubino, T. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.06.013 · Cited by 17 · see citing works

Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Cinquina, V., Keimpema, E., Pollak, D. D., & Harkany, T. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13320 · Cited by 15 · see citing works

Sex Differences in Response-Contingent Cannabis Vapor Administration During Adolescence Mediate Enduring Effects on Behavioral Flexibility and Prefrontal Microglia Activation in Rats

Freels, T. G., Westbrook, S. R., Zamberletti, E., Kuyat, J. R., Wright, H. R., Malena, A. N., Melville, M. W., Brown, A. M., Glodosky, N. C., Ginder, D. E., et al. (2024) · Cannabis and Cannabinoid Research · doi:10.1089/can.2023.0014 · Cited by 18 · see citing works

The cannabidiol conundrum: potential benefits and risks of cannabidiol products for children

Singer, L., Tokish, H., Park, F., Campisi, C., & Milanaik, R. L. (2019) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000861 · Cited by 16 · see citing works

Developmental differences in the effects of CB1/2R agonist WIN55212-2 on extinction of learned fear

Bisby, M. A., Richardson, R., & Baker, K. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109834 · Cited by 15 · see citing works

Longitudinal Alterations in Prefrontal Resting Brain Connectivity in Non-Treatment-Seeking Young Adults With Cannabis Use Disorder

Camchong, J., Collins, P. F., Becker, M. P., Lim, K. O., & Luciana, M. M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00514 · Cited by 14 · see citing works

Representation-mediated Aversion as a Model to Study Psychotic-like States in Mice

Busquets-García, A., Gómez, E. S., Ferreira, G., & Marsicano, G. (2017) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2358 · Cited by 14 · see citing works

Disrupting the endocannabinoid system in early adolescence negatively impacts sociability

Cossio, D. M., Stadler, H., Michas, Z., Johnston, C. J., & López, H. H. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172832 · Cited by 13 · see citing works

Exposure to the cannabinoid agonist WIN 55, 212–2 in adolescent rats causes sleep alterations that persist until adulthood

Macías-Triana, L., Romero-Cordero, K., Tatum-Kuri, A., Vera-Barrón, A., Millán‐Aldaco, D., Arankowsky‐Sandoval, G., Piomelli, D., & Murillo‐Rodríguez, E. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172911 · Cited by 13 · see citing works

THC exposure during adolescence does not modify nicotine reinforcing effects and relapse in adult male mice

Flores, Á., Maldonado, R. J., & Berrendero, F. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05416-8 · Cited by 13 · see citing works

Adolescent exposure to the Spice/K2 cannabinoid JWH-018 impairs sensorimotor gating and alters cortical perineuronal nets in a sex-dependent manner

Izquierdo-Luengo, C., Ten-Blanco, M., Ponce-Renilla, M., Perezzan, R., Pereda-Pérez, I., & Berrendero, F. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02469-4 · Cited by 12 · see citing works

Rapamycin prevents the long‐term impairing effects of adolescence Δ‐9‐tetrahydrocannabinol on memory and plasticity in male rats

Sabran‐Cohen, T., Bright, U., Zer‐Aviv, T. M., & Akirav, I. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15425 · Cited by 12 · see citing works

"Pro-Dopamine Regulation (KB220Z™)” as a Long-Term Therapeutic Modality to Overcome Reduced Resting State Dopamine Tone in Opiate /Opioid Epidemic in America

Blum, K., Marcelo, F., Dushaj, K., Fried, L., & Badgaiyan, R. D. (2016) · Journal of Systems and Integrative Neuroscience · doi:10.15761/jsin.1000129 · Cited by 12 · see citing works

Cognitive risk factors for alcohol and substance addictions

Castellanos-Ryan, N., & Conrod, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815298-0.00007-1 · Cited by 8 · see citing works

Cannabis et neurodéveloppement

Krebs, M., Demars, F., Frajerman, A., Kébir, O., & Jay, T. M. (2020) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2020.04.002 · Cited by 12 · see citing works

Cannabis abuse in adolescence and the risk of psychosis: A brief review of the preclinical evidence

Rubino, T., & Parolaro, D. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.07.020 · Cited by 57 · see citing works

Adolescent exposure to cannabis as a risk factor for psychiatric disorders

Rubino, T., Zamberletti, E., & Parolaro, D. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111405362 · Cited by 153 · see citing works

Susceptibility to Psychiatric Diseases After Cannabis Abuse in Adolescence: Animal Models

Rubino, T., & Parolaro, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_9 · Cited by 1 · see citing works

Adolescent cannabis use and psychosis: epidemiology and neurodevelopmental models

Malone, D. T., Hill, M. N., & Rubino, T. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00721.x · Cited by 237 · see citing works

The neural basis for the acute effects of cannabis on learning and psychosis

Bhattacharyya, S., & McGuire, P. K. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511706080.015 · Cited by 4 · see citing works